Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-10

AUTHORS

Kirsten I Bos, Kelly M Harkins, Alexander Herbig, Mireia Coscolla, Nico Weber, Iñaki Comas, Stephen A Forrest, Josephine M Bryant, Simon R Harris, Verena J Schuenemann, Tessa J Campbell, Kerttu Majander, Alicia K Wilbur, Ricardo A Guichon, Dawnie L Wolfe Steadman, Della Collins Cook, Stefan Niemann, Marcel A Behr, Martin Zumarraga, Ricardo Bastida, Daniel Huson, Kay Nieselt, Douglas Young, Julian Parkhill, Jane E Buikstra, Sebastien Gagneux, Anne C Stone, Johannes Krause

ABSTRACT

Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean. More... »

PAGES

494

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature13591

DOI

http://dx.doi.org/10.1038/nature13591

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004534918

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25141181


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