Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11

AUTHORS

Pedro Crevillén, Hongchun Yang, Xia Cui, Christiaan Greeff, Martin Trick, Qi Qiu, Xiaofeng Cao, Caroline Dean

ABSTRACT

The reprogramming of epigenetic states in gametes and embryos is essential for correct development in plants and mammals. In plants, the germ line arises from somatic tissues of the flower, necessitating the erasure of chromatin modifications that have accumulated at specific loci during development or in response to external stimuli. If this process occurs inefficiently, it can lead to epigenetic states being inherited from one generation to the next. However, in most cases, accumulated epigenetic modifications are efficiently erased before the next generation. An important example of epigenetic reprogramming in plants is the resetting of the expression of the floral repressor locus FLC in Arabidopsis thaliana. FLC is epigenetically silenced by prolonged cold in a process called vernalization. However, the locus is reactivated before the completion of seed development, ensuring the requirement for vernalization in every generation. In contrast to our detailed understanding of the polycomb-mediated epigenetic silencing induced by vernalization, little is known about the mechanism involved in the reactivation of FLC. Here we show that a hypomorphic mutation in the jumonji-domain-containing protein ELF6 impaired the reactivation of FLC in reproductive tissues, leading to the inheritance of a partially vernalized state. ELF6 has H3K27me3 demethylase activity, and the mutation reduced this enzymatic activity in planta. Consistent with this, in the next generation of mutant plants, H3K27me3 levels at the FLC locus stayed higher, and FLC expression remained lower, than in the wild type. Our data reveal an ancient role for H3K27 demethylation in the reprogramming of epigenetic states in plant and mammalian embryos. More... »

