A molecular marker of artemisinin-resistant Plasmodium falciparum malaria View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12-18

AUTHORS

Frédéric Ariey, Benoit Witkowski, Chanaki Amaratunga, Johann Beghain, Anne-Claire Langlois, Nimol Khim, Saorin Kim, Valentine Duru, Christiane Bouchier, Laurence Ma, Pharath Lim, Rithea Leang, Socheat Duong, Sokunthea Sreng, Seila Suon, Char Meng Chuor, Denis Mey Bout, Sandie Ménard, William O. Rogers, Blaise Genton, Thierry Fandeur, Olivo Miotto, Pascal Ringwald, Jacques Le Bras, Antoine Berry, Jean-Christophe Barale, Rick M. Fairhurst, Françoise Benoit-Vical, Odile Mercereau-Puijalon, Didier Ménard

ABSTRACT

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch propeller domain (‘K13-propeller’) with artemisinin resistance in vitro and in vivo. Mutant K13-propeller alleles cluster in Cambodian provinces where resistance is prevalent, and the increasing frequency of a dominant mutant K13-propeller allele correlates with the recent spread of resistance in western Cambodia. Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance. K13-propeller polymorphism constitutes a useful molecular marker for large-scale surveillance efforts to contain artemisinin resistance in the Greater Mekong Subregion and prevent its global spread. More... »

PAGES

50-55

Journal

TITLE

Nature

ISSUE

7481

VOLUME

505

Author Affiliations

  • Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Santé et de la Recherche Médicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Université Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unité de Biologie et Génétique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.).
  • Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia
  • Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA
  • Centre National de la Recherche Scientifique, Unité de Recherche Associée 2581, 75724 Paris Cedex 15, France
  • Département Génomes et Génétique, Institut Pasteur, Plate-forme Génomique, 75724 Paris Cedex 15, France
  • National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
  • SSA WHO, Drug Monitoring in Cambodia, National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
  • Naval Medical Research Unit #2 Detachment, Phnom Penh, Cambodia
  • Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland
  • Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
  • Global Malaria Program, World Health Organization, 1211 Geneva, Switzerland
  • Centre National de Référence du Paludisme, CHU Bichat-Claude Bernard, APHP, PRES Sorbonne Paris Cité, 75018 Paris, France
  • Université de Toulouse, UPS, Institut National Polytechnique de Toulouse, 31077 Toulouse Cedex 4, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature12876

