Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01-07

AUTHORS

Kai Deng, Mihaela Pertea, Anthony Rongvaux, Leyao Wang, Christine M. Durand, Gabriel Ghiaur, Jun Lai, Holly L. McHugh, Haiping Hao, Hao Zhang, Joseph B. Margolick, Cagan Gurer, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Steven G. Deeks, Till Strowig, Priti Kumar, Janet D. Siliciano, Steven L. Salzberg, Richard A. Flavell, Liang Shan, Robert F. Siliciano

ABSTRACT

Despite receiving antiretroviral therapy, most patients with HIV still have latent reservoirs of the virus; here, these reservoirs are shown to be dominated by viruses with cytotoxic T lymphocyte escape mutations, with potential implications for the development of therapeutic vaccines.

PAGES

381-385

References to SciGraph publications

  • 2003-05-18. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells in NATURE MEDICINE
  • 2009-03-12. The role of IFN-γ Elispot assay in HIV vaccine research in NATURE PROTOCOLS
  • 1997-02-01. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS in NATURE MEDICINE
  • 2014-03-16. Development and function of human innate immune cells in a humanized mouse model in NATURE BIOTECHNOLOGY
  • 1991-12-12. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition in NATURE
  • 1997-05. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection in NATURE
  • 1997-02-01. Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus in NATURE MEDICINE
  • 2012-07-25. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy in NATURE
  • 2009-12-11. The immune response during acute HIV-1 infection: clues for vaccine development in NATURE REVIEWS IMMUNOLOGY
  • 2001-07. Evolution and transmission of stable CTL escape mutations in HIV infection in NATURE
  • 1987-07-23. HIV-specific cytotoxic T lymphocytes in seropositive individuals in NATURE
  • 2004-08. HIV and SIV CTL escape: implications for vaccine design in NATURE REVIEWS IMMUNOLOGY
  • 2014-07-20. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys in NATURE
  • 2012-03-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • Journal