PAGES

587

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature13722

DOI

http://dx.doi.org/10.1038/nature13722

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042044219

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25219852


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arabidopsis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arabidopsis Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cellular Reprogramming", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Plant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Silencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MADS Domain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Alignment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "John Innes Centre", 
          "id": "https://www.grid.ac/institutes/grid.14830.3e", 
          "name": [
            "Department of Cell & Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crevill\u00e9n", 
        "givenName": "Pedro", 
        "id": "sg:person.01025675501.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025675501.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "John Innes Centre", 
          "id": "https://www.grid.ac/institutes/grid.14830.3e", 
          "name": [
            "Department of Cell & Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Hongchun", 
        "id": "sg:person.01077760760.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077760760.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Genetics and Developmental Biology", 
          "id": "https://www.grid.ac/institutes/grid.418558.5", 
          "name": [
            "State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. Beijing 100101, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cui", 
        "givenName": "Xia", 
        "id": "sg:person.0775226511.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775226511.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "John Innes Centre", 
          "id": "https://www.grid.ac/institutes/grid.14830.3e", 
          "name": [
            "Department of Cell & Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Greeff", 
        "givenName": "Christiaan", 
        "id": "sg:person.01310425513.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310425513.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "John Innes Centre", 
          "id": "https://www.grid.ac/institutes/grid.14830.3e", 
          "name": [
            "Department of Cell & Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trick", 
        "givenName": "Martin", 
        "id": "sg:person.01333714500.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333714500.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Genetics and Developmental Biology", 
          "id": "https://www.grid.ac/institutes/grid.418558.5", 
          "name": [
            "State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. Beijing 100101, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qiu", 
        "givenName": "Qi", 
        "id": "sg:person.01317602776.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317602776.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Genetics and Developmental Biology", 
          "id": "https://www.grid.ac/institutes/grid.418558.5", 
          "name": [
            "State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. Beijing 100101, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Xiaofeng", 
        "id": "sg:person.012363751107.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012363751107.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "John Innes Centre", 
          "id": "https://www.grid.ac/institutes/grid.14830.3e", 
          "name": [
            "Department of Cell & Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dean", 
        "givenName": "Caroline", 
        "id": "sg:person.0652710401.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652710401.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.1119112109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003949617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004639381", 
          "https://doi.org/10.1038/nature08084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004639381", 
          "https://doi.org/10.1038/nature08084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pbi.2011.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005205211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jxb/ern070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005490308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2012.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008311992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.12.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008615511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0611459104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009092999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2012.324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010698162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011587700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.403602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012195556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10555", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015477262", 
          "https://doi.org/10.1038/nature10555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0711453105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015977367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00573-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017269306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019430621", 
          "https://doi.org/10.1038/ng.854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2010.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021266935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-313x.2008.03776.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022548681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027524172", 
          "https://doi.org/10.1038/nature10241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1105/tpc.104.025353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027684472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1105/tpc.11.3.445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028141727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-313x.2008.03709.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033315953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037201488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0808687105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037442368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1212959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037556256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-0500-1-93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037569167", 
