Transcription initiation complex structures elucidate DNA opening View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-05

AUTHORS

C. Plaschka, M. Hantsche, C. Dienemann, C. Burzinski, J. Plitzko, P. Cramer

ABSTRACT

Transcription of eukaryotic protein-coding genes begins with assembly of the RNA polymerase (Pol) II initiation complex and promoter DNA opening. Here we report cryo-electron microscopy (cryo-EM) structures of yeast initiation complexes containing closed and open DNA at resolutions of 8.8 Å and 3.6 Å, respectively. DNA is positioned and retained over the Pol II cleft by a network of interactions between the TATA-box-binding protein TBP and transcription factors TFIIA, TFIIB, TFIIE, and TFIIF. DNA opening occurs around the tip of the Pol II clamp and the TFIIE 'extended winged helix' domain, and can occur in the absence of TFIIH. Loading of the DNA template strand into the active centre may be facilitated by movements of obstructing protein elements triggered by allosteric binding of the TFIIE 'E-ribbon' domain. The results suggest a unified model for transcription initiation with a key event, the trapping of open promoter DNA by extended protein-protein and protein-DNA contacts. More... »

PAGES

353

References to SciGraph publications

  • 2009-11. RNA polymerase II–TFIIB structure and mechanism of transcription initiation in NATURE
  • 1995-09. Crystal structure of a TFIIB–TBP–TATA-element ternary complex in NATURE
  • 2007-10. TFIIB and the regulation of transcription by RNA polymerase II in CHROMOSOMA
  • 2010-02. Using Situs for the integration of multi-resolution structures in BIOPHYSICAL REVIEWS
  • 2014-12. Conserved architecture of the core RNA polymerase II initiation complex in NATURE COMMUNICATIONS
  • 2015-07. The architecture of the spliceosomal U4/U6.U5 tri-snRNP in NATURE
  • 2015-01. The I-TASSER Suite: protein structure and function prediction in NATURE METHODS
  • 2013-03. Structural visualization of key steps in human transcription initiation in NATURE
  • 1994-03. Regulation of TFIIH ATPase and kinase activities by TFIIE during active initiation complex formation in NATURE
  • 2012-11-14. Structure and function of the initially transcribing RNA polymerase II–TFIIB complex in NATURE
  • 2007-08. The positions of TFIIF and TFIIE in the RNA polymerase II transcription preinitiation complex in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1993-10. Crystal structure of a yeast TBP/TATA-box complex in NATURE
  • 2015-03. Structural basis of transcription initiation by RNA polymerase II in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-02. Architecture of the RNA polymerase II–Mediator core initiation complex in NATURE
  • 1996-05. Crystal structure of a yeast TFIIA/TBP/DNA complex in NATURE
  • 2006-07. A DNA-tethered cleavage probe reveals the path for promoter DNA in the yeast preinitiation complex in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-08. Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature17990