    TITLE

    Nature

    ISSUE

    7534

    VOLUME

    517

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature14053

    DOI

    http://dx.doi.org/10.1038/nature14053

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035285592

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25561180


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acute Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-HIV Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD4-Positive T-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chronic Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epitopes, T-Lymphocyte", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Dominant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Viral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HIV Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HIV-1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Viral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes, Cytotoxic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Viral Load", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Virus Latency", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Virus Replication", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "gag Gene Products, Human Immunodeficiency Virus", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deng", 
            "givenName": "Kai", 
            "id": "sg:person.0717205555.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717205555.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Computational Biology, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
                "Center for Computational Biology, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pertea", 
            "givenName": "Mihaela", 
            "id": "sg:person.0720234625.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720234625.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Immunobiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Immunobiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rongvaux", 
            "givenName": "Anthony", 
            "id": "sg:person.01307127473.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307127473.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Chronic Disease Epidemiology, Yale School of Public Health, 06510, New Haven, Connecticut, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Chronic Disease Epidemiology, Yale School of Public Health, 06510, New Haven, Connecticut, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Leyao", 
            "id": "sg:person.01012474047.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012474047.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Durand", 
            "givenName": "Christine M.", 
            "id": "sg:person.01063121561.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063121561.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Oncology, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ghiaur", 
            "givenName": "Gabriel", 
            "id": "sg:person.01144676622.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144676622.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lai", 
            "givenName": "Jun", 
            "id": "sg:person.0773702117.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773702117.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McHugh", 
            "givenName": "Holly L.", 
            "id": "sg:person.01310110315.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310110315.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Deep Sequencing and Microarray Core, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Deep Sequencing and Microarray Core, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hao", 
            "givenName": "Haiping", 
            "id": "sg:person.01200133610.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200133610.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Hao", 
            "id": "sg:person.015550266771.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015550266771.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Margolick", 
            "givenName": "Joseph B.", 
            "id": "sg:person.01157304405.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157304405.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Regeneron Pharmaceuticals Inc., 10591, Tarrytown, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.418961.3", 
              "name": [
                "Regeneron Pharmaceuticals Inc., 10591, Tarrytown, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gurer", 
            "givenName": "Cagan", 
            "id": "sg:person.01256324327.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256324327.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Regeneron Pharmaceuticals Inc., 10591, Tarrytown, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.418961.3", 
              "name": [
                "Regeneron Pharmaceuticals Inc., 10591, Tarrytown, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murphy", 
            "givenName": "Andrew J.", 
            "id": "sg:person.07551207301.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07551207301.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Regeneron Pharmaceuticals Inc., 10591, Tarrytown, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.418961.3", 
              "name": [
                "Regeneron Pharmaceuticals Inc., 10591, Tarrytown, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Valenzuela", 
            "givenName": "David M.", 
            "id": "sg:person.0746742366.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746742366.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Regeneron Pharmaceuticals Inc., 10591, Tarrytown, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.418961.3", 
              "name": [
                "Regeneron Pharmaceuticals Inc., 10591, Tarrytown, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yancopoulos", 
            "givenName": "George D.", 
            "id": "sg:person.01274702531.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274702531.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, University of California, San Francisco, San Francisco, California 94110, USA", 
              "id": "http://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Department of Medicine, University of California, San Francisco, San Francisco, California 94110, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deeks", 
            "givenName": "Steven G.", 
            "id": "sg:person.012534455317.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012534455317.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Immunobiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Immunobiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Strowig", 
            "givenName": "Till", 
            "id": "sg:person.01152042325.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152042325.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Medicine, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kumar", 