    DOI

    http://dx.doi.org/10.1038/nature12876

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010217292

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24352242


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alleles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antimalarials", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Artemisinins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cambodia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Markers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Half-Life", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Malaria, Falciparum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Parasitic Sensitivity Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plasmodium falciparum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Structure, Tertiary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protozoan Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Universit\u00e9 Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unit\u00e9 de Biologie et G\u00e9n\u00e9tique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.).", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Institut Pasteur, Parasite Molecular Immunology Unit, 75724 Paris Cedex 15, France", 
                "Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 2581, 75724 Paris Cedex 15, France", 
                "Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Universit\u00e9 Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unit\u00e9 de Biologie et G\u00e9n\u00e9tique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.)."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ariey", 
            "givenName": "Fr\u00e9d\u00e9ric", 
            "id": "sg:person.016427327407.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016427327407.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Witkowski", 
            "givenName": "Benoit", 
            "id": "sg:person.0655254770.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655254770.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.419681.3", 
              "name": [
                "Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Amaratunga", 
            "givenName": "Chanaki", 
            "id": "sg:person.0611767613.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611767613.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Universit\u00e9 Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unit\u00e9 de Biologie et G\u00e9n\u00e9tique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.).", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Institut Pasteur, Parasite Molecular Immunology Unit, 75724 Paris Cedex 15, France", 
                "Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 2581, 75724 Paris Cedex 15, France", 
                "Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Universit\u00e9 Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unit\u00e9 de Biologie et G\u00e9n\u00e9tique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.)."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beghain", 
            "givenName": "Johann", 
            "id": "sg:person.01230153603.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230153603.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 2581, 75724 Paris Cedex 15, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Institut Pasteur, Parasite Molecular Immunology Unit, 75724 Paris Cedex 15, France", 
                "Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 2581, 75724 Paris Cedex 15, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Langlois", 
            "givenName": "Anne-Claire", 
            "id": "sg:person.01334750674.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334750674.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Khim", 
            "givenName": "Nimol", 
            "id": "sg:person.01246467524.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246467524.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Saorin", 
            "id": "sg:person.0667736036.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667736036.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Duru", 
            "givenName": "Valentine", 
            "id": "sg:person.01144037560.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144037560.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "D\u00e9partement G\u00e9nomes et G\u00e9n\u00e9tique, Institut Pasteur, Plate-forme G\u00e9nomique, 75724 Paris Cedex 15, France", 
              "id": "http://www.grid.ac/institutes/grid.428999.7", 
              "name": [
                "D\u00e9partement G\u00e9nomes et G\u00e9n\u00e9tique, Institut Pasteur, Plate-forme G\u00e9nomique, 75724 Paris Cedex 15, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bouchier", 
            "givenName": "Christiane", 
            "id": "sg:person.0703375136.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703375136.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "D\u00e9partement G\u00e9nomes et G\u00e9n\u00e9tique, Institut Pasteur, Plate-forme G\u00e9nomique, 75724 Paris Cedex 15, France", 
              "id": "http://www.grid.ac/institutes/grid.428999.7", 
              "name": [
                "D\u00e9partement G\u00e9nomes et G\u00e9n\u00e9tique, Institut Pasteur, Plate-forme G\u00e9nomique, 75724 Paris Cedex 15, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ma", 
            "givenName": "Laurence", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.452707.3", 
              "name": [
                "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia", 
                "Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA", 
                "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lim", 
            "givenName": "Pharath", 
            "id": "sg:person.01273121613.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273121613.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.452707.3", 
              "name": [
                "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leang", 
            "givenName": "Rithea", 
            "id": "sg:person.01226021470.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226021470.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.452707.3", 
              "name": [
                "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Duong", 
            "givenName": "Socheat", 
            "id": "sg:person.01073630124.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073630124.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.452707.3", 
              "name": [
                "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sreng", 
            "givenName": "Sokunthea", 
            "id": "sg:person.01013050014.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013050014.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.452707.3", 
              "name": [
                "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suon", 
            "givenName": "Seila", 
            "id": "sg:person.01174717674.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174717674.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.452707.3", 
              "name": [
                "National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chuor", 
            "givenName": "Char Meng", 
            "id": "sg:person.0736216222.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736216222.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "SSA WHO, Drug Monitoring in Cambodia, National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.452707.3", 
              "name": [
                "SSA WHO, Drug Monitoring in Cambodia, National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bout", 
            "givenName": "Denis Mey", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Universit\u00e9 Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unit\u00e9 de Biologie et G\u00e9n\u00e9tique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.).", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de Parasitologie et Mycologie, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse Cedex 9, France", 
                "Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Universit\u00e9 Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unit\u00e9 de Biologie et G\u00e9n\u00e9tique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.)."
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00e9nard", 
            "givenName": "Sandie", 
            "id": "sg:person.01262331277.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262331277.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Naval Medical Research Unit #2 Detachment, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Naval Medical Research Unit #2 Detachment, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rogers", 
            "givenName": "William O.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.416786.a", 
              "name": [
                "Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Genton", 
            "givenName": "Blaise", 
            "id": "sg:person.01152127032.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152127032.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Institut Pasteur, Parasite Molecular Immunology Unit, 75724 Paris Cedex 15, France", 
                "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fandeur", 
            "givenName": "Thierry", 
            "id": "sg:person.01301166762.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301166762.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK", 
              "id": "http://www.grid.ac/institutes/grid.10306.34", 
              "name": [
                "MRC Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, UK", 
                "Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok 10400, Thailand", 
                "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miotto", 
            "givenName": "Olivo", 
            "id": "sg:person.01034621114.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034621114.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Global Malaria Program, World Health Organization, 1211 Geneva, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.3575.4", 
              "name": [
