Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04-23

AUTHORS

Daniel W. Bellott, Jennifer F. Hughes, Helen Skaletsky, Laura G. Brown, Tatyana Pyntikova, Ting-Jan Cho, Natalia Koutseva, Sara Zaghlul, Tina Graves, Susie Rock, Colin Kremitzki, Robert S. Fulton, Shannon Dugan, Yan Ding, Donna Morton, Ziad Khan, Lora Lewis, Christian Buhay, Qiaoyan Wang, Jennifer Watt, Michael Holder, Sandy Lee, Lynne Nazareth, Jessica Alföldi, Steve Rozen, Donna M. Muzny, Wesley C. Warren, Richard A. Gibbs, Richard K. Wilson, David C. Page

ABSTRACT

The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes. Our findings indicate that survival was nonrandom, and in two cases, convergent across placental and marsupial mammals. We conclude that the gene content of the Y chromosome became specialized through selection to maintain the ancestral dosage of homologous X–Y gene pairs that function as broadly expressed regulators of transcription, translation and protein stability. We propose that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner’s syndrome and in phenotypic differences between the sexes in health and disease. More... »

PAGES

494-499

References to SciGraph publications

  • 2013-01-25. Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate in HUMAN GENETICS
  • 2000-03. Del(X)(p21.1) in a mother and two daughters: genotype-phenotype correlation of Turner features in HUMAN GENETICS
  • 2008-01-30. Familial deletion within NLGN4 associated with autism and Tourette syndrome in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2005-03. X-inactivation profile reveals extensive variability in X-linked gene expression in females in NATURE
  • 1992-08. Interchromosomal gene conversion as a possible mechanism for explaining divergence patterns of ZFY-related genes in JOURNAL OF MOLECULAR EVOLUTION
  • 1990-07. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes in NATURE
  • 1998-08. A proposed path by which genes common to mammalian X and Y chromosomes evolve to become X inactivated in NATURE
  • 1998-05. A study of females with deletions of the short arm of the X chromosome in HUMAN GENETICS
  • 1990-07. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif in NATURE
  • 1983-07. The distribution of chromosomal genotypes associated with Turner's syndrome: livebirth prevalence rates and evidence for diminished fetal mortality and severity in genotypes associated with structural X abnormalities or mosaicism in HUMAN GENETICS
  • 2005-09. Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee in NATURE
  • 2003-06. Abundant gene conversion between arms of palindromes in human and ape Y chromosomes in NATURE
  • 2003-06. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes in NATURE
  • 1992-12. Deletion of the short arm of the X chromosome: A hereditary form of Turner syndrome in EUROPEAN JOURNAL OF PEDIATRICS
  • 2012-02-22. Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes in NATURE
  • 1967. Sex Chromosomes and Sex-Linked Genes in NONE
  • 2009-10-14. Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype–phenotype correlation in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2013-07-18. Large-scale gene function analysis with the PANTHER classification system in NATURE PROTOCOLS
  • 1993-07. Functional equivalence of human X– and Y–encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome in NATURE GENETICS
  • 2005-03. The DNA sequence of the human X chromosome in NATURE
  • 2001-10-22. The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men in NATURE GENETICS
  • 2013-07-21. Independent specialization of the human and mouse X chromosomes for the male germ line in NATURE GENETICS
  • 1996-11. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned in NATURE GENETICS
  • 2010-01-13. Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content in NATURE
  • 2010-07-11. Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature13206