            "givenName": "Priti", 
            "id": "sg:person.013104322607.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013104322607.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Siliciano", 
            "givenName": "Janet D.", 
            "id": "sg:person.011314115547.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011314115547.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Center for Computational Biology, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
                "Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salzberg", 
            "givenName": "Steven L.", 
            "id": "sg:person.01223441713.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223441713.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, 06510, New Haven, Connecticut, USA", 
              "id": "http://www.grid.ac/institutes/grid.413575.1", 
              "name": [
                "Department of Immunobiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
                "Howard Hughes Medical Institute, 06510, New Haven, Connecticut, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Flavell", 
            "givenName": "Richard A.", 
            "id": "sg:person.013636762157.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013636762157.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Immunobiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Immunobiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shan", 
            "givenName": "Liang", 
            "id": "sg:person.07641375037.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07641375037.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, 21205, Baltimore, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.413575.1", 
              "name": [
                "Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
                "Howard Hughes Medical Institute, 21205, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Siliciano", 
            "givenName": "Robert F.", 
            "id": "sg:person.01117551521.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117551521.49"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature13594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050124782", 
              "https://doi.org/10.1038/nature13594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034344807", 
              "https://doi.org/10.1038/nri1417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/328345a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022500911", 
              "https://doi.org/10.1038/328345a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029331458", 
              "https://doi.org/10.1038/nri2674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35085576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005637789", 
              "https://doi.org/10.1038/35085576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006541515", 
              "https://doi.org/10.1038/nmeth.1923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2858", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004838832", 
              "https://doi.org/10.1038/nbt.2858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/387183a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036513917", 
              "https://doi.org/10.1038/387183a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013312562", 
              "https://doi.org/10.1038/nature11286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0297-212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005909019", 
              "https://doi.org/10.1038/nm0297-212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm880", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005517496", 
              "https://doi.org/10.1038/nm880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/354453a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029680452", 
              "https://doi.org/10.1038/354453a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0297-205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012809998", 
              "https://doi.org/10.1038/nm0297-205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2009.7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037363244", 
              "https://doi.org/10.1038/nprot.2009.7"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-01-07", 
        "datePublishedReg": "2015-01-07", 
        "description": "Despite receiving antiretroviral therapy, most patients with HIV still have latent reservoirs of the virus; here, these reservoirs are shown to be dominated by viruses with cytotoxic T lymphocyte escape mutations, with potential implications for the development of therapeutic vaccines.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nature14053", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2454136", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438718", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438688", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2681749", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2684726", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2695893", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2455700", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5476639", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2695895", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3932133", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7534", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "517"
          }
        ], 
        "keywords": [
          "escape mutations", 
          "cytotoxic T lymphocyte escape mutations", 
          "latent HIV-1", 
          "broad CTL response", 
          "antiretroviral therapy", 
          "most patients", 
          "CTL responses", 
          "latent reservoir", 
          "therapeutic vaccines", 
          "HIV-1", 
          "virus", 
          "HIV", 
          "potential implications", 
          "patients", 
          "therapy", 
          "vaccine", 
          "mutations", 
          "response", 
          "development", 
          "implications", 
          "reservoir", 
          "dominance"
        ], 
        "name": "Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations", 
        "pagination": "381-385", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1035285592"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature14053"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25561180"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature14053", 
          "https://app.dimensions.ai/details/publication/pub.1035285592"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T15:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_654.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nature14053"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature14053'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature14053'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature14053'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature14053'