          "https://doi.org/10.1186/1756-0500-1-93"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1105/tpc.112.104760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038265590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/sqb.2004.69.457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039565615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/sqb.2004.69.457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039565615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/16.22.10881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044175954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1190614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044510133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.084764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044544245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-313x.2005.02617.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044620157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-313x.2005.02617.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044620157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.078212.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047542880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1199/tab.0075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048919233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049666501", 
          "https://doi.org/10.1038/nature02269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049666501", 
          "https://doi.org/10.1038/nature02269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051471226", 
          "https://doi.org/10.1038/nature11272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1105/tpc.109.067967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051552779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.290.5490.344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062571708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3870872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070468714"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-11", 
    "datePublishedReg": "2014-11-01", 
    "description": "The reprogramming of epigenetic states in gametes and embryos is essential for correct development in plants and mammals. In plants, the germ line arises from somatic tissues of the flower, necessitating the erasure of chromatin modifications that have accumulated at specific loci during development or in response to external stimuli. If this process occurs inefficiently, it can lead to epigenetic states being inherited from one generation to the next. However, in most cases, accumulated epigenetic modifications are efficiently erased before the next generation. An important example of epigenetic reprogramming in plants is the resetting of the expression of the floral repressor locus FLC in Arabidopsis thaliana. FLC is epigenetically silenced by prolonged cold in a process called vernalization. However, the locus is reactivated before the completion of seed development, ensuring the requirement for vernalization in every generation. In contrast to our detailed understanding of the polycomb-mediated epigenetic silencing induced by vernalization, little is known about the mechanism involved in the reactivation of FLC. Here we show that a hypomorphic mutation in the jumonji-domain-containing protein ELF6 impaired the reactivation of FLC in reproductive tissues, leading to the inheritance of a partially vernalized state. ELF6 has H3K27me3 demethylase activity, and the mutation reduced this enzymatic activity in planta. Consistent with this, in the next generation of mutant plants, H3K27me3 levels at the FLC locus stayed higher, and FLC expression remained lower, than in the wild type. Our data reveal an ancient role for H3K27 demethylation in the reprogramming of epigenetic states in plant and mammalian embryos. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature13722", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2755144", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2764314", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3772594", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2765679", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7205733", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7528", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "515"
      }
    ], 
    "name": "Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state", 
    "pagination": "587", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c84742ab80976cc77eb65d775cd7cce1566b3481adc7acc8bfc48a0af2e83f5a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25219852"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature13722"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042044219"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature13722", 
      "https://app.dimensions.ai/details/publication/pub.1042044219"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78972_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature13722"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature13722'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature13722'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature13722'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature13722'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      21 PREDICATES      80 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature13722 schema:about N0fd3dc9dfeae4827b192a1dd4242d38f
2 N2926e9d3434346babd9b1ba7246f80b9
3 N688de8e9fc0b4e888b0804f1f8172d9d
4 N827beb95a3964fb58406a1ef9c26c143
5 N91bb3c5bd519477c8c6090cb9ae17bf0
6 Na1ceee805d3c4532a8cf9d4ce324cbe7
7 Na3c2eb3e13e84227b6768d04f1e0fe38
8 Nad2298fb371d4ba4964874de114cb082
9 Naf418e1147cc48e5aa78ae485efd7dd6
10 Nc96411aded1b415fbd6c73f01e120551
11 Ncbf09c4f533e470eb0a53c16477f71c9
12 Nd458335acbe74cba98eda7de12c9ea7f
13 Nd9b4dc10b8624b959406eaae5725764c
14 Ndce15e61d5bd4cf5bd76067fe19005f4
15 anzsrc-for:06
16 anzsrc-for:0604
17 schema:author Naf0a816a8b7641c1a474485ba2f166f3
18 schema:citation sg:pub.10.1038/nature02269
19 sg:pub.10.1038/nature08084
20 sg:pub.10.1038/nature10241
21 sg:pub.10.1038/nature10555
22 sg:pub.10.1038/nature11272
23 sg:pub.10.1038/ng.854
24 sg:pub.10.1186/1756-0500-1-93
25 https://doi.org/10.1016/j.cell.2007.02.010
26 https://doi.org/10.1016/j.cell.2008.12.038
27 https://doi.org/10.1016/j.cell.2013.02.006
28 https://doi.org/10.1016/j.cub.2010.11.012
29 https://doi.org/10.1016/j.pbi.2011.01.002
30 https://doi.org/10.1016/j.tig.2012.06.002
31 https://doi.org/10.1016/s0092-8674(01)00573-6
32 https://doi.org/10.1038/emboj.2012.324
33 https://doi.org/10.1073/pnas.0611459104
34 https://doi.org/10.1073/pnas.0711453105
35 https://doi.org/10.1073/pnas.0808687105
36 https://doi.org/10.1073/pnas.1119112109
37 https://doi.org/10.1093/jxb/ern070
38 https://doi.org/10.1093/nar/16.22.10881
39 https://doi.org/10.1101/gr.078212.108
40 https://doi.org/10.1101/gr.403602
41 https://doi.org/10.1101/sqb.2004.69.457
42 https://doi.org/10.1105/tpc.104.025353
43 https://doi.org/10.1105/tpc.109.067967
44 https://doi.org/10.1105/tpc.11.3.445
45 https://doi.org/10.1105/tpc.112.104760
46 https://doi.org/10.1111/j.1365-313x.2005.02617.x
47 https://doi.org/10.1111/j.1365-313x.2008.03709.x
48 https://doi.org/10.1111/j.1365-313x.2008.03776.x
49 https://doi.org/10.1126/science.1190614
50 https://doi.org/10.1126/science.1212959
51 https://doi.org/10.1126/science.290.5490.344
52 https://doi.org/10.1199/tab.0075
53 https://doi.org/10.1242/jcs.084764
54 https://doi.org/10.2307/3870872
55 schema:datePublished 2014-11
56 schema:datePublishedReg 2014-11-01
