Regulation of endoplasmic reticulum turnover by selective autophagy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Aliaksandr Khaminets, Theresa Heinrich, Muriel Mari, Paolo Grumati, Antje K. Huebner, Masato Akutsu, Lutz Liebmann, Alexandra Stolz, Sandor Nietzsche, Nicole Koch, Mario Mauthe, Istvan Katona, Britta Qualmann, Joachim Weis, Fulvio Reggiori, Ingo Kurth, Christian A. Hübner, Ivan Dikic

ABSTRACT

The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins and organelle communication. Constant ER turnover and modulation is needed to meet different cellular requirements and autophagy has an important role in this process. However, its underlying regulatory mechanisms remain unexplained. Here we show that members of the FAM134 reticulon protein family are ER-resident receptors that bind to autophagy modifiers LC3 and GABARAP, and facilitate ER degradation by autophagy ('ER-phagy'). Downregulation of FAM134B protein in human cells causes an expansion of the ER, while FAM134B overexpression results in ER fragmentation and lysosomal degradation. Mutant FAM134B proteins that cause sensory neuropathy in humans are unable to act as ER-phagy receptors. Consistently, disruption of Fam134b in mice causes expansion of the ER, inhibits ER turnover, sensitizes cells to stress-induced apoptotic cell death and leads to degeneration of sensory neurons. Therefore, selective ER-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans. More... »

PAGES

354

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature14498

DOI

http://dx.doi.org/10.1038/nature14498

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018718750

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26040720


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