     

    This table displays all metadata directly associated to this object as RDF triples.

    431 TRIPLES      21 PREDICATES      83 URIs      60 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature14053 schema:about N1261b32d1e4541e0a66a2fbd803f5bca
    2 N14974ab0a2ed4353bd7d730600cd9cdc
    3 N3ab6dd44874c44b7b641bbab5b5963c5
    4 N4670f5da2b4f4243a7b18c22d76d7940
    5 N529bd0b05d7140e49985a7ab8d879007
    6 N610551426d4941da9b6a22b97d90fdce
    7 N6dfe4789dd9741cd9b3ff2b1b72647ad
    8 N7819b1b55dc04fe9a8e5423c6ab025e9
    9 N8231df00afb54fcebe38fbe1f3d7c700
    10 N8e9ef21bf78746099fab4d920cde0c48
    11 N9c977b86a30147ed9e3a019fe162f5a9
    12 N9f388cebf37c439e8914d3354b02ac9c
    13 Nb261c2a329e14c8b9522b4771a57046c
    14 Nb2b2499a3d8849718ae2371b704965f9
    15 Nc868bb8777a24d6a93963eecc33a1f71
    16 Nd966e2191c5e488b95d6d50962060c0f
    17 Ndcbdbcc7f06b4eb896ca4da6086d6178
    18 Neb83f908b5e24039b88edfe2063f0b04
    19 Nee4bd98abf89431db235d49ba6e2a3ba
    20 Nf74e3ffa41a246d78a6888883b8c92da
    21 Nfc32761557ae486098ffe64ee24bd8f3
    22 anzsrc-for:11
    23 anzsrc-for:1107
    24 anzsrc-for:1108
    25 schema:author N349f3b3feb734d4dbe7f07882e43a879
    26 schema:citation sg:pub.10.1038/328345a0
    27 sg:pub.10.1038/35085576
    28 sg:pub.10.1038/354453a0
    29 sg:pub.10.1038/387183a0
    30 sg:pub.10.1038/nature11286
    31 sg:pub.10.1038/nature13594
    32 sg:pub.10.1038/nbt.2858
    33 sg:pub.10.1038/nm0297-205
    34 sg:pub.10.1038/nm0297-212
    35 sg:pub.10.1038/nm880
    36 sg:pub.10.1038/nmeth.1923
    37 sg:pub.10.1038/nprot.2009.7
    38 sg:pub.10.1038/nri1417
    39 sg:pub.10.1038/nri2674
    40 schema:datePublished 2015-01-07
    41 schema:datePublishedReg 2015-01-07
    42 schema:description Despite receiving antiretroviral therapy, most patients with HIV still have latent reservoirs of the virus; here, these reservoirs are shown to be dominated by viruses with cytotoxic T lymphocyte escape mutations, with potential implications for the development of therapeutic vaccines.
    43 schema:genre article
    44 schema:isAccessibleForFree true
    45 schema:isPartOf N65999579b3334969ad8da959f7c3edca
    46 Nb53d0d122c56463d9a291a7c8d23cf5d
    47 sg:journal.1018957
    48 schema:keywords CTL responses
    49 HIV
    50 HIV-1
    51 antiretroviral therapy
    52 broad CTL response
    53 cytotoxic T lymphocyte escape mutations
    54 development
    55 dominance
    56 escape mutations
    57 implications
    58 latent HIV-1
    59 latent reservoir
    60 most patients
    61 mutations
    62 patients
    63 potential implications
    64 reservoir
    65 response
    66 therapeutic vaccines
    67 therapy
    68 vaccine
    69 virus
    70 schema:name Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations
    71 schema:pagination 381-385
    72 schema:productId N4a6b8725392143d19b73d3b79443d6e3
    73 N8443b5768cab42d180027d087b9f7919
    74 Ndc6f2ce8fa2b4a13b4730f9fea4f8e54
    75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035285592
    76 https://doi.org/10.1038/nature14053
    77 schema:sdDatePublished 2022-09-02T15:58
    78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    79 schema:sdPublisher N024dc21c09634d4887d68238c5673043
    80 schema:url https://doi.org/10.1038/nature14053
    81 sgo:license sg:explorer/license/
    82 sgo:sdDataset articles
    83 rdf:type schema:ScholarlyArticle
    84 N024dc21c09634d4887d68238c5673043 schema:name Springer Nature - SN SciGraph project
    85 rdf:type schema:Organization
    86 N04b9a7112f8d4e7d80e85227086067bc rdf:first sg:person.01157304405.69
    87 rdf:rest Nb85790d7938b4e90b6be64c0dfba3e11
    88 N059ed213302f4578b252def8b1010588 rdf:first sg:person.01144676622.88
    89 rdf:rest Na2ebda650c4a4a77a701b641afc65b31
    90 N1261b32d1e4541e0a66a2fbd803f5bca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Chronic Disease
    92 rdf:type schema:DefinedTerm
    93 N14974ab0a2ed4353bd7d730600cd9cdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Anti-HIV Agents
    95 rdf:type schema:DefinedTerm
    96 N1a3fd86bb6b4425a813b26cf3a9683ca rdf:first sg:person.07551207301.41
    97 rdf:rest N97239d3bd2474d24883d2879783a791e
    98 N1f22bc816d6f437cbba51ea6211771be rdf:first sg:person.01223441713.02
    99 rdf:rest Ne9c984c8abd34552bcf52094f1b380af
    100 N30a27934c1054d7f8cf1bddbeeba8b1f rdf:first sg:person.01117551521.49
    101 rdf:rest rdf:nil
    102 N349f3b3feb734d4dbe7f07882e43a879 rdf:first sg:person.0717205555.17
    103 rdf:rest Na1e3d3d3b25942dfba8d7628ddcf58ee