57 schema:description The reprogramming of epigenetic states in gametes and embryos is essential for correct development in plants and mammals. In plants, the germ line arises from somatic tissues of the flower, necessitating the erasure of chromatin modifications that have accumulated at specific loci during development or in response to external stimuli. If this process occurs inefficiently, it can lead to epigenetic states being inherited from one generation to the next. However, in most cases, accumulated epigenetic modifications are efficiently erased before the next generation. An important example of epigenetic reprogramming in plants is the resetting of the expression of the floral repressor locus FLC in Arabidopsis thaliana. FLC is epigenetically silenced by prolonged cold in a process called vernalization. However, the locus is reactivated before the completion of seed development, ensuring the requirement for vernalization in every generation. In contrast to our detailed understanding of the polycomb-mediated epigenetic silencing induced by vernalization, little is known about the mechanism involved in the reactivation of FLC. Here we show that a hypomorphic mutation in the jumonji-domain-containing protein ELF6 impaired the reactivation of FLC in reproductive tissues, leading to the inheritance of a partially vernalized state. ELF6 has H3K27me3 demethylase activity, and the mutation reduced this enzymatic activity in planta. Consistent with this, in the next generation of mutant plants, H3K27me3 levels at the FLC locus stayed higher, and FLC expression remained lower, than in the wild type. Our data reveal an ancient role for H3K27 demethylation in the reprogramming of epigenetic states in plant and mammalian embryos.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf N4ac2daa826824076aa554c5537d95ad3
62 N8d8a3225af8544f8a3effa7b8226737a
63 sg:journal.1018957
64 schema:name Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state
65 schema:pagination 587
66 schema:productId N07024e3e3f8344ffa47f8315c697fd4e
67 N0a682b29a07547708b1e2e19e27cfb18
68 N29afdcbc28d54040ba0bfe3017299655
69 N8f1d136222364994b89fe9eee3bf8f15
70 N91db207e9072452c97fe8880a392d28e
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042044219
72 https://doi.org/10.1038/nature13722
73 schema:sdDatePublished 2019-04-11T13:20
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N13daaea47fd04e06942906fe48ef79d5
76 schema:url https://www.nature.com/articles/nature13722
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N07024e3e3f8344ffa47f8315c697fd4e schema:name dimensions_id
81 schema:value pub.1042044219
82 rdf:type schema:PropertyValue
83 N0a682b29a07547708b1e2e19e27cfb18 schema:name nlm_unique_id
84 schema:value 0410462
85 rdf:type schema:PropertyValue
86 N0fd3dc9dfeae4827b192a1dd4242d38f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name MADS Domain Proteins
88 rdf:type schema:DefinedTerm
89 N10d9a02290f34bcabdb5bf3a5c7f79eb rdf:first sg:person.0775226511.54
90 rdf:rest N553629a894084eb494b5e86b9e8ea6db
91 N13daaea47fd04e06942906fe48ef79d5 schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 N2926e9d3434346babd9b1ba7246f80b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Molecular Sequence Data
95 rdf:type schema:DefinedTerm
96 N29afdcbc28d54040ba0bfe3017299655 schema:name pubmed_id
97 schema:value 25219852
98 rdf:type schema:PropertyValue
99 N4ac2daa826824076aa554c5537d95ad3 schema:volumeNumber 515
100 rdf:type schema:PublicationVolume
101 N553629a894084eb494b5e86b9e8ea6db rdf:first sg:person.01310425513.34
102 rdf:rest N95835ef436014b7399bdd460fb68b21a
103 N688de8e9fc0b4e888b0804f1f8172d9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Gene Silencing
105 rdf:type schema:DefinedTerm
106 N827beb95a3964fb58406a1ef9c26c143 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Arabidopsis
108 rdf:type schema:DefinedTerm
109 N8d8a3225af8544f8a3effa7b8226737a schema:issueNumber 7528
110 rdf:type schema:PublicationIssue
111 N8f1d136222364994b89fe9eee3bf8f15 schema:name doi
112 schema:value 10.1038/nature13722
113 rdf:type schema:PropertyValue
114 N91bb3c5bd519477c8c6090cb9ae17bf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Amino Acid Sequence
116 rdf:type schema:DefinedTerm
117 N91db207e9072452c97fe8880a392d28e schema:name readcube_id
118 schema:value c84742ab80976cc77eb65d775cd7cce1566b3481adc7acc8bfc48a0af2e83f5a
119 rdf:type schema:PropertyValue
120 N95835ef436014b7399bdd460fb68b21a rdf:first sg:person.01333714500.31
121 rdf:rest Nd7c8dd1a86b545a0896dcb9aa000ab40
122 N9aa3046c814b4a23abfb7f21dd19abe5 rdf:first sg:person.012363751107.54
123 rdf:rest Nf13df9be758c410fb4bad09cc330b05b
124 Na1ceee805d3c4532a8cf9d4ce324cbe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Mutation
126 rdf:type schema:DefinedTerm
127 Na3c2eb3e13e84227b6768d04f1e0fe38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name DNA Methylation
129 rdf:type schema:DefinedTerm
130 Nad2298fb371d4ba4964874de114cb082 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Cellular Reprogramming
132 rdf:type schema:DefinedTerm
133 Naf0a816a8b7641c1a474485ba2f166f3 rdf:first sg:person.01025675501.75
134 rdf:rest Nf35fd54a20424b78be47e83c87e330a4
135 Naf418e1147cc48e5aa78ae485efd7dd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Epigenesis, Genetic
137 rdf:type schema:DefinedTerm
138 Nc96411aded1b415fbd6c73f01e120551 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Gene Expression Regulation, Plant
140 rdf:type schema:DefinedTerm
141 Ncbf09c4f533e470eb0a53c16477f71c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Chromosome Mapping
143 rdf:type schema:DefinedTerm
144 Nd458335acbe74cba98eda7de12c9ea7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Sequence Alignment
146 rdf:type schema:DefinedTerm
147 Nd7c8dd1a86b545a0896dcb9aa000ab40 rdf:first sg:person.01317602776.27
148 rdf:rest N9aa3046c814b4a23abfb7f21dd19abe5
149 Nd9b4dc10b8624b959406eaae5725764c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Transcription Factors
151 rdf:type schema:DefinedTerm
152 Ndce15e61d5bd4cf5bd76067fe19005f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Arabidopsis Proteins
154 rdf:type schema:DefinedTerm
155 Nf13df9be758c410fb4bad09cc330b05b rdf:first sg:person.0652710401.30
156 rdf:rest rdf:nil
157 Nf35fd54a20424b78be47e83c87e330a4 rdf:first sg:person.01077760760.70
158 rdf:rest N10d9a02290f34bcabdb5bf3a5c7f79eb
159 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
160 schema:name Biological Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
163 schema:name Genetics
164 rdf:type schema:DefinedTerm
165 sg:grant.2755144 http://pending.schema.org/fundedItem sg:pub.10.1038/nature13722
166 rdf:type schema:MonetaryGrant
167 sg:grant.2764314 http://pending.schema.org/fundedItem sg:pub.10.1038/nature13722
168 rdf:type schema:MonetaryGrant
169 sg:grant.2765679 http://pending.schema.org/fundedItem sg:pub.10.1038/nature13722
170 rdf:type schema:MonetaryGrant
171 sg:grant.3772594 http://pending.schema.org/fundedItem sg:pub.10.1038/nature13722
172 rdf:type schema:MonetaryGrant
173 sg:grant.7205733 http://pending.schema.org/fundedItem sg:pub.10.1038/nature13722
174 rdf:type schema:MonetaryGrant
175 sg:journal.1018957 schema:issn 0090-0028
176 1476-4687
177 schema:name Nature
178 rdf:type schema:Periodical
179 sg:person.01025675501.75 schema:affiliation https://www.grid.ac/institutes/grid.14830.3e
180 schema:familyName Crevillén
181 schema:givenName Pedro
