Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-08-12

AUTHORS

Alexandra Van Keymeulen, May Yin Lee, Marielle Ousset, Sylvain Brohée, Sandrine Rorive, Rajshekhar R. Giraddi, Aline Wuidart, Gaëlle Bouvencourt, Christine Dubois, Isabelle Salmon, Christos Sotiriou, Wayne A. Phillips, Cédric Blanpain

ABSTRACT

Breast cancer is the most frequent cancer in women and consists of heterogeneous types of tumours that are classified into different histological and molecular subtypes. PIK3CA and P53 (also known as TP53) are the two most frequently mutated genes and are associated with different types of human breast cancers. The cellular origin and the mechanisms leading to PIK3CA-induced tumour heterogeneity remain unknown. Here we used a genetic approach in mice to define the cellular origin of Pik3ca-derived tumours and the impact of mutations in this gene on tumour heterogeneity. Surprisingly, oncogenic Pik3ca(H1047R) mutant expression at physiological levels in basal cells using keratin (K)5-CreER(T2) mice induced the formation of luminal oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive tumours, while its expression in luminal cells using K8-CReER(T2) mice gave rise to luminal ER(+)PR(+) tumours or basal-like ER(-)PR(-) tumours. Concomitant deletion of p53 and expression of Pik3ca(H1047R) accelerated tumour development and induced more aggressive mammary tumours. Interestingly, expression of Pik3ca(H1047R) in unipotent basal cells gave rise to luminal-like cells, while its expression in unipotent luminal cells gave rise to basal-like cells before progressing into invasive tumours. Transcriptional profiling of cells that underwent cell fate transition upon Pik3ca(H1047R) expression in unipotent progenitors demonstrated a profound oncogene-induced reprogramming of these newly formed cells and identified gene signatures characteristic of the different cell fate switches that occur upon Pik3ca(H1047R) expression in basal and luminal cells, which correlated with the cell of origin, tumour type and different clinical outcomes. Altogether our study identifies the cellular origin of Pik3ca-induced tumours and reveals that oncogenic Pik3ca(H1047R) activates a multipotent genetic program in normally lineage-restricted populations at the early stage of tumour initiation, setting the stage for future intratumoural heterogeneity. These results have important implications for our understanding of the mechanisms controlling tumour heterogeneity and the development of new strategies to block PIK3CA breast cancer initiation. More... »

