Chromothripsis from DNA damage in micronuclei View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-06

AUTHORS

Cheng-Zhong Zhang, Alexander Spektor, Hauke Cornils, Joshua M. Francis, Emily K. Jackson, Shiwei Liu, Matthew Meyerson, David Pellman

ABSTRACT

Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromothripsis is unknown, but we previously proposed that it could occur through the physical isolation of chromosomes in aberrant nuclear structures called micronuclei. Here, using a combination of live cell imaging and single-cell genome sequencing, we demonstrate that micronucleus formation can indeed generate a spectrum of genomic rearrangements, some of which recapitulate all known features of chromothripsis. These events are restricted to the mis-segregated chromosome and occur within one cell division. We demonstrate that the mechanism for chromothripsis can involve the fragmentation and subsequent reassembly of a single chromatid from a micronucleus. Collectively, these experiments establish a new mutational process of which chromothripsis is one extreme outcome. More... »

PAGES

179

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature14493

DOI

http://dx.doi.org/10.1038/nature14493

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001545095

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26017310


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Breakage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Segregation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Copy Number Variations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Rearrangement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomic Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Micronuclei, Chromosome-Defective", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "S Phase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Single-Cell Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
            "Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
            "Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA", 
            "Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Cheng-Zhong", 
        "id": "sg:person.0753202054.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753202054.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
            "Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spektor", 
        "givenName": "Alexander", 
        "id": "sg:person.0727463764.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727463764.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
            "Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cornils", 
        "givenName": "Hauke", 
        "id": "sg:person.01355231313.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355231313.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
            "Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Francis", 
        "givenName": "Joshua M.", 
        "id": "sg:person.0744302314.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744302314.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
            "Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jackson", 
        "givenName": "Emily K.", 
        "id": "sg:person.0576321015.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576321015.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
            "Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Shiwei", 
        "id": "sg:person.0644434215.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644434215.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
            "Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA", 
            "Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meyerson", 
        "givenName": "Matthew", 
        "id": "sg:person.016012142422.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016012142422.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
            "Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA", 
            "Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pellman", 
        "givenName": "David", 
        "id": "sg:person.01156360632.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156360632.48"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/511155b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001763248", 
          "https://doi.org/10.1038/511155b"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2010.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002377658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006843731", 
          "https://doi.org/10.1038/ng.2202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1181369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007401642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1181369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007401642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008061452", 
          "https://doi.org/10.1038/nature10802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506497102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008135198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1002080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008324413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010635813", 
          "https://doi.org/10.1038/nature08822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010635813", 
          "https://doi.org/10.1038/nature08822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mrrev.2010.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011136760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201210040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011757343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2014.12.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013277282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013331797", 
          "https://doi.org/10.1038/nrg3317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014160655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.8.4.1525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018781111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00412-004-0284-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020567428", 
          "https://doi.org/10.1007/s00412-004-0284-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.377203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021139438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6750-7-19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021474711", 
          "https://doi.org/10.1186/1472-6750-7-19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.01222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022601905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-7-216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023149012", 
          "https://doi.org/10.1186/1471-2164-7-216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1415287111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023383926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025645333", 
          "https://doi.org/10.1038/nsmb.2245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks1039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026279367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-13-0879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026650950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.143677.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026776834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2014.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027036987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.07.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027560099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0105585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028593760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.02.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030611397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gde.2012.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031037849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1210214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031573445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035306231", 
          "https://doi.org/10.1038/nature13600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1229164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035460900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkt345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036641243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.106252.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036779886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038110714", 
          "https://doi.org/10.1038/nrm2651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038110714", 
          "https://doi.org/10.1038/nrm2651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.09.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038558052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gku525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038966517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040701456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.082089499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042072026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042520483", 
          "https://doi.org/10.1038/ng.2760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms7822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045382274", 
          "https://doi.org/10.1038/ncomms7822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg3729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045403173", 
          "https://doi.org/10.1038/nrg3729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.11.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045686167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2012.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049708712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050797629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.229559.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053068720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1206412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062464740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079409808", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-06", 
    "datePublishedReg": "2015-06-01", 
    "description": "Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromothripsis is unknown, but we previously proposed that it could occur through the physical isolation of chromosomes in aberrant nuclear structures called micronuclei. Here, using a combination of live cell imaging and single-cell genome sequencing, we demonstrate that micronucleus formation can indeed generate a spectrum of genomic rearrangements, some of which recapitulate all known features of chromothripsis. These events are restricted to the mis-segregated chromosome and occur within one cell division. We demonstrate that the mechanism for chromothripsis can involve the fragmentation and subsequent reassembly of a single chromatid from a micronucleus. Collectively, these experiments establish a new mutational process of which chromothripsis is one extreme outcome. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature14493", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3803578", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2516623", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2519874", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7555", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "522"
      }
    ], 
    "name": "Chromothripsis from DNA damage in\u00a0micronuclei", 
    "pagination": "179", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "075c038bece6ca46fca3f69ea8c352c1186a200258ddbf0d7b8132baac412898"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26017310"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature14493"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1001545095"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature14493", 
      "https://app.dimensions.ai/details/publication/pub.1001545095"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000549.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature14493"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature14493'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature14493'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature14493'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature14493'


