PD-1 blockade induces responses by inhibiting adaptive immune resistance View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11-26

AUTHORS

Paul C. Tumeh, Christina L. Harview, Jennifer H. Yearley, I. Peter Shintaku, Emma J. M. Taylor, Lidia Robert, Bartosz Chmielowski, Marko Spasic, Gina Henry, Voicu Ciobanu, Alisha N. West, Manuel Carmona, Christine Kivork, Elizabeth Seja, Grace Cherry, Antonio J. Gutierrez, Tristan R. Grogan, Christine Mateus, Gorana Tomasic, John A. Glaspy, Ryan O. Emerson, Harlan Robins, Robert H. Pierce, David A. Elashoff, Caroline Robert, Antoni Ribas

ABSTRACT

The dynamics of T-cell responses are investigated in tumour tissue from patients with advanced melanoma who were treated with a PD-1-blocking monoclonal antibody, revealing that clinical efficacy of the treatment correlates with increased frequencies of pre-existing CD8+ T cells and PD-1 and PD-L1 expression.

PAGES

568-571

Journal

TITLE

Nature

ISSUE

7528

VOLUME

515

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature13954

    DOI

    http://dx.doi.org/10.1038/nature13954

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020455470

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25428505


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