PAGES

119

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature14665

DOI

http://dx.doi.org/10.1038/nature14665

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006527545

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26266985


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Lineage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Class I Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Neoplasms, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Progesterone", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Libre de Bruxelles", 
          "id": "https://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "Universit\u00e9 Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Keymeulen", 
        "givenName": "Alexandra", 
        "id": "sg:person.0627062221.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627062221.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Libre de Bruxelles", 
          "id": "https://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "Universit\u00e9 Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "May Yin", 
        "id": "sg:person.01136730642.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136730642.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Libre de Bruxelles", 
          "id": "https://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "Universit\u00e9 Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ousset", 
        "givenName": "Marielle", 
        "id": "sg:person.01101372176.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101372176.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Jules Bordet", 
          "id": "https://www.grid.ac/institutes/grid.418119.4", 
          "name": [
            "Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Brussels B-1000, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Broh\u00e9e", 
        "givenName": "Sylvain", 
        "id": "sg:person.01240233771.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240233771.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Erasme Hospital, Universit\u00e9 Libre de Bruxelles, Brussels B-1070, Belgium", 
            "DIAPATH \u2014 Center for Microscopy and Molecular Imaging (CMMI), Gosselies B-6041, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rorive", 
        "givenName": "Sandrine", 
        "id": "sg:person.0634066547.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634066547.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Libre de Bruxelles", 
          "id": "https://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "Universit\u00e9 Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giraddi", 
        "givenName": "Rajshekhar R.", 
        "id": "sg:person.01032030154.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032030154.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Libre de Bruxelles", 
          "id": "https://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "Universit\u00e9 Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wuidart", 
        "givenName": "Aline", 
        "id": "sg:person.0711353621.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711353621.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Libre de Bruxelles", 
          "id": "https://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "Universit\u00e9 Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouvencourt", 
        "givenName": "Ga\u00eblle", 
        "id": "sg:person.01215620576.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215620576.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Libre de Bruxelles", 
          "id": "https://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "Universit\u00e9 Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dubois", 
        "givenName": "Christine", 
        "id": "sg:person.01223654444.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223654444.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Erasme Hospital, Universit\u00e9 Libre de Bruxelles, Brussels B-1070, Belgium", 
            "DIAPATH \u2014 Center for Microscopy and Molecular Imaging (CMMI), Gosselies B-6041, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salmon", 
        "givenName": "Isabelle", 
        "id": "sg:person.0772641113.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772641113.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Jules Bordet", 
          "id": "https://www.grid.ac/institutes/grid.418119.4", 
          "name": [
            "Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles, Brussels B-1000, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sotiriou", 
        "givenName": "Christos", 
        "id": "sg:person.01352311331.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352311331.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne 3002, Australia", 
            "Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville 3002, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Phillips", 
        "givenName": "Wayne A.", 
        "id": "sg:person.0705640631.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705640631.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Libre de Bruxelles", 
          "id": "https://www.grid.ac/institutes/grid.4989.c", 
          "name": [
            "Universit\u00e9 Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium", 
            "WELBIO, Universit\u00e9 Libre de Bruxelles, Brussels B-1070, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blanpain", 
        "givenName": "C\u00e9dric", 
        "id": "sg:person.0774010601.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774010601.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s12026-012-8283-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001764891", 
          "https://doi.org/10.1007/s12026-012-8283-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.24831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002203934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-6854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002831536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004160265", 
          "https://doi.org/10.1038/onc.2011.227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-3827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005207782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009808673", 
          "https://doi.org/10.1038/nature10573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(02)00184-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009992466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011100488", 
          "https://doi.org/10.1038/nature10525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgq180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011503037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.152238499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014513729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014607335", 
          "https://doi.org/10.1038/nature10983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0036924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015059968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015107623", 
          "https://doi.org/10.1038/nm.2402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017721211", 
          "https://doi.org/10.1038/nature13851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018457673", 
          "https://doi.org/10.1186/gb-2004-5-10-r80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018720128", 