    DOI

    http://dx.doi.org/10.1038/nature13206

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001655907

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24759411


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human, X", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human, Y", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Evolution, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Dosage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Health", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mammals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Marsupialia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Annotation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Biosynthesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Stability", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Selection, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Homology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sex Characteristics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spermatogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Testis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Turner Syndrome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "X Chromosome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Y Chromosome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bellott", 
            "givenName": "Daniel W.", 
            "id": "sg:person.0732100335.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732100335.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hughes", 
            "givenName": "Jennifer F.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Skaletsky", 
            "givenName": "Helen", 
            "id": "sg:person.01266753034.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266753034.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brown", 
            "givenName": "Laura G.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pyntikova", 
            "givenName": "Tatyana", 
            "id": "sg:person.01224563513.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224563513.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cho", 
            "givenName": "Ting-Jan", 
            "id": "sg:person.01003610713.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003610713.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koutseva", 
            "givenName": "Natalia", 
            "id": "sg:person.01051724113.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051724113.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zaghlul", 
            "givenName": "Sara", 
            "id": "sg:person.01344737353.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344737353.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Graves", 
            "givenName": "Tina", 
            "id": "sg:person.01123736653.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123736653.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rock", 
            "givenName": "Susie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kremitzki", 
            "givenName": "Colin", 
            "id": "sg:person.0732660570.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732660570.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fulton", 
            "givenName": "Robert S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dugan", 
            "givenName": "Shannon", 
            "id": "sg:person.011050340001.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011050340001.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ding", 
            "givenName": "Yan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morton", 
            "givenName": "Donna", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Khan", 
            "givenName": "Ziad", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lewis", 
            "givenName": "Lora", 
            "id": "sg:person.01337676570.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337676570.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buhay", 
            "givenName": "Christian", 
            "id": "sg:person.01165437301.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165437301.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Qiaoyan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watt", 
            "givenName": "Jennifer", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holder", 
            "givenName": "Michael", 
            "id": "sg:person.01245263754.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245263754.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Sandy", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nazareth", 
            "givenName": "Lynne", 
            "id": "sg:person.01045742732.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045742732.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alf\u00f6ldi", 
            "givenName": "Jessica", 
            "id": "sg:person.01046060300.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046060300.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rozen", 
            "givenName": "Steve", 
            "id": "sg:person.015311242432.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015311242432.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muzny", 
            "givenName": "Donna M.", 
            "id": "sg:person.0706133702.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706133702.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Warren", 
            "givenName": "Wesley C.", 
            "id": "sg:person.015042057437.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015042057437.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gibbs", 
            "givenName": "Richard A.", 
            "id": "sg:person.01145707302.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145707302.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilson", 
            "givenName": "Richard K.", 
            "id": "sg:person.013076541047.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013076541047.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "& Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Page", 
            "givenName": "David C.", 
            "id": "sg:person.01224407762.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224407762.64"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040986528", 
              "https://doi.org/10.1038/ng757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004855828", 
              "https://doi.org/10.1038/nature09172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007477207", 
              "https://doi.org/10.1038/nature03479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004390000253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054516680", 
              "https://doi.org/10.1007/s004390000253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00289473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046997393", 
              "https://doi.org/10.1007/bf00289473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-013-1263-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000665471", 
              "https://doi.org/10.1007/s00439-013-1263-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038888280", 
              "https://doi.org/10.1038/nature04101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ejhg.5202006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045725774", 
              "https://doi.org/10.1038/sj.ejhg.5202006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032168678", 
              "https://doi.org/10.1038/nature01722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-88178-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017975083", 
              "https://doi.org/10.1007/978-3-642-88178-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/346245a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045781048", 
              "https://doi.org/10.1038/346245a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/29522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052618075", 
              "https://doi.org/10.1038/29522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/346240a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041191003", 
              "https://doi.org/10.1038/346240a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022287415", 
              "https://doi.org/10.1038/nature08700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0793-268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011115322", 
              "https://doi.org/10.1038/ng0793-268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2009.175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030845278", 
              "https://doi.org/10.1038/ejhg.2009.175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002596939", 
              "https://doi.org/10.1038/nature01723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033211555", 
              "https://doi.org/10.1038/nprot.2013.092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03440", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026661886", 
              "https://doi.org/10.1038/nature03440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00183228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010593955", 
              "https://doi.org/10.1007/bf00183228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044796103", 
              "https://doi.org/10.1038/nature10843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004390050733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028065767", 
              "https://doi.org/10.1007/s004390050733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01954124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007589770", 
              "https://doi.org/10.1007/bf01954124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005155678", 
              "https://doi.org/10.1038/ng.2705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1196-292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012147825", 
              "https://doi.org/10.1038/ng1196-292"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-04-23", 
        "datePublishedReg": "2014-04-23", 
        "description": "The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes. Our findings indicate that survival was nonrandom, and in two cases, convergent across placental and marsupial mammals. We conclude that the gene content of the Y chromosome became specialized through selection to maintain the ancestral dosage of homologous X\u2013Y gene pairs that function as broadly expressed regulators of transcription, translation and protein stability. We propose that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner\u2019s syndrome and in phenotypic differences between the sexes in health and disease.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nature13206", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2441138", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2699330", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2699329", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7497", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "508"
          }
        ], 
        "keywords": [
          "Y chromosome", 
          "ancestral gene", 
          "gene content", 
          "mammalian Y chromosome", 
          "Y gene pairs", 
          "regulators of transcription", 
          "dosage-sensitive regulator", 
          "genetic decay", 
          "testis determination", 
          "millions of years", 
          "male viability", 
          "gene pairs", 
          "marsupial mammals", 
          "protein stability", 
          "selective pressure", 
          "chromosomes", 
          "phenotypic differences", 
          "ordinary pair", 
          "unappreciated role", 
          "mammals", 
          "genes", 
          "regulator", 
          "autosomes", 
          "transcription", 
          "spermatogenesis", 
          "role", 
          "Turner syndrome", 
          "nonrandom", 
          "viability", 
          "translation", 
          "pairs", 
          "evolution", 
          "selection", 
          "survival", 
          "content", 
          "millions", 
          "disease", 
          "findings", 
          "syndrome", 
          "differences", 
          "sex", 
          "stability", 
          "determination", 
          "health", 
          "biases", 
          "decay", 
          "years", 
          "dosage", 
          "convergent", 
          "pressure", 
          "cases", 
          "cent"
        ], 
        "name": "Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators", 
        "pagination": "494-499", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1001655907"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature13206"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24759411"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature13206", 
          "https://app.dimensions.ai/details/publication/pub.1001655907"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T20:58", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_640.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nature13206"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature13206'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature13206'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature13206'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature13206'


     

    This table displays all metadata directly associated to this object as RDF triples.

