Lagging-strand replication shapes the mutational landscape of the genome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-02

AUTHORS

Martin A. M. Reijns, Harriet Kemp, James Ding, Sophie Marion de Procé, Andrew P. Jackson, Martin S. Taylor

ABSTRACT

The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we report that the 5' ends of Okazaki fragments have significantly increased levels of nucleotide substitution, indicating a replicative origin for such mutations. Using a novel method, emRiboSeq, we map the genome-wide contribution of polymerases, and show that despite Okazaki fragment processing, DNA synthesized by error-prone polymerase-α (Pol-α) is retained in vivo, comprising approximately 1.5% of the mature genome. We propose that DNA-binding proteins that rapidly re-associate post-replication act as partial barriers to Pol-δ-mediated displacement of Pol-α-synthesized DNA, resulting in incorporation of such Pol-α tracts and increased mutation rates at specific sites. We observe a mutational cost to chromatin and regulatory protein binding, resulting in mutation hotspots at regulatory elements, with signatures of this process detectable in both yeast and humans. More... »

PAGES

502

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature14183

DOI

http://dx.doi.org/10.1038/nature14183

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045598554

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25624100


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