Interconnected microbiomes and resistomes in low-income human habitats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05-11

AUTHORS

Erica C. Pehrsson, Pablo Tsukayama, Sanket Patel, Melissa Mejía-Bautista, Giordano Sosa-Soto, Karla M. Navarrete, Maritza Calderon, Lilia Cabrera, William Hoyos-Arango, M. Teresita Bertoli, Douglas E. Berg, Robert H. Gilman, Gautam Dantas

ABSTRACT

Antibiotic-resistant infections annually claim hundreds of thousands of lives worldwide. This problem is exacerbated by exchange of resistance genes between pathogens and benign microbes from diverse habitats. Mapping resistance gene dissemination between humans and their environment is a public health priority. Here we characterized the bacterial community structure and resistance exchange networks of hundreds of interconnected human faecal and environmental samples from two low-income Latin American communities. We found that resistomes across habitats are generally structured by bacterial phylogeny along ecological gradients, but identified key resistance genes that cross habitat boundaries and determined their association with mobile genetic elements. We also assessed the effectiveness of widely used excreta management strategies in reducing faecal bacteria and resistance genes in these settings representative of low- and middle-income countries. Our results lay the foundation for quantitative risk assessment and surveillance of resistance gene dissemination across interconnected habitats in settings representing over two-thirds of the world’s population. More... »

PAGES

212-216

References to SciGraph publications

  • 2010-04-11. QIIME allows analysis of high-throughput community sequencing data in NATURE METHODS
  • 2014-07-08. Improved annotation of antibiotic resistance determinants reveals microbial resistomes cluster by ecology in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2014-05-21. Bacterial phylogeny structures soil resistomes across habitats in NATURE
  • 2006-12-10. Accurate phylogenetic classification of variable-length DNA fragments in NATURE METHODS
  • 2010-03-01. Call of the wild: antibiotic resistance genes in natural environments in NATURE REVIEWS MICROBIOLOGY
  • 2013-10-24. Quantitative and qualitative impact of hospital effluent on dissemination of the integron pool in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2013-07-23. Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota in NATURE COMMUNICATIONS
  • 2011-08-31. Antibiotic resistance is ancient in NATURE
  • 2012-03-08. Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2015-09-30. Limited dissemination of the wastewater treatment plant core resistome in NATURE COMMUNICATIONS
  • 2011-07-17. Bayesian community-wide culture-independent microbial source tracking in NATURE METHODS
  • 2014-12-15. What is a resistance gene? Ranking risk in resistomes in NATURE REVIEWS MICROBIOLOGY
  • 2011-06-24. Metagenomic biomarker discovery and explanation in GENOME BIOLOGY
  • 2007-03. The antibiotic resistome: the nexus of chemical and genetic diversity in NATURE REVIEWS MICROBIOLOGY
  • 2012-05-09. Human gut microbiome viewed across age and geography in NATURE
  • 2015-04-28. Metagenomic and network analysis reveal wide distribution and co-occurrence of environmental antibiotic resistance genes in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2011-10-30. Ecology drives a global network of gene exchange connecting the human microbiome in NATURE
  • 2013-08-18. UPARSE: highly accurate OTU sequences from microbial amplicon reads in NATURE METHODS
  • 2015-03-25. Subsistence strategies in traditional societies distinguish gut microbiomes in NATURE COMMUNICATIONS
  • 2008-10-09. Functional metagenomics reveals diverse β-lactamases in a remote Alaskan soil in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/nature17672

    DOI

    http://dx.doi.org/10.1038/nature17672

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033691835

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27172044


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