    522 TRIPLES      21 PREDICATES      128 URIs      95 LITERALS      33 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature13206 schema:about N0e015b915c224b6bba9e1d8537d597a2
    2 N10e3de79e4c9455892679297555fb5eb
    3 N128adb0c02754a0e85897658a8ba3f5f
    4 N20eeed1d7a4049179c1ada3385d28511
    5 N2466d353a85849ebaf1b2dd42f9246e0
    6 N37270fd9778d4ec1ac0752fb9286203f
    7 N40302bdf31ec469a8200db039e71aa0a
    8 N47e5c27e12a8416f8ced466f446f0049
    9 N4839b7a455df4f4ea12b96054ba1a930
    10 N580ff691685b47b7a8a6006291bc8e86
    11 N7178de948b3a4a7cb3fbf4de980e48d6
    12 N7291c05c608c4cba89396be27ed5d593
    13 N7d4f06caec2d40bf87fb0e5c988cd7e9
    14 N8155f4c0bf0e439ab649e59bf7bacc13
    15 N85744359d772429b8754b933b0fa36c2
    16 N880aa1e9cafa4d60aadc6b64d20df9ac
    17 N8fa5b648b58b45caae014c53ae7e779e
    18 N936096d514984a358d7b72ff0e52de1e
    19 N9d9024f7ed8a4e9db518a28abb1aeb01
    20 Nc42e51034ec540f6b1edd49decfcd0e6
    21 Nd1d086a78d6442e582a089d73814ba19
    22 Nd7b02701a44e4edc88c6ff1acb774ea3
    23 Ndfab4bd2e9fa4f23af1d15c5adc18d59
    24 Ne2ed916ae6c347c5bb3432a8a26bfa17
    25 Neac0592ab2af4b9bb03b6b309114f432
    26 Nedbb1e1dd0184c7293bb1e20bf01c9f1
    27 anzsrc-for:06
    28 anzsrc-for:0604
    29 schema:author Nfc2ab16603024d2485452b56c36b55a0
    30 schema:citation sg:pub.10.1007/978-3-642-88178-7
    31 sg:pub.10.1007/bf00183228
    32 sg:pub.10.1007/bf00289473
    33 sg:pub.10.1007/bf01954124
    34 sg:pub.10.1007/s00439-013-1263-x
    35 sg:pub.10.1007/s004390000253
    36 sg:pub.10.1007/s004390050733
    37 sg:pub.10.1038/29522
    38 sg:pub.10.1038/346240a0
    39 sg:pub.10.1038/346245a0
    40 sg:pub.10.1038/ejhg.2009.175
    41 sg:pub.10.1038/nature01722
    42 sg:pub.10.1038/nature01723
    43 sg:pub.10.1038/nature03440
    44 sg:pub.10.1038/nature03479
    45 sg:pub.10.1038/nature04101
    46 sg:pub.10.1038/nature08700
    47 sg:pub.10.1038/nature09172
    48 sg:pub.10.1038/nature10843
    49 sg:pub.10.1038/ng.2705
    50 sg:pub.10.1038/ng0793-268
    51 sg:pub.10.1038/ng1196-292
    52 sg:pub.10.1038/ng757
    53 sg:pub.10.1038/nprot.2013.092
    54 sg:pub.10.1038/sj.ejhg.5202006
    55 schema:datePublished 2014-04-23
    56 schema:datePublishedReg 2014-04-23
    57 schema:description The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes. Our findings indicate that survival was nonrandom, and in two cases, convergent across placental and marsupial mammals. We conclude that the gene content of the Y chromosome became specialized through selection to maintain the ancestral dosage of homologous X–Y gene pairs that function as broadly expressed regulators of transcription, translation and protein stability. We propose that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner’s syndrome and in phenotypic differences between the sexes in health and disease.
    58 schema:genre article
    59 schema:isAccessibleForFree true
    60 schema:isPartOf N4af368d3864244b5893b3130a24a9a89
    61 N794ae8eca706484792cc7ddeb588354b
    62 sg:journal.1018957
    63 schema:keywords Turner syndrome
    64 Y chromosome
    65 Y gene pairs
    66 ancestral gene
    67 autosomes
    68 biases
    69 cases
    70 cent
    71 chromosomes
    72 content
    73 convergent
    74 decay
    75 determination
    76 differences
    77 disease
    78 dosage
    79 dosage-sensitive regulator
    80 evolution
    81 findings
    82 gene content
    83 gene pairs
    84 genes
    85 genetic decay
    86 health
    87 male viability
    88 mammalian Y chromosome
    89 mammals
    90 marsupial mammals
    91 millions
    92 millions of years
    93 nonrandom
    94 ordinary pair
    95 pairs
    96 phenotypic differences
    97 pressure
    98 protein stability
    99 regulator
    100 regulators of transcription
    101 role
    102 selection
    103 selective pressure
    104 sex
    105 spermatogenesis
    106 stability
    107 survival
    108 syndrome
    109 testis determination
    110 transcription
    111 translation
    112 unappreciated role
    113 viability
    114 years
    115 schema:name Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
    116 schema:pagination 494-499
    117 schema:productId N25030d91b049472099fa465b673012f2
    118 N6f1c07b912da4936b464168adca059e2
    119 Nd5227baf43b64f9b97ced93bf078dd74
    120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001655907