    104 N375f52f1bb394d0ea61b0031250afebd rdf:first sg:person.07641375037.37
    105 rdf:rest N30a27934c1054d7f8cf1bddbeeba8b1f
    106 N3ab6dd44874c44b7b641bbab5b5963c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Viral Load
    108 rdf:type schema:DefinedTerm
    109 N4670f5da2b4f4243a7b18c22d76d7940 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Mutation
    111 rdf:type schema:DefinedTerm
    112 N4a6b8725392143d19b73d3b79443d6e3 schema:name pubmed_id
    113 schema:value 25561180
    114 rdf:type schema:PropertyValue
    115 N529bd0b05d7140e49985a7ab8d879007 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name gag Gene Products, Human Immunodeficiency Virus
    117 rdf:type schema:DefinedTerm
    118 N610551426d4941da9b6a22b97d90fdce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Genes, Viral
    120 rdf:type schema:DefinedTerm
    121 N65999579b3334969ad8da959f7c3edca schema:volumeNumber 517
    122 rdf:type schema:PublicationVolume
    123 N69df87bc46674ab5a45ded1100720518 rdf:first sg:person.013104322607.25
    124 rdf:rest Nb2614d31ab94499daf7b9f54befd44ab
    125 N6d84095f26ef4ee682b15e96ae22d446 rdf:first sg:person.01274702531.47
    126 rdf:rest N7b66464597c4413ca016c50a2080120d
    127 N6dfe4789dd9741cd9b3ff2b1b72647ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Virus Replication
    129 rdf:type schema:DefinedTerm
    130 N74ca3952cce64a8f8f1bea836f14cf95 rdf:first sg:person.01310110315.60
    131 rdf:rest Na333d104eab7464caa95939868b87be3
    132 N7819b1b55dc04fe9a8e5423c6ab025e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Humans
    134 rdf:type schema:DefinedTerm
    135 N7b66464597c4413ca016c50a2080120d rdf:first sg:person.012534455317.24
    136 rdf:rest N8f453af4b8d94ec8bd0f00b5f6d2d802
    137 N8231df00afb54fcebe38fbe1f3d7c700 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Virus Latency
    139 rdf:type schema:DefinedTerm
    140 N8443b5768cab42d180027d087b9f7919 schema:name dimensions_id
    141 schema:value pub.1035285592
    142 rdf:type schema:PropertyValue
    143 N8e9ef21bf78746099fab4d920cde0c48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Female
    145 rdf:type schema:DefinedTerm
    146 N8f453af4b8d94ec8bd0f00b5f6d2d802 rdf:first sg:person.01152042325.24
    147 rdf:rest N69df87bc46674ab5a45ded1100720518
    148 N97239d3bd2474d24883d2879783a791e rdf:first sg:person.0746742366.38
    149 rdf:rest N6d84095f26ef4ee682b15e96ae22d446
    150 N9af74a96a2924bb0a817220af01fd536 rdf:first sg:person.015550266771.25
    151 rdf:rest N04b9a7112f8d4e7d80e85227086067bc
    152 N9c977b86a30147ed9e3a019fe162f5a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name CD4-Positive T-Lymphocytes
    154 rdf:type schema:DefinedTerm
    155 N9f388cebf37c439e8914d3354b02ac9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name RNA, Viral
    157 rdf:type schema:DefinedTerm
    158 Na1e3d3d3b25942dfba8d7628ddcf58ee rdf:first sg:person.0720234625.35
    159 rdf:rest Nbf2e68a1205f4cf8875ad66dff3b73d6
    160 Na2ebda650c4a4a77a701b641afc65b31 rdf:first sg:person.0773702117.09
    161 rdf:rest N74ca3952cce64a8f8f1bea836f14cf95
    162 Na333d104eab7464caa95939868b87be3 rdf:first sg:person.01200133610.00
    163 rdf:rest N9af74a96a2924bb0a817220af01fd536
    164 Nb2614d31ab94499daf7b9f54befd44ab rdf:first sg:person.011314115547.20
    165 rdf:rest N1f22bc816d6f437cbba51ea6211771be
    166 Nb261c2a329e14c8b9522b4771a57046c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Mice
    168 rdf:type schema:DefinedTerm
    169 Nb2b2499a3d8849718ae2371b704965f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Acute Disease
    171 rdf:type schema:DefinedTerm
    172 Nb53d0d122c56463d9a291a7c8d23cf5d schema:issueNumber 7534
    173 rdf:type schema:PublicationIssue
    174 Nb5f5a56ea9d8449c9520045a3dd430f8 rdf:first sg:person.01063121561.31
    175 rdf:rest N059ed213302f4578b252def8b1010588
    176 Nb85790d7938b4e90b6be64c0dfba3e11 rdf:first sg:person.01256324327.48
    177 rdf:rest N1a3fd86bb6b4425a813b26cf3a9683ca
    178 Nbf2e68a1205f4cf8875ad66dff3b73d6 rdf:first sg:person.01307127473.55
    179 rdf:rest Ndd57d762f22348e5b6276699b8d70d6b
    180 Nc868bb8777a24d6a93963eecc33a1f71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name T-Lymphocytes, Cytotoxic
    182 rdf:type schema:DefinedTerm
    183 Nd966e2191c5e488b95d6d50962060c0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name HIV Infections
    185 rdf:type schema:DefinedTerm
    186 Ndc6f2ce8fa2b4a13b4730f9fea4f8e54 schema:name doi
    187 schema:value 10.1038/nature14053
