Ontology type: schema:ScholarlyArticle Open Access: True
2015-02
AUTHORSPeter Eirew, Adi Steif, Jaswinder Khattra, Gavin Ha, Damian Yap, Hossein Farahani, Karen Gelmon, Stephen Chia, Colin Mar, Adrian Wan, Emma Laks, Justina Biele, Karey Shumansky, Jamie Rosner, Andrew McPherson, Cydney Nielsen, Andrew J. L. Roth, Calvin Lefebvre, Ali Bashashati, Camila de Souza, Celia Siu, Radhouane Aniba, Jazmine Brimhall, Arusha Oloumi, Tomo Osako, Alejandra Bruna, Jose L. Sandoval, Teresa Algara, Wendy Greenwood, Kaston Leung, Hongwei Cheng, Hui Xue, Yuzhuo Wang, Dong Lin, Andrew J. Mungall, Richard Moore, Yongjun Zhao, Julie Lorette, Long Nguyen, David Huntsman, Connie J. Eaves, Carl Hansen, Marco A. Marra, Carlos Caldas, Sohrab P. Shah, Samuel Aparicio
ABSTRACTHuman cancers, including breast cancers, comprise clones differing in mutation content. Clones evolve dynamically in space and time following principles of Darwinian evolution, underpinning important emergent features such as drug resistance and metastasis. Human breast cancer xenoengraftment is used as a means of capturing and studying tumour biology, and breast tumour xenografts are generally assumed to be reasonable models of the originating tumours. However, the consequences and reproducibility of engraftment and propagation on the genomic clonal architecture of tumours have not been systematically examined at single-cell resolution. Here we show, using deep-genome and single-cell sequencing methods, the clonal dynamics of initial engraftment and subsequent serial propagation of primary and metastatic human breast cancers in immunodeficient mice. In all 15 cases examined, clonal selection on engraftment was observed in both primary and metastatic breast tumours, varying in degree from extreme selective engraftment of minor (<5% of starting population) clones to moderate, polyclonal engraftment. Furthermore, ongoing clonal dynamics during serial passaging is a feature of tumours experiencing modest initial selection. Through single-cell sequencing, we show that major mutation clusters estimated from tumour population sequencing relate predictably to the most abundant clonal genotypes, even in clonally complex and rapidly evolving cases. Finally, we show that similar clonal expansion patterns can emerge in independent grafts of the same starting tumour population, indicating that genomic aberrations can be reproducible determinants of evolutionary trajectories. Our results show that measurement of genomically defined clonal population dynamics will be highly informative for functional studies using patient-derived breast cancer xenoengraftment. More... »
PAGES422
http://scigraph.springernature.com/pub.10.1038/nature13952
DOIhttp://dx.doi.org/10.1038/nature13952
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1003619190
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25470049
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Clone Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Mutational Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genome, Human",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genomics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "High-Throughput Nucleotide Sequencing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Single-Cell Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Time Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transplantation, Heterologous",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Xenograft Model Antitumor Assays",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Eirew",
"givenName": "Peter",
"id": "sg:person.0714641415.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714641415.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Steif",
"givenName": "Adi",
"id": "sg:person.015036502705.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015036502705.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Khattra",
"givenName": "Jaswinder",
"id": "sg:person.01062254540.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062254540.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Ha",
"givenName": "Gavin",
"id": "sg:person.01011335463.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011335463.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Yap",
"givenName": "Damian",
"id": "sg:person.01165547170.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165547170.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Farahani",
"givenName": "Hossein",
"id": "sg:person.01173306363.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173306363.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Medical Oncology, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada"
],
"type": "Organization"
},
"familyName": "Gelmon",
"givenName": "Karen",
"id": "sg:person.01173252503.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173252503.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Medical Oncology, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada"
],
"type": "Organization"
},
"familyName": "Chia",
"givenName": "Stephen",
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Medical Oncology, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada"
],
"type": "Organization"
},
"familyName": "Mar",
"givenName": "Colin",
"id": "sg:person.01155041104.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155041104.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Wan",
"givenName": "Adrian",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Laks",
"givenName": "Emma",
"id": "sg:person.01051016654.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051016654.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Biele",
"givenName": "Justina",
"id": "sg:person.01117132054.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117132054.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Shumansky",
"givenName": "Karey",
"id": "sg:person.0713074677.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713074677.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Rosner",
"givenName": "Jamie",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "McPherson",
"givenName": "Andrew",
"id": "sg:person.0703707310.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703707310.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Nielsen",
"givenName": "Cydney",
"id": "sg:person.0625762426.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625762426.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Roth",
"givenName": "Andrew J. L.",
"id": "sg:person.01130720202.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130720202.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Lefebvre",
"givenName": "Calvin",
"id": "sg:person.01177033402.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177033402.90"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Bashashati",
"givenName": "Ali",
"id": "sg:person.01056245563.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056245563.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "de Souza",
"givenName": "Camila",
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Siu",
"givenName": "Celia",
"id": "sg:person.01361375202.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361375202.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Aniba",
"givenName": "Radhouane",
"id": "sg:person.0667757657.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667757657.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Brimhall",
"givenName": "Jazmine",