    121 https://doi.org/10.1038/nature13206
    122 schema:sdDatePublished 2022-11-24T20:58
    123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    124 schema:sdPublisher N7199e77afa034da9a0e3acdda651f712
    125 schema:url https://doi.org/10.1038/nature13206
    126 sgo:license sg:explorer/license/
    127 sgo:sdDataset articles
    128 rdf:type schema:ScholarlyArticle
    129 N01d0c1d491e54ae3b98bb6a7a9ff8e47 rdf:first Neb32b25718214c80892a2d05cba4c67b
    130 rdf:rest N7d08076af8af4f03954a159c8bcc38d9
    131 N0277f97890e645c6a330de43bc3accc5 rdf:first Nb7417ec39aa64f418b21a76f03f05c1d
    132 rdf:rest N9c3136e119dc49b39bb345859613f6cc
    133 N03194d3daf7c46afa951a341f94ea661 rdf:first sg:person.0706133702.96
    134 rdf:rest N7c0e1bafbdc24d6393ba5b23b535ae4c
    135 N08b9fe7fc8984a7a973cea5cf78538d4 rdf:first N29c72af7508c4bdea0d847a1a80e09af
    136 rdf:rest Nafe4f1357a1643c3abc60ea29637f8ea
    137 N0e015b915c224b6bba9e1d8537d597a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Marsupialia
    139 rdf:type schema:DefinedTerm
    140 N10e3de79e4c9455892679297555fb5eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name X Chromosome
    142 rdf:type schema:DefinedTerm
    143 N128adb0c02754a0e85897658a8ba3f5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Turner Syndrome
    145 rdf:type schema:DefinedTerm
    146 N1aba4a0383bb435bb475a2d0dd452bd7 schema:affiliation grid-institutes:grid.4367.6
    147 schema:familyName Rock
    148 schema:givenName Susie
    149 rdf:type schema:Person
    150 N20eeed1d7a4049179c1ada3385d28511 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Protein Biosynthesis
    152 rdf:type schema:DefinedTerm
    153 N22a6b8c2200f48fe8d7441cdb5aa2b63 rdf:first Ndcb73ab1d1004a1d82c157bbb59c07a2
    154 rdf:rest N4d14e113d9634b078f39cd6e3d5d1af9
    155 N2466d353a85849ebaf1b2dd42f9246e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Humans
    157 rdf:type schema:DefinedTerm
    158 N25030d91b049472099fa465b673012f2 schema:name pubmed_id
    159 schema:value 24759411
    160 rdf:type schema:PropertyValue
    161 N26ee89c9807e4a188b3ef24c2f3be3f5 rdf:first sg:person.01051724113.63
    162 rdf:rest N3e02272a134945e1a193a00667614d98
    163 N29c72af7508c4bdea0d847a1a80e09af schema:affiliation grid-institutes:grid.270301.7
    164 schema:familyName Brown
    165 schema:givenName Laura G.
    166 rdf:type schema:Person
    167 N3178042d21f0494d95423dbd5c9f9c41 rdf:first N6b740e5d25a34341a9fada8d98dea149
    168 rdf:rest N7d77b42ce9234bf79fd7f5a1be57c4f1
    169 N37270fd9778d4ec1ac0752fb9286203f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Animals
    171 rdf:type schema:DefinedTerm
    172 N3e02272a134945e1a193a00667614d98 rdf:first sg:person.01344737353.31
    173 rdf:rest N43cfe27c70624a97aa22aa53ae7c7285
    174 N40302bdf31ec469a8200db039e71aa0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Health
    176 rdf:type schema:DefinedTerm
    177 N43cfe27c70624a97aa22aa53ae7c7285 rdf:first sg:person.01123736653.38
    178 rdf:rest N5ca2afbec7cc46d38f2a2283a3b3ab03
    179 N47e5c27e12a8416f8ced466f446f0049 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Gene Expression Regulation
    181 rdf:type schema:DefinedTerm
    182 N4839b7a455df4f4ea12b96054ba1a930 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Chromosomes, Human, X
    184 rdf:type schema:DefinedTerm
    185 N4af368d3864244b5893b3130a24a9a89 schema:issueNumber 7497
    186 rdf:type schema:PublicationIssue
    187 N4d14e113d9634b078f39cd6e3d5d1af9 rdf:first sg:person.011050340001.50
    188 rdf:rest N57e056c90459479ebb56617f8e559e64
    189 N51539386f9d34eb296dddf0aacc92b9e rdf:first sg:person.015311242432.72
    190 rdf:rest N03194d3daf7c46afa951a341f94ea661
    191 N54b95b2732e34c42803cd387cc2619fc rdf:first sg:person.01145707302.20
    192 rdf:rest N6f8418e5ead94ebebdf881f6e7de3ad3
    193 N57e056c90459479ebb56617f8e559e64 rdf:first N78481e79d5774570a0f4612a7e4b7607
    194 rdf:rest N01d0c1d491e54ae3b98bb6a7a9ff8e47
    195 N580ff691685b47b7a8a6006291bc8e86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Male
    197 rdf:type schema:DefinedTerm
    198 N585a7e0d8df84abb8f3ed74169113dd6 schema:affiliation grid-institutes:grid.39382.33
    199 schema:familyName Khan
    200 schema:givenName Ziad
    201 rdf:type schema:Person
    202 N5c89b70398e24b93817261ab55f12070 rdf:first Nb6b5c27c209c46bf85fd18ed4260b9e8