    DOI

    http://dx.doi.org/10.1038/nature17990

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052707958

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27193681


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Allosteric Site", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cryoelectron Microscopy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Movement", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multiprotein Complexes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nucleic Acid Conformation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Promoter Regions, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Structure, Tertiary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Polymerase II", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Saccharomyces cerevisiae", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "TATA-Box Binding Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Templates, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription Factors, TFII", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription Initiation, Genetic", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Biophysical Chemistry", 
              "id": "https://www.grid.ac/institutes/grid.418140.8", 
              "name": [
                "Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 G\u00f6ttingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plaschka", 
            "givenName": "C.", 
            "id": "sg:person.01262642224.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262642224.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Biophysical Chemistry", 
              "id": "https://www.grid.ac/institutes/grid.418140.8", 
              "name": [
                "Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 G\u00f6ttingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hantsche", 
            "givenName": "M.", 
            "id": "sg:person.01147063246.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147063246.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Biophysical Chemistry", 
              "id": "https://www.grid.ac/institutes/grid.418140.8", 
              "name": [
                "Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 G\u00f6ttingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dienemann", 
            "givenName": "C.", 
            "id": "sg:person.0751564643.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751564643.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Biophysical Chemistry", 
              "id": "https://www.grid.ac/institutes/grid.418140.8", 
              "name": [
                "Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 G\u00f6ttingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Burzinski", 
            "givenName": "C.", 
            "id": "sg:person.01120072516.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120072516.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute of Biochemistry", 
              "id": "https://www.grid.ac/institutes/grid.418615.f", 
              "name": [
                "Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plitzko", 
            "givenName": "J.", 
            "id": "sg:person.0576723312.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576723312.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Biophysical Chemistry", 
              "id": "https://www.grid.ac/institutes/grid.418140.8", 
              "name": [
                "Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 G\u00f6ttingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cramer", 
            "givenName": "P.", 
            "id": "sg:person.01045113153.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045113153.17"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ultramic.2013.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000304364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms5310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000608941", 
              "https://doi.org/10.1038/ncomms5310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2009.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001298278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2011.64", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003524648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003871257", 
              "https://doi.org/10.1038/nsmb.2334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2013.08.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004034768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aab1478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005949408"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1182015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006258231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1182015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006258231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.7.6.1021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006573771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.08378", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006854027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.24.3.1122-1131.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007678266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcc.20084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008225564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1104591108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008308448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009664227", 
              "https://doi.org/10.1038/nature08548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009664227", 
              "https://doi.org/10.1038/nature08548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.8.5.515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010748044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011975079", 
              "https://doi.org/10.1038/nature11715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0800256105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014826453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1059493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015760622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2009.386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015831494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2009.386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015831494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2011.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016283998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.288.5470.1418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016316092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016952603", 
              "https://doi.org/10.1038/nature14229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1238724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017230122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909042073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018458004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909042073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018458004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.06242-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019305795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019909427", 
              "https://doi.org/10.1038/nsmb1117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019909427", 
              "https://doi.org/10.1038/nsmb1117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2012.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019988217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444904019158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020281098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909052925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020777046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909052925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020777046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0027595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020852592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.06.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021767742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/368160a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022812854", 
              "https://doi.org/10.1038/368160a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1227786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024680802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.04.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025547286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2011.05.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025827087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.31.19866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026295436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026949821", 
              "https://doi.org/10.1038/nmeth.3213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.10.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028057614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m307874200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028140656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.271.15.8517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028288768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/19.6.1346", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030271046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2014.11.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031002456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471250953.bi0506s15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031320355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m404722200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031961802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909047337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032162623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909047337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032162623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(96)10050-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035467098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1311010110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037010917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1218716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038538272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.08504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038769422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038891424", 
              "https://doi.org/10.1038/nature11991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2013.04.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039187167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.23217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039488680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2006.05.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040267501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040399474", 
              "https://doi.org/10.1038/nature14548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/381127a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040648123", 
              "https://doi.org/10.1038/381127a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.297572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041285673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2008.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041951577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90578-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042328884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2012.01.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043171000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2013.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044004732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377119a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044250366", 
              "https://doi.org/10.1038/377119a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2015.08.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045219124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/365512a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045509514", 
              "https://doi.org/10.1038/365512a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2015.03.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047137864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12551-009-0026-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047359709", 
              "https://doi.org/10.1007/s12551-009-0026-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1518255112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047671463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048916764", 
              "https://doi.org/10.1038/nsmb1272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444904016427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049496527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.2000.4110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051034638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m413466200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051253113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90084-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051419661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3952", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052324318", 
              "https://doi.org/10.1038/nrm3952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.88.17.7509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053570060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-007-0113-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053621679", 
              "https://doi.org/10.1007/s00412-007-0113-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-007-0113-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053621679", 
              "https://doi.org/10.1007/s00412-007-0113-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0968-0004(96)10050-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054566600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.272.5263.830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062552977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8342041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062654753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1995.tb07059.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082549465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082593965", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00512.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082879612"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-05", 
        "datePublishedReg": "2016-05-01", 
        "description": "Transcription of eukaryotic protein-coding genes begins with assembly of the RNA polymerase (Pol) II initiation complex and promoter DNA opening. Here we report cryo-electron microscopy (cryo-EM) structures of yeast initiation complexes containing closed and open DNA at resolutions of 8.8\u2009\u00c5 and 3.6\u2009\u00c5, respectively. DNA is positioned and retained over the Pol II cleft by a network of interactions between the TATA-box-binding protein TBP and transcription factors TFIIA, TFIIB, TFIIE, and TFIIF. DNA opening occurs around the tip of the Pol II clamp and the TFIIE 'extended winged helix' domain, and can occur in the absence of TFIIH. Loading of the DNA template strand into the active centre may be facilitated by movements of obstructing protein elements triggered by allosteric binding of the TFIIE 'E-ribbon' domain. The results suggest a unified model for transcription initiation with a key event, the trapping of open promoter DNA by extended protein-protein and protein-DNA contacts.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature17990", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7603", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "533"
          }
        ], 
        "name": "Transcription initiation complex structures elucidate DNA opening", 
        "pagination": "353", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "fb106e823287807c03e7b0b77f6ae8c69ed3e1b3dad82d4ff45dea973bf97a78"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27193681"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature17990"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1052707958"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature17990", 
          "https://app.dimensions.ai/details/publication/pub.1052707958"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000426.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature17990"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature17990'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature17990'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature17990'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature17990'


