Ontology type: schema:ScholarlyArticle Open Access: True
2015-11-11
AUTHORSMarco Linari, Elisabetta Brunello, Massimo Reconditi, Luca Fusi, Marco Caremani, Theyencheri Narayanan, Gabriella Piazzesi, Vincenzo Lombardi, Malcolm Irving
ABSTRACTIt is widely accepted that contraction of skeletal muscle and the heart involves structural changes in actin-containing thin filaments to allow binding of myosin motors from neighbouring thick filaments, thus driving filament sliding; here, X-ray diffraction of single skeletal muscle cells reveals that this thin-filament mechanism can regulate muscle contraction against low load, but high-load contraction requires a second permissive step involving a structural change in the thick filament. More... »
PAGES276-279
http://scigraph.springernature.com/pub.10.1038/nature15727
DOIhttp://dx.doi.org/10.1038/nature15727
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26560032
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