    203 rdf:rest Nb8ca010b81964d708ff5677ab0c59887
    204 N5ca2afbec7cc46d38f2a2283a3b3ab03 rdf:first N1aba4a0383bb435bb475a2d0dd452bd7
    205 rdf:rest Nd0d01cf7461a46a19583ac7e7cfa8c76
    206 N5efad19db2394d13b76ec6803ffdf2b8 rdf:first sg:person.01224407762.64
    207 rdf:rest rdf:nil
    208 N634b865f5ebe4b3f920d9fc630167e16 rdf:first sg:person.01046060300.80
    209 rdf:rest N51539386f9d34eb296dddf0aacc92b9e
    210 N6b740e5d25a34341a9fada8d98dea149 schema:affiliation grid-institutes:grid.39382.33
    211 schema:familyName Lee
    212 schema:givenName Sandy
    213 rdf:type schema:Person
    214 N6f1c07b912da4936b464168adca059e2 schema:name dimensions_id
    215 schema:value pub.1001655907
    216 rdf:type schema:PropertyValue
    217 N6f8418e5ead94ebebdf881f6e7de3ad3 rdf:first sg:person.013076541047.38
    218 rdf:rest N5efad19db2394d13b76ec6803ffdf2b8
    219 N7178de948b3a4a7cb3fbf4de980e48d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Gene Dosage
    221 rdf:type schema:DefinedTerm
    222 N7199e77afa034da9a0e3acdda651f712 schema:name Springer Nature - SN SciGraph project
    223 rdf:type schema:Organization
    224 N7291c05c608c4cba89396be27ed5d593 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Molecular Sequence Data
    226 rdf:type schema:DefinedTerm
    227 N78481e79d5774570a0f4612a7e4b7607 schema:affiliation grid-institutes:grid.39382.33
    228 schema:familyName Ding
    229 schema:givenName Yan
    230 rdf:type schema:Person
    231 N794ae8eca706484792cc7ddeb588354b schema:volumeNumber 508
    232 rdf:type schema:PublicationVolume
    233 N7ae20bd5fe63467398385d6646cddbdf rdf:first sg:person.01165437301.29
    234 rdf:rest N5c89b70398e24b93817261ab55f12070
    235 N7c0e1bafbdc24d6393ba5b23b535ae4c rdf:first sg:person.015042057437.96
    236 rdf:rest N54b95b2732e34c42803cd387cc2619fc
    237 N7d08076af8af4f03954a159c8bcc38d9 rdf:first N585a7e0d8df84abb8f3ed74169113dd6
    238 rdf:rest N96ba64c175df4ab88046104440a9a167
    239 N7d4f06caec2d40bf87fb0e5c988cd7e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    240 schema:name Testis
    241 rdf:type schema:DefinedTerm
    242 N7d77b42ce9234bf79fd7f5a1be57c4f1 rdf:first sg:person.01045742732.06
    243 rdf:rest N634b865f5ebe4b3f920d9fc630167e16
    244 N8155f4c0bf0e439ab649e59bf7bacc13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    245 schema:name Sex Characteristics
    246 rdf:type schema:DefinedTerm
    247 N85744359d772429b8754b933b0fa36c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    248 schema:name Chromosomes, Human, Y
    249 rdf:type schema:DefinedTerm
    250 N880aa1e9cafa4d60aadc6b64d20df9ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    251 schema:name Mammals
    252 rdf:type schema:DefinedTerm
    253 N8b7459d009a646d8ba54f1556135e59d rdf:first sg:person.01245263754.64
    254 rdf:rest N3178042d21f0494d95423dbd5c9f9c41
    255 N8fa5b648b58b45caae014c53ae7e779e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    256 schema:name Spermatogenesis
    257 rdf:type schema:DefinedTerm
    258 N936096d514984a358d7b72ff0e52de1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    259 schema:name Protein Stability
    260 rdf:type schema:DefinedTerm
    261 N96ba64c175df4ab88046104440a9a167 rdf:first sg:person.01337676570.11
    262 rdf:rest N7ae20bd5fe63467398385d6646cddbdf
    263 N9c3136e119dc49b39bb345859613f6cc rdf:first sg:person.01266753034.97
    264 rdf:rest N08b9fe7fc8984a7a973cea5cf78538d4
    265 N9d9024f7ed8a4e9db518a28abb1aeb01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    266 schema:name Molecular Sequence Annotation
    267 rdf:type schema:DefinedTerm
    268 Nafe4f1357a1643c3abc60ea29637f8ea rdf:first sg:person.01224563513.92
    269 rdf:rest Nc95bbf8b81e34cae84c04f70a9d2e6e5
    270 Nb6b5c27c209c46bf85fd18ed4260b9e8 schema:affiliation grid-institutes:grid.39382.33
    271 schema:familyName Wang
    272 schema:givenName Qiaoyan
    273 rdf:type schema:Person
    274 Nb7417ec39aa64f418b21a76f03f05c1d schema:affiliation grid-institutes:grid.270301.7
    275 schema:familyName Hughes
    276 schema:givenName Jennifer F.
    277 rdf:type schema:Person
    278 Nb8ca010b81964d708ff5677ab0c59887 rdf:first Nec64af9fba2d4d1fa16f9bc69d85ce79
    279 rdf:rest N8b7459d009a646d8ba54f1556135e59d
    280 Nc42e51034ec540f6b1edd49decfcd0e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    281 schema:name Selection, Genetic
