Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06

AUTHORS

Rachel J. Perry, Liang Peng, Natasha A. Barry, Gary W. Cline, Dongyan Zhang, Rebecca L. Cardone, Kitt Falk Petersen, Richard G. Kibbey, Andrew L. Goodman, Gerald I. Shulman

ABSTRACT

Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity. More... »

PAGES

213

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature18309

DOI

http://dx.doi.org/10.1038/nature18309

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044560114

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27279214


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acetates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diet, High-Fat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Microbiome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ghrelin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperphagia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Secreting Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolic Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Parasympathetic Nervous System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perry", 
        "givenName": "Rachel J.", 
        "id": "sg:person.01067272153.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067272153.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peng", 
        "givenName": "Liang", 
        "id": "sg:person.01027240611.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027240611.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06510, USA", 
            "Microbial Sciences Institute, Yale University School of Medicine, New Haven, Connecticut 06516, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barry", 
        "givenName": "Natasha A.", 
        "id": "sg:person.0734412432.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734412432.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cline", 
        "givenName": "Gary W.", 
        "id": "sg:person.015643466277.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015643466277.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06519, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Dongyan", 
        "id": "sg:person.016322134257.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016322134257.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cardone", 
        "givenName": "Rebecca L.", 
        "id": "sg:person.01265577013.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265577013.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA", 
            "Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen 2200, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petersen", 
        "givenName": "Kitt Falk", 
        "id": "sg:person.014300404317.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014300404317.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA", 
            "Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kibbey", 
        "givenName": "Richard G.", 
        "id": "sg:person.0577162774.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577162774.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06510, USA", 
            "Microbial Sciences Institute, Yale University School of Medicine, New Haven, Connecticut 06516, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goodman", 
        "givenName": "Andrew L.", 
        "id": "sg:person.01325760611.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325760611.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA", 
            "Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06519, USA", 
            "Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen 2200, Denmark", 
            "Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shulman", 
        "givenName": "Gerald I.", 
        "id": "sg:person.01340446106.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340446106.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/gut.2010.215665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001977399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(79)90028-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003212869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(79)90028-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003212869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00203-015-1089-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006972020", 
          "https://doi.org/10.1007/s00203-015-1089-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013383274", 
          "https://doi.org/10.1007/s001250051322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250051322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013383274", 
          "https://doi.org/10.1007/s001250051322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013830289", 
          "https://doi.org/10.1038/nature12820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ijo.2014.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016026321", 
          "https://doi.org/10.1038/ijo.2014.46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ijo.2014.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016026321", 
          "https://doi.org/10.1038/ijo.2014.46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0113864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020884141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.5.1030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021029460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2013.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023578540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023893418", 
          "https://doi.org/10.1038/nature05414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023893418", 
          "https://doi.org/10.1038/nature05414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023893418", 
          "https://doi.org/10.1038/nature05414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.2007.s434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029947676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nutd.2014.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033221812", 
          "https://doi.org/10.1038/nutd.2014.23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/jns.2014.8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033774151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-015-2355-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037787129", 
          "https://doi.org/10.1007/s10096-015-2355-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00149.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041653768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00149.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041653768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.21701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045515823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m800119200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052979053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-112-3-904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064257066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-117-1-307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064258979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.142.2.7983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064284197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.86.3.1253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064301789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.16.7.443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070731367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3920/bm2013.0071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071703776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1973.225.2.481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080550434"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-06", 
    "datePublishedReg": "2016-06-01", 
    "description": "Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature18309", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2521856", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2494009", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2404276", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2447669", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5475983", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2500469", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439003", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2355198", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2696394", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438990", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683414", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7606", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "534"
      }
    ], 
    "name": "Acetate mediates a microbiome\u2013brain\u2013\u03b2-cell axis to promote metabolic syndrome", 
    "pagination": "213", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d44132494b5ac4df1be309b6d802a1f9fea8b93500657874bb1ea58724a4bc93"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27279214"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature18309"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044560114"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature18309", 
      "https://app.dimensions.ai/details/publication/pub.1044560114"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature18309"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature18309'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature18309'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature18309'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature18309'


 

This table displays all metadata directly associated to this object as RDF triples.

