Allosteric receptor activation by the plant peptide hormone phytosulfokine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09

AUTHORS

Jizong Wang, Hongju Li, Zhifu Han, Heqiao Zhang, Tong Wang, Guangzhong Lin, Junbiao Chang, Weicai Yang, Jijie Chai

ABSTRACT

Phytosulfokine (PSK) is a disulfated pentapeptide that has a ubiquitous role in plant growth and development. PSK is perceived by its receptor PSKR, a leucine-rich repeat receptor kinase (LRR-RK). The mechanisms underlying the recognition of PSK, the activation of PSKR and the identity of the components downstream of the initial binding remain elusive. Here we report the crystal structures of the extracellular LRR domain of PSKR in free, PSK- and co-receptor-bound forms. The structures reveal that PSK interacts mainly with a β-strand from the island domain of PSKR, forming an anti-β-sheet. The two sulfate moieties of PSK interact directly with PSKR, sensitizing PSKR recognition of PSK. Supported by biochemical, structural and genetic evidence, PSK binding enhances PSKR heterodimerization with the somatic embryogenesis receptor-like kinases (SERKs). However, PSK is not directly involved in PSKR-SERK interaction but stabilizes PSKR island domain for recruitment of a SERK. Our data reveal the structural basis for PSKR recognition of PSK and allosteric activation of PSKR by PSK, opening up new avenues for the design of PSKR-specific small molecules. More... »

PAGES

265

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature14858

DOI

http://dx.doi.org/10.1038/nature14858

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039676048

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26308901


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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature14858'


 

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322 https://www.grid.ac/institutes/grid.418558.5 schema:alternateName Institute of Genetics and Developmental Biology
323 schema:name State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
324 rdf:type schema:Organization
 




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