 

This table displays all metadata directly associated to this object as RDF triples.

359 TRIPLES      21 PREDICATES      91 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature14493 schema:about N16b68d3922164bdc8dade4ca8f032524
2 N2230f631b98545ceb0ebf329d4a00e5c
3 N22d75785c476400d92a7c054dad09bf6
4 N2740f89ec4dd4de49642c6487e5d172a
5 N28eca0d79eee46e6a0d537b5b37eab24
6 N63002a9abb8d406898049a8d6e9d420c
7 N63c78b3af3c94a3d80df62e2a9e24e3c
8 N82db0b7a71de4066acf59a48cf7adb92
9 Na9125cdcc27f44bca26a04895b9dbb5d
10 Nb06649f995f84c86acfcab729048c137
11 Nbcacc197738e47c592de3cc07f356dd6
12 Nbdc0ab5e93be45e79e637e814934613f
13 Nd1127f3373d946d69fa6d82e0430775a
14 Neb7fd77b787f4ab19663edd0ec6850ec
15 anzsrc-for:06
16 anzsrc-for:0604
17 schema:author N930a18fa5bf54ba1b4c61c1203ee194d
18 schema:citation sg:pub.10.1007/s00412-004-0284-6
19 sg:pub.10.1038/511155b
20 sg:pub.10.1038/nature08822
21 sg:pub.10.1038/nature10802
22 sg:pub.10.1038/nature13600
23 sg:pub.10.1038/ncomms7822
24 sg:pub.10.1038/ng.2202
25 sg:pub.10.1038/ng.2760
26 sg:pub.10.1038/nrg3317
27 sg:pub.10.1038/nrg3729
28 sg:pub.10.1038/nrm2651
29 sg:pub.10.1038/nsmb.2245
30 sg:pub.10.1186/1471-2164-7-216
31 sg:pub.10.1186/1472-6750-7-19
32 https://app.dimensions.ai/details/publication/pub.1079409808
33 https://doi.org/10.1016/j.ccell.2014.09.010
34 https://doi.org/10.1016/j.cell.2010.11.055
35 https://doi.org/10.1016/j.cell.2011.07.042
36 https://doi.org/10.1016/j.cell.2011.12.013
37 https://doi.org/10.1016/j.cell.2012.09.035
38 https://doi.org/10.1016/j.cell.2013.02.023
39 https://doi.org/10.1016/j.cell.2013.06.007
40 https://doi.org/10.1016/j.celrep.2012.05.009
41 https://doi.org/10.1016/j.cub.2010.08.018
42 https://doi.org/10.1016/j.gde.2012.02.012
43 https://doi.org/10.1016/j.mrrev.2010.03.004
44 https://doi.org/10.1016/j.neuron.2014.12.028
45 https://doi.org/10.1073/pnas.0506497102
46 https://doi.org/10.1073/pnas.082089499
47 https://doi.org/10.1073/pnas.1415287111
48 https://doi.org/10.1083/jcb.201210040
49 https://doi.org/10.1093/nar/gks001
50 https://doi.org/10.1093/nar/gks1039
51 https://doi.org/10.1093/nar/gkt345
52 https://doi.org/10.1093/nar/gku525
53 https://doi.org/10.1101/gad.229559.113
54 https://doi.org/10.1101/gr.106252.110
55 https://doi.org/10.1101/gr.143677.112
56 https://doi.org/10.1101/gr.377203
57 https://doi.org/10.1126/science.1181369
58 https://doi.org/10.1126/science.1206412
59 https://doi.org/10.1126/science.1210214
60 https://doi.org/10.1126/science.1229164
61 https://doi.org/10.1128/mcb.8.4.1525
62 https://doi.org/10.1158/2159-8290.cd-13-0879
63 https://doi.org/10.1371/journal.pgen.1002080
64 https://doi.org/10.1371/journal.pone.0105585
65 https://doi.org/10.7554/elife.01222
66 schema:datePublished 2015-06
67 schema:datePublishedReg 2015-06-01
68 schema:description Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromothripsis is unknown, but we previously proposed that it could occur through the physical isolation of chromosomes in aberrant nuclear structures called micronuclei. Here, using a combination of live cell imaging and single-cell genome sequencing, we demonstrate that micronucleus formation can indeed generate a spectrum of genomic rearrangements, some of which recapitulate all known features of chromothripsis. These events are restricted to the mis-segregated chromosome and occur within one cell division. We demonstrate that the mechanism for chromothripsis can involve the fragmentation and subsequent reassembly of a single chromatid from a micronucleus. Collectively, these experiments establish a new mutational process of which chromothripsis is one extreme outcome.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf Nba026465395f4223b641eee9a39ec111
73 Nd66970370c4247fe92fb13a884ca883c
74 sg:journal.1018957
75 schema:name Chromothripsis from DNA damage in micronuclei
76 schema:pagination 179
77 schema:productId N0fcc4c453fd44a4bb699196692a6bca0
78 N2e297358088d41ebb81b387d39071922
79 N503b3e29f2bd48e8acd1858bc5a049e3
80 N6127b8e4ac5e4654bf9f0d257e6f9851
81 Nccd3b83f56c54a7ba95e530f1758c9bf
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001545095
83 https://doi.org/10.1038/nature14493
84 schema:sdDatePublished 2019-04-10T19:15
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N278b281d605c40e3aef0933e2a4f4a96
87 schema:url https://www.nature.com/articles/nature14493
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N03ef3dc5e09140e9ab163bd0769b0cba rdf:first sg:person.01355231313.27
92 rdf:rest N0e8e092fc69a465492e570fbf87b29f4
93 N0e8e092fc69a465492e570fbf87b29f4 rdf:first sg:person.0744302314.40
94 rdf:rest N4e7fdbaab61e4b0ea54cbb314c48a58c
95 N0fcc4c453fd44a4bb699196692a6bca0 schema:name readcube_id
