Mutational heterogeneity in cancer and the search for new cancer-associated genes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07

AUTHORS

Michael S. Lawrence, Petar Stojanov, Paz Polak, Gregory V. Kryukov, Kristian Cibulskis, Andrey Sivachenko, Scott L. Carter, Chip Stewart, Craig H. Mermel, Steven A. Roberts, Adam Kiezun, Peter S. Hammerman, Aaron McKenna, Yotam Drier, Lihua Zou, Alex H. Ramos, Trevor J. Pugh, Nicolas Stransky, Elena Helman, Jaegil Kim, Carrie Sougnez, Lauren Ambrogio, Elizabeth Nickerson, Erica Shefler, Maria L. Cortés, Daniel Auclair, Gordon Saksena, Douglas Voet, Michael Noble, Daniel DiCara, Pei Lin, Lee Lichtenstein, David I. Heiman, Timothy Fennell, Marcin Imielinski, Bryan Hernandez, Eran Hodis, Sylvan Baca, Austin M. Dulak, Jens Lohr, Dan-Avi Landau, Catherine J. Wu, Jorge Melendez-Zajgla, Alfredo Hidalgo-Miranda, Amnon Koren, Steven A. McCarroll, Jaume Mora, Ryan S. Lee, Brian Crompton, Robert Onofrio, Melissa Parkin, Wendy Winckler, Kristin Ardlie, Stacey B. Gabriel, Charles W. M. Roberts, Jaclyn A. Biegel, Kimberly Stegmaier, Adam J. Bass, Levi A. Garraway, Matthew Meyerson, Todd R. Golub, Dmitry A. Gordenin, Shamil Sunyaev, Eric S. Lander, Gad Getz

ABSTRACT

Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched tumour-normal samples followed by mathematical analysis to identify those genes in which mutations occur more frequently than expected by random chance. Here we describe a fundamental problem with cancer genome studies: as the sample size increases, the list of putatively significant genes produced by current analytical methods burgeons into the hundreds. The list includes many implausible genes (such as those encoding olfactory receptors and the muscle protein titin), suggesting extensive false-positive findings that overshadow true driver events. We show that this problem stems largely from mutational heterogeneity and provide a novel analytical methodology, MutSigCV, for resolving the problem. We apply MutSigCV to exome sequences from 3,083 tumour-normal pairs and discover extraordinary variation in mutation frequency and spectrum within cancer types, which sheds light on mutational processes and disease aetiology, and in mutation frequency across the genome, which is strongly correlated with DNA replication timing and also with transcriptional activity. By incorporating mutational heterogeneity into the analyses, MutSigCV is able to eliminate most of the apparent artefactual findings and enable the identification of genes truly associated with cancer. More... »

PAGES

214

References to SciGraph publications

  • 2008-10-23. Somatic mutations affect key pathways in lung adenocarcinoma in NATURE
  • 2013-03. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples in NATURE BIOTECHNOLOGY
  • 2011-11. Variation in the mutation rate across mammalian genomes in NATURE REVIEWS GENETICS
  • 2012-07. Comprehensive molecular characterization of human colon and rectal cancer in NATURE
  • 2011-08. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma in NATURE
  • 2010-01. A comprehensive catalogue of somatic mutations from a human cancer genome in NATURE
  • 2010-08. Diverse somatic mutation patterns and pathway alterations in human cancers in NATURE
  • 2012-05. Melanoma genome sequencing reveals frequent PREX2 mutations in NATURE
  • 2009-04. Human mutation rate associated with DNA replication timing in NATURE GENETICS
  • 2011-03. Initial genome sequencing and analysis of multiple myeloma in NATURE
  • 2008-01. Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects in CELL RESEARCH
  • 2007-03. Patterns of somatic mutation in human cancer genomes in NATURE
  • 2010-01. A small-cell lung cancer genome with complex signatures of tobacco exposure in NATURE
  • 2012-09. Comprehensive genomic characterization of squamous cell lung cancers in NATURE
  • 2008-10-23. Comprehensive genomic characterization defines human glioblastoma genes and core pathways in NATURE
  • 2011-06-29. Integrated genomic analyses of ovarian carcinoma in NATURE
  • 2012-06. The landscape of cancer genes and mutational processes in breast cancer in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    7457