          "https://doi.org/10.1038/nature12948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-0738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018977932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biostatistics/kxp059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020140411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biostatistics/kxp059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020140411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molonc.2010.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021321273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021342247", 
          "https://doi.org/10.1038/modpathol.2010.136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021342247", 
          "https://doi.org/10.1038/modpathol.2010.136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-013-2798-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024615719", 
          "https://doi.org/10.1007/s10549-013-2798-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024942368", 
          "https://doi.org/10.1038/nature11412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025078414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027457561", 
          "https://doi.org/10.1038/nature10933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-14-0053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028217570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13058-014-0411-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028229003", 
          "https://doi.org/10.1186/s13058-014-0411-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13058-014-0411-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028229003", 
          "https://doi.org/10.1186/s13058-014-0411-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/database/bar049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031978003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35021093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033846543", 
          "https://doi.org/10.1038/35021093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2012.53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035924367", 
          "https://doi.org/10.1038/onc.2012.53"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djr545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036542469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037658738", 
          "https://doi.org/10.1038/nature04372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037658738", 
          "https://doi.org/10.1038/nature04372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037658738", 
          "https://doi.org/10.1038/nature04372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040185730", 
          "https://doi.org/10.1038/nature04496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040185730", 
          "https://doi.org/10.1038/nature04496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040185730", 
          "https://doi.org/10.1038/nature04496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.07.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040550108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btl117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040779948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041030245", 
          "https://doi.org/10.1038/ng747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041030245", 
          "https://doi.org/10.1038/ng747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2011.178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041438461", 
          "https://doi.org/10.1038/nrclinonc.2011.178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2010.087718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042834707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-213x-1-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042905963", 
          "https://doi.org/10.1186/1471-213x-1-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.1370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045851448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.047332.114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046307378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr3334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047302426", 
          "https://doi.org/10.1186/bcr3334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2007.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047318775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2014.8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052701202", 
          "https://doi.org/10.1038/onc.2014.8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-08-12", 
    "datePublishedReg": "2015-08-12", 
    "description": "Breast cancer is the most frequent cancer in women and consists of heterogeneous types of tumours that are classified into different histological and molecular subtypes. PIK3CA and P53 (also known as TP53) are the two most frequently mutated genes and are associated with different types of human breast cancers. The cellular origin and the mechanisms leading to PIK3CA-induced tumour heterogeneity remain unknown. Here we used a genetic approach in mice to define the cellular origin of Pik3ca-derived tumours and the impact of mutations in this gene on tumour heterogeneity. Surprisingly, oncogenic Pik3ca(H1047R) mutant expression at physiological levels in basal cells using keratin (K)5-CreER(T2) mice induced the formation of luminal oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive tumours, while its expression in luminal cells using K8-CReER(T2) mice gave rise to luminal ER(+)PR(+) tumours or basal-like ER(-)PR(-) tumours. Concomitant deletion of p53 and expression of Pik3ca(H1047R) accelerated tumour development and induced more aggressive mammary tumours. Interestingly, expression of Pik3ca(H1047R) in unipotent basal cells gave rise to luminal-like cells, while its expression in unipotent luminal cells gave rise to basal-like cells before progressing into invasive tumours. Transcriptional profiling of cells that underwent cell fate transition upon Pik3ca(H1047R) expression in unipotent progenitors demonstrated a profound oncogene-induced reprogramming of these newly formed cells and identified gene signatures characteristic of the different cell fate switches that occur upon Pik3ca(H1047R) expression in basal and luminal cells, which correlated with the cell of origin, tumour type and different clinical outcomes. Altogether our study identifies the cellular origin of Pik3ca-induced tumours and reveals that oncogenic Pik3ca(H1047R) activates a multipotent genetic program in normally lineage-restricted populations at the early stage of tumour initiation, setting the stage for future intratumoural heterogeneity. These results have important implications for our understanding of the mechanisms controlling tumour heterogeneity and the development of new strategies to block PIK3CA breast cancer initiation. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature14665", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7567", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "525"
      }
    ], 
    "name": "Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity", 
    "pagination": "119", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1f177b3c90321417d526caf4f70219b2ab1b25317448c8093b30475f44e8e892"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26266985"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature14665"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006527545"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature14665", 
      "https://app.dimensions.ai/details/publication/pub.1006527545"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature14665"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature14665'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature14665'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature14665'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature14665'


