Deterministic direct reprogramming of somatic cells to pluripotency View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-10

AUTHORS

Yoach Rais, Asaf Zviran, Shay Geula, Ohad Gafni, Elad Chomsky, Sergey Viukov, Abed AlFatah Mansour, Inbal Caspi, Vladislav Krupalnik, Mirie Zerbib, Itay Maza, Nofar Mor, Dror Baran, Leehee Weinberger, Diego A. Jaitin, David Lara-Astiaso, Ronnie Blecher-Gonen, Zohar Shipony, Zohar Mukamel, Tzachi Hagai, Shlomit Gilad, Daniela Amann-Zalcenstein, Amos Tanay, Ido Amit, Noa Novershtern, Jacob H. Hanna

ABSTRACT

Somatic cells can be inefficiently and stochastically reprogrammed into induced pluripotent stem (iPS) cells by exogenous expression of Oct4 (also called Pou5f1), Sox2, Klf4 and Myc (hereafter referred to as OSKM). The nature of the predominant rate-limiting barrier(s) preventing the majority of cells to successfully and synchronously reprogram remains to be defined. Here we show that depleting Mbd3, a core member of the Mbd3/NuRD (nucleosome remodelling and deacetylation) repressor complex, together with OSKM transduction and reprogramming in naive pluripotency promoting conditions, result in deterministic and synchronized iPS cell reprogramming (near 100% efficiency within seven days from mouse and human cells). Our findings uncover a dichotomous molecular function for the reprogramming factors, serving to reactivate endogenous pluripotency networks while simultaneously directly recruiting the Mbd3/NuRD repressor complex that potently restrains the reactivation of OSKM downstream target genes. Subsequently, the latter interactions, which are largely depleted during early pre-implantation development in vivo, lead to a stochastic and protracted reprogramming trajectory towards pluripotency in vitro. The deterministic reprogramming approach devised here offers a novel platform for the dissection of molecular dynamics leading to establishing pluripotency at unprecedented flexibility and resolution. More... »

