N6-methyladenosine-dependent regulation of messenger RNA stability View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11-27

AUTHORS

Xiao Wang, Zhike Lu, Adrian Gomez, Gary C. Hon, Yanan Yue, Dali Han, Ye Fu, Marc Parisien, Qing Dai, Guifang Jia, Bing Ren, Tao Pan, Chuan He

ABSTRACT

The mRNAs of higher eukaryotes are extensively modified internally with N6-methyladenosine, but the specific functional role of this modification has been unclear; here this modification on mRNA is shown to be recognized by several proteins, the modification and its recognition serve to regulate the RNA’s lifetime.

PAGES

117-120

Journal

TITLE

Nature

ISSUE

7481

VOLUME

505

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature12730

DOI

http://dx.doi.org/10.1038/nature12730

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045996872

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24284625


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HeLa Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Minor Histocompatibility Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleotide Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organelles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Biosynthesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Stability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Untranslated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substrate Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Xiao", 
        "id": "sg:person.0644070443.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644070443.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Zhike", 
        "id": "sg:person.0756073554.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756073554.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gomez", 
        "givenName": "Adrian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, UCSD Moores Cancer Center and Institute of Genome Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA", 
          "id": "http://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, UCSD Moores Cancer Center and Institute of Genome Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hon", 
        "givenName": "Gary C.", 
        "id": "sg:person.01237222045.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237222045.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yue", 
        "givenName": "Yanan", 
        "id": "sg:person.01346106510.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346106510.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Dali", 
        "id": "sg:person.0732131732.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732131732.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fu", 
        "givenName": "Ye", 
        "id": "sg:person.01071451721.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071451721.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parisien", 
        "givenName": "Marc", 
        "id": "sg:person.0603501530.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603501530.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dai", 
        "givenName": "Qing", 
        "id": "sg:person.011425010257.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011425010257.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemical Biology and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, 100871, Beijing, China", 
          "id": "http://www.grid.ac/institutes/grid.11135.37", 
          "name": [
            "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
            "Department of Chemical Biology and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, 100871, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jia", 
        "givenName": "Guifang", 
        "id": "sg:person.01314657777.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314657777.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, UCSD Moores Cancer Center and Institute of Genome Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA", 
          "id": "http://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, UCSD Moores Cancer Center and Institute of Genome Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ren", 
        "givenName": "Bing", 
        "id": "sg:person.01174702157.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174702157.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pan", 
        "givenName": "Tao", 
        "id": "sg:person.01261440612.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261440612.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA", 
          "id": "http://www.grid.ac/institutes/grid.170205.1", 
          "name": [
            "Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Chuan", 
        "id": "sg:person.012740030027.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740030027.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature11112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040794705", 
          "https://doi.org/10.1038/nature11112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045483645", 
          "https://doi.org/10.1038/nprot.2006.82"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025585804", 
          "https://doi.org/10.1038/nmeth.1608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59745-033-1_8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028584528", 
          "https://doi.org/10.1007/978-1-59745-033-1_8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2011-12-8-r79", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044311993", 