     

    This table displays all metadata directly associated to this object as RDF triples.

    435 TRIPLES      21 PREDICATES      127 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature17990 schema:about N095ef4e188eb477a9c5cde900c375d1b
    2 N1a5eead57c064c1caeb284e043465e27
    3 N51d14b58f91c47a996f6a3b878c3d796
    4 N5b9256f51a6d465fa3856357f1b8aeb1
    5 N60047c153e9d4023b619cc5213e212b9
    6 N8811ed560bba4545b64e0df94d878b8d
    7 N99ccbbaa573143cda2d0c9ccdc9ec50e
    8 Na822f3d514624e3bb777a7bbbc3145b1
    9 Nbc97d8b5467a4ddba0abb48c8e14b577
    10 Nc0d046fab48e4c8482213a915901cee9
    11 Ncddc6ff815b145f7b3a2923be1352e23
    12 Nce7070ef03bb4457b4827e7958641df0
    13 Nd1e057d5fb3144a4acf5d04e40ee3a83
    14 Ndf26183765714e878c822b9e940285c1
    15 Ne16b79f9672642a282f228c941ba999d
    16 Ne472cd13c33d4da3a3fd1e22456a91d0
    17 Nea8800684b644551ba159a8eb4771a06
    18 Necc3981a7e58437b85b8c1e0ea0af918
    19 anzsrc-for:06
    20 anzsrc-for:0601
    21 schema:author N370de66a490f4087a0fa8ffd68743dda
    22 schema:citation sg:pub.10.1007/s00412-007-0113-9
    23 sg:pub.10.1007/s12551-009-0026-3
    24 sg:pub.10.1038/365512a0
    25 sg:pub.10.1038/368160a0
    26 sg:pub.10.1038/377119a0
    27 sg:pub.10.1038/381127a0
    28 sg:pub.10.1038/nature08548
    29 sg:pub.10.1038/nature11715
    30 sg:pub.10.1038/nature11991
    31 sg:pub.10.1038/nature14229
    32 sg:pub.10.1038/nature14548
    33 sg:pub.10.1038/ncomms5310
    34 sg:pub.10.1038/nmeth.3213
    35 sg:pub.10.1038/nrm3952
    36 sg:pub.10.1038/nsmb.2334
    37 sg:pub.10.1038/nsmb1117
    38 sg:pub.10.1038/nsmb1272
    39 https://app.dimensions.ai/details/publication/pub.1082593965
    40 https://doi.org/10.1002/0471250953.bi0506s15
    41 https://doi.org/10.1002/j.1460-2075.1995.tb07059.x
    42 https://doi.org/10.1002/j.1460-2075.1996.tb00512.x
    43 https://doi.org/10.1002/jcc.20084
    44 https://doi.org/10.1002/prot.23217
    45 https://doi.org/10.1006/jmbi.2000.4110
    46 https://doi.org/10.1016/0092-8674(89)90578-3
    47 https://doi.org/10.1016/0092-8674(92)90084-p
    48 https://doi.org/10.1016/0968-0004(96)10050-5
    49 https://doi.org/10.1016/j.cell.2011.10.041
    50 https://doi.org/10.1016/j.cell.2013.04.033
    51 https://doi.org/10.1016/j.jsb.2006.05.009
    52 https://doi.org/10.1016/j.jsb.2011.06.003
    53 https://doi.org/10.1016/j.jsb.2012.09.006
    54 https://doi.org/10.1016/j.jsb.2013.08.005
    55 https://doi.org/10.1016/j.jsb.2014.11.010
    56 https://doi.org/10.1016/j.jsb.2015.08.008
    57 https://doi.org/10.1016/j.molcel.2008.06.021
    58 https://doi.org/10.1016/j.molcel.2009.06.002
    59 https://doi.org/10.1016/j.molcel.2011.05.030
    60 https://doi.org/10.1016/j.molcel.2012.01.023
    61 https://doi.org/10.1016/j.molcel.2015.03.010
    62 https://doi.org/10.1016/j.tibs.2013.04.006
    63 https://doi.org/10.1016/j.tibs.2013.09.002
    64 https://doi.org/10.1016/j.ultramic.2013.06.004
    65 https://doi.org/10.1016/s0968-0004(96)10050-5
    66 https://doi.org/10.1038/emboj.2008.47
    67 https://doi.org/10.1038/emboj.2009.386
    68 https://doi.org/10.1038/emboj.2011.64
    69 https://doi.org/10.1073/pnas.0800256105
    70 https://doi.org/10.1073/pnas.1104591108
    71 https://doi.org/10.1073/pnas.1311010110
    72 https://doi.org/10.1073/pnas.1518255112
    73 https://doi.org/10.1073/pnas.88.17.7509
    74 https://doi.org/10.1074/jbc.271.15.8517
    75 https://doi.org/10.1074/jbc.273.31.19866
    76 https://doi.org/10.1074/jbc.m111.297572
    77 https://doi.org/10.1074/jbc.m307874200
    78 https://doi.org/10.1074/jbc.m404722200
    79 https://doi.org/10.1074/jbc.m413466200
    80 https://doi.org/10.1093/emboj/19.6.1346
    81 https://doi.org/10.1101/gad.7.6.1021
    82 https://doi.org/10.1101/gad.8.5.515
    83 https://doi.org/10.1107/s0907444904016427
    84 https://doi.org/10.1107/s0907444904019158
    85 https://doi.org/10.1107/s0907444909042073
    86 https://doi.org/10.1107/s0907444909047337
    87 https://doi.org/10.1107/s0907444909052925
    88 https://doi.org/10.1126/science.1059493
    89 https://doi.org/10.1126/science.1182015
    90 https://doi.org/10.1126/science.1218716
    91 https://doi.org/10.1126/science.1227786
    92 https://doi.org/10.1126/science.1238724
    93 https://doi.org/10.1126/science.272.5263.830
    94 https://doi.org/10.1126/science.288.5470.1418
    95 https://doi.org/10.1126/science.8342041
    96 https://doi.org/10.1126/science.aab1478
    97 https://doi.org/10.1128/mcb.06242-11
    98 https://doi.org/10.1128/mcb.24.3.1122-1131.2004
    99 https://doi.org/10.1371/journal.pone.0027595
    100 https://doi.org/10.7554/elife.08378
    101 https://doi.org/10.7554/elife.08504
    102 schema:datePublished 2016-05
    103 schema:datePublishedReg 2016-05-01