96 schema:value 075c038bece6ca46fca3f69ea8c352c1186a200258ddbf0d7b8132baac412898
97 rdf:type schema:PropertyValue
98 N135fb9bbcd1e489884777ae08024a762 rdf:first sg:person.0727463764.72
99 rdf:rest N03ef3dc5e09140e9ab163bd0769b0cba
100 N16b68d3922164bdc8dade4ca8f032524 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Chromosome Segregation
102 rdf:type schema:DefinedTerm
103 N2230f631b98545ceb0ebf329d4a00e5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Cell Survival
105 rdf:type schema:DefinedTerm
106 N22d75785c476400d92a7c054dad09bf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name DNA Copy Number Variations
108 rdf:type schema:DefinedTerm
109 N2740f89ec4dd4de49642c6487e5d172a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Micronuclei, Chromosome-Defective
111 rdf:type schema:DefinedTerm
112 N278b281d605c40e3aef0933e2a4f4a96 schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N28eca0d79eee46e6a0d537b5b37eab24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name DNA Damage
116 rdf:type schema:DefinedTerm
117 N29ca08bc89d341a388b2bce87e1a05ac rdf:first sg:person.0644434215.55
118 rdf:rest N9fe825c8b0e44d3f9145fd6dea92e2e3
119 N2e297358088d41ebb81b387d39071922 schema:name pubmed_id
120 schema:value 26017310
121 rdf:type schema:PropertyValue
122 N4e7fdbaab61e4b0ea54cbb314c48a58c rdf:first sg:person.0576321015.20
123 rdf:rest N29ca08bc89d341a388b2bce87e1a05ac
124 N503b3e29f2bd48e8acd1858bc5a049e3 schema:name dimensions_id
125 schema:value pub.1001545095
126 rdf:type schema:PropertyValue
127 N6127b8e4ac5e4654bf9f0d257e6f9851 schema:name doi
128 schema:value 10.1038/nature14493
129 rdf:type schema:PropertyValue
130 N63002a9abb8d406898049a8d6e9d420c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N63c78b3af3c94a3d80df62e2a9e24e3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Line
135 rdf:type schema:DefinedTerm
136 N82db0b7a71de4066acf59a48cf7adb92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Chromosome Breakage
138 rdf:type schema:DefinedTerm
139 N930a18fa5bf54ba1b4c61c1203ee194d rdf:first sg:person.0753202054.57
140 rdf:rest N135fb9bbcd1e489884777ae08024a762
141 N9fe825c8b0e44d3f9145fd6dea92e2e3 rdf:first sg:person.016012142422.14
142 rdf:rest Nbaa84bd240b14a82a60747d222bbc47b
143 Na9125cdcc27f44bca26a04895b9dbb5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Mutation
145 rdf:type schema:DefinedTerm
146 Nb06649f995f84c86acfcab729048c137 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Genomic Instability
148 rdf:type schema:DefinedTerm
149 Nba026465395f4223b641eee9a39ec111 schema:issueNumber 7555
150 rdf:type schema:PublicationIssue
151 Nbaa84bd240b14a82a60747d222bbc47b rdf:first sg:person.01156360632.48
152 rdf:rest rdf:nil
153 Nbcacc197738e47c592de3cc07f356dd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Single-Cell Analysis
155 rdf:type schema:DefinedTerm
156 Nbdc0ab5e93be45e79e637e814934613f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name S Phase
158 rdf:type schema:DefinedTerm
159 Nccd3b83f56c54a7ba95e530f1758c9bf schema:name nlm_unique_id
160 schema:value 0410462
161 rdf:type schema:PropertyValue
162 Nd1127f3373d946d69fa6d82e0430775a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Gene Rearrangement
164 rdf:type schema:DefinedTerm
165 Nd66970370c4247fe92fb13a884ca883c schema:volumeNumber 522
166 rdf:type schema:PublicationVolume
167 Neb7fd77b787f4ab19663edd0ec6850ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Neoplasms
169 rdf:type schema:DefinedTerm
170 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
171 schema:name Biological Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
174 schema:name Genetics
175 rdf:type schema:DefinedTerm
176 sg:grant.2516623 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14493
177 rdf:type schema:MonetaryGrant
178 sg:grant.2519874 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14493
179 rdf:type schema:MonetaryGrant
180 sg:grant.3803578 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14493
181 rdf:type schema:MonetaryGrant
182 sg:journal.1018957 schema:issn 0090-0028
183 1476-4687
184 schema:name Nature
185 rdf:type schema:Periodical
186 sg:person.01156360632.48 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
187 schema:familyName Pellman
188 schema:givenName David
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156360632.48
190 rdf:type schema:Person
191 sg:person.01355231313.27 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
192 schema:familyName Cornils
193 schema:givenName Hauke
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355231313.27
195 rdf:type schema:Person
196 sg:person.016012142422.14 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
197 schema:familyName Meyerson
198 schema:givenName Matthew