 

This table displays all metadata directly associated to this object as RDF triples.

391 TRIPLES      21 PREDICATES      89 URIs      38 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature14665 schema:about N1669c5859bab4773ae39594b67ca6bb3
2 N1eb4438d97fd47b29d1ae7e8d41bb924
3 N22e5f55398cc46eeac817334d27ccb2d
4 N4ddb3cbd0ec844ad9923e3ddb38d9f1e
5 N5211c0a89e5f433eb73dd2230ede6247
6 N57929eac8ae3427eb2efbf6bba99e975
7 N69b3d5daffab4cb6be350e38d961b23c
8 N80cf2094f4e4486b9abcd5beb92ad405
9 N847e1b74e6d1455483597667fa8e9577
10 N85a29251535a45a3a70d02439f96f822
11 N8b0ff92e48494cc79f981f7dc068adc6
12 N965196d8923a43eca600640f14fb177a
13 N9974ce3fe6ed4456814ef28975286c16
14 Nb78af8f978a94b22ae02fe5d9b718af4
15 Nccc3fa0d70874a8383e70bb035ddaca3
16 Ndace45a686f0462f9343b4d5ccd1d6a0
17 Nf78eb2c6e2d4403d962b0fbd02e3c062
18 Nfce4affe095449939cfa0aef4268fd00
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N98864b9298144cff9d319f9011c32e98
22 schema:citation sg:pub.10.1007/s10549-013-2798-1
23 sg:pub.10.1007/s12026-012-8283-9
24 sg:pub.10.1038/35021093
25 sg:pub.10.1038/modpathol.2010.136
26 sg:pub.10.1038/nature04372
27 sg:pub.10.1038/nature04496
28 sg:pub.10.1038/nature10525
29 sg:pub.10.1038/nature10573
30 sg:pub.10.1038/nature10933
31 sg:pub.10.1038/nature10983
32 sg:pub.10.1038/nature11412
33 sg:pub.10.1038/nature12948
34 sg:pub.10.1038/nature13851
35 sg:pub.10.1038/ng747
36 sg:pub.10.1038/nm.2402
37 sg:pub.10.1038/nrclinonc.2011.178
38 sg:pub.10.1038/onc.2011.227
39 sg:pub.10.1038/onc.2012.53
40 sg:pub.10.1038/onc.2014.8
41 sg:pub.10.1186/1471-213x-1-4
42 sg:pub.10.1186/bcr3334
43 sg:pub.10.1186/gb-2004-5-10-r80
44 sg:pub.10.1186/s13058-014-0411-0
45 https://doi.org/10.1002/ijc.24831
46 https://doi.org/10.1016/j.ccr.2007.11.012
47 https://doi.org/10.1016/j.cell.2006.07.036
48 https://doi.org/10.1016/j.molonc.2010.04.004
49 https://doi.org/10.1016/s1535-6108(02)00184-8
50 https://doi.org/10.1073/pnas.152238499
51 https://doi.org/10.1093/bioinformatics/btl117
52 https://doi.org/10.1093/bioinformatics/bts034
53 https://doi.org/10.1093/biostatistics/kxp059
54 https://doi.org/10.1093/carcin/bgq180
55 https://doi.org/10.1093/database/bar049
56 https://doi.org/10.1093/jnci/djr545
57 https://doi.org/10.1136/jcp.2010.087718
58 https://doi.org/10.1158/0008-5472.can-07-6854
59 https://doi.org/10.1158/0008-5472.can-10-0738
60 https://doi.org/10.1158/0008-5472.can-10-3827
61 https://doi.org/10.1158/0008-5472.can-14-0053
62 https://doi.org/10.1200/jco.2008.18.1370
63 https://doi.org/10.1261/rna.047332.114
64 https://doi.org/10.1371/journal.pone.0036924
65 schema:datePublished 2015-08-12
66 schema:datePublishedReg 2015-08-12
67 schema:description Breast cancer is the most frequent cancer in women and consists of heterogeneous types of tumours that are classified into different histological and molecular subtypes. PIK3CA and P53 (also known as TP53) are the two most frequently mutated genes and are associated with different types of human breast cancers. The cellular origin and the mechanisms leading to PIK3CA-induced tumour heterogeneity remain unknown. Here we used a genetic approach in mice to define the cellular origin of Pik3ca-derived tumours and the impact of mutations in this gene on tumour heterogeneity. Surprisingly, oncogenic Pik3ca(H1047R) mutant expression at physiological levels in basal cells using keratin (K)5-CreER(T2) mice induced the formation of luminal oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive tumours, while its expression in luminal cells using K8-CReER(T2) mice gave rise to luminal ER(+)PR(+) tumours or basal-like ER(-)PR(-) tumours. Concomitant deletion of p53 and expression of Pik3ca(H1047R) accelerated tumour development and induced more aggressive mammary tumours. Interestingly, expression of Pik3ca(H1047R) in unipotent basal cells gave rise to luminal-like cells, while its expression in unipotent luminal cells gave rise to basal-like cells before progressing into invasive tumours. Transcriptional profiling of cells that underwent cell fate transition upon Pik3ca(H1047R) expression in unipotent progenitors demonstrated a profound oncogene-induced reprogramming of these newly formed cells and identified gene signatures characteristic of the different cell fate switches that occur upon Pik3ca(H1047R) expression in basal and luminal cells, which correlated with the cell of origin, tumour type and different clinical outcomes. Altogether our study identifies the cellular origin of Pik3ca-induced tumours and reveals that oncogenic Pik3ca(H1047R) activates a multipotent genetic program in normally lineage-restricted populations at the early stage of tumour initiation, setting the stage for future intratumoural heterogeneity. These results have important implications for our understanding of the mechanisms controlling tumour heterogeneity and the development of new strategies to block PIK3CA breast cancer initiation.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree false