PAGES

65

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature12587

DOI

http://dx.doi.org/10.1038/nature12587

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040499216

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24048479


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cellular Reprogramming", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HEK293 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Induced Pluripotent Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rais", 
        "givenName": "Yoach", 
        "id": "sg:person.01140554217.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140554217.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zviran", 
        "givenName": "Asaf", 
        "id": "sg:person.01174525007.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174525007.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geula", 
        "givenName": "Shay", 
        "id": "sg:person.01016024307.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016024307.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gafni", 
        "givenName": "Ohad", 
        "id": "sg:person.01303463766.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303463766.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chomsky", 
        "givenName": "Elad", 
        "id": "sg:person.01351577166.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351577166.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viukov", 
        "givenName": "Sergey", 
        "id": "sg:person.01064137507.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064137507.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mansour", 
        "givenName": "Abed AlFatah", 
        "id": "sg:person.01012163207.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012163207.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caspi", 
        "givenName": "Inbal", 
        "id": "sg:person.01330156021.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330156021.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krupalnik", 
        "givenName": "Vladislav", 
        "id": "sg:person.01357066607.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357066607.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zerbib", 
        "givenName": "Mirie", 
        "id": "sg:person.0633462507.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633462507.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maza", 
        "givenName": "Itay", 
        "id": "sg:person.01200361202.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200361202.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mor", 
        "givenName": "Nofar", 
        "id": "sg:person.01343517767.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343517767.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baran", 
        "givenName": "Dror", 
        "id": "sg:person.01122427365.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122427365.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weinberger", 
        "givenName": "Leehee", 
        "id": "sg:person.0721274545.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721274545.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jaitin", 
        "givenName": "Diego A.", 
        "id": "sg:person.01033001365.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033001365.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lara-Astiaso", 
        "givenName": "David", 
        "id": "sg:person.0743304702.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743304702.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blecher-Gonen", 
        "givenName": "Ronnie", 
        "id": "sg:person.01237143562.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237143562.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel", 
            "The Department of Computer Science, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shipony", 
        "givenName": "Zohar", 
        "id": "sg:person.0760270226.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760270226.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel", 
            "The Department of Computer Science, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukamel", 
        "givenName": "Zohar", 
        "id": "sg:person.0633200124.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633200124.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hagai", 
        "givenName": "Tzachi", 
        "id": "sg:person.0727672260.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727672260.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gilad", 
        "givenName": "Shlomit", 
        "id": "sg:person.01103754255.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103754255.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amann-Zalcenstein", 
        "givenName": "Daniela", 
        "id": "sg:person.0701575707.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701575707.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel", 
            "The Department of Computer Science, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanay", 
        "givenName": "Amos", 
        "id": "sg:person.01170214474.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170214474.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amit", 
        "givenName": "Ido", 
        "id": "sg:person.01330120620.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330120620.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Novershtern", 
        "givenName": "Noa", 
        "id": "sg:person.0764232054.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764232054.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hanna", 
        "givenName": "Jacob H.", 
        "id": "sg:person.0643150035.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643150035.03"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cell.2009.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001400503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002329819", 
          "https://doi.org/10.1038/nature10960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002812701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.03.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004352286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009099013", 
          "https://doi.org/10.1038/ncb1372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009099013", 
          "https://doi.org/10.1038/ncb1372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2012.02.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009869867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.1374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009982940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.07.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014573758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2011.431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017476658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.050427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018759783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.2039011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019299402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021191816", 
          "https://doi.org/10.1038/nature11537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.26.3.843-851.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026049646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2010.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027563924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030291386", 
          "https://doi.org/10.1038/nature08592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030291386", 
          "https://doi.org/10.1038/nature08592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030833745", 
          "https://doi.org/10.1038/ng1760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030833745", 
          "https://doi.org/10.1038/ng1760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1213230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033539717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036216819", 
          "https://doi.org/10.1038/nature06008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biostatistics/4.2.249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037543114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037743725", 
          "https://doi.org/10.1038/nature07056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039955191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2008.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040008680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2009.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041412295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.09.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042051782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.02.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045431611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046760203", 
          "https://doi.org/10.1038/nbt.1632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.02802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047501529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047844983", 
          "https://doi.org/10.1038/nbt.1927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049638413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049638413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2012.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049803509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2008-1075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049957596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2013.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050194372", 
          "https://doi.org/10.1038/nprot.2013.023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050347178", 
          "https://doi.org/10.1038/nature09017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051471226", 
          "https://doi.org/10.1038/nature11272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051799046", 
          "https://doi.org/10.1038/nature10953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.07.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052718634"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-10", 
    "datePublishedReg": "2013-10-01", 
    "description": "Somatic cells can be inefficiently and stochastically reprogrammed into induced pluripotent stem (iPS) cells by exogenous expression of Oct4 (also called Pou5f1), Sox2, Klf4 and Myc (hereafter referred to as OSKM). The nature of the predominant rate-limiting barrier(s) preventing the majority of cells to successfully and synchronously reprogram remains to be defined. Here we show that depleting Mbd3, a core member of the Mbd3/NuRD (nucleosome remodelling and deacetylation) repressor complex, together with OSKM transduction and reprogramming in naive pluripotency promoting conditions, result in deterministic and synchronized iPS cell reprogramming (near 100% efficiency within seven days from mouse and human cells). Our findings uncover a dichotomous molecular function for the reprogramming factors, serving to reactivate endogenous pluripotency networks while simultaneously directly recruiting the Mbd3/NuRD repressor complex that potently restrains the reactivation of OSKM downstream target genes. Subsequently, the latter interactions, which are largely depleted during early pre-implantation development in vivo, lead to a stochastic and protracted reprogramming trajectory towards pluripotency in vitro. The deterministic reprogramming approach devised here offers a novel platform for the dissection of molecular dynamics leading to establishing pluripotency at unprecedented flexibility and resolution. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature12587", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3784022", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3793340", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7469", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "502"
      }
    ], 
    "name": "Deterministic direct reprogramming of somatic cells to pluripotency", 
    "pagination": "65", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c0ec2564f2b381fe725e4dd8a6b3ebe6ff5abab6e12cbd79eb77b29fdd9e3da6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24048479"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature12587"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040499216"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature12587", 
      "https://app.dimensions.ai/details/publication/pub.1040499216"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature12587"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature12587'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature12587'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature12587'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature12587'


 

This table displays all metadata directly associated to this object as RDF triples.

