Ontology type: schema:ScholarlyArticle Open Access: True
2015-02
AUTHORSAlexander M. Tsankov, Hongcang Gu, Veronika Akopian, Michael J. Ziller, Julie Donaghey, Ido Amit, Andreas Gnirke, Alexander Meissner
ABSTRACTPluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics that regulate cell fate changes during mammalian development. Here we report the integrative analysis of genome-wide binding data for 38 transcription factors with extensive epigenome and transcriptional data across the differentiation of human embryonic stem cells to the three germ layers. We describe core regulatory dynamics and show the lineage-specific behaviour of selected factors. In addition to the orchestrated remodelling of the chromatin landscape, we find that the binding of several transcription factors is strongly associated with specific loss of DNA methylation in one germ layer, and in many cases a reciprocal gain in the other layers. Taken together, our work shows context-dependent rewiring of transcription factor binding, downstream signalling effectors, and the epigenome during human embryonic stem cell differentiation. More... »
PAGES344
http://scigraph.springernature.com/pub.10.1038/nature14233
DOIhttp://dx.doi.org/10.1038/nature14233
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25693565
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{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1001073525"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nature14233",
"https://app.dimensions.ai/details/publication/pub.1001073525"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T18:26",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000549.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/nature14233"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature14233'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature14233'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature14233'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature14233'
This table displays all metadata directly associated to this object as RDF triples.
364 TRIPLES
21 PREDICATES
95 URIs
38 LITERALS
26 BLANK NODES