71 schema:isPartOf N3afeb505ebc4487db6995c8a4e51afd3
72 Nfaaa9be645f644db900b8caf151bdb9b
73 sg:journal.1018957
74 schema:name Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
75 schema:pagination 119
76 schema:productId N0c8a9c0cd13d4948ac28f97a063c16b6
77 N5ef482a2682f46efa8c2118ecb751363
78 N73aaef2daf244058bd59da276258a2c9
79 Nc434107d0e2c48fea118b9c43d8056dd
80 Nc89e3f570f334aafaa885b6b31d8451c
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006527545
82 https://doi.org/10.1038/nature14665
83 schema:sdDatePublished 2019-04-11T00:54
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N1de63fd658904c9cb7cd1d1207c4c855
86 schema:url https://www.nature.com/articles/nature14665
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N0c8a9c0cd13d4948ac28f97a063c16b6 schema:name readcube_id
91 schema:value 1f177b3c90321417d526caf4f70219b2ab1b25317448c8093b30475f44e8e892
92 rdf:type schema:PropertyValue
93 N116707558a9949ccaf314f4f643f4cad rdf:first sg:person.0774010601.05
94 rdf:rest rdf:nil
95 N1669c5859bab4773ae39594b67ca6bb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Female
97 rdf:type schema:DefinedTerm
98 N1a75fa2c95ac4cb39c7c16562ba31112 rdf:first sg:person.01032030154.08
99 rdf:rest N6a074357a9c047c0bce3465c7c96589c
100 N1cacf835cf794cf390b8879b15387526 rdf:first sg:person.01136730642.53
101 rdf:rest Na1e9167363844d919bbeb77d455e94ba
102 N1da8f5ab07c14bf9bc75fc9093e67dbe rdf:first sg:person.01240233771.51
103 rdf:rest N4d3d0a1bdd2f40f88e7d15f33361e975
104 N1de63fd658904c9cb7cd1d1207c4c855 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N1eb4438d97fd47b29d1ae7e8d41bb924 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Breast Neoplasms
108 rdf:type schema:DefinedTerm
109 N22e5f55398cc46eeac817334d27ccb2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Neoplasm Invasiveness
111 rdf:type schema:DefinedTerm
112 N321bf72bc7324f00b463a4577959ca2b schema:name DIAPATH — Center for Microscopy and Molecular Imaging (CMMI), Gosselies B-6041, Belgium
113 Department of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels B-1070, Belgium
114 rdf:type schema:Organization
115 N3afeb505ebc4487db6995c8a4e51afd3 schema:issueNumber 7567
116 rdf:type schema:PublicationIssue
117 N4d3d0a1bdd2f40f88e7d15f33361e975 rdf:first sg:person.0634066547.60
118 rdf:rest N1a75fa2c95ac4cb39c7c16562ba31112
119 N4ddb3cbd0ec844ad9923e3ddb38d9f1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Mutation
121 rdf:type schema:DefinedTerm
122 N5211c0a89e5f433eb73dd2230ede6247 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Phosphatidylinositol 3-Kinases
124 rdf:type schema:DefinedTerm
125 N57929eac8ae3427eb2efbf6bba99e975 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Receptors, Estrogen
127 rdf:type schema:DefinedTerm
128 N5ef482a2682f46efa8c2118ecb751363 schema:name dimensions_id
129 schema:value pub.1006527545
130 rdf:type schema:PropertyValue
131 N69b3d5daffab4cb6be350e38d961b23c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cell Lineage
133 rdf:type schema:DefinedTerm
134 N6a074357a9c047c0bce3465c7c96589c rdf:first sg:person.0711353621.12
135 rdf:rest N7433c47c73e248c388b35c86fb55a7db
136 N73aaef2daf244058bd59da276258a2c9 schema:name doi
137 schema:value 10.1038/nature14665
138 rdf:type schema:PropertyValue
139 N7433c47c73e248c388b35c86fb55a7db rdf:first sg:person.01215620576.43
140 rdf:rest Nfd30df68c974435998f58d90544d33a9
141 N80cf2094f4e4486b9abcd5beb92ad405 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Class I Phosphatidylinositol 3-Kinases
143 rdf:type schema:DefinedTerm
144 N847e1b74e6d1455483597667fa8e9577 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Phenotype
146 rdf:type schema:DefinedTerm