          "https://doi.org/10.1186/gb-2011-12-8-r79"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031035095", 
          "https://doi.org/10.1038/nbt.1621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051460393", 
          "https://doi.org/10.1038/nchembio.482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-56298-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018872798", 
          "https://doi.org/10.1007/978-3-642-56298-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2010-11-10-r106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031289083", 
          "https://doi.org/10.1186/gb-2010-11-10-r106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2008-9-9-r137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027608848", 
          "https://doi.org/10.1186/gb-2008-9-9-r137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051364702", 
          "https://doi.org/10.1038/nchembio.687"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-11-27", 
    "datePublishedReg": "2013-11-27", 
    "description": "The mRNAs of higher eukaryotes are extensively modified internally with N6-methyladenosine, but the specific functional role of this modification has been unclear; here this modification on mRNA is shown to be recognized by several proteins, the modification and its recognition serve to regulate the RNA\u2019s lifetime.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nature12730", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3120521", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2520562", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2404592", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2518424", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7481", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "505"
      }
    ], 
    "keywords": [
      "messenger RNA stability", 
      "specific functional roles", 
      "higher eukaryotes", 
      "RNA stability", 
      "RNA lifetime", 
      "dependent regulation", 
      "functional role", 
      "mRNA", 
      "eukaryotes", 
      "protein", 
      "regulation", 
      "modification", 
      "role", 
      "recognition", 
      "stability", 
      "lifetime"
    ], 
    "name": "N6-methyladenosine-dependent regulation of messenger RNA stability", 
    "pagination": "117-120", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045996872"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature12730"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24284625"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature12730", 
      "https://app.dimensions.ai/details/publication/pub.1045996872"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_586.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nature12730"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature12730'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature12730'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature12730'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature12730'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      21 PREDICATES      68 URIs      49 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature12730 schema:about N02d862f30c58488b9d70c17307d63b18
2 N149dd70723254166bf09aa16eed936e1
3 N2bc0e7980fc14372b8e5c9a3c0bc9ba6
4 N2ee0e04657f647a38917131d0fec23b7
5 N35e5181a658a4a35b4de9af56e9922e5
6 N3f58b368bdd14c55bd8ceb9bf44d165b
7 N504fc956f2ad41c9a2b7134c33a36811
8 N5fe8c1707cd84a7babd0f97804795597
9 N6be20666b2da41edb66c3e03f8db91c8
10 N7755b58c56674d178727c2f3ba0dbe51
11 N7efb0a1558dc4fedaaf93b92edf7f6ee
12 N85bc1513a4e74fd299227f9938db003f
13 N8dd1794b092347399df4f9c6c8201acd
14 N98a2e675312d4603ae0c8c7a2a1a65ba
15 Nb48705c0de2c4312b6f854fe9c4108c1
16 Ne1f80e2b5efc4de98bb31249172e9d19
17 anzsrc-for:06
18 anzsrc-for:0604
19 schema:author N00a19550c3a445bbb8d99e243cc6690c
20 schema:citation sg:pub.10.1007/978-1-59745-033-1_8
21 sg:pub.10.1007/978-3-642-56298-3
22 sg:pub.10.1038/nature11112
23 sg:pub.10.1038/nbt.1621
24 sg:pub.10.1038/nchembio.482
25 sg:pub.10.1038/nchembio.687
26 sg:pub.10.1038/nmeth.1608
27 sg:pub.10.1038/nprot.2006.82
28 sg:pub.10.1186/gb-2008-9-9-r137
29 sg:pub.10.1186/gb-2010-11-10-r106
30 sg:pub.10.1186/gb-2011-12-8-r79
31 schema:datePublished 2013-11-27
32 schema:datePublishedReg 2013-11-27
33 schema:description The mRNAs of higher eukaryotes are extensively modified internally with N6-methyladenosine, but the specific functional role of this modification has been unclear; here this modification on mRNA is shown to be recognized by several proteins, the modification and its recognition serve to regulate the RNA’s lifetime.
34 schema:genre article
35 schema:isAccessibleForFree true
36 schema:isPartOf N2e9a0817e0b847e9ac3ea88ce98510b8
37 Nacbab78c56864019a281baeadfe803a4
38 sg:journal.1018957
39 schema:keywords RNA lifetime
40 RNA stability
41 dependent regulation
42 eukaryotes
43 functional role
44 higher eukaryotes
45 lifetime
46 mRNA
47 messenger RNA stability
48 modification
49 protein
50 recognition
51 regulation
52 role
53 specific functional roles
54 stability
55 schema:name N6-methyladenosine-dependent regulation of messenger RNA stability
56 schema:pagination 117-120
57 schema:productId N2d136980de384c3895aa8233b734eb58
58 Nc66a202253d443999c4d1dcf124da5e3
59 Ne149ca60c0fa4d0aa9ff7aa62c8a92e8
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045996872
61 https://doi.org/10.1038/nature12730
62 schema:sdDatePublished 2022-12-01T06:30
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N929231a135834d13bd74f16c4729a3cf