    VOLUME

    499

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature12213

    DOI

    http://dx.doi.org/10.1038/nature12213

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021761707

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23770567


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Artifacts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Replication Timing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Exome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "False Positive Reactions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Heterogeneity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms, Squamous Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oncogenes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproducibility of Results", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sample Size", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lawrence", 
            "givenName": "Michael S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stojanov", 
            "givenName": "Petar", 
            "id": "sg:person.01307024142.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307024142.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Brigham and Women's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Brigham and Women's Hospital, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Polak", 
            "givenName": "Paz", 
            "id": "sg:person.0624257534.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624257534.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Brigham and Women's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Brigham and Women's Hospital, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kryukov", 
            "givenName": "Gregory V.", 
            "id": "sg:person.01364476163.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364476163.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cibulskis", 
            "givenName": "Kristian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sivachenko", 
            "givenName": "Andrey", 
            "id": "sg:person.0715340031.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715340031.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carter", 
            "givenName": "Scott L.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stewart", 
            "givenName": "Chip", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Massachusetts General Hospital, Boston, Massachusetts 02114, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mermel", 
            "givenName": "Craig H.", 
            "id": "sg:person.01066471003.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066471003.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Environmental Health Sciences", 
              "id": "https://www.grid.ac/institutes/grid.280664.e", 
              "name": [
                "Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Durham, North Carolina 27709, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roberts", 
            "givenName": "Steven A.", 
            "id": "sg:person.01204572121.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204572121.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kiezun", 
            "givenName": "Adam", 
            "id": "sg:person.01274672135.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274672135.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hammerman", 
            "givenName": "Peter S.", 
            "id": "sg:person.01154617550.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154617550.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Genome Sciences, University of Washington, Seattle, Washington 98195, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McKenna", 
            "givenName": "Aaron", 
            "id": "sg:person.01331401712.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331401712.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute", 
              "id": "https://www.grid.ac/institutes/grid.413575.1", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Massachusetts General Hospital, Boston, Massachusetts 02114, USA", 
                "Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Drier", 
            "givenName": "Yotam", 
            "id": "sg:person.01113243415.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113243415.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zou", 
            "givenName": "Lihua", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ramos", 
            "givenName": "Alex H.", 
            "id": "sg:person.01260766452.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260766452.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pugh", 
            "givenName": "Trevor J.", 
            "id": "sg:person.011314310445.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011314310445.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Blueprint Medicines (United States)", 
              "id": "https://www.grid.ac/institutes/grid.497611.c", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Blueprint Medicines, Cambridge, Massachusetts 02142, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stransky", 
            "givenName": "Nicolas", 
            "id": "sg:person.01007052650.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007052650.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Helman", 
            "givenName": "Elena", 
            "id": "sg:person.0737423437.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737423437.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Jaegil", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sougnez", 
            "givenName": "Carrie", 
            "id": "sg:person.0727475244.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727475244.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ambrogio", 
            "givenName": "Lauren", 
            "id": "sg:person.01011536500.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011536500.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nickerson", 
            "givenName": "Elizabeth", 
            "id": "sg:person.01132741370.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132741370.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shefler", 
            "givenName": "Erica", 
            "id": "sg:person.01075022055.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075022055.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cort\u00e9s", 
            "givenName": "Maria L.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Auclair", 
            "givenName": "Daniel", 
            "id": "sg:person.01237362200.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237362200.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saksena", 
            "givenName": "Gordon", 
            "id": "sg:person.01027152075.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027152075.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Voet", 
            "givenName": "Douglas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Noble", 
            "givenName": "Michael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "DiCara", 
            "givenName": "Daniel", 
            "id": "sg:person.01321575735.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321575735.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lin", 
            "givenName": "Pei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lichtenstein", 
            "givenName": "Lee", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heiman", 