147 N85a29251535a45a3a70d02439f96f822 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 N8b0ff92e48494cc79f981f7dc068adc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Mammary Neoplasms, Animal
152 rdf:type schema:DefinedTerm
153 N965196d8923a43eca600640f14fb177a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cell Division
155 rdf:type schema:DefinedTerm
156 N982268e7cde6473584a4f43d1862cc33 schema:name DIAPATH — Center for Microscopy and Molecular Imaging (CMMI), Gosselies B-6041, Belgium
157 Department of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels B-1070, Belgium
158 rdf:type schema:Organization
159 N98864b9298144cff9d319f9011c32e98 rdf:first sg:person.0627062221.57
160 rdf:rest N1cacf835cf794cf390b8879b15387526
161 N9974ce3fe6ed4456814ef28975286c16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cell Differentiation
163 rdf:type schema:DefinedTerm
164 Na1e9167363844d919bbeb77d455e94ba rdf:first sg:person.01101372176.24
165 rdf:rest N1da8f5ab07c14bf9bc75fc9093e67dbe
166 Na7bb0aeae029429cb1e4e66acfd6b1a8 rdf:first sg:person.01352311331.95
167 rdf:rest Nc55d1da7c2c74b31ba37b1fadc51beed
168 Nb641430754f54098a54c03d43c9c4104 rdf:first sg:person.0772641113.37
169 rdf:rest Na7bb0aeae029429cb1e4e66acfd6b1a8
170 Nb78af8f978a94b22ae02fe5d9b718af4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Cell Transformation, Neoplastic
172 rdf:type schema:DefinedTerm
173 Nc434107d0e2c48fea118b9c43d8056dd schema:name pubmed_id
174 schema:value 26266985
175 rdf:type schema:PropertyValue
176 Nc55d1da7c2c74b31ba37b1fadc51beed rdf:first sg:person.0705640631.51
177 rdf:rest N116707558a9949ccaf314f4f643f4cad
178 Nc89e3f570f334aafaa885b6b31d8451c schema:name nlm_unique_id
179 schema:value 0410462
180 rdf:type schema:PropertyValue
181 Nccc3fa0d70874a8383e70bb035ddaca3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Genes, p53
183 rdf:type schema:DefinedTerm
184 Ndace45a686f0462f9343b4d5ccd1d6a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Receptors, Progesterone
186 rdf:type schema:DefinedTerm
187 Nf78eb2c6e2d4403d962b0fbd02e3c062 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Mice
189 rdf:type schema:DefinedTerm
190 Nfaaa9be645f644db900b8caf151bdb9b schema:volumeNumber 525
191 rdf:type schema:PublicationVolume
192 Nfce4affe095449939cfa0aef4268fd00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Animals
194 rdf:type schema:DefinedTerm
195 Nfd30df68c974435998f58d90544d33a9 rdf:first sg:person.01223654444.43
196 rdf:rest Nb641430754f54098a54c03d43c9c4104
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
201 schema:name Oncology and Carcinogenesis
202 rdf:type schema:DefinedTerm
203 sg:journal.1018957 schema:issn 0090-0028
204 1476-4687
205 schema:name Nature
206 rdf:type schema:Periodical
207 sg:person.01032030154.08 schema:affiliation https://www.grid.ac/institutes/grid.4989.c
208 schema:familyName Giraddi
209 schema:givenName Rajshekhar R.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032030154.08
211 rdf:type schema:Person
212 sg:person.01101372176.24 schema:affiliation https://www.grid.ac/institutes/grid.4989.c
213 schema:familyName Ousset
214 schema:givenName Marielle
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101372176.24
216 rdf:type schema:Person
217 sg:person.01136730642.53 schema:affiliation https://www.grid.ac/institutes/grid.4989.c
218 schema:familyName Lee
219 schema:givenName May Yin
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136730642.53
221 rdf:type schema:Person
222 sg:person.01215620576.43 schema:affiliation https://www.grid.ac/institutes/grid.4989.c
223 schema:familyName Bouvencourt
224 schema:givenName Gaëlle
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215620576.43
226 rdf:type schema:Person
227 sg:person.01223654444.43 schema:affiliation https://www.grid.ac/institutes/grid.4989.c
228 schema:familyName Dubois
229 schema:givenName Christine
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223654444.43
231 rdf:type schema:Person
232 sg:person.01240233771.51 schema:affiliation https://www.grid.ac/institutes/grid.418119.4
233 schema:familyName Brohée
234 schema:givenName Sylvain
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240233771.51
236 rdf:type schema:Person
237 sg:person.01352311331.95 schema:affiliation https://www.grid.ac/institutes/grid.418119.4
238 schema:familyName Sotiriou
239 schema:givenName Christos
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352311331.95