434 TRIPLES      21 PREDICATES      80 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature12587 schema:about N0e9a2f22afe1431b97db14255a8bdbda
2 N2b66c1cceb8c4e8594f6cc6d6f82bdb6
3 N329706110cd849929836c3ca244c411f
4 N51ce489ac737429099c249cbb83fb204
5 N6908b678a25e4f2ab664e64cc2ecaef4
6 N78eb476ac342499fa1cedd85513ac348
7 N83377a8f6e1044858078719efc493dfb
8 N8925b3da294749b582dd84d745056048
9 N9a056163c0a049bbb8ac43cfbb4bbcde
10 N9a2c22efd0a947828fb74705db6f1b69
11 Nca94573e606e4da4acdb8e4024170c17
12 Nceb02541957f4a27b9c33942474dfe58
13 Ndcf49ecc59eb4405a7b80f52731ced65
14 Neecd67520ae3426eb8373159b97bfd51
15 Nfa2398c4b3ed448086b5bffbbcec7eee
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author N1185482f9247411899d45c99fd3b0dd8
19 schema:citation sg:pub.10.1038/nature06008
20 sg:pub.10.1038/nature07056
21 sg:pub.10.1038/nature08592
22 sg:pub.10.1038/nature09017
23 sg:pub.10.1038/nature10953
24 sg:pub.10.1038/nature10960
25 sg:pub.10.1038/nature11272
26 sg:pub.10.1038/nature11537
27 sg:pub.10.1038/nbt.1632
28 sg:pub.10.1038/nbt.1927
29 sg:pub.10.1038/ncb1372
30 sg:pub.10.1038/ng1760
31 sg:pub.10.1038/nprot.2013.023
32 https://doi.org/10.1002/stem.1374
33 https://doi.org/10.1016/j.cell.2005.08.020
34 https://doi.org/10.1016/j.cell.2006.07.024
35 https://doi.org/10.1016/j.cell.2008.02.039
36 https://doi.org/10.1016/j.cell.2008.03.028
37 https://doi.org/10.1016/j.cell.2009.01.001
38 https://doi.org/10.1016/j.cell.2009.07.039
39 https://doi.org/10.1016/j.cell.2010.10.008
40 https://doi.org/10.1016/j.cell.2011.03.003
41 https://doi.org/10.1016/j.cell.2012.09.045
42 https://doi.org/10.1016/j.stem.2008.08.014
43 https://doi.org/10.1016/j.stem.2009.04.015
44 https://doi.org/10.1016/j.stem.2010.08.012
45 https://doi.org/10.1016/j.stem.2012.02.020
46 https://doi.org/10.1016/j.stem.2012.04.011
47 https://doi.org/10.1038/emboj.2011.431
48 https://doi.org/10.1093/biostatistics/4.2.249
49 https://doi.org/10.1101/gad.2039011
50 https://doi.org/10.1126/science.1213230
51 https://doi.org/10.1128/mcb.26.3.843-851.2006
52 https://doi.org/10.1242/dev.02802
53 https://doi.org/10.1242/dev.050427
54 https://doi.org/10.1634/stemcells.2008-1075
55 schema:datePublished 2013-10
56 schema:datePublishedReg 2013-10-01
57 schema:description Somatic cells can be inefficiently and stochastically reprogrammed into induced pluripotent stem (iPS) cells by exogenous expression of Oct4 (also called Pou5f1), Sox2, Klf4 and Myc (hereafter referred to as OSKM). The nature of the predominant rate-limiting barrier(s) preventing the majority of cells to successfully and synchronously reprogram remains to be defined. Here we show that depleting Mbd3, a core member of the Mbd3/NuRD (nucleosome remodelling and deacetylation) repressor complex, together with OSKM transduction and reprogramming in naive pluripotency promoting conditions, result in deterministic and synchronized iPS cell reprogramming (near 100% efficiency within seven days from mouse and human cells). Our findings uncover a dichotomous molecular function for the reprogramming factors, serving to reactivate endogenous pluripotency networks while simultaneously directly recruiting the Mbd3/NuRD repressor complex that potently restrains the reactivation of OSKM downstream target genes. Subsequently, the latter interactions, which are largely depleted during early pre-implantation development in vivo, lead to a stochastic and protracted reprogramming trajectory towards pluripotency in vitro. The deterministic reprogramming approach devised here offers a novel platform for the dissection of molecular dynamics leading to establishing pluripotency at unprecedented flexibility and resolution.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree false
61 schema:isPartOf Nb18c30eb809e4b389034cdf0d30be481
62 Nb644cfaa6af04a9bbe2b594279d805ce
63 sg:journal.1018957
64 schema:name Deterministic direct reprogramming of somatic cells to pluripotency
65 schema:pagination 65
66 schema:productId N2b857acd6ca945a49ac8409cdcc2462b
67 N488877770128481b94401c1a47a1022a
68 N4c3436a85c0445a7a3e2f006c8204bd9
69 N51bdcb6eac5247a9922e014e268737f4
70 Ne5185921edf84a5ca4132f8024b8a2f5
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040499216
72 https://doi.org/10.1038/nature12587
73 schema:sdDatePublished 2019-04-10T22:19
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Naf279c156b0742d6be9b9b99a7b659da
76 schema:url https://www.nature.com/articles/nature12587
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0b5af339af8241e2941d882f20c3f516 rdf:first sg:person.0701575707.50
81 rdf:rest Nf174da97e1ef4d998ac7e14a275ba4f0