298 TRIPLES      21 PREDICATES      67 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature18309 schema:about N0ea4750709a64c55b5d1ab6d19592f64
2 N1e9f83528ea04b69bc583cab0f0193ce
3 N2d00f4dce9fa4cd8a019e987b079980c
4 N422afb097d6a4fe698a799a656d7349a
5 N497998f130d54562bdf97bd3335f06c3
6 N4a83967a0aa441c5b3065cdb2f86f91f
7 N4da53d4d6fa741d0bd100a3298b78d2e
8 N7913eb7d23584dcc84387f3fe434600e
9 N9f71fa75c710402584c8dc1ffed07f4f
10 Nab7b348d9b754311990c4de65a84f0c0
11 Nc1acc7cda2ab45fda6760a55dc44e5f2
12 Nc50f2bae3e044b09ba2c1b12995f95f8
13 Nd7e6ff458842407bbff9500c1dcd2430
14 Ne667960372b2442188fdeef476f1aa09
15 anzsrc-for:11
16 anzsrc-for:1109
17 schema:author N117bcd5dae2a4bbf8cf2e17f8a2d935a
18 schema:citation sg:pub.10.1007/s001250051322
19 sg:pub.10.1007/s00203-015-1089-0
20 sg:pub.10.1007/s10096-015-2355-4
21 sg:pub.10.1038/ijo.2014.46
22 sg:pub.10.1038/nature05414
23 sg:pub.10.1038/nature12820
24 sg:pub.10.1038/nutd.2014.23
25 https://doi.org/10.1002/jcb.21701
26 https://doi.org/10.1016/0006-8993(79)90028-3
27 https://doi.org/10.1016/j.chom.2013.09.012
28 https://doi.org/10.1017/jns.2014.8
29 https://doi.org/10.1074/jbc.m800119200
30 https://doi.org/10.1136/gut.2010.215665
31 https://doi.org/10.1152/ajpendo.00149.2005
32 https://doi.org/10.1152/ajplegacy.1973.225.2.481
33 https://doi.org/10.1210/endo-112-3-904
34 https://doi.org/10.1210/endo-117-1-307
35 https://doi.org/10.1210/endo.142.2.7983
36 https://doi.org/10.1210/jc.86.3.1253
37 https://doi.org/10.1371/journal.pone.0113864
38 https://doi.org/10.2337/diab.16.7.443
39 https://doi.org/10.2337/diabetes.50.5.1030
40 https://doi.org/10.2337/diabetes.51.2007.s434
41 https://doi.org/10.3920/bm2013.0071
42 schema:datePublished 2016-06
43 schema:datePublishedReg 2016-06-01
44 schema:description Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota in rodents leads to activation of the parasympathetic nervous system, which, in turn, promotes increased glucose-stimulated insulin secretion, increased ghrelin secretion, hyperphagia, obesity and related sequelae. Together, these findings identify increased acetate production resulting from a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree true
48 schema:isPartOf N745fa355196f46dfa691d9aba5f8f1f1
49 Ne2638c8b714d4c2abdf79beb6f93c153
50 sg:journal.1018957
51 schema:name Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome
52 schema:pagination 213
53 schema:productId N1629f0a1c50d4f1390f53d72232dd39f
54 N376ce62b57174c4ea14b911c7a08dd6b
55 N801b15e8e57c42a69e1b68d3f6cd5805
56 N85509ec5c80d436ca89d226762316fc6
57 Ne21a3e4253cd4c01a8b801f26e1535c1
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044560114
59 https://doi.org/10.1038/nature18309
60 schema:sdDatePublished 2019-04-10T22:19
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N7b99b8619e6d46d698cc643c0bcedcc4
63 schema:url https://www.nature.com/articles/nature18309
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0ea4750709a64c55b5d1ab6d19592f64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Brain
69 rdf:type schema:DefinedTerm
70 N117bcd5dae2a4bbf8cf2e17f8a2d935a rdf:first sg:person.01067272153.16
71 rdf:rest N190567fb1d4544ba92ff7bbb00d1908c
72 N1629f0a1c50d4f1390f53d72232dd39f schema:name readcube_id
73 schema:value d44132494b5ac4df1be309b6d802a1f9fea8b93500657874bb1ea58724a4bc93
74 rdf:type schema:PropertyValue
75 N190567fb1d4544ba92ff7bbb00d1908c rdf:first sg:person.01027240611.51
76 rdf:rest N39c9f487ec174e51813b0e5e22d1f801
77 N1d1685d28dd14ca2985c0354b2dc869d rdf:first sg:person.015643466277.02
78 rdf:rest N4f68bcac94d84cadb58196e72749894f
79 N1e9f83528ea04b69bc583cab0f0193ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Insulin
81 rdf:type schema:DefinedTerm
82 N2d00f4dce9fa4cd8a019e987b079980c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Diet, High-Fat
84 rdf:type schema:DefinedTerm
85 N376ce62b57174c4ea14b911c7a08dd6b schema:name pubmed_id
86 schema:value 27279214
87 rdf:type schema:PropertyValue
88 N39c9f487ec174e51813b0e5e22d1f801 rdf:first sg:person.0734412432.62
89 rdf:rest N1d1685d28dd14ca2985c0354b2dc869d
90 N3f948d5342454d29a9d49d80d746bf40 rdf:first sg:person.014300404317.81
91 rdf:rest N897f5d52d77a49deb28a43710897e629
92 N422afb097d6a4fe698a799a656d7349a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Acetates
94 rdf:type schema:DefinedTerm
95 N497998f130d54562bdf97bd3335f06c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Ghrelin
97 rdf:type schema:DefinedTerm
98 N4a83967a0aa441c5b3065cdb2f86f91f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Hyperphagia
100 rdf:type schema:DefinedTerm
101 N4da53d4d6fa741d0bd100a3298b78d2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Metabolic Syndrome
103 rdf:type schema:DefinedTerm
104 N4f68bcac94d84cadb58196e72749894f rdf:first sg:person.016322134257.96
105 rdf:rest Nc5d584180c4e4f7899afbb564075f11f
106 N52df5a966e3548e2ad23825bc0544b9e rdf:first sg:person.01325760611.03
107 rdf:rest Nd457e312e6aa483ebf521479255d2ac6
