Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-06-30

AUTHORS

Kathryn Blaschke, Kevin T. Ebata, Mohammad M. Karimi, Jorge A. Zepeda-Martínez, Preeti Goyal, Sahasransu Mahapatra, Angela Tam, Diana J. Laird, Martin Hirst, Anjana Rao, Matthew C. Lorincz, Miguel Ramalho-Santos

ABSTRACT

Vitamin C is a direct regulator of Tet enzyme activity and DNA methylation fidelity in mouse ES cells; addition of vitamin C promotes Tet activity, increases 5-hydroxymethlycytosine (5hmC) and DNA demethylation of many gene promoters, upregulates demethylated germline genes, and induces a state that more closely approximates that of the inner cell mass of the blastocyst. More... »

PAGES

222-226

References to SciGraph publications

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  • Journal

    TITLE

    Nature

    ISSUE

    7461

    VOLUME

    500

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature12362

    DOI

    http://dx.doi.org/10.1038/nature12362

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008910662

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23812591


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