82 N0e9a2f22afe1431b97db14255a8bdbda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Cell Line
84 rdf:type schema:DefinedTerm
85 N1185482f9247411899d45c99fd3b0dd8 rdf:first sg:person.01140554217.29
86 rdf:rest Na23bff30b4434ad98aa857c79285697d
87 N222add3a72f94f7ea076f34646915f3e rdf:first sg:person.01200361202.29
88 rdf:rest N501c1fbd606545aaae5f9c6bfded9ee3
89 N2b66c1cceb8c4e8594f6cc6d6f82bdb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name DNA-Binding Proteins
91 rdf:type schema:DefinedTerm
92 N2b857acd6ca945a49ac8409cdcc2462b schema:name readcube_id
93 schema:value c0ec2564f2b381fe725e4dd8a6b3ebe6ff5abab6e12cbd79eb77b29fdd9e3da6
94 rdf:type schema:PropertyValue
95 N2cde5d7409574aa8965f3e950b95f920 rdf:first sg:person.0643150035.03
96 rdf:rest rdf:nil
97 N329706110cd849929836c3ca244c411f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Cellular Reprogramming
99 rdf:type schema:DefinedTerm
100 N3418fe1620e44baf9ffd7926a52d3c5d rdf:first sg:person.0743304702.43
101 rdf:rest Ncacbd5ccd6f14a1fb130a4073546fd79
102 N39c1817b46de46379e21752c30b6a667 rdf:first sg:person.0764232054.39
103 rdf:rest N2cde5d7409574aa8965f3e950b95f920
104 N42462a0836924492a8d74b8e7c58fbe9 rdf:first sg:person.01330156021.51
105 rdf:rest Ne6e1224f77fb4df38183152abf1759f7
106 N460f08753c17400a9f98c824c564c24a rdf:first sg:person.01016024307.39
107 rdf:rest N9e9cf4edf9d04616b4aa8f8bb7620792
108 N4761267e396c429f986c72ec306deb53 rdf:first sg:person.01330120620.44
109 rdf:rest N39c1817b46de46379e21752c30b6a667
110 N488877770128481b94401c1a47a1022a schema:name doi
111 schema:value 10.1038/nature12587
112 rdf:type schema:PropertyValue
113 N4c3436a85c0445a7a3e2f006c8204bd9 schema:name dimensions_id
114 schema:value pub.1040499216
115 rdf:type schema:PropertyValue
116 N501c1fbd606545aaae5f9c6bfded9ee3 rdf:first sg:person.01343517767.18
117 rdf:rest Nc22cf68125b74f52800da442aa79c090
118 N51bdcb6eac5247a9922e014e268737f4 schema:name nlm_unique_id
119 schema:value 0410462
120 rdf:type schema:PropertyValue
121 N51ce489ac737429099c249cbb83fb204 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name HEK293 Cells
123 rdf:type schema:DefinedTerm
124 N6908b678a25e4f2ab664e64cc2ecaef4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Animals
126 rdf:type schema:DefinedTerm
127 N6d8fefddad014e41add63be012ded41e rdf:first sg:person.0727672260.14
128 rdf:rest N79fd46d6f58744ebb53ca185e7c60e27
129 N78eb476ac342499fa1cedd85513ac348 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Embryonic Stem Cells
131 rdf:type schema:DefinedTerm
132 N79fd46d6f58744ebb53ca185e7c60e27 rdf:first sg:person.01103754255.04
133 rdf:rest N0b5af339af8241e2941d882f20c3f516
134 N83377a8f6e1044858078719efc493dfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Cells, Cultured
136 rdf:type schema:DefinedTerm
137 N8497d075b60340ff8c3f4ee0a767b252 rdf:first sg:person.01012163207.92
138 rdf:rest N42462a0836924492a8d74b8e7c58fbe9
139 N8925b3da294749b582dd84d745056048 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Gene Expression Regulation
141 rdf:type schema:DefinedTerm
142 N92eecfc01806486b8656dc75b4d891a1 rdf:first sg:person.01064137507.47
143 rdf:rest N8497d075b60340ff8c3f4ee0a767b252
144 N9a056163c0a049bbb8ac43cfbb4bbcde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Induced Pluripotent Stem Cells
146 rdf:type schema:DefinedTerm
147 N9a2c22efd0a947828fb74705db6f1b69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Female
149 rdf:type schema:DefinedTerm
150 N9d001fccb56f4a6d80deaa65930583ac rdf:first sg:person.0633200124.53
151 rdf:rest N6d8fefddad014e41add63be012ded41e
152 N9e9cf4edf9d04616b4aa8f8bb7620792 rdf:first sg:person.01303463766.68
153 rdf:rest Ncefe8dfd637341a7900536d80e9b998c
154 Na23bff30b4434ad98aa857c79285697d rdf:first sg:person.01174525007.57
155 rdf:rest N460f08753c17400a9f98c824c564c24a
156 Naec4d91921094d11a519cc089231c1e1 rdf:first sg:person.0633462507.46
157 rdf:rest N222add3a72f94f7ea076f34646915f3e
158 Naf279c156b0742d6be9b9b99a7b659da schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 Nb18c30eb809e4b389034cdf0d30be481 schema:issueNumber 7469
161 rdf:type schema:PublicationIssue
162 Nb644cfaa6af04a9bbe2b594279d805ce schema:volumeNumber 502
163 rdf:type schema:PublicationVolume
164 Nbf2c6d9b00604771a490ec0c505d35fe rdf:first sg:person.0760270226.12
165 rdf:rest N9d001fccb56f4a6d80deaa65930583ac
166 Nc22cf68125b74f52800da442aa79c090 rdf:first sg:person.01122427365.40
167 rdf:rest Nee7f4bcf0b7042a9a995d5ba653f52c8
168 Nca94573e606e4da4acdb8e4024170c17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Models, Biological