"id": "sg:person.0704104302.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704104302.93"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Oloumi",
"givenName": "Arusha",
"id": "sg:person.0630530027.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630530027.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Osako",
"givenName": "Tomo",
"id": "sg:person.0730272022.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730272022.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cancer Research UK Cambridge Institute",
"id": "https://www.grid.ac/institutes/grid.470869.4",
"name": [
"Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK",
"Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK"
],
"type": "Organization"
},
"familyName": "Bruna",
"givenName": "Alejandra",
"id": "sg:person.01356624531.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356624531.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cancer Research UK Cambridge Institute",
"id": "https://www.grid.ac/institutes/grid.470869.4",
"name": [
"Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK",
"Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK"
],
"type": "Organization"
},
"familyName": "Sandoval",
"givenName": "Jose L.",
"id": "sg:person.0705174731.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705174731.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada"
],
"type": "Organization"
},
"familyName": "Algara",
"givenName": "Teresa",
"id": "sg:person.01202674502.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202674502.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cancer Research UK Cambridge Institute",
"id": "https://www.grid.ac/institutes/grid.470869.4",
"name": [
"Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK",
"Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK"
],
"type": "Organization"
},
"familyName": "Greenwood",
"givenName": "Wendy",
"id": "sg:person.0701333631.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701333631.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada",
"Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada"
],
"type": "Organization"
},
"familyName": "Leung",
"givenName": "Kaston",
"id": "sg:person.01144102027.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144102027.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Experimental Therapeutics, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"The Vancouver Prostate Centre, Vancouver General Hospital and Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada"
],
"type": "Organization"
},
"familyName": "Cheng",
"givenName": "Hongwei",
"id": "sg:person.010451701347.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010451701347.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Experimental Therapeutics, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"The Vancouver Prostate Centre, Vancouver General Hospital and Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada"
],
"type": "Organization"
},
"familyName": "Xue",
"givenName": "Hui",
"id": "sg:person.01241656703.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241656703.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Experimental Therapeutics, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"The Vancouver Prostate Centre, Vancouver General Hospital and Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada"
],
"type": "Organization"
},
"familyName": "Wang",
"givenName": "Yuzhuo",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Department of Experimental Therapeutics, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"The Vancouver Prostate Centre, Vancouver General Hospital and Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada"
],
"type": "Organization"
},
"familyName": "Lin",
"givenName": "Dong",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Canada's Michael Smith Genome Sciences Centre",
"id": "https://www.grid.ac/institutes/grid.434706.2",
"name": [
"Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Mungall",
"givenName": "Andrew J.",
"id": "sg:person.0627357425.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627357425.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Canada's Michael Smith Genome Sciences Centre",
"id": "https://www.grid.ac/institutes/grid.434706.2",
"name": [
"Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Moore",
"givenName": "Richard",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Canada's Michael Smith Genome Sciences Centre",
"id": "https://www.grid.ac/institutes/grid.434706.2",
"name": [
"Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Zhao",
"givenName": "Yongjun",
"id": "sg:person.013415760017.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013415760017.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada"
],
"type": "Organization"
},
"familyName": "Lorette",
"givenName": "Julie",
"id": "sg:person.01240420607.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240420607.85"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada",
"Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Nguyen",
"givenName": "Long",
"id": "sg:person.0615044451.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615044451.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada",
"Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada"
],
"type": "Organization"
},
"familyName": "Huntsman",
"givenName": "David",
"id": "sg:person.015140454124.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015140454124.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada",
"Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Eaves",
"givenName": "Connie J.",
"id": "sg:person.01034353664.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034353664.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of British Columbia",
"id": "https://www.grid.ac/institutes/grid.17091.3e",
"name": [
"Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada",
"Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada"
],
"type": "Organization"
},
"familyName": "Hansen",
"givenName": "Carl",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Canada's Michael Smith Genome Sciences Centre",
"id": "https://www.grid.ac/institutes/grid.434706.2",
"name": [
"Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Marra",
"givenName": "Marco A.",
"id": "sg:person.01150455763.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cancer Research UK Cambridge Institute",
"id": "https://www.grid.ac/institutes/grid.470869.4",
"name": [
"Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK",
"Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK"
],
"type": "Organization"
},
"familyName": "Caldas",
"givenName": "Carlos",
"id": "sg:person.01072152660.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072152660.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Canada's Michael Smith Genome Sciences Centre",
"id": "https://www.grid.ac/institutes/grid.434706.2",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada",
"Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
],
"type": "Organization"
},
"familyName": "Shah",
"givenName": "Sohrab P.",
"id": "sg:person.01201274527.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201274527.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"Department of Molecular Oncology, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada",
"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada",
"Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada",
"Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada"