108 N745fa355196f46dfa691d9aba5f8f1f1 schema:issueNumber 7606
109 rdf:type schema:PublicationIssue
110 N7913eb7d23584dcc84387f3fe434600e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Glucose
112 rdf:type schema:DefinedTerm
113 N7b99b8619e6d46d698cc643c0bcedcc4 schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 N801b15e8e57c42a69e1b68d3f6cd5805 schema:name nlm_unique_id
116 schema:value 0410462
117 rdf:type schema:PropertyValue
118 N85509ec5c80d436ca89d226762316fc6 schema:name doi
119 schema:value 10.1038/nature18309
120 rdf:type schema:PropertyValue
121 N897f5d52d77a49deb28a43710897e629 rdf:first sg:person.0577162774.40
122 rdf:rest N52df5a966e3548e2ad23825bc0544b9e
123 N9f71fa75c710402584c8dc1ffed07f4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Animals
125 rdf:type schema:DefinedTerm
126 Nab7b348d9b754311990c4de65a84f0c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Gastrointestinal Microbiome
128 rdf:type schema:DefinedTerm
129 Nc1acc7cda2ab45fda6760a55dc44e5f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Insulin-Secreting Cells
131 rdf:type schema:DefinedTerm
132 Nc50f2bae3e044b09ba2c1b12995f95f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Rats
134 rdf:type schema:DefinedTerm
135 Nc5d584180c4e4f7899afbb564075f11f rdf:first sg:person.01265577013.17
136 rdf:rest N3f948d5342454d29a9d49d80d746bf40
137 Nd457e312e6aa483ebf521479255d2ac6 rdf:first sg:person.01340446106.39
138 rdf:rest rdf:nil
139 Nd7e6ff458842407bbff9500c1dcd2430 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Parasympathetic Nervous System
141 rdf:type schema:DefinedTerm
142 Ne21a3e4253cd4c01a8b801f26e1535c1 schema:name dimensions_id
143 schema:value pub.1044560114
144 rdf:type schema:PropertyValue
145 Ne2638c8b714d4c2abdf79beb6f93c153 schema:volumeNumber 534
146 rdf:type schema:PublicationVolume
147 Ne667960372b2442188fdeef476f1aa09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Obesity
149 rdf:type schema:DefinedTerm
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
154 schema:name Neurosciences
155 rdf:type schema:DefinedTerm
156 sg:grant.2355198 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
157 rdf:type schema:MonetaryGrant
158 sg:grant.2404276 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
159 rdf:type schema:MonetaryGrant
160 sg:grant.2438990 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
161 rdf:type schema:MonetaryGrant
162 sg:grant.2439003 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
163 rdf:type schema:MonetaryGrant
164 sg:grant.2447669 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
165 rdf:type schema:MonetaryGrant
166 sg:grant.2494009 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
167 rdf:type schema:MonetaryGrant
168 sg:grant.2500469 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
169 rdf:type schema:MonetaryGrant
170 sg:grant.2521856 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
171 rdf:type schema:MonetaryGrant
172 sg:grant.2683414 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
173 rdf:type schema:MonetaryGrant
174 sg:grant.2696394 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
175 rdf:type schema:MonetaryGrant
176 sg:grant.5475983 http://pending.schema.org/fundedItem sg:pub.10.1038/nature18309
177 rdf:type schema:MonetaryGrant
178 sg:journal.1018957 schema:issn 0090-0028
179 1476-4687
180 schema:name Nature
181 rdf:type schema:Periodical
182 sg:person.01027240611.51 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
183 schema:familyName Peng
184 schema:givenName Liang
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027240611.51
186 rdf:type schema:Person
187 sg:person.01067272153.16 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
188 schema:familyName Perry
189 schema:givenName Rachel J.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067272153.16
191 rdf:type schema:Person
192 sg:person.01265577013.17 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
193 schema:familyName Cardone
194 schema:givenName Rebecca L.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265577013.17
196 rdf:type schema:Person
197 sg:person.01325760611.03 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
198 schema:familyName Goodman
199 schema:givenName Andrew L.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325760611.03
201 rdf:type schema:Person
202 sg:person.01340446106.39 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
203 schema:familyName Shulman
204 schema:givenName Gerald I.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340446106.39
206 rdf:type schema:Person
207 sg:person.014300404317.81 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
208 schema:familyName Petersen
209 schema:givenName Kitt Falk
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014300404317.81
211 rdf:type schema:Person
212 sg:person.015643466277.02 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
213 schema:familyName Cline
214 schema:givenName Gary W.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015643466277.02
216 rdf:type schema:Person