170 rdf:type schema:DefinedTerm
171 Ncacbd5ccd6f14a1fb130a4073546fd79 rdf:first sg:person.01237143562.46
172 rdf:rest Nbf2c6d9b00604771a490ec0c505d35fe
173 Nceb02541957f4a27b9c33942474dfe58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Male
175 rdf:type schema:DefinedTerm
176 Ncefe8dfd637341a7900536d80e9b998c rdf:first sg:person.01351577166.11
177 rdf:rest N92eecfc01806486b8656dc75b4d891a1
178 Ndcf49ecc59eb4405a7b80f52731ced65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 Ne4717cc96dcb4d66a7e3311e9931bdea rdf:first sg:person.01033001365.78
182 rdf:rest N3418fe1620e44baf9ffd7926a52d3c5d
183 Ne5185921edf84a5ca4132f8024b8a2f5 schema:name pubmed_id
184 schema:value 24048479
185 rdf:type schema:PropertyValue
186 Ne6e1224f77fb4df38183152abf1759f7 rdf:first sg:person.01357066607.11
187 rdf:rest Naec4d91921094d11a519cc089231c1e1
188 Nee7f4bcf0b7042a9a995d5ba653f52c8 rdf:first sg:person.0721274545.40
189 rdf:rest Ne4717cc96dcb4d66a7e3311e9931bdea
190 Neecd67520ae3426eb8373159b97bfd51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Transcription Factors
192 rdf:type schema:DefinedTerm
193 Nf174da97e1ef4d998ac7e14a275ba4f0 rdf:first sg:person.01170214474.16
194 rdf:rest N4761267e396c429f986c72ec306deb53
195 Nfa2398c4b3ed448086b5bffbbcec7eee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Mice
197 rdf:type schema:DefinedTerm
198 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
199 schema:name Biological Sciences
200 rdf:type schema:DefinedTerm
201 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
202 schema:name Biochemistry and Cell Biology
203 rdf:type schema:DefinedTerm
204 sg:grant.3784022 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12587
205 rdf:type schema:MonetaryGrant
206 sg:grant.3793340 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12587
207 rdf:type schema:MonetaryGrant
208 sg:journal.1018957 schema:issn 0090-0028
209 1476-4687
210 schema:name Nature
211 rdf:type schema:Periodical
212 sg:person.01012163207.92 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
213 schema:familyName Mansour
214 schema:givenName Abed AlFatah
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012163207.92
216 rdf:type schema:Person
217 sg:person.01016024307.39 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
218 schema:familyName Geula
219 schema:givenName Shay
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016024307.39
221 rdf:type schema:Person
222 sg:person.01033001365.78 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
223 schema:familyName Jaitin
224 schema:givenName Diego A.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033001365.78
226 rdf:type schema:Person
227 sg:person.01064137507.47 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
228 schema:familyName Viukov
229 schema:givenName Sergey
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064137507.47
231 rdf:type schema:Person
232 sg:person.01103754255.04 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
233 schema:familyName Gilad
234 schema:givenName Shlomit
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103754255.04
236 rdf:type schema:Person
237 sg:person.01122427365.40 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
238 schema:familyName Baran
239 schema:givenName Dror
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122427365.40
241 rdf:type schema:Person
242 sg:person.01140554217.29 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
243 schema:familyName Rais
244 schema:givenName Yoach
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140554217.29
246 rdf:type schema:Person
247 sg:person.01170214474.16 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
248 schema:familyName Tanay
249 schema:givenName Amos
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170214474.16
251 rdf:type schema:Person
252 sg:person.01174525007.57 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
253 schema:familyName Zviran
254 schema:givenName Asaf
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174525007.57
256 rdf:type schema:Person
257 sg:person.01200361202.29 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
258 schema:familyName Maza
259 schema:givenName Itay
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200361202.29
261 rdf:type schema:Person
262 sg:person.01237143562.46 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
263 schema:familyName Blecher-Gonen
264 schema:givenName Ronnie
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237143562.46
266 rdf:type schema:Person
267 sg:person.01303463766.68 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