65 schema:url https://doi.org/10.1038/nature12730
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N00a19550c3a445bbb8d99e243cc6690c rdf:first sg:person.0644070443.34
70 rdf:rest N2b3a445ed8b14d229e73ae7d2369cd80
71 N02d862f30c58488b9d70c17307d63b18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Base Sequence
73 rdf:type schema:DefinedTerm
74 N149dd70723254166bf09aa16eed936e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name RNA, Messenger
76 rdf:type schema:DefinedTerm
77 N263995a19cbd4e8cb84f1c1f9cc9cd81 rdf:first sg:person.011425010257.19
78 rdf:rest Na05a8d131581492a8ff4154857a8bd00
79 N2b3a445ed8b14d229e73ae7d2369cd80 rdf:first sg:person.0756073554.72
80 rdf:rest N6219737e65f04d4eabe79f56580da0d4
81 N2bc0e7980fc14372b8e5c9a3c0bc9ba6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name RNA, Untranslated
83 rdf:type schema:DefinedTerm
84 N2d136980de384c3895aa8233b734eb58 schema:name doi
85 schema:value 10.1038/nature12730
86 rdf:type schema:PropertyValue
87 N2e9a0817e0b847e9ac3ea88ce98510b8 schema:issueNumber 7481
88 rdf:type schema:PublicationIssue
89 N2ee0e04657f647a38917131d0fec23b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name RNA Stability
91 rdf:type schema:DefinedTerm
92 N35e5181a658a4a35b4de9af56e9922e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name RNA Transport
94 rdf:type schema:DefinedTerm
95 N3f58b368bdd14c55bd8ceb9bf44d165b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N504fc956f2ad41c9a2b7134c33a36811 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Protein Binding
100 rdf:type schema:DefinedTerm
101 N50adc40715634859800c35d3a0206025 rdf:first sg:person.01237222045.60
102 rdf:rest N664d929240f74012afc7283cc2199b78
103 N5fe8c1707cd84a7babd0f97804795597 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Protein Biosynthesis
105 rdf:type schema:DefinedTerm
106 N6219737e65f04d4eabe79f56580da0d4 rdf:first N9ac20a1433814f31938b1562b3c72a7c
107 rdf:rest N50adc40715634859800c35d3a0206025
108 N664d929240f74012afc7283cc2199b78 rdf:first sg:person.01346106510.51
109 rdf:rest Nd55f7cff41a04419a9687471e2017414
110 N69db307def0440b49ef4edd2c4ee4153 rdf:first sg:person.01174702157.48
111 rdf:rest Nc42c7cce3ae84648aaf8b263fd2a0845
112 N6be20666b2da41edb66c3e03f8db91c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Minor Histocompatibility Antigens
114 rdf:type schema:DefinedTerm
115 N7755b58c56674d178727c2f3ba0dbe51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name HeLa Cells
117 rdf:type schema:DefinedTerm
118 N7efb0a1558dc4fedaaf93b92edf7f6ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name RNA-Binding Proteins
120 rdf:type schema:DefinedTerm
121 N85bc1513a4e74fd299227f9938db003f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Substrate Specificity
123 rdf:type schema:DefinedTerm
124 N8dd1794b092347399df4f9c6c8201acd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Organelles
126 rdf:type schema:DefinedTerm
127 N929231a135834d13bd74f16c4729a3cf schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N98a2e675312d4603ae0c8c7a2a1a65ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Nucleotide Motifs
131 rdf:type schema:DefinedTerm
132 N9ac20a1433814f31938b1562b3c72a7c schema:affiliation grid-institutes:grid.170205.1
133 schema:familyName Gomez
134 schema:givenName Adrian
135 rdf:type schema:Person
136 Na05a8d131581492a8ff4154857a8bd00 rdf:first sg:person.01314657777.51
137 rdf:rest N69db307def0440b49ef4edd2c4ee4153
138 Nacbab78c56864019a281baeadfe803a4 schema:volumeNumber 505
139 rdf:type schema:PublicationVolume
140 Nb48705c0de2c4312b6f854fe9c4108c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Adenosine
142 rdf:type schema:DefinedTerm
143 Nbdc33bbcad174e52a51ca8fb1e77668c rdf:first sg:person.0603501530.11
144 rdf:rest N263995a19cbd4e8cb84f1c1f9cc9cd81
145 Nc42c7cce3ae84648aaf8b263fd2a0845 rdf:first sg:person.01261440612.04
146 rdf:rest Nf0aa7c20f91847648d0ff80479f4141f
147 Nc66a202253d443999c4d1dcf124da5e3 schema:name pubmed_id
148 schema:value 24284625
149 rdf:type schema:PropertyValue
150 Nd55f7cff41a04419a9687471e2017414 rdf:first sg:person.0732131732.46
151 rdf:rest Ne2a44eb034184fb68c85f940af37b19b
152 Ne149ca60c0fa4d0aa9ff7aa62c8a92e8 schema:name dimensions_id
153 schema:value pub.1045996872
154 rdf:type schema:PropertyValue
155 Ne1f80e2b5efc4de98bb31249172e9d19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name DNA-Binding Proteins
157 rdf:type schema:DefinedTerm
158 Ne2a44eb034184fb68c85f940af37b19b rdf:first sg:person.01071451721.96
159 rdf:rest Nbdc33bbcad174e52a51ca8fb1e77668c
160 Nf0aa7c20f91847648d0ff80479f4141f rdf:first sg:person.012740030027.82
161 rdf:rest rdf:nil
162 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
163 schema:name Biological Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
166 schema:name Genetics
167 rdf:type schema:DefinedTerm
168 sg:grant.2404592 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12730
169 rdf:type schema:MonetaryGrant
170 sg:grant.2518424 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12730
171 rdf:type schema:MonetaryGrant
172 sg:grant.2520562 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12730
173 rdf:type schema:MonetaryGrant
174 sg:grant.3120521 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12730
175 rdf:type schema:MonetaryGrant
176 sg:journal.1018957 schema:issn 0028-0836
177 1476-4687
178 schema:name Nature
179 schema:publisher Springer Nature
180 rdf:type schema:Periodical
181 sg:person.01071451721.96 schema:affiliation grid-institutes:grid.170205.1
182 schema:familyName Fu
183 schema:givenName Ye