                "Global Malaria Program, World Health Organization, 1211 Geneva, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ringwald", 
            "givenName": "Pascal", 
            "id": "sg:person.0727072567.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727072567.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre National de R\u00e9f\u00e9rence du Paludisme, CHU Bichat-Claude Bernard, APHP, PRES Sorbonne Paris Cit\u00e9, 75018 Paris, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Centre National de R\u00e9f\u00e9rence du Paludisme, CHU Bichat-Claude Bernard, APHP, PRES Sorbonne Paris Cit\u00e9, 75018 Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Le Bras", 
            "givenName": "Jacques", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Universit\u00e9 Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unit\u00e9 de Biologie et G\u00e9n\u00e9tique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.).", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de Parasitologie et Mycologie, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse Cedex 9, France", 
                "Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Universit\u00e9 Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unit\u00e9 de Biologie et G\u00e9n\u00e9tique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.)."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Berry", 
            "givenName": "Antoine", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Universit\u00e9 Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unit\u00e9 de Biologie et G\u00e9n\u00e9tique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.).", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Institut Pasteur, Parasite Molecular Immunology Unit, 75724 Paris Cedex 15, France", 
                "Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 2581, 75724 Paris Cedex 15, France", 
                "Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Universit\u00e9 Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unit\u00e9 de Biologie et G\u00e9n\u00e9tique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.)."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barale", 
            "givenName": "Jean-Christophe", 
            "id": "sg:person.0773561452.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773561452.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.419681.3", 
              "name": [
                "Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fairhurst", 
            "givenName": "Rick M.", 
            "id": "sg:person.01223571744.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223571744.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 de Toulouse, UPS, Institut National Polytechnique de Toulouse, 31077 Toulouse Cedex 4, France", 
              "id": "http://www.grid.ac/institutes/grid.15781.3a", 
              "name": [
                "Centre National de la Recherche Scientifique, Laboratoire de Chimie de Coordination UPR8241, 31077 Toulouse Cedex 4, France", 
                "Universit\u00e9 de Toulouse, UPS, Institut National Polytechnique de Toulouse, 31077 Toulouse Cedex 4, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benoit-Vical", 
            "givenName": "Fran\u00e7oise", 
            "id": "sg:person.01062463455.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062463455.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 2581, 75724 Paris Cedex 15, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Institut Pasteur, Parasite Molecular Immunology Unit, 75724 Paris Cedex 15, France", 
                "Centre National de la Recherche Scientifique, Unit\u00e9 de Recherche Associ\u00e9e 2581, 75724 Paris Cedex 15, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mercereau-Puijalon", 
            "givenName": "Odile", 
            "id": "sg:person.0106442510.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0106442510.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia", 
              "id": "http://www.grid.ac/institutes/grid.418537.c", 
              "name": [
                "Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00e9nard", 
            "givenName": "Didier", 
            "id": "sg:person.0755351436.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755351436.01"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/1475-2875-11-355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028137830", 
              "https://doi.org/10.1186/1475-2875-11-355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-3-23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030807251", 
              "https://doi.org/10.1186/1475-2875-3-23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-11-499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012764952", 
              "https://doi.org/10.1186/1471-2164-11-499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature00813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002262999", 
              "https://doi.org/10.1038/nature00813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016345544", 
              "https://doi.org/10.1038/ng.2624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-4-42", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037190372", 
              "https://doi.org/10.1186/1471-2105-4-42"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-8-89", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041383647", 
              "https://doi.org/10.1186/1475-2875-8-89"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027026856", 
              "https://doi.org/10.1038/nsb899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-10-278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039355196", 
              "https://doi.org/10.1186/1475-2875-10-278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-10-339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036683505", 
              "https://doi.org/10.1186/1475-2875-10-339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039812741", 
              "https://doi.org/10.1038/nature10814"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-12-18", 
        "datePublishedReg": "2013-12-18", 
        "description": "Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch propeller domain (\u2018K13-propeller\u2019) with artemisinin resistance in vitro and in vivo. Mutant K13-propeller alleles cluster in Cambodian provinces where resistance is prevalent, and the increasing frequency of a dominant mutant K13-propeller allele correlates with the recent spread of resistance in western Cambodia. Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance. K13-propeller polymorphism constitutes a useful molecular marker for large-scale surveillance efforts to contain artemisinin resistance in the Greater Mekong Subregion and prevent its global spread.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nature12876", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3636410", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3641762", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2784542", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2723216", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2709085", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2723274", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7481", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "505"
          }
        ], 
        "keywords": [
          "artemisinin resistance", 
          "artemisinin-resistant Plasmodium falciparum malaria", 
          "artemisinin resistant parasite line", 
          "parasite survival rate", 
          "K13-propeller mutations", 
          "K13-propeller polymorphisms", 
          "Plasmodium falciparum malaria", 
          "Plasmodium falciparum resistance", 
          "kelch propeller domain", 
          "falciparum malaria", 
          "falciparum resistance", 
          "survival rate", 
          "western Cambodia", 
          "malaria control", 
          "clearance rate", 
          "parasite lines", 
          "molecular markers", 
          "elimination activities", 
          "Cambodian provinces", 
          "surveillance efforts", 
          "Greater Mekong Subregion", 
          "whole-genome sequencing", 
          "useful molecular marker", 
          "markers", 
          "vivo", 
          "important determinant", 
          "Mekong Subregion", 
          "global spread", 
          "propeller domain", 
          "malaria", 
          "strong correlation", 
          "mutations", 
          "alleles", 
          "spread", 
          "resistance", 
          "mutant alleles", 
          "vitro", 
          "recent spread", 
          "rate", 
          "parasites", 
          "polymorphism", 
          "determinants", 
          "Cambodia", 
          "control", 
          "activity", 
          "sequencing", 
          "subregions", 
          "correlation", 
          "alleles cluster", 
          "presence", 
          "Southeast Asia", 
          "frequency", 
          "lines", 
          "Africa", 
          "efforts", 
          "Province", 
          "derivatives", 
          "Asia", 
          "domain", 
          "clusters", 
          "clinical parasite", 
          "Mutant K13-propeller alleles cluster", 
          "K13-propeller alleles cluster", 
          "dominant mutant K13-propeller allele", 
          "mutant K13-propeller allele", 
          "K13-propeller allele", 
          "large-scale surveillance efforts"
        ], 
        "name": "A molecular marker of artemisinin-resistant Plasmodium falciparum malaria", 
        "pagination": "50-55", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010217292"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature12876"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24352242"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature12876", 
          "https://app.dimensions.ai/details/publication/pub.1010217292"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_600.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nature12876"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature12876'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature12876'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature12876'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature12876'


