Ontology type: schema:ScholarlyArticle Open Access: True
2015-04
AUTHORSHiroaki Tanabe, Yoshifumi Fujii, Miki Okada-Iwabu, Masato Iwabu, Yoshihiro Nakamura, Toshiaki Hosaka, Kanna Motoyama, Mariko Ikeda, Motoaki Wakiyama, Takaho Terada, Noboru Ohsawa, Masakatsu Hato, Satoshi Ogasawara, Tomoya Hino, Takeshi Murata, So Iwata, Kunio Hirata, Yoshiaki Kawano, Masaki Yamamoto, Tomomi Kimura-Someya, Mikako Shirouzu, Toshimasa Yamauchi, Takashi Kadowaki, Shigeyuki Yokoyama
ABSTRACTAdiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules. AdipoR1 and AdipoR2 were predicted to contain seven transmembrane helices with the opposite topology to G-protein-coupled receptors. Here we report the crystal structures of human AdipoR1 and AdipoR2 at 2.9 and 2.4 Å resolution, respectively, which represent a novel class of receptor structure. The seven-transmembrane helices, conformationally distinct from those of G-protein-coupled receptors, enclose a large cavity where three conserved histidine residues coordinate a zinc ion. The zinc-binding structure may have a role in the adiponectin-stimulated AMPK phosphorylation and UCP2 upregulation. Adiponectin may broadly interact with the extracellular face, rather than the carboxy-terminal tail, of the receptors. The present information will facilitate the understanding of novel structure-function relationships and the development and optimization of AdipoR agonists for the treatment of obesity-related diseases, such as type 2 diabetes. More... »
PAGES312
http://scigraph.springernature.com/pub.10.1038/nature14301
DOIhttp://dx.doi.org/10.1038/nature14301
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1009453256
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25855295
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amino Acid Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Binding Sites",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Crystallography, X-Ray",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Histidine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Molecular",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Sequence Data",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Conformation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Adiponectin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Structure-Activity Relationship",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Zinc",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Department of Biophysics and Biochemistry and Laboratory of Structural Biology, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan",
"Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Tanabe",
"givenName": "Hiroaki",
"id": "sg:person.0604740544.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604740544.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Fujii",
"givenName": "Yoshifumi",
"id": "sg:person.01266072544.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266072544.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan",
"Department of Integrated Molecular Science on Metabolic Diseases, 22nd Century Medical and Research Center, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"
],
"type": "Organization"
},
"familyName": "Okada-Iwabu",
"givenName": "Miki",
"id": "sg:person.01004767325.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004767325.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Japan Science and Technology Agency",
"id": "https://www.grid.ac/institutes/grid.419082.6",
"name": [
"Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan",
"Department of Integrated Molecular Science on Metabolic Diseases, 22nd Century Medical and Research Center, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan",
"PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan"
],
"type": "Organization"
},
"familyName": "Iwabu",
"givenName": "Masato",
"id": "sg:person.01346102065.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346102065.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Nakamura",
"givenName": "Yoshihiro",
"id": "sg:person.01040302123.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040302123.92"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Hosaka",
"givenName": "Toshiaki",
"id": "sg:person.01213524105.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213524105.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Motoyama",
"givenName": "Kanna",
"id": "sg:person.0750460541.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750460541.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Ikeda",
"givenName": "Mariko",
"id": "sg:person.0734243370.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734243370.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Wakiyama",
"givenName": "Motoaki",
"id": "sg:person.01034032025.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034032025.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Terada",
"givenName": "Takaho",
"id": "sg:person.013626202062.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013626202062.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Ohsawa",
"givenName": "Noboru",
"id": "sg:person.01071370106.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071370106.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Hato",
"givenName": "Masakatsu",
"id": "sg:person.01100236664.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100236664.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kyoto University",
"id": "https://www.grid.ac/institutes/grid.258799.8",
"name": [
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"
],
"type": "Organization"
},
"familyName": "Ogasawara",
"givenName": "Satoshi",
"id": "sg:person.01004221112.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004221112.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Japan Science and Technology Agency",
"id": "https://www.grid.ac/institutes/grid.419082.6",
"name": [
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan",
"JST, Research Acceleration Program, Membrane Protein Crystallography Project, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan"
],
"type": "Organization"
},
"familyName": "Hino",
"givenName": "Tomoya",
"id": "sg:person.0626523575.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626523575.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chiba University",
"id": "https://www.grid.ac/institutes/grid.136304.3",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan",
"JST, Research Acceleration Program, Membrane Protein Crystallography Project, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan",
"Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage, Chiba 263-8522, Japan"
],
"type": "Organization"
},
"familyName": "Murata",
"givenName": "Takeshi",
"id": "sg:person.01370160306.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370160306.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Diamond Light Source (United Kingdom)",
"id": "https://www.grid.ac/institutes/grid.18785.33",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Department of Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan",
"JST, Research Acceleration Program, Membrane Protein Crystallography Project, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan",
"Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London SW7 2AZ, UK",
"Diamond Light Source, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire OX11 0DE, UK",
"RIKEN SPring-8 Center, Harima Institute, Kouto, Sayo, Hyogo 679-5148, Japan"
],
"type": "Organization"
},
"familyName": "Iwata",
"givenName": "So",
"id": "sg:person.01337410152.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337410152.19"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"RIKEN SPring-8 Center, Harima Institute, Kouto, Sayo, Hyogo 679-5148, Japan"
],
"type": "Organization"
},
"familyName": "Hirata",
"givenName": "Kunio",
"id": "sg:person.01256470305.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256470305.03"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"RIKEN SPring-8 Center, Harima Institute, Kouto, Sayo, Hyogo 679-5148, Japan"