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071451721.96
185 rdf:type schema:Person
186 sg:person.011425010257.19 schema:affiliation grid-institutes:grid.170205.1
187 schema:familyName Dai
188 schema:givenName Qing
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011425010257.19
190 rdf:type schema:Person
191 sg:person.01174702157.48 schema:affiliation grid-institutes:grid.266100.3
192 schema:familyName Ren
193 schema:givenName Bing
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174702157.48
195 rdf:type schema:Person
196 sg:person.01237222045.60 schema:affiliation grid-institutes:grid.266100.3
197 schema:familyName Hon
198 schema:givenName Gary C.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237222045.60
200 rdf:type schema:Person
201 sg:person.01261440612.04 schema:affiliation grid-institutes:grid.170205.1
202 schema:familyName Pan
203 schema:givenName Tao
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261440612.04
205 rdf:type schema:Person
206 sg:person.012740030027.82 schema:affiliation grid-institutes:grid.170205.1
207 schema:familyName He
208 schema:givenName Chuan
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740030027.82
210 rdf:type schema:Person
211 sg:person.01314657777.51 schema:affiliation grid-institutes:grid.11135.37
212 schema:familyName Jia
213 schema:givenName Guifang
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314657777.51
215 rdf:type schema:Person
216 sg:person.01346106510.51 schema:affiliation grid-institutes:grid.170205.1
217 schema:familyName Yue
218 schema:givenName Yanan
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346106510.51
220 rdf:type schema:Person
221 sg:person.0603501530.11 schema:affiliation grid-institutes:grid.170205.1
222 schema:familyName Parisien
223 schema:givenName Marc
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603501530.11
225 rdf:type schema:Person
226 sg:person.0644070443.34 schema:affiliation grid-institutes:grid.170205.1
227 schema:familyName Wang
228 schema:givenName Xiao
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644070443.34
230 rdf:type schema:Person
231 sg:person.0732131732.46 schema:affiliation grid-institutes:grid.170205.1
232 schema:familyName Han
233 schema:givenName Dali
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732131732.46
235 rdf:type schema:Person
236 sg:person.0756073554.72 schema:affiliation grid-institutes:grid.170205.1
237 schema:familyName Lu
238 schema:givenName Zhike
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756073554.72
240 rdf:type schema:Person
241 sg:pub.10.1007/978-1-59745-033-1_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028584528
242 https://doi.org/10.1007/978-1-59745-033-1_8
243 rdf:type schema:CreativeWork
244 sg:pub.10.1007/978-3-642-56298-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018872798
245 https://doi.org/10.1007/978-3-642-56298-3
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/nature11112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040794705
248 https://doi.org/10.1038/nature11112
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nbt.1621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031035095
251 https://doi.org/10.1038/nbt.1621
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nchembio.482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051460393
254 https://doi.org/10.1038/nchembio.482
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/nchembio.687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051364702
257 https://doi.org/10.1038/nchembio.687
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nmeth.1608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025585804
260 https://doi.org/10.1038/nmeth.1608
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nprot.2006.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045483645
263 https://doi.org/10.1038/nprot.2006.82
264 rdf:type schema:CreativeWork
265 sg:pub.10.1186/gb-2008-9-9-r137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027608848
266 https://doi.org/10.1186/gb-2008-9-9-r137
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/gb-2010-11-10-r106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031289083
269 https://doi.org/10.1186/gb-2010-11-10-r106
270 rdf:type schema:CreativeWork
271 sg:pub.10.1186/gb-2011-12-8-r79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044311993
272 https://doi.org/10.1186/gb-2011-12-8-r79
273 rdf:type schema:CreativeWork
274 grid-institutes:grid.11135.37 schema:alternateName Department of Chemical Biology and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, 100871, Beijing, China
275 schema:name Department of Chemical Biology and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, 100871, Beijing, China
276 Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
277 rdf:type schema:Organization
278 grid-institutes:grid.170205.1 schema:alternateName Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
279 Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
280 schema:name Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
281 Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
282 rdf:type schema:Organization
283 grid-institutes:grid.266100.3 schema:alternateName Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, UCSD Moores Cancer Center and Institute of Genome Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA
284 schema:name Department of Cellular and Molecular Medicine, Ludwig Institute for Cancer Research, UCSD Moores Cancer Center and Institute of Genome Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...