    282 rdf:type schema:DefinedTerm
    283 Nc95bbf8b81e34cae84c04f70a9d2e6e5 rdf:first sg:person.01003610713.31
    284 rdf:rest N26ee89c9807e4a188b3ef24c2f3be3f5
    285 Nd0d01cf7461a46a19583ac7e7cfa8c76 rdf:first sg:person.0732660570.67
    286 rdf:rest N22a6b8c2200f48fe8d7441cdb5aa2b63
    287 Nd1d086a78d6442e582a089d73814ba19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    288 schema:name Transcription, Genetic
    289 rdf:type schema:DefinedTerm
    290 Nd5227baf43b64f9b97ced93bf078dd74 schema:name doi
    291 schema:value 10.1038/nature13206
    292 rdf:type schema:PropertyValue
    293 Nd7b02701a44e4edc88c6ff1acb774ea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    294 schema:name Y Chromosome
    295 rdf:type schema:DefinedTerm
    296 Ndcb73ab1d1004a1d82c157bbb59c07a2 schema:affiliation grid-institutes:grid.4367.6
    297 schema:familyName Fulton
    298 schema:givenName Robert S.
    299 rdf:type schema:Person
    300 Ndfab4bd2e9fa4f23af1d15c5adc18d59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    301 schema:name Disease
    302 rdf:type schema:DefinedTerm
    303 Ne2ed916ae6c347c5bb3432a8a26bfa17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    304 schema:name Evolution, Molecular
    305 rdf:type schema:DefinedTerm
    306 Neac0592ab2af4b9bb03b6b309114f432 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    307 schema:name Sequence Homology
    308 rdf:type schema:DefinedTerm
    309 Neb32b25718214c80892a2d05cba4c67b schema:affiliation grid-institutes:grid.39382.33
    310 schema:familyName Morton
    311 schema:givenName Donna
    312 rdf:type schema:Person
    313 Nec64af9fba2d4d1fa16f9bc69d85ce79 schema:affiliation grid-institutes:grid.39382.33
    314 schema:familyName Watt
    315 schema:givenName Jennifer
    316 rdf:type schema:Person
    317 Nedbb1e1dd0184c7293bb1e20bf01c9f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    318 schema:name Female
    319 rdf:type schema:DefinedTerm
    320 Nfc2ab16603024d2485452b56c36b55a0 rdf:first sg:person.0732100335.78
    321 rdf:rest N0277f97890e645c6a330de43bc3accc5
    322 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    323 schema:name Biological Sciences
    324 rdf:type schema:DefinedTerm
    325 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    326 schema:name Genetics
    327 rdf:type schema:DefinedTerm
    328 sg:grant.2441138 http://pending.schema.org/fundedItem sg:pub.10.1038/nature13206
    329 rdf:type schema:MonetaryGrant
    330 sg:grant.2699329 http://pending.schema.org/fundedItem sg:pub.10.1038/nature13206
    331 rdf:type schema:MonetaryGrant
    332 sg:grant.2699330 http://pending.schema.org/fundedItem sg:pub.10.1038/nature13206
    333 rdf:type schema:MonetaryGrant
    334 sg:journal.1018957 schema:issn 0028-0836
    335 1476-4687
    336 schema:name Nature
    337 schema:publisher Springer Nature
    338 rdf:type schema:Periodical
    339 sg:person.01003610713.31 schema:affiliation grid-institutes:grid.270301.7
    340 schema:familyName Cho
    341 schema:givenName Ting-Jan
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003610713.31
    343 rdf:type schema:Person
    344 sg:person.01045742732.06 schema:affiliation grid-institutes:grid.39382.33
    345 schema:familyName Nazareth
    346 schema:givenName Lynne
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045742732.06
    348 rdf:type schema:Person
    349 sg:person.01046060300.80 schema:affiliation grid-institutes:grid.270301.7
    350 schema:familyName Alföldi
    351 schema:givenName Jessica
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046060300.80
    353 rdf:type schema:Person
    354 sg:person.01051724113.63 schema:affiliation grid-institutes:grid.270301.7
    355 schema:familyName Koutseva
    356 schema:givenName Natalia
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051724113.63
    358 rdf:type schema:Person
    359 sg:person.011050340001.50 schema:affiliation grid-institutes:grid.39382.33
    360 schema:familyName Dugan
    361 schema:givenName Shannon
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011050340001.50
    363 rdf:type schema:Person
    364 sg:person.01123736653.38 schema:affiliation grid-institutes:grid.4367.6
    365 schema:familyName Graves
    366 schema:givenName Tina
    367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123736653.38
    368 rdf:type schema:Person