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016012142422.14
200 rdf:type schema:Person
201 sg:person.0576321015.20 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
202 schema:familyName Jackson
203 schema:givenName Emily K.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576321015.20
205 rdf:type schema:Person
206 sg:person.0644434215.55 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
207 schema:familyName Liu
208 schema:givenName Shiwei
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644434215.55
210 rdf:type schema:Person
211 sg:person.0727463764.72 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
212 schema:familyName Spektor
213 schema:givenName Alexander
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727463764.72
215 rdf:type schema:Person
216 sg:person.0744302314.40 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
217 schema:familyName Francis
218 schema:givenName Joshua M.
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744302314.40
220 rdf:type schema:Person
221 sg:person.0753202054.57 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
222 schema:familyName Zhang
223 schema:givenName Cheng-Zhong
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753202054.57
225 rdf:type schema:Person
226 sg:pub.10.1007/s00412-004-0284-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020567428
227 https://doi.org/10.1007/s00412-004-0284-6
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/511155b schema:sameAs https://app.dimensions.ai/details/publication/pub.1001763248
230 https://doi.org/10.1038/511155b
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/nature08822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010635813
233 https://doi.org/10.1038/nature08822
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/nature10802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008061452
236 https://doi.org/10.1038/nature10802
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/nature13600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035306231
239 https://doi.org/10.1038/nature13600
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/ncomms7822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045382274
242 https://doi.org/10.1038/ncomms7822
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/ng.2202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006843731
245 https://doi.org/10.1038/ng.2202
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/ng.2760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042520483
248 https://doi.org/10.1038/ng.2760
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nrg3317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013331797
251 https://doi.org/10.1038/nrg3317
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nrg3729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045403173
254 https://doi.org/10.1038/nrg3729
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nrm2651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038110714
257 https://doi.org/10.1038/nrm2651
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nsmb.2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025645333
260 https://doi.org/10.1038/nsmb.2245
261 rdf:type schema:CreativeWork
262 sg:pub.10.1186/1471-2164-7-216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023149012
263 https://doi.org/10.1186/1471-2164-7-216
264 rdf:type schema:CreativeWork
265 sg:pub.10.1186/1472-6750-7-19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021474711
266 https://doi.org/10.1186/1472-6750-7-19
267 rdf:type schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1079409808 schema:CreativeWork
269 https://doi.org/10.1016/j.ccell.2014.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027036987
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.cell.2010.11.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045686167
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.cell.2011.07.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027560099
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.cell.2011.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050797629
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.cell.2012.09.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038558052
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.cell.2013.02.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030611397
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.cell.2013.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014160655
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.celrep.2012.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049708712
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.cub.2010.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002377658
