Insights from biochemical reconstitution into the architecture of human kinetochores View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-08-31

AUTHORS

John R. Weir, Alex C. Faesen, Kerstin Klare, Arsen Petrovic, Federica Basilico, Josef Fischböck, Satyakrishna Pentakota, Jenny Keller, Marion E. Pesenti, Dongqing Pan, Doro Vogt, Sabine Wohlgemuth, Franz Herzog, Andrea Musacchio

ABSTRACT

Biochemical reconstitution of a synthetic human kinetochore with 21 protein subunits and centromeric nucleosomal DNA unveils fundamental principles of kinetochore organization and function.

PAGES

249-253

References to SciGraph publications

  • 2004-07. Structural determinants for generating centromeric chromatin in NATURE
  • 2009-04-12. Enzymatic assembly of DNA molecules up to several hundred kilobases in NATURE METHODS
  • 2010-11-24. Tension directly stabilizes reconstituted kinetochore-microtubule attachments in NATURE
  • 2011-08-28. In vitro centromere and kinetochore assembly on defined chromatin templates in NATURE
  • 2006-12-31. The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-09-20. A cell-free system for functional centromere and kinetochore assembly in NATURE PROTOCOLS
  • 2015-09-08. A quantitative description of Ndc80 complex linkage to human kinetochores in NATURE COMMUNICATIONS
  • 2009-06-21. Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N in NATURE CELL BIOLOGY
  • 2012-12-21. Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-04-16. The human CENP-A centromeric nucleosome-associated complex in NATURE CELL BIOLOGY
  • 2012-08-12. The structure of purified kinetochores reveals multiple microtubule-attachment sites in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2014-10-10. Signalling dynamics in the spindle checkpoint response in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2012-05-06. CENP-T proteins are conserved centromere receptors of the Ndc80 complex in NATURE CELL BIOLOGY
  • 2012-04-24. Erratum to: BTI-Tnao38, a new cell line derived from Trichoplusia ni, is permissive for AcMNPV infection and produces high levels of recombinant proteins in BMC BIOTECHNOLOGY
  • 2006-04-16. The CENP-H–I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature19333

    DOI

    http://dx.doi.org/10.1038/nature19333

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011203668

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27580032


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