Cerebral organoids model human brain development and microcephaly View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09

AUTHORS

Madeline A. Lancaster, Magdalena Renner, Carol-Anne Martin, Daniel Wenzel, Louise S. Bicknell, Matthew E. Hurles, Tessa Homfray, Josef M. Penninger, Andrew P. Jackson, Juergen A. Knoblich

ABSTRACT

The complexity of the human brain has made it difficult to study many brain disorders in model organisms, highlighting the need for an in vitro model of human brain development. Here we have developed a human pluripotent stem cell-derived three-dimensional organoid culture system, termed cerebral organoids, that develop various discrete, although interdependent, brain regions. These include a cerebral cortex containing progenitor populations that organize and produce mature cortical neuron subtypes. Furthermore, cerebral organoids are shown to recapitulate features of human cortical development, namely characteristic progenitor zone organization with abundant outer radial glial stem cells. Finally, we use RNA interference and patient-specific induced pluripotent stem cells to model microcephaly, a disorder that has been difficult to recapitulate in mice. We demonstrate premature neuronal differentiation in patient organoids, a defect that could help to explain the disease phenotype. Together, these data show that three-dimensional organoids can recapitulate development and disease even in this most complex human tissue. More... »

PAGES

373

References to SciGraph publications

  • 2009-05. Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche in NATURE
  • 2005-04. A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size in NATURE GENETICS
  • 2009. Differentiation of Neuroepithelia from Human Embryonic Stem Cells in NEURAL CELL TRANSPLANTATION
  • 2008-09-18. An intrinsic mechanism of corticogenesis from embryonic stem cells in NATURE
  • 2005-10. Developmental cell biology: The cell biology of neurogenesis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2010-03. Neurogenic radial glia in the outer subventricular zone of human neocortex in NATURE
  • 2010-02-17. Directed Differentiation of Neural-stem cells and Subtype-Specific Neurons from hESCs in CELLULAR PROGRAMMING AND REPROGRAMMING
  • 2011-11. MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1–Cdc25 pathway in NATURE CELL BIOLOGY
  • 2007-07. Generation of germline-competent induced pluripotent stem cells in NATURE
  • 1998-04. Making sense of the multiple MAP-2 transcripts and their role in the neuron in MOLECULAR NEUROBIOLOGY
  • 2010-06. OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling in NATURE NEUROSCIENCE
  • 2007-06. A ROCK inhibitor permits survival of dissociated human embryonic stem cells in NATURE BIOTECHNOLOGY
  • 2011-01. CEP152 is a genome maintenance protein disrupted in Seckel syndrome in NATURE GENETICS
  • 2013-12. Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex in NATURE COMMUNICATIONS
  • 2008-01. Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis in NATURE CELL BIOLOGY
  • 2011-11-09. Self-formation of functional adenohypophysis in three-dimensional culture in NATURE
  • 2011-04. Self-organizing optic-cup morphogenesis in three-dimensional culture in NATURE
  • 2010-10. Ontogeny-recapitulating generation and tissue integration of ES cell–derived Purkinje cells in NATURE NEUROSCIENCE
  • 2011-08. MicroRNA-mediated conversion of human fibroblasts to neurons in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    7467

    VOLUME

    501

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature12517

    DOI

    http://dx.doi.org/10.1038/nature12517

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019617574

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23995685


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