    369 sg:person.01145707302.20 schema:affiliation grid-institutes:grid.39382.33
    370 schema:familyName Gibbs
    371 schema:givenName Richard A.
    372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145707302.20
    373 rdf:type schema:Person
    374 sg:person.01165437301.29 schema:affiliation grid-institutes:grid.39382.33
    375 schema:familyName Buhay
    376 schema:givenName Christian
    377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165437301.29
    378 rdf:type schema:Person
    379 sg:person.01224407762.64 schema:affiliation grid-institutes:grid.270301.7
    380 schema:familyName Page
    381 schema:givenName David C.
    382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224407762.64
    383 rdf:type schema:Person
    384 sg:person.01224563513.92 schema:affiliation grid-institutes:grid.270301.7
    385 schema:familyName Pyntikova
    386 schema:givenName Tatyana
    387 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224563513.92
    388 rdf:type schema:Person
    389 sg:person.01245263754.64 schema:affiliation grid-institutes:grid.39382.33
    390 schema:familyName Holder
    391 schema:givenName Michael
    392 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245263754.64
    393 rdf:type schema:Person
    394 sg:person.01266753034.97 schema:affiliation grid-institutes:grid.270301.7
    395 schema:familyName Skaletsky
    396 schema:givenName Helen
    397 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266753034.97
    398 rdf:type schema:Person
    399 sg:person.013076541047.38 schema:affiliation grid-institutes:grid.4367.6
    400 schema:familyName Wilson
    401 schema:givenName Richard K.
    402 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013076541047.38
    403 rdf:type schema:Person
    404 sg:person.01337676570.11 schema:affiliation grid-institutes:grid.39382.33
    405 schema:familyName Lewis
    406 schema:givenName Lora
    407 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337676570.11
    408 rdf:type schema:Person
    409 sg:person.01344737353.31 schema:affiliation grid-institutes:grid.270301.7
    410 schema:familyName Zaghlul
    411 schema:givenName Sara
    412 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344737353.31
    413 rdf:type schema:Person
    414 sg:person.015042057437.96 schema:affiliation grid-institutes:grid.4367.6
    415 schema:familyName Warren
    416 schema:givenName Wesley C.
    417 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015042057437.96
    418 rdf:type schema:Person
    419 sg:person.015311242432.72 schema:affiliation grid-institutes:grid.270301.7
    420 schema:familyName Rozen
    421 schema:givenName Steve
    422 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015311242432.72
    423 rdf:type schema:Person
    424 sg:person.0706133702.96 schema:affiliation grid-institutes:grid.39382.33
    425 schema:familyName Muzny
    426 schema:givenName Donna M.
    427 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706133702.96
    428 rdf:type schema:Person
    429 sg:person.0732100335.78 schema:affiliation grid-institutes:grid.270301.7
    430 schema:familyName Bellott
    431 schema:givenName Daniel W.
    432 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732100335.78
    433 rdf:type schema:Person
    434 sg:person.0732660570.67 schema:affiliation grid-institutes:grid.4367.6
    435 schema:familyName Kremitzki
    436 schema:givenName Colin
    437 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732660570.67
    438 rdf:type schema:Person
    439 sg:pub.10.1007/978-3-642-88178-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017975083
    440 https://doi.org/10.1007/978-3-642-88178-7
    441 rdf:type schema:CreativeWork
    442 sg:pub.10.1007/bf00183228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010593955
    443 https://doi.org/10.1007/bf00183228
    444 rdf:type schema:CreativeWork
    445 sg:pub.10.1007/bf00289473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046997393
    446 https://doi.org/10.1007/bf00289473
    447 rdf:type schema:CreativeWork
    448 sg:pub.10.1007/bf01954124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007589770
    449 https://doi.org/10.1007/bf01954124
    450 rdf:type schema:CreativeWork
    451 sg:pub.10.1007/s00439-013-1263-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000665471
    452 https://doi.org/10.1007/s00439-013-1263-x