268 schema:familyName Gafni
269 schema:givenName Ohad
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303463766.68
271 rdf:type schema:Person
272 sg:person.01330120620.44 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
273 schema:familyName Amit
274 schema:givenName Ido
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330120620.44
276 rdf:type schema:Person
277 sg:person.01330156021.51 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
278 schema:familyName Caspi
279 schema:givenName Inbal
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330156021.51
281 rdf:type schema:Person
282 sg:person.01343517767.18 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
283 schema:familyName Mor
284 schema:givenName Nofar
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343517767.18
286 rdf:type schema:Person
287 sg:person.01351577166.11 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
288 schema:familyName Chomsky
289 schema:givenName Elad
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351577166.11
291 rdf:type schema:Person
292 sg:person.01357066607.11 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
293 schema:familyName Krupalnik
294 schema:givenName Vladislav
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357066607.11
296 rdf:type schema:Person
297 sg:person.0633200124.53 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
298 schema:familyName Mukamel
299 schema:givenName Zohar
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633200124.53
301 rdf:type schema:Person
302 sg:person.0633462507.46 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
303 schema:familyName Zerbib
304 schema:givenName Mirie
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633462507.46
306 rdf:type schema:Person
307 sg:person.0643150035.03 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
308 schema:familyName Hanna
309 schema:givenName Jacob H.
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643150035.03
311 rdf:type schema:Person
312 sg:person.0701575707.50 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
313 schema:familyName Amann-Zalcenstein
314 schema:givenName Daniela
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701575707.50
316 rdf:type schema:Person
317 sg:person.0721274545.40 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
318 schema:familyName Weinberger
319 schema:givenName Leehee
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721274545.40
321 rdf:type schema:Person
322 sg:person.0727672260.14 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
323 schema:familyName Hagai
324 schema:givenName Tzachi
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727672260.14
326 rdf:type schema:Person
327 sg:person.0743304702.43 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
328 schema:familyName Lara-Astiaso
329 schema:givenName David
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743304702.43
331 rdf:type schema:Person
332 sg:person.0760270226.12 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
333 schema:familyName Shipony
334 schema:givenName Zohar
335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760270226.12
336 rdf:type schema:Person
337 sg:person.0764232054.39 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
338 schema:familyName Novershtern
339 schema:givenName Noa
340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764232054.39
341 rdf:type schema:Person
342 sg:pub.10.1038/nature06008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036216819
343 https://doi.org/10.1038/nature06008
344 rdf:type schema:CreativeWork
345 sg:pub.10.1038/nature07056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037743725
346 https://doi.org/10.1038/nature07056
347 rdf:type schema:CreativeWork
348 sg:pub.10.1038/nature08592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030291386
349 https://doi.org/10.1038/nature08592
350 rdf:type schema:CreativeWork
351 sg:pub.10.1038/nature09017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050347178
352 https://doi.org/10.1038/nature09017
353 rdf:type schema:CreativeWork
354 sg:pub.10.1038/nature10953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051799046
355 https://doi.org/10.1038/nature10953
356 rdf:type schema:CreativeWork
357 sg:pub.10.1038/nature10960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002329819
358 https://doi.org/10.1038/nature10960
359 rdf:type schema:CreativeWork
360 sg:pub.10.1038/nature11272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051471226
361 https://doi.org/10.1038/nature11272
362 rdf:type schema:CreativeWork