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.gde.2012.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031037849
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.mrrev.2010.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011136760
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.neuron.2014.12.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013277282
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1073/pnas.0506497102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008135198
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1073/pnas.082089499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042072026
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.1415287111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023383926
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1083/jcb.201210040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011757343
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/nar/gks001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040701456
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/nar/gks1039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026279367
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1093/nar/gkt345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036641243
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1093/nar/gku525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038966517
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1101/gad.229559.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053068720
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1101/gr.106252.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036779886
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1101/gr.143677.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026776834
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1101/gr.377203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021139438
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1126/science.1181369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007401642
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1126/science.1206412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062464740
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1126/science.1210214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031573445
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1126/science.1229164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035460900
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1128/mcb.8.4.1525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018781111
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1158/2159-8290.cd-13-0879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026650950
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1371/journal.pgen.1002080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008324413
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1371/journal.pone.0105585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028593760
332 rdf:type schema:CreativeWork
333 https://doi.org/10.7554/elife.01222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022601905
334 rdf:type schema:CreativeWork
335 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
336 schema:name Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
337 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
338 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
339 Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
340 rdf:type schema:Organization
341 https://www.grid.ac/institutes/grid.413575.1 schema:alternateName Howard Hughes Medical Institute
342 schema:name Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
343 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
344 Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
345 Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
346 rdf:type schema:Organization
347 https://www.grid.ac/institutes/grid.65499.37 schema:alternateName Dana–Farber Cancer Institute
348 schema:name Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
349 Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
350 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
351 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
352 Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
353 Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
354 Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
355 rdf:type schema:Organization
356 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
357 schema:name Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
358 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
359 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...