Mitochondrial reticulum for cellular energy distribution in muscle View Full Text


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Article Info

DATE

2015-07

AUTHORS

Brian Glancy, Lisa M. Hartnell, Daniela Malide, Zu-Xi Yu, Christian A. Combs, Patricia S. Connelly, Sriram Subramaniam, Robert S. Balaban

ABSTRACT

Intracellular energy distribution has attracted much interest and has been proposed to occur in skeletal muscle via metabolite-facilitated diffusion; however, genetic evidence suggests that facilitated diffusion is not critical for normal function. We hypothesized that mitochondrial structure minimizes metabolite diffusion distances in skeletal muscle. Here we demonstrate a mitochondrial reticulum providing a conductive pathway for energy distribution, in the form of the proton-motive force, throughout the mouse skeletal muscle cell. Within this reticulum, we find proteins associated with mitochondrial proton-motive force production preferentially in the cell periphery and proteins that use the proton-motive force for ATP production in the cell interior near contractile and transport ATPases. Furthermore, we show a rapid, coordinated depolarization of the membrane potential component of the proton-motive force throughout the cell in response to spatially controlled uncoupling of the cell interior. We propose that membrane potential conduction via the mitochondrial reticulum is the dominant pathway for skeletal muscle energy distribution. More... »

PAGES

617

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature14614

DOI

http://dx.doi.org/10.1038/nature14614

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040863238

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26223627


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