    188 rdf:type schema:PropertyValue
    189 Ndcbdbcc7f06b4eb896ca4da6086d6178 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Animals
    191 rdf:type schema:DefinedTerm
    192 Ndd57d762f22348e5b6276699b8d70d6b rdf:first sg:person.01012474047.99
    193 rdf:rest Nb5f5a56ea9d8449c9520045a3dd430f8
    194 Ne9c984c8abd34552bcf52094f1b380af rdf:first sg:person.013636762157.29
    195 rdf:rest N375f52f1bb394d0ea61b0031250afebd
    196 Neb83f908b5e24039b88edfe2063f0b04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name HIV-1
    198 rdf:type schema:DefinedTerm
    199 Nee4bd98abf89431db235d49ba6e2a3ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Genes, Dominant
    201 rdf:type schema:DefinedTerm
    202 Nf74e3ffa41a246d78a6888883b8c92da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Epitopes, T-Lymphocyte
    204 rdf:type schema:DefinedTerm
    205 Nfc32761557ae486098ffe64ee24bd8f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Male
    207 rdf:type schema:DefinedTerm
    208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    209 schema:name Medical and Health Sciences
    210 rdf:type schema:DefinedTerm
    211 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Immunology
    213 rdf:type schema:DefinedTerm
    214 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    215 schema:name Medical Microbiology
    216 rdf:type schema:DefinedTerm
    217 sg:grant.2438688 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14053
    218 rdf:type schema:MonetaryGrant
    219 sg:grant.2438718 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14053
    220 rdf:type schema:MonetaryGrant
    221 sg:grant.2454136 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14053
    222 rdf:type schema:MonetaryGrant
    223 sg:grant.2455700 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14053
    224 rdf:type schema:MonetaryGrant
    225 sg:grant.2681749 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14053
    226 rdf:type schema:MonetaryGrant
    227 sg:grant.2684726 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14053
    228 rdf:type schema:MonetaryGrant
    229 sg:grant.2695893 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14053
    230 rdf:type schema:MonetaryGrant
    231 sg:grant.2695895 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14053
    232 rdf:type schema:MonetaryGrant
    233 sg:grant.3932133 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14053
    234 rdf:type schema:MonetaryGrant
    235 sg:grant.5476639 http://pending.schema.org/fundedItem sg:pub.10.1038/nature14053
    236 rdf:type schema:MonetaryGrant
    237 sg:journal.1018957 schema:issn 0028-0836
    238 1476-4687
    239 schema:name Nature
    240 schema:publisher Springer Nature
    241 rdf:type schema:Periodical
    242 sg:person.01012474047.99 schema:affiliation grid-institutes:grid.47100.32
    243 schema:familyName Wang
    244 schema:givenName Leyao
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012474047.99
    246 rdf:type schema:Person
    247 sg:person.01063121561.31 schema:affiliation grid-institutes:grid.21107.35
    248 schema:familyName Durand
    249 schema:givenName Christine M.
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063121561.31
    251 rdf:type schema:Person
    252 sg:person.01117551521.49 schema:affiliation grid-institutes:grid.413575.1
    253 schema:familyName Siliciano
    254 schema:givenName Robert F.
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117551521.49
    256 rdf:type schema:Person
    257 sg:person.011314115547.20 schema:affiliation grid-institutes:grid.21107.35
    258 schema:familyName Siliciano
    259 schema:givenName Janet D.
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011314115547.20
    261 rdf:type schema:Person
    262 sg:person.01144676622.88 schema:affiliation grid-institutes:grid.21107.35
    263 schema:familyName Ghiaur
    264 schema:givenName Gabriel
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144676622.88
    266 rdf:type schema:Person
    267 sg:person.01152042325.24 schema:affiliation grid-institutes:grid.47100.32
    268 schema:familyName Strowig
    269 schema:givenName Till
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152042325.24
    271 rdf:type schema:Person
    272 sg:person.01157304405.69 schema:affiliation grid-institutes:grid.21107.35
    273 schema:familyName Margolick
    274 schema:givenName Joseph B.
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157304405.69
    276 rdf:type schema:Person
    277 sg:person.01200133610.00 schema:affiliation grid-institutes:grid.21107.35