     

    This table displays all metadata directly associated to this object as RDF triples.

    495 TRIPLES      22 PREDICATES      122 URIs      103 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature12876 schema:about N003732287e6a4a92a04ddbcff7536cfd
    2 N01b57990dc014cb7af533eced385aebb
    3 N19f8b3febac246b6b383cd1ba0b21ff8
    4 N22e36004c3684620b0ebf30e3b7c2beb
    5 N27e0a61611084e2c9dc6a2e69ea12dfc
    6 N38075e1a918a49a29d97c79304f0c4d2
    7 N42b721de43af4dc3a53ac06ecb822144
    8 N496a33c7fd1d4906acd7e322caed7b93
    9 N9df07731e2e342db9c565f9befc8b8e5
    10 Na699427f40d54ad5a6edc4ea0f24ba78
    11 Nbfa70cd8b795459e8b763d5c09bd67ee
    12 Nc884dbb3d9834b16bf10104a3672ef7d
    13 Nc90a533ba225486a98d07f62f06e1dc0
    14 Nccc3b00fbb0d457f848a43d0e9802cb3
    15 Ndc9e31bccdab4a9196c989c8217b193a
    16 Neb67dbd08d5a41d1a1a990477bbe2f3b
    17 Nebb28150af2343aaa3e3ef871d7cd4c3
    18 Ned67ba9d3137459094e548ee087c727d
    19 anzsrc-for:11
    20 anzsrc-for:1108
    21 schema:author N2ba600cb6d0a4b019522aecd4ab53772
    22 schema:citation sg:pub.10.1038/nature00813
    23 sg:pub.10.1038/nature10814
    24 sg:pub.10.1038/ng.2624
    25 sg:pub.10.1038/nsb899
    26 sg:pub.10.1186/1471-2105-4-42
    27 sg:pub.10.1186/1471-2164-11-499
    28 sg:pub.10.1186/1475-2875-10-278
    29 sg:pub.10.1186/1475-2875-10-339
    30 sg:pub.10.1186/1475-2875-11-355
    31 sg:pub.10.1186/1475-2875-3-23
    32 sg:pub.10.1186/1475-2875-8-89
    33 schema:datePublished 2013-12-18
    34 schema:datePublishedReg 2013-12-18
    35 schema:description Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing of an artemisinin-resistant parasite line from Africa and clinical parasite isolates from Cambodia, we associate mutations in the PF3D7_1343700 kelch propeller domain (‘K13-propeller’) with artemisinin resistance in vitro and in vivo. Mutant K13-propeller alleles cluster in Cambodian provinces where resistance is prevalent, and the increasing frequency of a dominant mutant K13-propeller allele correlates with the recent spread of resistance in western Cambodia. Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance. K13-propeller polymorphism constitutes a useful molecular marker for large-scale surveillance efforts to contain artemisinin resistance in the Greater Mekong Subregion and prevent its global spread.
    36 schema:genre article
    37 schema:inLanguage en
    38 schema:isAccessibleForFree true
    39 schema:isPartOf Na35d1aaa53154ef0bb1c284c937f9d31
    40 Nf3137d41cb0d46f6b623c9d12d81d578
    41 sg:journal.1018957
    42 schema:keywords Africa
    43 Asia
    44 Cambodia
    45 Cambodian provinces
    46 Greater Mekong Subregion
    47 K13-propeller allele
    48 K13-propeller alleles cluster
    49 K13-propeller mutations
    50 K13-propeller polymorphisms
    51 Mekong Subregion
    52 Mutant K13-propeller alleles cluster
    53 Plasmodium falciparum malaria
    54 Plasmodium falciparum resistance
    55 Province
    56 Southeast Asia
    57 activity
    58 alleles
    59 alleles cluster
    60 artemisinin resistance
    61 artemisinin resistant parasite line
    62 artemisinin-resistant Plasmodium falciparum malaria
    63 clearance rate
    64 clinical parasite
    65 clusters
    66 control
    67 correlation
    68 derivatives
    69 determinants
    70 domain
    71 dominant mutant K13-propeller allele
    72 efforts
    73 elimination activities
    74 falciparum malaria
    75 falciparum resistance
    76 frequency
    77 global spread
    78 important determinant
    79 kelch propeller domain
    80 large-scale surveillance efforts
    81 lines
    82 malaria
    83 malaria control
    84 markers
    85 molecular markers
    86 mutant K13-propeller allele
    87 mutant alleles
    88 mutations
    89 parasite lines
    90 parasite survival rate
    91 parasites
    92 polymorphism
    93 presence
    94 propeller domain
    95 rate
    96 recent spread
    97 resistance
    98 sequencing
    99 spread
    100 strong correlation
    101 subregions
    102 surveillance efforts
    103 survival rate
    104 useful molecular marker
    105 vitro
    106 vivo
    107 western Cambodia
    108 whole-genome sequencing
    109 schema:name A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
    110 schema:pagination 50-55
    111 schema:productId N5bdb3f926812491480cf9a67fa26aa78
    112 Na312475b49e24283914003241c010cc8
    113 Na7798176146c48c4b1a9ea7c34fb4d96
    114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010217292
    115 https://doi.org/10.1038/nature12876
    116 schema:sdDatePublished 2022-01-01T18:30
    117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    118 schema:sdPublisher N5fc7e62e023b49628f99748badbd3167
    119 schema:url https://doi.org/10.1038/nature12876
    120 sgo:license sg:explorer/license/
    121 sgo:sdDataset articles
    122 rdf:type schema:ScholarlyArticle
    123 N003732287e6a4a92a04ddbcff7536cfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Artemisinins
    125 rdf:type schema:DefinedTerm
    126 N01b57990dc014cb7af533eced385aebb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Drug Resistance
    128 rdf:type schema:DefinedTerm
    129 N0c1eac70ca6a47868097f2ebf939b9aa rdf:first sg:person.01226021470.74
    130 rdf:rest N6c06020cb3a84f94b4b5ad5986632ec2
    131 N13c4196929ce477ebecaf1e8517435a7 rdf:first sg:person.01246467524.81
    132 rdf:rest N512b5508de874faca902355dbc715eed