            "givenName": "David I.", 
            "id": "sg:person.01240025770.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240025770.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fennell", 
            "givenName": "Timothy", 
            "id": "sg:person.016012720777.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016012720777.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Massachusetts General Hospital, Boston, Massachusetts 02114, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Imielinski", 
            "givenName": "Marcin", 
            "id": "sg:person.01107557716.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107557716.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hernandez", 
            "givenName": "Bryan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hodis", 
            "givenName": "Eran", 
            "id": "sg:person.0767312615.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767312615.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baca", 
            "givenName": "Sylvan", 
            "id": "sg:person.01222257656.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222257656.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dulak", 
            "givenName": "Austin M.", 
            "id": "sg:person.01311401332.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311401332.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dana\u2013Farber Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lohr", 
            "givenName": "Jens", 
            "id": "sg:person.01175212076.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175212076.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yale Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.433818.5", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Yale Cancer Center, Department of Hematology, New Haven, Connecticut 06510, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Landau", 
            "givenName": "Dan-Avi", 
            "id": "sg:person.0770137570.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770137570.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Catherine J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Genomic Medicine", 
              "id": "https://www.grid.ac/institutes/grid.452651.1", 
              "name": [
                "Instituto Nacional de Medicina Gen\u00f3mica, Mexico City 14610, Mexico"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Melendez-Zajgla", 
            "givenName": "Jorge", 
            "id": "sg:person.0617251630.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617251630.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Genomic Medicine", 
              "id": "https://www.grid.ac/institutes/grid.452651.1", 
              "name": [
                "Instituto Nacional de Medicina Gen\u00f3mica, Mexico City 14610, Mexico"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hidalgo-Miranda", 
            "givenName": "Alfredo", 
            "id": "sg:person.01316543563.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316543563.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koren", 
            "givenName": "Amnon", 
            "id": "sg:person.01347663634.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347663634.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCarroll", 
            "givenName": "Steven A.", 
            "id": "sg:person.0736420010.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736420010.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Sant Joan de D\u00e9u Barcelona", 
              "id": "https://www.grid.ac/institutes/grid.411160.3", 
              "name": [
                "Department of Pediatric Oncology, Hospital Sant Joan de D\u00e9u, Barcelona 08950, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mora", 
            "givenName": "Jaume", 
            "id": "sg:person.0672531221.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672531221.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Boston Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Boston Children\u2019s Hospital, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Ryan S.", 
            "id": "sg:person.01244337231.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244337231.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Boston Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Boston Children\u2019s Hospital, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Crompton", 
            "givenName": "Brian", 
            "id": "sg:person.01144144366.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144144366.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Onofrio", 
            "givenName": "Robert", 
            "id": "sg:person.01234470615.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234470615.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parkin", 
            "givenName": "Melissa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Winckler", 
            "givenName": "Wendy", 
            "id": "sg:person.01346637410.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346637410.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ardlie", 
            "givenName": "Kristin", 
            "id": "sg:person.01131126727.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131126727.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gabriel", 
            "givenName": "Stacey B.", 
            "id": "sg:person.012151177437.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012151177437.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Boston Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Boston Children\u2019s Hospital, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roberts", 
            "givenName": "Charles W. M.", 
            "id": "sg:person.012404741132.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012404741132.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Children's Hospital of Philadelphia", 
              "id": "https://www.grid.ac/institutes/grid.239552.a", 
              "name": [
                "Children\u2019s Hospital, Philadelphia, Pennsylvania 19104, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Biegel", 
            "givenName": "Jaclyn A.", 
            "id": "sg:person.01001427435.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001427435.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Boston Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Boston Children\u2019s Hospital, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stegmaier", 
            "givenName": "Kimberly", 
            "id": "sg:person.01323203047.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323203047.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bass", 
            "givenName": "Adam J.", 
            "id": "sg:person.01111016005.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111016005.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Garraway", 
            "givenName": "Levi A.", 
            "id": "sg:person.01354065210.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354065210.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meyerson", 
            "givenName": "Matthew", 
            "id": "sg:person.0707456775.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707456775.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute", 
              "id": "https://www.grid.ac/institutes/grid.413575.1", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Golub", 
            "givenName": "Todd R.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Environmental Health Sciences", 
