Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12-02

AUTHORS

Kristoffer Forslund, Falk Hildebrand, Trine Nielsen, Gwen Falony, Emmanuelle Le Chatelier, Shinichi Sunagawa, Edi Prifti, Sara Vieira-Silva, Valborg Gudmundsdottir, Helle Krogh Pedersen, Manimozhiyan Arumugam, Karsten Kristiansen, Anita Yvonne Voigt, Henrik Vestergaard, Rajna Hercog, Paul Igor Costea, Jens Roat Kultima, Junhua Li, Torben Jørgensen, Florence Levenez, Joël Dore, H. Bjørn Nielsen, Søren Brunak, Jeroen Raes, Torben Hansen, Jun Wang, S. Dusko Ehrlich, Peer Bork, Oluf Pedersen

ABSTRACT

Growing evidence from metagenome-wide association studies link multiple common disorders to microbial dysbiosis but effects of drug treatment are often not accounted for; here, the authors re-analyse two previous metagenomic studies of type 2 diabetes mellitus patients together with a novel cohort to determine the effects of the widely prescribed antidiabetic drug metformin and highlight the need to distinguish the effects of a disease from the effects of treatment on the gut microbiota. More... »

PAGES

262-266

Journal

TITLE

Nature

ISSUE

7581

VOLUME

528

Author Affiliations

  • European Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117, Heidelberg, Germany
  • Department of Bioscience Engineering, Vrije Universiteit Brussel, 1040, Brussels, Belgium
  • The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark
  • Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, Katholieke Universiteit Leuven, 3000, Leuven, Belgium
  • Metagenopolis, Institut National de la Recherche Agronomique, 78352, Jouy en Josas, France
  • Institute of Cardiometabolism and Nutrition, 75013, Paris, France
  • Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, 2800, Kongens Lyngby, Denmark
  • Department of Biology, University of Copenhagen, 2100, Copenhagen, Denmark
  • Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, 69120, Heidelberg, Germany
  • Bejing Genomics Institute (BGI)-Shenzhen, 518083, Shenzhen, China
  • Faculty of Medicine, University of Aalborg, 9100, Aalborg, Denmark
  • Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark
  • Faculty of Health Sciences, University of Southern Denmark, 5000, Odense, Denmark
  • Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong
  • Centre for Host-Microbiome Interactions, Dental Institute Central Office, Guy’s Hospital, King’s College London, London SE1 9RT , UK
  • Department of Bioinformatics, University of Wuerzburg, 97074, Würzburg, Germany
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature15766

    DOI

    http://dx.doi.org/10.1038/nature15766

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014535385

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26633628


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