Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11

AUTHORS

Matthew M. Gubin, Xiuli Zhang, Heiko Schuster, Etienne Caron, Jeffrey P. Ward, Takuro Noguchi, Yulia Ivanova, Jasreet Hundal, Cora D. Arthur, Willem-Jan Krebber, Gwenn E. Mulder, Mireille Toebes, Matthew D. Vesely, Samuel S. K. Lam, Alan J. Korman, James P. Allison, Gordon J. Freeman, Arlene H. Sharpe, Erika L. Pearce, Ton N. Schumacher, Ruedi Aebersold, Hans-Georg Rammensee, Cornelis J. M. Melief, Elaine R. Mardis, William E. Gillanders, Maxim N. Artyomov, Robert D. Schreiber

ABSTRACT

The immune system influences the fate of developing cancers by not only functioning as a tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts tumour cell immunogenicity, but also as an extrinsic tumour suppressor that either destroys developing tumours or restrains their expansion. Yet, clinically apparent cancers still arise in immunocompetent individuals in part as a consequence of cancer-induced immunosuppression. In many individuals, immunosuppression is mediated by cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and programmed death-1 (PD-1), two immunomodulatory receptors expressed on T cells. Monoclonal-antibody-based therapies targeting CTLA-4 and/or PD-1 (checkpoint blockade) have yielded significant clinical benefits-including durable responses--to patients with different malignancies. However, little is known about the identity of the tumour antigens that function as the targets of T cells activated by checkpoint blockade immunotherapy and whether these antigens can be used to generate vaccines that are highly tumour-specific. Here we use genomics and bioinformatics approaches to identify tumour-specific mutant proteins as a major class of T-cell rejection antigens following anti-PD-1 and/or anti-CTLA-4 therapy of mice bearing progressively growing sarcomas, and we show that therapeutic synthetic long-peptide vaccines incorporating these mutant epitopes induce tumour rejection comparably to checkpoint blockade immunotherapy. Although mutant tumour-antigen-specific T cells are present in progressively growing tumours, they are reactivated following treatment with anti-PD-1 and/or anti-CTLA-4 and display some overlapping but mostly treatment-specific transcriptional profiles, rendering them capable of mediating tumour rejection. These results reveal that tumour-specific mutant antigens are not only important targets of checkpoint blockade therapy, but they can also be used to develop personalized cancer-specific vaccines and to probe the mechanistic underpinnings of different checkpoint blockade treatments. More... »

PAGES

577

References to SciGraph publications

  • 2007-12. Adaptive immunity maintains occult cancer in an equilibrium state in NATURE
  • 2001-04. IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity in NATURE
  • 2012-04. The blockade of immune checkpoints in cancer immunotherapy in NATURE REVIEWS CANCER
  • 2012-02. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting in NATURE
  • 2004-03. Bystander elimination of antigen loss variants in established tumors in NATURE MEDICINE
  • 2013. Biochemical Large-Scale Identification of MHC Class I Ligands in ANTIGEN PROCESSING
  • 2009-01. NetMHCpan, a method for MHC class I binding prediction beyond humans in IMMUNOGENETICS
  • 2013-12. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application in NATURE IMMUNOLOGY
  • 2008-07. Cancer-related inflammation in NATURE
  • 2012-05. Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers in NATURE PROTOCOLS
  • 2006-02. Design and use of conditional MHC class I ligands in NATURE MEDICINE
  • 2002-11. Cancer immunoediting: from immunosurveillance to tumor escape in NATURE IMMUNOLOGY
  • 2011-06. T cell exhaustion in NATURE IMMUNOLOGY
  • 2013-06. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells in NATURE MEDICINE
  • 2010-07. Options and considerations when selecting a quantitative proteomics strategy in NATURE BIOTECHNOLOGY
  • 2005-04. The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage in IMMUNOGENETICS
  • 2005-12. Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method in BMC BIOINFORMATICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature13988

    DOI

    http://dx.doi.org/10.1038/nature13988

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017863023

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25428507


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