    133 N19f8b3febac246b6b383cd1ba0b21ff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Genetic Markers
    135 rdf:type schema:DefinedTerm
    136 N1e19ded1f3844ce4953e96b5c9280308 rdf:first sg:person.01174717674.76
    137 rdf:rest Ne469e4c3c7be4fe9a4bec6cdf51722c9
    138 N1ff995f7fcfe411f9be0f88808ec865f rdf:first Ncca29a6268fd4bcb8a7e285125bfc8b1
    139 rdf:rest N3290a9d7e27544d3b643d1c96fe9b5ac
    140 N22e36004c3684620b0ebf30e3b7c2beb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Humans
    142 rdf:type schema:DefinedTerm
    143 N27e0a61611084e2c9dc6a2e69ea12dfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Cambodia
    145 rdf:type schema:DefinedTerm
    146 N2ba600cb6d0a4b019522aecd4ab53772 rdf:first sg:person.016427327407.98
    147 rdf:rest N888d5b523a2e43e5a75678fa92ecfe52
    148 N3196c363d8424f538b69d0045c549b3a rdf:first sg:person.01223571744.44
    149 rdf:rest Na7c8c151ee204b68a15bf2758f7fe50e
    150 N3290a9d7e27544d3b643d1c96fe9b5ac rdf:first sg:person.01152127032.85
    151 rdf:rest Nb85f56f3943d42e5b8b11d10dbea8a93
    152 N38075e1a918a49a29d97c79304f0c4d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Protein Structure, Tertiary
    154 rdf:type schema:DefinedTerm
    155 N3927b7591b4f4e9787eeae071557dea2 rdf:first Nbe25b6dc1318446aa18e4b068c109037
    156 rdf:rest N5dbfa2fc926840c2bab9bd3786b089e7
    157 N42b721de43af4dc3a53ac06ecb822144 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Animals
    159 rdf:type schema:DefinedTerm
    160 N48e4a8afe34d483e80ac248bde31e40a schema:affiliation grid-institutes:None
    161 schema:familyName Le Bras
    162 schema:givenName Jacques
    163 rdf:type schema:Person
    164 N496a33c7fd1d4906acd7e322caed7b93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Parasitic Sensitivity Tests
    166 rdf:type schema:DefinedTerm
    167 N4b911e07ccff43c7b813b64d6e2fc7aa rdf:first sg:person.01013050014.75
    168 rdf:rest N1e19ded1f3844ce4953e96b5c9280308
    169 N512b5508de874faca902355dbc715eed rdf:first sg:person.0667736036.69
    170 rdf:rest Ne85a1a6378794a82bee3979adcf05bcc
    171 N53f1643b166240719785a8f0b8b333b0 rdf:first sg:person.0727072567.02
    172 rdf:rest Nc87f4955b63d4532a2719aca6d47942b
    173 N5bdb3f926812491480cf9a67fa26aa78 schema:name pubmed_id
    174 schema:value 24352242
    175 rdf:type schema:PropertyValue
    176 N5dbfa2fc926840c2bab9bd3786b089e7 rdf:first sg:person.01273121613.50
    177 rdf:rest N0c1eac70ca6a47868097f2ebf939b9aa
    178 N5fc7e62e023b49628f99748badbd3167 schema:name Springer Nature - SN SciGraph project
    179 rdf:type schema:Organization
    180 N679a83fbd44042d5a2cb1ac3769f71b5 schema:affiliation grid-institutes:grid.452707.3
    181 schema:familyName Bout
    182 schema:givenName Denis Mey
    183 rdf:type schema:Person
    184 N6b1829e9b9cf459795839c5f56cbc107 rdf:first sg:person.01334750674.18
    185 rdf:rest N13c4196929ce477ebecaf1e8517435a7
    186 N6c06020cb3a84f94b4b5ad5986632ec2 rdf:first sg:person.01073630124.62
    187 rdf:rest N4b911e07ccff43c7b813b64d6e2fc7aa
    188 N888d5b523a2e43e5a75678fa92ecfe52 rdf:first sg:person.0655254770.59
    189 rdf:rest N9abc96f2f70a4d08a5a62397d5e30cb0
    190 N9abc96f2f70a4d08a5a62397d5e30cb0 rdf:first sg:person.0611767613.73
    191 rdf:rest Nb1f6f5ad10384d4fbff73ea9cf4bc725
    192 N9df07731e2e342db9c565f9befc8b8e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Polymorphism, Single Nucleotide
    194 rdf:type schema:DefinedTerm
    195 Na312475b49e24283914003241c010cc8 schema:name doi
    196 schema:value 10.1038/nature12876
    197 rdf:type schema:PropertyValue
    198 Na35d1aaa53154ef0bb1c284c937f9d31 schema:volumeNumber 505
    199 rdf:type schema:PublicationVolume
    200 Na699427f40d54ad5a6edc4ea0f24ba78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Time Factors
    202 rdf:type schema:DefinedTerm
    203 Na7798176146c48c4b1a9ea7c34fb4d96 schema:name dimensions_id
    204 schema:value pub.1010217292
    205 rdf:type schema:PropertyValue
    206 Na7c8c151ee204b68a15bf2758f7fe50e rdf:first sg:person.01062463455.54
    207 rdf:rest Nc5a48d2f11af466692320e90c0b2dc6e
    208 Nb1f6f5ad10384d4fbff73ea9cf4bc725 rdf:first sg:person.01230153603.17
    209 rdf:rest N6b1829e9b9cf459795839c5f56cbc107
    210 Nb85f56f3943d42e5b8b11d10dbea8a93 rdf:first sg:person.01301166762.19
    211 rdf:rest Nf7b2cf4079b64a1d9319de1f9577481f
    212 Nbc3ad6db21e04b9eb394db01fd4a78da schema:affiliation grid-institutes:None
    213 schema:familyName Berry
    214 schema:givenName Antoine
    215 rdf:type schema:Person
    216 Nbe25b6dc1318446aa18e4b068c109037 schema:affiliation grid-institutes:grid.428999.7
    217 schema:familyName Ma
    218 schema:givenName Laurence
    219 rdf:type schema:Person
    220 Nbe354e2e06cb4b7aa8548c6c13b50213 rdf:first sg:person.0755351436.01
    221 rdf:rest rdf:nil
    222 Nbfa70cd8b795459e8b763d5c09bd67ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Malaria, Falciparum
    224 rdf:type schema:DefinedTerm
    225 Nc5a48d2f11af466692320e90c0b2dc6e rdf:first sg:person.0106442510.63
    226 rdf:rest Nbe354e2e06cb4b7aa8548c6c13b50213
    227 Nc6413be00de447738a94b42aa7e0578d rdf:first sg:person.01262331277.40
    228 rdf:rest N1ff995f7fcfe411f9be0f88808ec865f
    229 Nc87f4955b63d4532a2719aca6d47942b rdf:first N48e4a8afe34d483e80ac248bde31e40a
    230 rdf:rest Ne26111cecc304ac4b90d4ee3b2b951ff