],
"type": "Organization"
},
"familyName": "Kawano",
"givenName": "Yoshiaki",
"id": "sg:person.0756317004.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756317004.75"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"RIKEN SPring-8 Center, Harima Institute, Kouto, Sayo, Hyogo 679-5148, Japan"
],
"type": "Organization"
},
"familyName": "Yamamoto",
"givenName": "Masaki",
"id": "sg:person.012771421304.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012771421304.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Kimura-Someya",
"givenName": "Tomomi",
"id": "sg:person.01104104440.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104104440.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "RIKEN",
"id": "https://www.grid.ac/institutes/grid.7597.c",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Shirouzu",
"givenName": "Mikako",
"id": "sg:person.01274360652.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274360652.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Japan Science and Technology Agency",
"id": "https://www.grid.ac/institutes/grid.419082.6",
"name": [
"Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan",
"Department of Integrated Molecular Science on Metabolic Diseases, 22nd Century Medical and Research Center, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan",
"CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan"
],
"type": "Organization"
},
"familyName": "Yamauchi",
"givenName": "Toshimasa",
"id": "sg:person.012027672272.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012027672272.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan",
"Department of Integrated Molecular Science on Metabolic Diseases, 22nd Century Medical and Research Center, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"
],
"type": "Organization"
},
"familyName": "Kadowaki",
"givenName": "Takashi",
"id": "sg:person.01353472360.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353472360.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Tokyo",
"id": "https://www.grid.ac/institutes/grid.26999.3d",
"name": [
"RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan",
"Department of Biophysics and Biochemistry and Laboratory of Structural Biology, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan",
"RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"
],
"type": "Organization"
},
"familyName": "Yokoyama",
"givenName": "Shigeyuki",
"id": "sg:person.0723444525.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723444525.34"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1107/s0907444910007493",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000235100"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444910007493",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000235100"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/bbrc.1996.0587",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000410466"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1215904",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001612051"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0076-6879(97)76066-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004907170"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.222657499",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005787192"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35013000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007859471",
"https://doi.org/10.1038/35013000"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35013000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007859471",
"https://doi.org/10.1038/35013000"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1150577",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008512367"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11896",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008732026",
"https://doi.org/10.1038/nature11896"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10361",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008768060",
"https://doi.org/10.1038/nature10361"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1249489",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008878848"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1249489",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008878848"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/415339a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009350695",
"https://doi.org/10.1038/415339a"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/415339a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009350695",
"https://doi.org/10.1038/415339a"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/prot.340040406",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010728632"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/prot.340040406",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010728632"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10136",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012148072",
"https://doi.org/10.1038/nature10136"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/jm2011589",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012345714"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/jm2011589",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012345714"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0021889807021206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012753217"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08991",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013311707",
"https://doi.org/10.1038/nature08991"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08991",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013311707",
"https://doi.org/10.1038/nature08991"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909042073",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018458004"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909042073",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018458004"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkq366",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019751093"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909052925",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020777046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909052925",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020777046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0014-5793(96)01209-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021556977"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.49.4.527",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026870914"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/358164a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027644880",
"https://doi.org/10.1038/358164a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.c200312200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027797945"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1557",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029456603",
"https://doi.org/10.1038/nm1557"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.atv.20.6.1595",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029685152"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1103943",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031643892"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/90992",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032134285",
"https://doi.org/10.1038/90992"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909047337",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032162623"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444909047337",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032162623"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1404",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032371643",
"https://doi.org/10.1038/ncb1404"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1404",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032371643",
