Human gut microbes impact host serum metabolome and insulin sensitivity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07-13

AUTHORS

Helle Krogh Pedersen, Valborg Gudmundsdottir, Henrik Bjørn Nielsen, Tuulia Hyotylainen, Trine Nielsen, Benjamin A. H. Jensen, Kristoffer Forslund, Falk Hildebrand, Edi Prifti, Gwen Falony, Emmanuelle Le Chatelier, Florence Levenez, Joel Doré, Ismo Mattila, Damian R. Plichta, Päivi Pöhö, Lars I. Hellgren, Manimozhiyan Arumugam, Shinichi Sunagawa, Sara Vieira-Silva, Torben Jørgensen, Jacob Bak Holm, Kajetan Trošt, MetaHIT Consortium, Karsten Kristiansen, Susanne Brix, Jeroen Raes, Jun Wang, Torben Hansen, Peer Bork, Søren Brunak, Matej Oresic, S. Dusko Ehrlich, Oluf Pedersen

ABSTRACT

Increased potential for branched-chain amino acid and lipopolysaccharide biosynthesis in the gut microbiome of insulin-resistant individuals suggests that changes in the serum metabolome induced by dysbiosis, and driven by only a handful of species, contribute to the development of diabetes.

PAGES

376-381

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  • Journal

    TITLE

    Nature

    ISSUE

    7612

    VOLUME

    535

    Author Affiliations

  • Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, DK-2800, Kongens Lyngby, Denmark
  • VTT Technical Research Centre of Finland, FI-02044, Espoo, Finland
  • The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark
  • Department of Biology, Laboratory of Genomics and Molecular Biomedicine, University of Copenhagen, DK-2100, Copenhagen, Denmark
  • European Molecular Biology Laboratory, 69117, Heidelberg, Germany
  • Center for the Biology of Disease, VIB, 3000, Leuven, Belgium
  • Institute of Cardiometabolism and Nutrition (ICAN), 75013, Paris, France
  • Department of Microbiology and Immunology, Rega Institute, 3000, KU Leuven, Leuven, Belgium
  • MGP MetaGénoPolis, INRA, Université Paris-Saclay, 78350, Jouy en Josas, France
  • Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France
  • Steno Diabetes Center, DK-2820, Gentofte, Denmark
  • Faculty of Pharmacy, University of Helsinki, FI-00014, Helsinki, Finland
  • Institute of Microbiology, CH-8092, ETH Zurich, Zurich, Switzerland
  • Research Centre for Prevention and Health, Centre for Health, Capital region, Glostrup Hospital, DK-2600, Glostrup, Denmark
  • BGI-Shenzhen, 518083, Shenzhen, China
  • Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong
  • Faculty of Health Sciences, University of Southern Denmark, DK-5000, Odense, Denmark
  • Department of Bioinformatics, University of Wuerzburg, D-97074, Würzburg, Germany
  • Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark
  • King’s College London, Centre for Host–Microbiome Interactions, Dental Institute Central Office, Guy’s Hospital, SE1 9RT, London, UK
  • Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen, Denmark
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature18646

    DOI

    http://dx.doi.org/10.1038/nature18646

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017924056

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27409811


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