    231 Nc884dbb3d9834b16bf10104a3672ef7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Mutation
    233 rdf:type schema:DefinedTerm
    234 Nc90a533ba225486a98d07f62f06e1dc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Alleles
    236 rdf:type schema:DefinedTerm
    237 Ncca29a6268fd4bcb8a7e285125bfc8b1 schema:affiliation grid-institutes:None
    238 schema:familyName Rogers
    239 schema:givenName William O.
    240 rdf:type schema:Person
    241 Nccc3b00fbb0d457f848a43d0e9802cb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Plasmodium falciparum
    243 rdf:type schema:DefinedTerm
    244 Nda661ed57ac449c2b0ab22e91db8ae04 rdf:first sg:person.0773561452.49
    245 rdf:rest N3196c363d8424f538b69d0045c549b3a
    246 Ndc9e31bccdab4a9196c989c8217b193a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    247 schema:name Antimalarials
    248 rdf:type schema:DefinedTerm
    249 Ne1a988642a554e5682b753a8024eea55 rdf:first N679a83fbd44042d5a2cb1ac3769f71b5
    250 rdf:rest Nc6413be00de447738a94b42aa7e0578d
    251 Ne26111cecc304ac4b90d4ee3b2b951ff rdf:first Nbc3ad6db21e04b9eb394db01fd4a78da
    252 rdf:rest Nda661ed57ac449c2b0ab22e91db8ae04
    253 Ne469e4c3c7be4fe9a4bec6cdf51722c9 rdf:first sg:person.0736216222.41
    254 rdf:rest Ne1a988642a554e5682b753a8024eea55
    255 Ne85a1a6378794a82bee3979adcf05bcc rdf:first sg:person.01144037560.65
    256 rdf:rest Nf1e08082c6824d90902cccf59bf0ac7a
    257 Neb67dbd08d5a41d1a1a990477bbe2f3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    258 schema:name Blood Cells
    259 rdf:type schema:DefinedTerm
    260 Nebb28150af2343aaa3e3ef871d7cd4c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    261 schema:name Protozoan Proteins
    262 rdf:type schema:DefinedTerm
    263 Ned67ba9d3137459094e548ee087c727d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    264 schema:name Half-Life
    265 rdf:type schema:DefinedTerm
    266 Nf1e08082c6824d90902cccf59bf0ac7a rdf:first sg:person.0703375136.68
    267 rdf:rest N3927b7591b4f4e9787eeae071557dea2
    268 Nf3137d41cb0d46f6b623c9d12d81d578 schema:issueNumber 7481
    269 rdf:type schema:PublicationIssue
    270 Nf7b2cf4079b64a1d9319de1f9577481f rdf:first sg:person.01034621114.04
    271 rdf:rest N53f1643b166240719785a8f0b8b333b0
    272 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    273 schema:name Medical and Health Sciences
    274 rdf:type schema:DefinedTerm
    275 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    276 schema:name Medical Microbiology
    277 rdf:type schema:DefinedTerm
    278 sg:grant.2709085 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12876
    279 rdf:type schema:MonetaryGrant
    280 sg:grant.2723216 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12876
    281 rdf:type schema:MonetaryGrant
    282 sg:grant.2723274 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12876
    283 rdf:type schema:MonetaryGrant
    284 sg:grant.2784542 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12876
    285 rdf:type schema:MonetaryGrant
    286 sg:grant.3636410 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12876
    287 rdf:type schema:MonetaryGrant
    288 sg:grant.3641762 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12876
    289 rdf:type schema:MonetaryGrant
    290 sg:journal.1018957 schema:issn 0028-0836
    291 1476-4687
    292 schema:name Nature
    293 schema:publisher Springer Nature
    294 rdf:type schema:Periodical
    295 sg:person.01013050014.75 schema:affiliation grid-institutes:grid.452707.3
    296 schema:familyName Sreng
    297 schema:givenName Sokunthea
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013050014.75
    299 rdf:type schema:Person
    300 sg:person.01034621114.04 schema:affiliation grid-institutes:grid.10306.34
    301 schema:familyName Miotto
    302 schema:givenName Olivo
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034621114.04
    304 rdf:type schema:Person
    305 sg:person.01062463455.54 schema:affiliation grid-institutes:grid.15781.3a
    306 schema:familyName Benoit-Vical
    307 schema:givenName Françoise
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062463455.54
    309 rdf:type schema:Person
    310 sg:person.0106442510.63 schema:affiliation grid-institutes:None
    311 schema:familyName Mercereau-Puijalon
    312 schema:givenName Odile
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0106442510.63
    314 rdf:type schema:Person
    315 sg:person.01073630124.62 schema:affiliation grid-institutes:grid.452707.3
    316 schema:familyName Duong
    317 schema:givenName Socheat
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073630124.62
    319 rdf:type schema:Person
    320 sg:person.01144037560.65 schema:affiliation grid-institutes:grid.418537.c
    321 schema:familyName Duru
    322 schema:givenName Valentine
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144037560.65
    324 rdf:type schema:Person
    325 sg:person.01152127032.85 schema:affiliation grid-institutes:grid.416786.a
    326 schema:familyName Genton
    327 schema:givenName Blaise
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152127032.85
    329 rdf:type schema:Person
    330 sg:person.01174717674.76 schema:affiliation grid-institutes:grid.452707.3
    331 schema:familyName Suon
    332 schema:givenName Seila
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174717674.76
    334 rdf:type schema:Person