241 rdf:type schema:Person
242 sg:person.0627062221.57 schema:affiliation https://www.grid.ac/institutes/grid.4989.c
243 schema:familyName Van Keymeulen
244 schema:givenName Alexandra
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627062221.57
246 rdf:type schema:Person
247 sg:person.0634066547.60 schema:affiliation N321bf72bc7324f00b463a4577959ca2b
248 schema:familyName Rorive
249 schema:givenName Sandrine
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634066547.60
251 rdf:type schema:Person
252 sg:person.0705640631.51 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
253 schema:familyName Phillips
254 schema:givenName Wayne A.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705640631.51
256 rdf:type schema:Person
257 sg:person.0711353621.12 schema:affiliation https://www.grid.ac/institutes/grid.4989.c
258 schema:familyName Wuidart
259 schema:givenName Aline
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711353621.12
261 rdf:type schema:Person
262 sg:person.0772641113.37 schema:affiliation N982268e7cde6473584a4f43d1862cc33
263 schema:familyName Salmon
264 schema:givenName Isabelle
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772641113.37
266 rdf:type schema:Person
267 sg:person.0774010601.05 schema:affiliation https://www.grid.ac/institutes/grid.4989.c
268 schema:familyName Blanpain
269 schema:givenName Cédric
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774010601.05
271 rdf:type schema:Person
272 sg:pub.10.1007/s10549-013-2798-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024615719
273 https://doi.org/10.1007/s10549-013-2798-1
274 rdf:type schema:CreativeWork
275 sg:pub.10.1007/s12026-012-8283-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001764891
276 https://doi.org/10.1007/s12026-012-8283-9
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/35021093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033846543
279 https://doi.org/10.1038/35021093
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/modpathol.2010.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021342247
282 https://doi.org/10.1038/modpathol.2010.136
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/nature04372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037658738
285 https://doi.org/10.1038/nature04372
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/nature04496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040185730
288 https://doi.org/10.1038/nature04496
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nature10525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011100488
291 https://doi.org/10.1038/nature10525
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/nature10573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009808673
294 https://doi.org/10.1038/nature10573
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/nature10933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027457561
297 https://doi.org/10.1038/nature10933
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/nature10983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014607335
300 https://doi.org/10.1038/nature10983
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
303 https://doi.org/10.1038/nature11412
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/nature12948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018720128
306 https://doi.org/10.1038/nature12948
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/nature13851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017721211
309 https://doi.org/10.1038/nature13851
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/ng747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041030245
312 https://doi.org/10.1038/ng747
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/nm.2402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015107623
315 https://doi.org/10.1038/nm.2402
316 rdf:type schema:CreativeWork
317 sg:pub.10.1038/nrclinonc.2011.178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041438461
318 https://doi.org/10.1038/nrclinonc.2011.178
319 rdf:type schema:CreativeWork
320 sg:pub.10.1038/onc.2011.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004160265
321 https://doi.org/10.1038/onc.2011.227
322 rdf:type schema:CreativeWork
323 sg:pub.10.1038/onc.2012.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035924367
324 https://doi.org/10.1038/onc.2012.53
