Piezo2 is the major transducer of mechanical forces for touch sensation in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12-03

AUTHORS

Sanjeev S. Ranade, Seung-Hyun Woo, Adrienne E. Dubin, Rabih A. Moshourab, Christiane Wetzel, Matt Petrus, Jayanti Mathur, Valérie Bégay, Bertrand Coste, James Mainquist, A. J. Wilson, Allain G. Francisco, Kritika Reddy, Zhaozhu Qiu, John N. Wood, Gary R. Lewin, Ardem Patapoutian

ABSTRACT

Mice lacking the mechanically activated ion channel Piezo2 in both sensory neurons and Merkel cells are almost totally incapable of light-touch sensation while other somatosensory functions, such as mechanical nociception, remain intact, implying that other mechanically activated ion channels must now be identified to account for painful touch sensation.

PAGES

121-125

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature13980

DOI

http://dx.doi.org/10.1038/nature13980

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002926131

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25471886


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