],
"type": "Organization"
},
"familyName": "Aparicio",
"givenName": "Samuel",
"id": "sg:person.0720022504.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720022504.02"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature11143",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000834660",
"https://doi.org/10.1038/nature11143"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20110105",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002796486"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11219",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004846070",
"https://doi.org/10.1038/nature11219"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2012.04.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012547698"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10983",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014607335",
"https://doi.org/10.1038/nature10983"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.2883",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018877372",
"https://doi.org/10.1038/nmeth.2883"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmra1204892",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022139407"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09460",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022310913",
"https://doi.org/10.1038/nature09460"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09460",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022310913",
"https://doi.org/10.1038/nature09460"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11412",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024942368",
"https://doi.org/10.1038/nature11412"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1227670",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025313806"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09733",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026717592",
"https://doi.org/10.1038/nature09733"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10933",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027457561",
"https://doi.org/10.1038/nature10933"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gr.180281.114",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030286874"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1113205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031166230"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0067316",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031301133"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2249.2008.03753.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034572584"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2013.08.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039118392"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.2454",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044243050",
"https://doi.org/10.1038/nm.2454"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/path.4230",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044827085"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-12-4081",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046982757"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/sysbio/sys029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049138722"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11154",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049222218",
"https://doi.org/10.1038/nature11154"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gr.137570.112",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050714911"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08989",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051657357",
"https://doi.org/10.1038/nature08989"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08989",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051657357",
"https://doi.org/10.1038/nature08989"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.959840",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062662765"
],
"type": "CreativeWork"
}
],
"datePublished": "2015-02",
"datePublishedReg": "2015-02-01",
"description": "Human cancers, including breast cancers, comprise clones differing in mutation content. Clones evolve dynamically in space and time following principles of Darwinian evolution, underpinning important emergent features such as drug resistance and metastasis. Human breast cancer xenoengraftment is used as a means of capturing and studying tumour biology, and breast tumour xenografts are generally assumed to be reasonable models of the originating tumours. However, the consequences and reproducibility of engraftment and propagation on the genomic clonal architecture of tumours have not been systematically examined at single-cell resolution. Here we show, using deep-genome and single-cell sequencing methods, the clonal dynamics of initial engraftment and subsequent serial propagation of primary and metastatic human breast cancers in immunodeficient mice. In all 15 cases examined, clonal selection on engraftment was observed in both primary and metastatic breast tumours, varying in degree from extreme selective engraftment of minor (<5% of starting population) clones to moderate, polyclonal engraftment. Furthermore, ongoing clonal dynamics during serial passaging is a feature of tumours experiencing modest initial selection. Through single-cell sequencing, we show that major mutation clusters estimated from tumour population sequencing relate predictably to the most abundant clonal genotypes, even in clonally complex and rapidly evolving cases. Finally, we show that similar clonal expansion patterns can emerge in independent grafts of the same starting tumour population, indicating that genomic aberrations can be reproducible determinants of evolutionary trajectories. Our results show that measurement of genomically defined clonal population dynamics will be highly informative for functional studies using patient-derived breast cancer xenoengraftment. ",
"genre": "research_article",
"id": "sg:pub.10.1038/nature13952",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0090-0028",
"1476-4687"
],
"name": "Nature",
"type": "Periodical"
},
{
"issueNumber": "7539",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "518"
}
],
"name": "Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution",
"pagination": "422",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"113da20c68947f75e83c5b8c0bbbf86d3f804ecda6b203f17e8da519313289e6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25470049"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0410462"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nature13952"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1003619190"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nature13952",
"https://app.dimensions.ai/details/publication/pub.1003619190"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T00:54",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000421.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/nature13952"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature13952'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature13952'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature13952'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature13952'
This table displays all metadata directly associated to this object as RDF triples.
545 TRIPLES
21 PREDICATES
69 URIs
36 LITERALS
24 BLANK NODES