    104 schema:description Transcription of eukaryotic protein-coding genes begins with assembly of the RNA polymerase (Pol) II initiation complex and promoter DNA opening. Here we report cryo-electron microscopy (cryo-EM) structures of yeast initiation complexes containing closed and open DNA at resolutions of 8.8 Å and 3.6 Å, respectively. DNA is positioned and retained over the Pol II cleft by a network of interactions between the TATA-box-binding protein TBP and transcription factors TFIIA, TFIIB, TFIIE, and TFIIF. DNA opening occurs around the tip of the Pol II clamp and the TFIIE 'extended winged helix' domain, and can occur in the absence of TFIIH. Loading of the DNA template strand into the active centre may be facilitated by movements of obstructing protein elements triggered by allosteric binding of the TFIIE 'E-ribbon' domain. The results suggest a unified model for transcription initiation with a key event, the trapping of open promoter DNA by extended protein-protein and protein-DNA contacts.
    105 schema:genre research_article
    106 schema:inLanguage en
    107 schema:isAccessibleForFree false
    108 schema:isPartOf N527b83e8ba374707bb8ad48f27a18244
    109 Nb6af38e17f064e798546d4ba29aac802
    110 sg:journal.1018957
    111 schema:name Transcription initiation complex structures elucidate DNA opening
    112 schema:pagination 353
    113 schema:productId N23803b93a6504606b37b576f689a1922
    114 N88b4d0fccd1a45b88743d12e98e7addd
    115 Na177e6c3b8774a56af43f03e32383f70
    116 Na5dfcaca95314fa7b80c0bc91b698bf2
    117 Ne2f7816d9ba640a18131aa6cc54d558a
    118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052707958
    119 https://doi.org/10.1038/nature17990
    120 schema:sdDatePublished 2019-04-10T14:48
    121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    122 schema:sdPublisher N7dfaf09763d44285a0df776e950d8d58
    123 schema:url https://www.nature.com/articles/nature17990
    124 sgo:license sg:explorer/license/
    125 sgo:sdDataset articles
    126 rdf:type schema:ScholarlyArticle
    127 N095ef4e188eb477a9c5cde900c375d1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Movement
    129 rdf:type schema:DefinedTerm
    130 N190942c511504a4eaf0a497d8e870f33 rdf:first sg:person.01045113153.17
    131 rdf:rest rdf:nil
    132 N1a5eead57c064c1caeb284e043465e27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name RNA Polymerase II
    134 rdf:type schema:DefinedTerm
    135 N23803b93a6504606b37b576f689a1922 schema:name readcube_id
    136 schema:value fb106e823287807c03e7b0b77f6ae8c69ed3e1b3dad82d4ff45dea973bf97a78
    137 rdf:type schema:PropertyValue
    138 N28252ffc8e4f494f8f2499980fdbad18 rdf:first sg:person.01120072516.33
    139 rdf:rest Na4ec361917804a2182225e6d6e838608
    140 N356b4a47300d4b709c6dbc3338a7ac57 rdf:first sg:person.01147063246.24
    141 rdf:rest Na660e1caba0249b1a7ad91d6464da470
    142 N370de66a490f4087a0fa8ffd68743dda rdf:first sg:person.01262642224.00
    143 rdf:rest N356b4a47300d4b709c6dbc3338a7ac57
    144 N51d14b58f91c47a996f6a3b878c3d796 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Models, Biological
    146 rdf:type schema:DefinedTerm
    147 N527b83e8ba374707bb8ad48f27a18244 schema:issueNumber 7603
    148 rdf:type schema:PublicationIssue
    149 N5b9256f51a6d465fa3856357f1b8aeb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Promoter Regions, Genetic
    151 rdf:type schema:DefinedTerm
    152 N60047c153e9d4023b619cc5213e212b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Molecular Sequence Data
    154 rdf:type schema:DefinedTerm
    155 N7dfaf09763d44285a0df776e950d8d58 schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 N8811ed560bba4545b64e0df94d878b8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Transcription Initiation, Genetic
    159 rdf:type schema:DefinedTerm
    160 N88b4d0fccd1a45b88743d12e98e7addd schema:name doi
    161 schema:value 10.1038/nature17990
    162 rdf:type schema:PropertyValue
    163 N99ccbbaa573143cda2d0c9ccdc9ec50e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Nucleic Acid Conformation
    165 rdf:type schema:DefinedTerm
    166 Na177e6c3b8774a56af43f03e32383f70 schema:name pubmed_id
    167 schema:value 27193681
    168 rdf:type schema:PropertyValue
    169 Na4ec361917804a2182225e6d6e838608 rdf:first sg:person.0576723312.32
    170 rdf:rest N190942c511504a4eaf0a497d8e870f33
    171 Na5dfcaca95314fa7b80c0bc91b698bf2 schema:name nlm_unique_id
    172 schema:value 0410462
    173 rdf:type schema:PropertyValue
    174 Na660e1caba0249b1a7ad91d6464da470 rdf:first sg:person.0751564643.29
    175 rdf:rest N28252ffc8e4f494f8f2499980fdbad18
    176 Na822f3d514624e3bb777a7bbbc3145b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name DNA
    178 rdf:type schema:DefinedTerm
    179 Nb6af38e17f064e798546d4ba29aac802 schema:volumeNumber 533
    180 rdf:type schema:PublicationVolume
    181 Nbc97d8b5467a4ddba0abb48c8e14b577 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Allosteric Site
    183 rdf:type schema:DefinedTerm
    184 Nc0d046fab48e4c8482213a915901cee9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name TATA-Box Binding Protein
