Hallmarks of pluripotency View Full Text


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Article Info

DATE

2015-09

AUTHORS

Alejandro De Los Angeles, Francesco Ferrari, Ruibin Xi, Yuko Fujiwara, Nissim Benvenisty, Hongkui Deng, Konrad Hochedlinger, Rudolf Jaenisch, Soohyun Lee, Harry G. Leitch, M. William Lensch, Ernesto Lujan, Duanqing Pei, Janet Rossant, Marius Wernig, Peter J. Park, George Q. Daley

ABSTRACT

Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance. More... »

PAGES

469

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    http://scigraph.springernature.com/pub.10.1038/nature15515

    DOI

    http://dx.doi.org/10.1038/nature15515

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040380214

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26399828


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