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025675501.75
183 rdf:type schema:Person
184 sg:person.01077760760.70 schema:affiliation https://www.grid.ac/institutes/grid.14830.3e
185 schema:familyName Yang
186 schema:givenName Hongchun
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077760760.70
188 rdf:type schema:Person
189 sg:person.012363751107.54 schema:affiliation https://www.grid.ac/institutes/grid.418558.5
190 schema:familyName Cao
191 schema:givenName Xiaofeng
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012363751107.54
193 rdf:type schema:Person
194 sg:person.01310425513.34 schema:affiliation https://www.grid.ac/institutes/grid.14830.3e
195 schema:familyName Greeff
196 schema:givenName Christiaan
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310425513.34
198 rdf:type schema:Person
199 sg:person.01317602776.27 schema:affiliation https://www.grid.ac/institutes/grid.418558.5
200 schema:familyName Qiu
201 schema:givenName Qi
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317602776.27
203 rdf:type schema:Person
204 sg:person.01333714500.31 schema:affiliation https://www.grid.ac/institutes/grid.14830.3e
205 schema:familyName Trick
206 schema:givenName Martin
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333714500.31
208 rdf:type schema:Person
209 sg:person.0652710401.30 schema:affiliation https://www.grid.ac/institutes/grid.14830.3e
210 schema:familyName Dean
211 schema:givenName Caroline
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652710401.30
213 rdf:type schema:Person
214 sg:person.0775226511.54 schema:affiliation https://www.grid.ac/institutes/grid.418558.5
215 schema:familyName Cui
216 schema:givenName Xia
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775226511.54
218 rdf:type schema:Person
219 sg:pub.10.1038/nature02269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049666501
220 https://doi.org/10.1038/nature02269
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/nature08084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004639381
223 https://doi.org/10.1038/nature08084
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/nature10241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027524172
226 https://doi.org/10.1038/nature10241
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nature10555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015477262
229 https://doi.org/10.1038/nature10555
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nature11272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051471226
232 https://doi.org/10.1038/nature11272
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/ng.854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019430621
235 https://doi.org/10.1038/ng.854
236 rdf:type schema:CreativeWork
237 sg:pub.10.1186/1756-0500-1-93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037569167
238 https://doi.org/10.1186/1756-0500-1-93
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.cell.2007.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011587700
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.cell.2008.12.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008615511
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.cell.2013.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037201488
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.cub.2010.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021266935
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.pbi.2011.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005205211
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.tig.2012.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008311992
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/s0092-8674(01)00573-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017269306
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1038/emboj.2012.324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010698162
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1073/pnas.0611459104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009092999
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1073/pnas.0711453105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015977367
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1073/pnas.0808687105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037442368
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1073/pnas.1119112109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003949617
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1093/jxb/ern070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005490308
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1093/nar/16.22.10881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044175954
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1101/gr.078212.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047542880
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1101/gr.403602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012195556
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1101/sqb.2004.69.457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039565615
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1105/tpc.104.025353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027684472
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1105/tpc.109.067967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051552779
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1105/tpc.11.3.445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028141727
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1105/tpc.112.104760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038265590
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1111/j.1365-313x.2005.02617.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044620157
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1111/j.1365-313x.2008.03709.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033315953
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1111/j.1365-313x.2008.03776.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022548681
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1126/science.1190614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044510133
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1126/science.1212959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037556256
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1126/science.290.5490.344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062571708
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1199/tab.0075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048919233
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1242/jcs.084764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044544245
297 rdf:type schema:CreativeWork
298 https://doi.org/10.2307/3870872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070468714
299 rdf:type schema:CreativeWork
300 https://www.grid.ac/institutes/grid.14830.3e schema:alternateName John Innes Centre
301 schema:name Department of Cell & Developmental Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.418558.5 schema:alternateName Institute of Genetics and Developmental Biology
304 schema:name State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. Beijing 100101, China
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...