"https://doi.org/10.1038/ncb1404"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09665",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033011382",
"https://doi.org/10.1038/nature09665"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cmet.2004.12.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033736922"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m209033200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035029420"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.271.18.10697",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035318566"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.270.45.26746",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035808233"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10969-014-9187-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035811374",
"https://doi.org/10.1007/s10969-014-9187-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10969-014-9187-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035811374",
"https://doi.org/10.1007/s10969-014-9187-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06325",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035993954",
"https://doi.org/10.1038/nature06325"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.98.4.2005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038814250"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444900005072",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038886912"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10236",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040196439",
"https://doi.org/10.1038/nature10236"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/90984",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040199616",
"https://doi.org/10.1038/90984"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.289.5480.739",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042667522"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12656",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043573676",
"https://doi.org/10.1038/nature12656"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1150609",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043965657"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1088/1742-6596/425/1/012002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044156712"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm788",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045145719",
"https://doi.org/10.1038/nm788"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm788",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045145719",
"https://doi.org/10.1038/nm788"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3802/jgo.2012.23.3.153",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046965904"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12393",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049819195",
"https://doi.org/10.1038/nature12393"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0909049505004735",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050248304"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0306324101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050826504"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature01705",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051052427",
"https://doi.org/10.1038/nature01705"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature01705",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051052427",
"https://doi.org/10.1038/nature01705"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10969-014-9192-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051554476",
"https://doi.org/10.1007/s10969-014-9192-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10969-014-9192-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051554476",
"https://doi.org/10.1007/s10969-014-9192-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09648",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052301824",
"https://doi.org/10.1038/nature09648"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1107/s0907444902018048",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053574286"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/oxfordjournals.jbchem.a021483",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059960285"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1150755",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062457156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.277.5332.1676",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062557968"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fasebj.11.5.9141501",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083085891"
],
"type": "CreativeWork"
}
],
"datePublished": "2015-04",
"datePublishedReg": "2015-04-01",
"description": "Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5'\u00a0AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules. AdipoR1 and AdipoR2 were predicted to contain seven transmembrane helices with the opposite topology to G-protein-coupled receptors. Here we report the crystal structures of human AdipoR1 and AdipoR2 at 2.9 and 2.4\u00a0\u00c5 resolution, respectively, which represent a novel class of receptor structure. The seven-transmembrane helices, conformationally distinct from those of G-protein-coupled receptors, enclose a large cavity where three conserved histidine residues coordinate a zinc ion. The zinc-binding structure may have a role in the adiponectin-stimulated AMPK phosphorylation and UCP2 upregulation. Adiponectin may broadly interact with the extracellular face, rather than\u00a0the carboxy-terminal tail, of the receptors. The present information will facilitate the understanding of novel structure-function relationships and the development and optimization of AdipoR agonists for the treatment of obesity-related diseases, such as type 2 diabetes. ",
"genre": "research_article",
"id": "sg:pub.10.1038/nature14301",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.6110996",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3627276",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6125761",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6138529",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3638357",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2752691",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5853513",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.5987049",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6128974",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6129108",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6146616",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0090-0028",
"1476-4687"
],
"name": "Nature",
"type": "Periodical"
},
{
"issueNumber": "7547",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "520"
}
],
"name": "Crystal structures of the human adiponectin receptors",
"pagination": "312",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"2d0828176c04ae1338a0f7653afc43fccd55ea4f21bf7dcfe236728b3dbe9741"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25855295"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0410462"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nature14301"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1009453256"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nature14301",
"https://app.dimensions.ai/details/publication/pub.1009453256"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T15:38",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000422.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/nature14301"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature14301'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature14301'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature14301'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature14301'
This table displays all metadata directly associated to this object as RDF triples.
529 TRIPLES
21 PREDICATES
97 URIs
32 LITERALS
20 BLANK NODES