    278 schema:familyName Hao
    279 schema:givenName Haiping
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200133610.00
    281 rdf:type schema:Person
    282 sg:person.01223441713.02 schema:affiliation grid-institutes:grid.21107.35
    283 schema:familyName Salzberg
    284 schema:givenName Steven L.
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223441713.02
    286 rdf:type schema:Person
    287 sg:person.012534455317.24 schema:affiliation grid-institutes:grid.266102.1
    288 schema:familyName Deeks
    289 schema:givenName Steven G.
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012534455317.24
    291 rdf:type schema:Person
    292 sg:person.01256324327.48 schema:affiliation grid-institutes:grid.418961.3
    293 schema:familyName Gurer
    294 schema:givenName Cagan
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256324327.48
    296 rdf:type schema:Person
    297 sg:person.01274702531.47 schema:affiliation grid-institutes:grid.418961.3
    298 schema:familyName Yancopoulos
    299 schema:givenName George D.
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274702531.47
    301 rdf:type schema:Person
    302 sg:person.01307127473.55 schema:affiliation grid-institutes:grid.47100.32
    303 schema:familyName Rongvaux
    304 schema:givenName Anthony
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307127473.55
    306 rdf:type schema:Person
    307 sg:person.01310110315.60 schema:affiliation grid-institutes:grid.21107.35
    308 schema:familyName McHugh
    309 schema:givenName Holly L.
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310110315.60
    311 rdf:type schema:Person
    312 sg:person.013104322607.25 schema:affiliation grid-institutes:grid.47100.32
    313 schema:familyName Kumar
    314 schema:givenName Priti
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013104322607.25
    316 rdf:type schema:Person
    317 sg:person.013636762157.29 schema:affiliation grid-institutes:grid.413575.1
    318 schema:familyName Flavell
    319 schema:givenName Richard A.
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013636762157.29
    321 rdf:type schema:Person
    322 sg:person.015550266771.25 schema:affiliation grid-institutes:grid.21107.35
    323 schema:familyName Zhang
    324 schema:givenName Hao
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015550266771.25
    326 rdf:type schema:Person
    327 sg:person.0717205555.17 schema:affiliation grid-institutes:grid.21107.35
    328 schema:familyName Deng
    329 schema:givenName Kai
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717205555.17
    331 rdf:type schema:Person
    332 sg:person.0720234625.35 schema:affiliation grid-institutes:grid.21107.35
    333 schema:familyName Pertea
    334 schema:givenName Mihaela
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720234625.35
    336 rdf:type schema:Person
    337 sg:person.0746742366.38 schema:affiliation grid-institutes:grid.418961.3
    338 schema:familyName Valenzuela
    339 schema:givenName David M.
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746742366.38
    341 rdf:type schema:Person
    342 sg:person.07551207301.41 schema:affiliation grid-institutes:grid.418961.3
    343 schema:familyName Murphy
    344 schema:givenName Andrew J.
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07551207301.41
    346 rdf:type schema:Person
    347 sg:person.07641375037.37 schema:affiliation grid-institutes:grid.47100.32
    348 schema:familyName Shan
    349 schema:givenName Liang
    350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07641375037.37
    351 rdf:type schema:Person
    352 sg:person.0773702117.09 schema:affiliation grid-institutes:grid.21107.35
    353 schema:familyName Lai
    354 schema:givenName Jun
    355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773702117.09
    356 rdf:type schema:Person
    357 sg:pub.10.1038/328345a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022500911
    358 https://doi.org/10.1038/328345a0
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/35085576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005637789
    361 https://doi.org/10.1038/35085576
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/354453a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029680452
    364 https://doi.org/10.1038/354453a0
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/387183a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036513917
    367 https://doi.org/10.1038/387183a0
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nature11286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013312562