    186 rdf:type schema:DefinedTerm
    187 Ncddc6ff815b145f7b3a2923be1352e23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Templates, Genetic
    189 rdf:type schema:DefinedTerm
    190 Nce7070ef03bb4457b4827e7958641df0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Base Sequence
    192 rdf:type schema:DefinedTerm
    193 Nd1e057d5fb3144a4acf5d04e40ee3a83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Saccharomyces cerevisiae
    195 rdf:type schema:DefinedTerm
    196 Ndf26183765714e878c822b9e940285c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Cryoelectron Microscopy
    198 rdf:type schema:DefinedTerm
    199 Ne16b79f9672642a282f228c941ba999d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Transcription Factors, TFII
    201 rdf:type schema:DefinedTerm
    202 Ne2f7816d9ba640a18131aa6cc54d558a schema:name dimensions_id
    203 schema:value pub.1052707958
    204 rdf:type schema:PropertyValue
    205 Ne472cd13c33d4da3a3fd1e22456a91d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Protein Binding
    207 rdf:type schema:DefinedTerm
    208 Nea8800684b644551ba159a8eb4771a06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Multiprotein Complexes
    210 rdf:type schema:DefinedTerm
    211 Necc3981a7e58437b85b8c1e0ea0af918 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Protein Structure, Tertiary
    213 rdf:type schema:DefinedTerm
    214 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    215 schema:name Biological Sciences
    216 rdf:type schema:DefinedTerm
    217 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    218 schema:name Biochemistry and Cell Biology
    219 rdf:type schema:DefinedTerm
    220 sg:journal.1018957 schema:issn 0090-0028
    221 1476-4687
    222 schema:name Nature
    223 rdf:type schema:Periodical
    224 sg:person.01045113153.17 schema:affiliation https://www.grid.ac/institutes/grid.418140.8
    225 schema:familyName Cramer
    226 schema:givenName P.
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045113153.17
    228 rdf:type schema:Person
    229 sg:person.01120072516.33 schema:affiliation https://www.grid.ac/institutes/grid.418140.8
    230 schema:familyName Burzinski
    231 schema:givenName C.
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120072516.33
    233 rdf:type schema:Person
    234 sg:person.01147063246.24 schema:affiliation https://www.grid.ac/institutes/grid.418140.8
    235 schema:familyName Hantsche
    236 schema:givenName M.
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147063246.24
    238 rdf:type schema:Person
    239 sg:person.01262642224.00 schema:affiliation https://www.grid.ac/institutes/grid.418140.8
    240 schema:familyName Plaschka
    241 schema:givenName C.
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262642224.00
    243 rdf:type schema:Person
    244 sg:person.0576723312.32 schema:affiliation https://www.grid.ac/institutes/grid.418615.f
    245 schema:familyName Plitzko
    246 schema:givenName J.
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576723312.32
    248 rdf:type schema:Person
    249 sg:person.0751564643.29 schema:affiliation https://www.grid.ac/institutes/grid.418140.8
    250 schema:familyName Dienemann
    251 schema:givenName C.
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751564643.29
    253 rdf:type schema:Person
    254 sg:pub.10.1007/s00412-007-0113-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053621679
    255 https://doi.org/10.1007/s00412-007-0113-9
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1007/s12551-009-0026-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047359709
    258 https://doi.org/10.1007/s12551-009-0026-3
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/365512a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045509514
    261 https://doi.org/10.1038/365512a0
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/368160a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022812854
    264 https://doi.org/10.1038/368160a0
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/377119a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044250366
    267 https://doi.org/10.1038/377119a0
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/381127a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040648123
    270 https://doi.org/10.1038/381127a0
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nature08548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009664227
    273 https://doi.org/10.1038/nature08548
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nature11715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011975079
    276 https://doi.org/10.1038/nature11715
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nature11991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038891424
    279 https://doi.org/10.1038/nature11991
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nature14229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016952603