    335 sg:person.01223571744.44 schema:affiliation grid-institutes:grid.419681.3
    336 schema:familyName Fairhurst
    337 schema:givenName Rick M.
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223571744.44
    339 rdf:type schema:Person
    340 sg:person.01226021470.74 schema:affiliation grid-institutes:grid.452707.3
    341 schema:familyName Leang
    342 schema:givenName Rithea
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226021470.74
    344 rdf:type schema:Person
    345 sg:person.01230153603.17 schema:affiliation grid-institutes:None
    346 schema:familyName Beghain
    347 schema:givenName Johann
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230153603.17
    349 rdf:type schema:Person
    350 sg:person.01246467524.81 schema:affiliation grid-institutes:grid.418537.c
    351 schema:familyName Khim
    352 schema:givenName Nimol
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246467524.81
    354 rdf:type schema:Person
    355 sg:person.01262331277.40 schema:affiliation grid-institutes:None
    356 schema:familyName Ménard
    357 schema:givenName Sandie
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262331277.40
    359 rdf:type schema:Person
    360 sg:person.01273121613.50 schema:affiliation grid-institutes:grid.452707.3
    361 schema:familyName Lim
    362 schema:givenName Pharath
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273121613.50
    364 rdf:type schema:Person
    365 sg:person.01301166762.19 schema:affiliation grid-institutes:grid.418537.c
    366 schema:familyName Fandeur
    367 schema:givenName Thierry
    368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301166762.19
    369 rdf:type schema:Person
    370 sg:person.01334750674.18 schema:affiliation grid-institutes:None
    371 schema:familyName Langlois
    372 schema:givenName Anne-Claire
    373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334750674.18
    374 rdf:type schema:Person
    375 sg:person.016427327407.98 schema:affiliation grid-institutes:None
    376 schema:familyName Ariey
    377 schema:givenName Frédéric
    378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016427327407.98
    379 rdf:type schema:Person
    380 sg:person.0611767613.73 schema:affiliation grid-institutes:grid.419681.3
    381 schema:familyName Amaratunga
    382 schema:givenName Chanaki
    383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611767613.73
    384 rdf:type schema:Person
    385 sg:person.0655254770.59 schema:affiliation grid-institutes:grid.418537.c
    386 schema:familyName Witkowski
    387 schema:givenName Benoit
    388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655254770.59
    389 rdf:type schema:Person
    390 sg:person.0667736036.69 schema:affiliation grid-institutes:grid.418537.c
    391 schema:familyName Kim
    392 schema:givenName Saorin
    393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667736036.69
    394 rdf:type schema:Person
    395 sg:person.0703375136.68 schema:affiliation grid-institutes:grid.428999.7
    396 schema:familyName Bouchier
    397 schema:givenName Christiane
    398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703375136.68
    399 rdf:type schema:Person
    400 sg:person.0727072567.02 schema:affiliation grid-institutes:grid.3575.4
    401 schema:familyName Ringwald
    402 schema:givenName Pascal
    403 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727072567.02
    404 rdf:type schema:Person
    405 sg:person.0736216222.41 schema:affiliation grid-institutes:grid.452707.3
    406 schema:familyName Chuor
    407 schema:givenName Char Meng
    408 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736216222.41
    409 rdf:type schema:Person
    410 sg:person.0755351436.01 schema:affiliation grid-institutes:grid.418537.c
    411 schema:familyName Ménard
    412 schema:givenName Didier
    413 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755351436.01
    414 rdf:type schema:Person
    415 sg:person.0773561452.49 schema:affiliation grid-institutes:None
    416 schema:familyName Barale
    417 schema:givenName Jean-Christophe
    418 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773561452.49
    419 rdf:type schema:Person
    420 sg:pub.10.1038/nature00813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002262999
    421 https://doi.org/10.1038/nature00813
    422 rdf:type schema:CreativeWork
    423 sg:pub.10.1038/nature10814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039812741
    424 https://doi.org/10.1038/nature10814
    425 rdf:type schema:CreativeWork
    426 sg:pub.10.1038/ng.2624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016345544
    427 https://doi.org/10.1038/ng.2624
    428 rdf:type schema:CreativeWork
    429 sg:pub.10.1038/nsb899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027026856
    430 https://doi.org/10.1038/nsb899
    431 rdf:type schema:CreativeWork
    432 sg:pub.10.1186/1471-2105-4-42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037190372
    433 https://doi.org/10.1186/1471-2105-4-42
    434 rdf:type schema:CreativeWork
    435 sg:pub.10.1186/1471-2164-11-499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012764952
    436 https://doi.org/10.1186/1471-2164-11-499
    437 rdf:type schema:CreativeWork
    438 sg:pub.10.1186/1475-2875-10-278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039355196
    439 https://doi.org/10.1186/1475-2875-10-278
    440 rdf:type schema:CreativeWork