325 rdf:type schema:CreativeWork
326 sg:pub.10.1038/onc.2014.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052701202
327 https://doi.org/10.1038/onc.2014.8
328 rdf:type schema:CreativeWork
329 sg:pub.10.1186/1471-213x-1-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042905963
330 https://doi.org/10.1186/1471-213x-1-4
331 rdf:type schema:CreativeWork
332 sg:pub.10.1186/bcr3334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047302426
333 https://doi.org/10.1186/bcr3334
334 rdf:type schema:CreativeWork
335 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
336 https://doi.org/10.1186/gb-2004-5-10-r80
337 rdf:type schema:CreativeWork
338 sg:pub.10.1186/s13058-014-0411-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028229003
339 https://doi.org/10.1186/s13058-014-0411-0
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1002/ijc.24831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002203934
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/j.ccr.2007.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047318775
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/j.cell.2006.07.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040550108
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/j.molonc.2010.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021321273
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/s1535-6108(02)00184-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009992466
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1073/pnas.152238499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014513729
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1093/bioinformatics/btl117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040779948
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1093/bioinformatics/bts034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025078414
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1093/biostatistics/kxp059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020140411
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1093/carcin/bgq180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011503037
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1093/database/bar049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031978003
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1093/jnci/djr545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036542469
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1136/jcp.2010.087718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042834707
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1158/0008-5472.can-07-6854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002831536
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1158/0008-5472.can-10-0738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018977932
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1158/0008-5472.can-10-3827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005207782
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1158/0008-5472.can-14-0053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028217570
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1200/jco.2008.18.1370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045851448
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1261/rna.047332.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046307378
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1371/journal.pone.0036924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015059968
380 rdf:type schema:CreativeWork
381 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
382 schema:name Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville 3002, Australia
383 Surgical Oncology Research Laboratory, Peter MacCallum Cancer Centre, Melbourne 3002, Australia
384 rdf:type schema:Organization
385 https://www.grid.ac/institutes/grid.418119.4 schema:alternateName Institut Jules Bordet
386 schema:name Institut Jules Bordet, Université Libre de Bruxelles, Brussels B-1000, Belgium
387 rdf:type schema:Organization
388 https://www.grid.ac/institutes/grid.4989.c schema:alternateName Université Libre de Bruxelles
389 schema:name Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
390 WELBIO, Université Libre de Bruxelles, Brussels B-1070, Belgium
391 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...