217 sg:person.016322134257.96 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
218 schema:familyName Zhang
219 schema:givenName Dongyan
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016322134257.96
221 rdf:type schema:Person
222 sg:person.0577162774.40 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
223 schema:familyName Kibbey
224 schema:givenName Richard G.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577162774.40
226 rdf:type schema:Person
227 sg:person.0734412432.62 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
228 schema:familyName Barry
229 schema:givenName Natasha A.
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734412432.62
231 rdf:type schema:Person
232 sg:pub.10.1007/s001250051322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013383274
233 https://doi.org/10.1007/s001250051322
234 rdf:type schema:CreativeWork
235 sg:pub.10.1007/s00203-015-1089-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006972020
236 https://doi.org/10.1007/s00203-015-1089-0
237 rdf:type schema:CreativeWork
238 sg:pub.10.1007/s10096-015-2355-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037787129
239 https://doi.org/10.1007/s10096-015-2355-4
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/ijo.2014.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016026321
242 https://doi.org/10.1038/ijo.2014.46
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/nature05414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023893418
245 https://doi.org/10.1038/nature05414
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/nature12820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013830289
248 https://doi.org/10.1038/nature12820
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nutd.2014.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033221812
251 https://doi.org/10.1038/nutd.2014.23
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/jcb.21701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045515823
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0006-8993(79)90028-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003212869
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.chom.2013.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023578540
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1017/jns.2014.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033774151
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1074/jbc.m800119200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052979053
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1136/gut.2010.215665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001977399
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1152/ajpendo.00149.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041653768
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1152/ajplegacy.1973.225.2.481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080550434
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1210/endo-112-3-904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064257066
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1210/endo-117-1-307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064258979
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1210/endo.142.2.7983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064284197
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1210/jc.86.3.1253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064301789
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1371/journal.pone.0113864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020884141
278 rdf:type schema:CreativeWork
279 https://doi.org/10.2337/diab.16.7.443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070731367
280 rdf:type schema:CreativeWork
281 https://doi.org/10.2337/diabetes.50.5.1030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021029460
282 rdf:type schema:CreativeWork
283 https://doi.org/10.2337/diabetes.51.2007.s434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029947676
284 rdf:type schema:CreativeWork
285 https://doi.org/10.3920/bm2013.0071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071703776
286 rdf:type schema:CreativeWork
287 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
288 schema:name Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
289 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
290 Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06510, USA
291 Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06519, USA
292 Microbial Sciences Institute, Yale University School of Medicine, New Haven, Connecticut 06516, USA
293 Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen 2200, Denmark
294 rdf:type schema:Organization
295 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
296 schema:name Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
297 Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen 2200, Denmark
298 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...