    282 https://doi.org/10.1038/nature14229
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nature14548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040399474
    285 https://doi.org/10.1038/nature14548
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/ncomms5310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000608941
    288 https://doi.org/10.1038/ncomms5310
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/nmeth.3213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026949821
    291 https://doi.org/10.1038/nmeth.3213
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nrm3952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052324318
    294 https://doi.org/10.1038/nrm3952
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nsmb.2334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003871257
    297 https://doi.org/10.1038/nsmb.2334
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nsmb1117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019909427
    300 https://doi.org/10.1038/nsmb1117
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/nsmb1272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048916764
    303 https://doi.org/10.1038/nsmb1272
    304 rdf:type schema:CreativeWork
    305 https://app.dimensions.ai/details/publication/pub.1082593965 schema:CreativeWork
    306 https://doi.org/10.1002/0471250953.bi0506s15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031320355
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1002/j.1460-2075.1995.tb07059.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082549465
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1002/j.1460-2075.1996.tb00512.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082879612
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1002/prot.23217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039488680
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1006/jmbi.2000.4110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051034638
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/0092-8674(89)90578-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042328884
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/0092-8674(92)90084-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1051419661
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/0968-0004(96)10050-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054566600
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/j.cell.2011.10.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028057614
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/j.cell.2013.04.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025547286
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1016/j.jsb.2006.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040267501
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1016/j.jsb.2011.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016283998
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/j.jsb.2012.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019988217
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1016/j.jsb.2013.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004034768
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1016/j.jsb.2014.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031002456
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1016/j.jsb.2015.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045219124
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1016/j.molcel.2008.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021767742
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1016/j.molcel.2009.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001298278
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1016/j.molcel.2011.05.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025827087
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1016/j.molcel.2012.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043171000
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1016/j.molcel.2015.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047137864
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/j.tibs.2013.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039187167
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/j.tibs.2013.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044004732
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/j.ultramic.2013.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000304364
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/s0968-0004(96)10050-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035467098
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1038/emboj.2008.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041951577
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1038/emboj.2009.386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015831494
