Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-04-20

AUTHORS

Alexis C. Komor, Yongjoo B. Kim, Michael S. Packer, John A. Zuris, David R. Liu

ABSTRACT

CRISPR/Cas9 DNA editing creates a double-stranded break in the target DNA, which can frequently generate random insertion or deletion of bases (indels); a new genome editing approach combining Cas9 with a cytidine deaminase is described here, which corrects point mutations more efficiently than canonical Cas9, while avoiding double-stranded breaks and indel formation. More... »

PAGES

420-424

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  • Journal

    TITLE

    Nature

    ISSUE

    7603

    VOLUME

    533

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature17946

    DOI

    http://dx.doi.org/10.1038/nature17946

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009172001

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27096365


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