    453 rdf:type schema:CreativeWork
    454 sg:pub.10.1007/s004390000253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054516680
    455 https://doi.org/10.1007/s004390000253
    456 rdf:type schema:CreativeWork
    457 sg:pub.10.1007/s004390050733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028065767
    458 https://doi.org/10.1007/s004390050733
    459 rdf:type schema:CreativeWork
    460 sg:pub.10.1038/29522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052618075
    461 https://doi.org/10.1038/29522
    462 rdf:type schema:CreativeWork
    463 sg:pub.10.1038/346240a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041191003
    464 https://doi.org/10.1038/346240a0
    465 rdf:type schema:CreativeWork
    466 sg:pub.10.1038/346245a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045781048
    467 https://doi.org/10.1038/346245a0
    468 rdf:type schema:CreativeWork
    469 sg:pub.10.1038/ejhg.2009.175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030845278
    470 https://doi.org/10.1038/ejhg.2009.175
    471 rdf:type schema:CreativeWork
    472 sg:pub.10.1038/nature01722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032168678
    473 https://doi.org/10.1038/nature01722
    474 rdf:type schema:CreativeWork
    475 sg:pub.10.1038/nature01723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002596939
    476 https://doi.org/10.1038/nature01723
    477 rdf:type schema:CreativeWork
    478 sg:pub.10.1038/nature03440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026661886
    479 https://doi.org/10.1038/nature03440
    480 rdf:type schema:CreativeWork
    481 sg:pub.10.1038/nature03479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007477207
    482 https://doi.org/10.1038/nature03479
    483 rdf:type schema:CreativeWork
    484 sg:pub.10.1038/nature04101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038888280
    485 https://doi.org/10.1038/nature04101
    486 rdf:type schema:CreativeWork
    487 sg:pub.10.1038/nature08700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022287415
    488 https://doi.org/10.1038/nature08700
    489 rdf:type schema:CreativeWork
    490 sg:pub.10.1038/nature09172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004855828
    491 https://doi.org/10.1038/nature09172
    492 rdf:type schema:CreativeWork
    493 sg:pub.10.1038/nature10843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044796103
    494 https://doi.org/10.1038/nature10843
    495 rdf:type schema:CreativeWork
    496 sg:pub.10.1038/ng.2705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005155678
    497 https://doi.org/10.1038/ng.2705
    498 rdf:type schema:CreativeWork
    499 sg:pub.10.1038/ng0793-268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011115322
    500 https://doi.org/10.1038/ng0793-268
    501 rdf:type schema:CreativeWork
    502 sg:pub.10.1038/ng1196-292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012147825
    503 https://doi.org/10.1038/ng1196-292
    504 rdf:type schema:CreativeWork
    505 sg:pub.10.1038/ng757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040986528
    506 https://doi.org/10.1038/ng757
    507 rdf:type schema:CreativeWork
    508 sg:pub.10.1038/nprot.2013.092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033211555
    509 https://doi.org/10.1038/nprot.2013.092
    510 rdf:type schema:CreativeWork
    511 sg:pub.10.1038/sj.ejhg.5202006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045725774
    512 https://doi.org/10.1038/sj.ejhg.5202006
    513 rdf:type schema:CreativeWork
    514 grid-institutes:grid.270301.7 schema:alternateName & Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA
    515 schema:name & Department of Biology, Whitehead Institute, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 02142, Cambridge, Massachusetts, USA
    516 rdf:type schema:Organization
    517 grid-institutes:grid.39382.33 schema:alternateName Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA
    518 schema:name Human Genome Sequencing Center, Baylor College of Medicine, 77030, Houston, Texas, USA
    519 rdf:type schema:Organization
    520 grid-institutes:grid.4367.6 schema:alternateName The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA
    521 schema:name The Genome Institute, Washington University School of Medicine, 63108, St. Louis, Missouri, USA
    522 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...