Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01-07

AUTHORS

Kai Deng, Mihaela Pertea, Anthony Rongvaux, Leyao Wang, Christine M. Durand, Gabriel Ghiaur, Jun Lai, Holly L. McHugh, Haiping Hao, Hao Zhang, Joseph B. Margolick, Cagan Gurer, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Steven G. Deeks, Till Strowig, Priti Kumar, Janet D. Siliciano, Steven L. Salzberg, Richard A. Flavell, Liang Shan, Robert F. Siliciano

ABSTRACT

Despite receiving antiretroviral therapy, most patients with HIV still have latent reservoirs of the virus; here, these reservoirs are shown to be dominated by viruses with cytotoxic T lymphocyte escape mutations, with potential implications for the development of therapeutic vaccines.

PAGES

381-385

References to SciGraph publications

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  • 2012-03-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • Journal

    TITLE

    Nature

    ISSUE

    7534

    VOLUME

    517

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature14053

    DOI

    http://dx.doi.org/10.1038/nature14053

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035285592

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25561180


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