    441 sg:pub.10.1186/1475-2875-10-339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036683505
    442 https://doi.org/10.1186/1475-2875-10-339
    443 rdf:type schema:CreativeWork
    444 sg:pub.10.1186/1475-2875-11-355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028137830
    445 https://doi.org/10.1186/1475-2875-11-355
    446 rdf:type schema:CreativeWork
    447 sg:pub.10.1186/1475-2875-3-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030807251
    448 https://doi.org/10.1186/1475-2875-3-23
    449 rdf:type schema:CreativeWork
    450 sg:pub.10.1186/1475-2875-8-89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041383647
    451 https://doi.org/10.1186/1475-2875-8-89
    452 rdf:type schema:CreativeWork
    453 grid-institutes:None schema:alternateName Centre National de Référence du Paludisme, CHU Bichat-Claude Bernard, APHP, PRES Sorbonne Paris Cité, 75018 Paris, France
    454 Centre National de la Recherche Scientifique, Unité de Recherche Associée 2581, 75724 Paris Cedex 15, France
    455 Naval Medical Research Unit #2 Detachment, Phnom Penh, Cambodia
    456 Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Santé et de la Recherche Médicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Université Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unité de Biologie et Génétique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.).
    457 schema:name Centre National de Référence du Paludisme, CHU Bichat-Claude Bernard, APHP, PRES Sorbonne Paris Cité, 75018 Paris, France
    458 Centre National de la Recherche Scientifique, Unité de Recherche Associée 2581, 75724 Paris Cedex 15, France
    459 Institut Pasteur, Parasite Molecular Immunology Unit, 75724 Paris Cedex 15, France
    460 Naval Medical Research Unit #2 Detachment, Phnom Penh, Cambodia
    461 Present addresses: Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, 75724 Paris Cedex 15, France (F.A.); Institut Pasteur, Functional Genetics of Infectious Diseases Unit, 75724 Paris Cedex 15, France (J.B.); Centre de Physiopathologie de Toulouse-Purpan, Institut National de la Santé et de la Recherche Médicale UMR1043, Centre National de la Recherche Scientifique UMR5282, Université Toulouse III, 31024 Toulouse Cedex 3, France(S.M. & A.B.); Institut Pasteur, Unité de Biologie et Génétique du Paludisme, Team Malaria Targets and Drug Development, 75724 Paris Cedex 15, France (J.-C.B.).
    462 Service de Parasitologie et Mycologie, Centre Hospitalier Universitaire de Toulouse, 31059 Toulouse Cedex 9, France
    463 rdf:type schema:Organization
    464 grid-institutes:grid.10306.34 schema:alternateName Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    465 schema:name MRC Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, UK
    466 Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok 10400, Thailand
    467 Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    468 rdf:type schema:Organization
    469 grid-institutes:grid.15781.3a schema:alternateName Université de Toulouse, UPS, Institut National Polytechnique de Toulouse, 31077 Toulouse Cedex 4, France
    470 schema:name Centre National de la Recherche Scientifique, Laboratoire de Chimie de Coordination UPR8241, 31077 Toulouse Cedex 4, France
    471 Université de Toulouse, UPS, Institut National Polytechnique de Toulouse, 31077 Toulouse Cedex 4, France
    472 rdf:type schema:Organization
    473 grid-institutes:grid.3575.4 schema:alternateName Global Malaria Program, World Health Organization, 1211 Geneva, Switzerland
    474 schema:name Global Malaria Program, World Health Organization, 1211 Geneva, Switzerland
    475 rdf:type schema:Organization
    476 grid-institutes:grid.416786.a schema:alternateName Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland
    477 schema:name Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland
    478 rdf:type schema:Organization
    479 grid-institutes:grid.418537.c schema:alternateName Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia
    480 schema:name Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia
    481 Institut Pasteur, Parasite Molecular Immunology Unit, 75724 Paris Cedex 15, France
    482 rdf:type schema:Organization
    483 grid-institutes:grid.419681.3 schema:alternateName Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA
    484 schema:name Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA
    485 rdf:type schema:Organization
    486 grid-institutes:grid.428999.7 schema:alternateName Département Génomes et Génétique, Institut Pasteur, Plate-forme Génomique, 75724 Paris Cedex 15, France
    487 schema:name Département Génomes et Génétique, Institut Pasteur, Plate-forme Génomique, 75724 Paris Cedex 15, France
    488 rdf:type schema:Organization
    489 grid-institutes:grid.452707.3 schema:alternateName National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    490 SSA WHO, Drug Monitoring in Cambodia, National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    491 schema:name Institut Pasteur du Cambodge, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia
    492 Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA
    493 National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    494 SSA WHO, Drug Monitoring in Cambodia, National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    495 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...