Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11-11

AUTHORS

Marco Linari, Elisabetta Brunello, Massimo Reconditi, Luca Fusi, Marco Caremani, Theyencheri Narayanan, Gabriella Piazzesi, Vincenzo Lombardi, Malcolm Irving

ABSTRACT

It is widely accepted that contraction of skeletal muscle and the heart involves structural changes in actin-containing thin filaments to allow binding of myosin motors from neighbouring thick filaments, thus driving filament sliding; here, X-ray diffraction of single skeletal muscle cells reveals that this thin-filament mechanism can regulate muscle contraction against low load, but high-load contraction requires a second permissive step involving a structural change in the thick filament. More... »

PAGES

276-279

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature15727

DOI

http://dx.doi.org/10.1038/nature15727

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048610042

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26560032


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