Visualizing transient Watson–Crick-like mispairs in DNA and RNA duplexes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-03

AUTHORS

Isaac J. Kimsey, Katja Petzold, Bharathwaj Sathyamoorthy, Zachary W. Stein, Hashim M. Al-Hashimi

ABSTRACT

Rare tautomeric and anionic nucleobases are believed to have fundamental biological roles, but their prevalence and functional importance has remained elusive because they exist transiently, in low abundance, and involve subtle movements of protons that are difficult to visualize. Using NMR relaxation dispersion, we show here that wobble dG•dT and rG•rU mispairs in DNA and RNA duplexes exist in dynamic equilibrium with short-lived, low-populated Watson-Crick-like mispairs that are stabilized by rare enolic or anionic bases. These mispairs can evade Watson-Crick fidelity checkpoints and form with probabilities (10(-3) to 10(-5)) that strongly imply a universal role in replication and translation errors. Our results indicate that rare tautomeric and anionic bases are widespread in nucleic acids, expanding their structural and functional complexity beyond that attainable with canonical bases. More... »

PAGES

315

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature14227

DOI

http://dx.doi.org/10.1038/nature14227

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033188171

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25762137


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