    370 https://doi.org/10.1038/nature11286
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nature13594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050124782
    373 https://doi.org/10.1038/nature13594
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/nbt.2858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004838832
    376 https://doi.org/10.1038/nbt.2858
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/nm0297-205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012809998
    379 https://doi.org/10.1038/nm0297-205
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/nm0297-212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005909019
    382 https://doi.org/10.1038/nm0297-212
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/nm880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005517496
    385 https://doi.org/10.1038/nm880
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/nmeth.1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006541515
    388 https://doi.org/10.1038/nmeth.1923
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/nprot.2009.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037363244
    391 https://doi.org/10.1038/nprot.2009.7
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1038/nri1417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034344807
    394 https://doi.org/10.1038/nri1417
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1038/nri2674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029331458
    397 https://doi.org/10.1038/nri2674
    398 rdf:type schema:CreativeWork
    399 grid-institutes:grid.21107.35 schema:alternateName Center for Computational Biology, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    400 Deep Sequencing and Microarray Core, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    401 Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    402 Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    403 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, Maryland, USA
    404 Department of Oncology, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    405 schema:name Center for Computational Biology, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    406 Deep Sequencing and Microarray Core, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    407 Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    408 Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    409 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 21205, Baltimore, Maryland, USA
    410 Department of Oncology, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    411 rdf:type schema:Organization
    412 grid-institutes:grid.266102.1 schema:alternateName Department of Medicine, University of California, San Francisco, San Francisco, California 94110, USA
    413 schema:name Department of Medicine, University of California, San Francisco, San Francisco, California 94110, USA
    414 rdf:type schema:Organization
    415 grid-institutes:grid.413575.1 schema:alternateName Howard Hughes Medical Institute, 06510, New Haven, Connecticut, USA
    416 Howard Hughes Medical Institute, 21205, Baltimore, Maryland, USA
    417 schema:name Department of Immunobiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
    418 Department of Medicine, Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
    419 Howard Hughes Medical Institute, 06510, New Haven, Connecticut, USA
    420 Howard Hughes Medical Institute, 21205, Baltimore, Maryland, USA
    421 rdf:type schema:Organization
    422 grid-institutes:grid.418961.3 schema:alternateName Regeneron Pharmaceuticals Inc., 10591, Tarrytown, New York, USA
    423 schema:name Regeneron Pharmaceuticals Inc., 10591, Tarrytown, New York, USA
    424 rdf:type schema:Organization
    425 grid-institutes:grid.47100.32 schema:alternateName Department of Chronic Disease Epidemiology, Yale School of Public Health, 06510, New Haven, Connecticut, USA
    426 Department of Immunobiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
    427 Department of Medicine, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
    428 schema:name Department of Chronic Disease Epidemiology, Yale School of Public Health, 06510, New Haven, Connecticut, USA
    429 Department of Immunobiology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
    430 Department of Medicine, Yale University School of Medicine, 06510, New Haven, Connecticut, USA
    431 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...