Origins and functional evolution of Y chromosomes across mammals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-04-23

AUTHORS

Diego Cortez, Ray Marin, Deborah Toledo-Flores, Laure Froidevaux, Angélica Liechti, Paul D. Waters, Frank Grützner, Henrik Kaessmann

ABSTRACT

Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has hampered sequencing and associated evolutionary studies. Here we trace Y evolution across 15 representative mammals on the basis of high-throughput genome and transcriptome sequencing. We uncover three independent sex chromosome originations in mammals and birds (the outgroup). The original placental and marsupial (therian) Y, containing the sex-determining gene SRY, emerged in the therian ancestor approximately 180 million years ago, in parallel with the first of five monotreme Y chromosomes, carrying the probable sex-determining gene AMH. The avian W chromosome arose approximately 140 million years ago in the bird ancestor. The small Y/W gene repertoires, enriched in regulatory functions, were rapidly defined following stratification (recombination arrest) and erosion events and have remained considerably stable. Despite expression decreases in therians, Y/W genes show notable conservation of proto-sex chromosome expression patterns, although various Y genes evolved testis-specificities through differential regulatory decay. Thus, although some genes evolved novel functions through spatial/temporal expression shifts, most Y genes probably endured, at least initially, because of dosage constraints. More... »

PAGES

488-493

References to SciGraph publications

  • 2012-05-14. Identification of avian W-linked contigs by short-read sequencing in BMC GENOMICS
  • 1990-07. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes in NATURE
  • 2000-05. Gene Ontology: tool for the unification of biology in NATURE GENETICS
  • 2013-01-18. Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration in NATURE REVIEWS GENETICS
  • 2004-10-24. In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomes in NATURE
  • 2009-01-14. Evolution of X-Degenerate Y Chromosome Genes in Greater Apes: Conservation of Gene Content in Human and Gorilla, But Not Chimpanzee in JOURNAL OF MOLECULAR EVOLUTION
  • 2014-01-19. The evolution of lncRNA repertoires and expression patterns in tetrapods in NATURE
  • 2009-03-04. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome in GENOME BIOLOGY
  • 2008-05. Genome analysis of the platypus reveals unique signatures of evolution in NATURE
  • 2003-06. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes in NATURE
  • 2011-10-19. The evolution of gene expression levels in mammalian organs in NATURE
  • 2012-02-22. Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes in NATURE
  • 2006-02. Hearing silence: non-neutral evolution at synonymous sites in mammals in NATURE REVIEWS GENETICS
  • 2007-11-16. The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z in GENOME BIOLOGY
  • 2013-03-25. RNA sequencing reveals sexually dimorphic gene expression before gonadal differentiation in chicken and allows comprehensive annotation of the W-chromosome in GENOME BIOLOGY
  • 2005-11-30. Fast Accumulation of Nonsynonymous Mutations on the Female-Specific W Chromosome in Birds in JOURNAL OF MOLECULAR EVOLUTION
  • 2012-01-04. Identification of mediator complex 26 (Crsp7) gametologs on platypus X1 and Y5 sex chromosomes: a candidate testis-determining gene in monotremes? in CHROMOSOME RESEARCH
  • 2005-03. The DNA sequence of the human X chromosome in NATURE
  • 2012-12-27. SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler in GIGASCIENCE
  • 2000-10. Evolution of the X-linked Zinc Finger Gene and the Y-linked Zinc Finger Gene in Primates in MOLECULES AND CELLS
  • 2010-04. The genome of a songbird in NATURE
  • 2009-08-26. The avian Z-linked gene DMRT1 is required for male sex determination in the chicken in NATURE
  • 2003-07. Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint in MAMMALIAN GENOME
  • 2009-08-14. Improved base calling for the Illumina Genome Analyzer using machine learning strategies in GENOME BIOLOGY
  • 2009-09-30. Physical mapping of the elephant X chromosome: conservation of gene order over 105 million years in CHROMOSOME RESEARCH
  • 2011-05-15. Full-length transcriptome assembly from RNA-Seq data without a reference genome in NATURE BIOTECHNOLOGY
  • 2010-07-13. BMGE (Block Mapping and Gathering with Entropy): a new software for selection of phylogenetic informative regions from multiple sequence alignments in BMC ECOLOGY AND EVOLUTION
  • 1991-12. Homology of a candidate spermatogenic gene from the mouse Y chromosome to the ubiquitin-activating enzyme El in NATURE
  • 2010-05-02. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation in NATURE BIOTECHNOLOGY
  • 2002-07. SRY Evolution in Cebidae (Platyrrhini: Primates) in JOURNAL OF MOLECULAR EVOLUTION
  • 2010-01-13. Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content in NATURE
  • 1993-08. Rapid sequence evolution of the mammalian sex-determining gene SRY in NATURE
  • 2005-12-02. Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm in GENOME BIOLOGY
  • 2004-09-15. Bioconductor: open software development for computational biology and bioinformatics in GENOME BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature13151

    DOI

    http://dx.doi.org/10.1038/nature13151

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044205043

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24759410


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