363 sg:pub.10.1038/nature11537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021191816
364 https://doi.org/10.1038/nature11537
365 rdf:type schema:CreativeWork
366 sg:pub.10.1038/nbt.1632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046760203
367 https://doi.org/10.1038/nbt.1632
368 rdf:type schema:CreativeWork
369 sg:pub.10.1038/nbt.1927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047844983
370 https://doi.org/10.1038/nbt.1927
371 rdf:type schema:CreativeWork
372 sg:pub.10.1038/ncb1372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009099013
373 https://doi.org/10.1038/ncb1372
374 rdf:type schema:CreativeWork
375 sg:pub.10.1038/ng1760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030833745
376 https://doi.org/10.1038/ng1760
377 rdf:type schema:CreativeWork
378 sg:pub.10.1038/nprot.2013.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050194372
379 https://doi.org/10.1038/nprot.2013.023
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1002/stem.1374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009982940
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1016/j.cell.2005.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049638413
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1016/j.cell.2006.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014573758
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1016/j.cell.2008.02.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045431611
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1016/j.cell.2008.03.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004352286
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1016/j.cell.2009.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001400503
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1016/j.cell.2009.07.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052718634
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1016/j.cell.2010.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039955191
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1016/j.cell.2011.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002812701
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1016/j.cell.2012.09.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042051782
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1016/j.stem.2008.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040008680
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1016/j.stem.2009.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041412295
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1016/j.stem.2010.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027563924
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1016/j.stem.2012.02.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009869867
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1016/j.stem.2012.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049803509
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1038/emboj.2011.431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017476658
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1093/biostatistics/4.2.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037543114
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1101/gad.2039011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019299402
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1126/science.1213230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033539717
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1128/mcb.26.3.843-851.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026049646
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1242/dev.02802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047501529
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1242/dev.050427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018759783
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1634/stemcells.2008-1075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049957596
426 rdf:type schema:CreativeWork
427 https://www.grid.ac/institutes/grid.13992.30 schema:alternateName Weizmann Institute of Science
428 schema:name The Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
429 The Department of Computer Science, Weizmann Institute of Science, Rehovot 76100, Israel
430 The Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
431 The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
432 The Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
433 The Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot 76100, Israel
434 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...