The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-06

AUTHORS

Rachel J. Perry, Varman T. Samuel, Kitt F. Petersen, Gerald I. Shulman

ABSTRACT

Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase Cε in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes. More... »

PAGES

84-91

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature13478

DOI

http://dx.doi.org/10.1038/nature13478

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027110907

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24899308


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