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1038/emboj.2011.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003524648
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1073/pnas.0800256105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014826453
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1073/pnas.1104591108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008308448
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1073/pnas.1311010110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037010917
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1073/pnas.1518255112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047671463
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1073/pnas.88.17.7509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053570060
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1074/jbc.271.15.8517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028288768
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1074/jbc.273.31.19866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026295436
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1074/jbc.m111.297572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041285673
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1074/jbc.m307874200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028140656
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1074/jbc.m404722200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031961802
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1074/jbc.m413466200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051253113
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1093/emboj/19.6.1346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030271046
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1101/gad.7.6.1021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006573771
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1101/gad.8.5.515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010748044
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1107/s0907444904016427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049496527
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1107/s0907444909042073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018458004
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1107/s0907444909047337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032162623
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1107/s0907444909052925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777046
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1126/science.1059493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015760622
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1126/science.1182015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006258231
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1126/science.1218716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038538272
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1126/science.1227786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024680802
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1126/science.1238724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017230122
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1126/science.272.5263.830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552977
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1126/science.288.5470.1418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016316092
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1126/science.8342041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062654753
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1126/science.aab1478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005949408
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1128/mcb.06242-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019305795
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1128/mcb.24.3.1122-1131.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007678266
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1371/journal.pone.0027595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020852592
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.7554/elife.08378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006854027
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.7554/elife.08504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038769422
    429 rdf:type schema:CreativeWork
    430 https://www.grid.ac/institutes/grid.418140.8 schema:alternateName Max Planck Institute for Biophysical Chemistry
    431 schema:name Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077 Göttingen, Germany
    432 rdf:type schema:Organization
    433 https://www.grid.ac/institutes/grid.418615.f schema:alternateName Max Planck Institute of Biochemistry
    434 schema:name Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    435 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...