              "id": "https://www.grid.ac/institutes/grid.280664.e", 
              "name": [
                "Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Durham, North Carolina 27709, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gordenin", 
            "givenName": "Dmitry A.", 
            "id": "sg:person.01265531737.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265531737.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Brigham and Women's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Brigham and Women's Hospital, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sunyaev", 
            "givenName": "Shamil", 
            "id": "sg:person.01310516710.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310516710.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lander", 
            "givenName": "Eric S.", 
            "id": "sg:person.01260666165.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260666165.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA", 
                "Massachusetts General Hospital, Boston, Massachusetts 02114, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Getz", 
            "givenName": "Gad", 
            "id": "sg:person.01316313531.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316313531.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nbt.2514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000477771", 
              "https://doi.org/10.1038/nbt.2514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000736346", 
              "https://doi.org/10.1038/nature10166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0806268105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005899106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006014163", 
              "https://doi.org/10.1038/nature11404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006014163", 
              "https://doi.org/10.1038/nature11404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09837", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007161398", 
              "https://doi.org/10.1038/nature09837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619765", 
              "https://doi.org/10.1038/nature11252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011180194", 
              "https://doi.org/10.1038/ng.363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.01.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012051399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1109016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012874418"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1121343109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014174095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014288207", 
              "https://doi.org/10.1038/nature08658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014288207", 
              "https://doi.org/10.1038/nature08658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015512980", 
              "https://doi.org/10.1038/nature11071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019649945", 
              "https://doi.org/10.1038/nature10351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199909)189:1<12::aid-path431>3.0.co;2-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021762873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2008.6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023098761", 
              "https://doi.org/10.1038/cr.2008.6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023931311", 
              "https://doi.org/10.1038/nrg3098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2012.10.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026704061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033482125", 
              "https://doi.org/10.1038/nature05610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034041413", 
              "https://doi.org/10.1038/nature11017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.098947.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037742049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1208130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038068253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1208130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038068253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039570773", 
              "https://doi.org/10.1038/nature07385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041012667", 
              "https://doi.org/10.1038/nature08629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041012667", 
              "https://doi.org/10.1038/nature08629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044282578", 
              "https://doi.org/10.1038/nature07423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.04.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045709558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1164382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048029720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048324405", 
              "https://doi.org/10.1038/nature09208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4111/kju.2012.53.4.240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048649629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2012.03.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051674590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1153201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062457319"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-07", 
        "datePublishedReg": "2013-07-01", 
        "description": "Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched tumour-normal samples followed by mathematical analysis to identify those genes in which mutations occur more frequently than expected by random chance. Here we describe a fundamental problem with cancer genome studies: as the sample size increases, the list of putatively significant genes produced by current analytical methods burgeons into the hundreds. The list includes many implausible genes (such as those encoding olfactory receptors and the muscle protein titin), suggesting extensive false-positive findings that overshadow true driver events. We show that this problem stems largely from mutational heterogeneity and provide a novel analytical methodology, MutSigCV, for resolving the problem. We apply MutSigCV to exome sequences from 3,083 tumour-normal pairs and discover extraordinary variation in mutation frequency and spectrum within cancer types, which sheds light on mutational processes and disease aetiology, and in mutation frequency across the genome, which is strongly correlated with DNA replication timing and also with transcriptional activity. By incorporating mutational heterogeneity into the analyses, MutSigCV is able to eliminate most of the apparent artefactual findings and enable the identification of genes truly associated with cancer. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature12213", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2699326", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2725232", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2682491", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2682506", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2696334", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2717523", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2683815", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7457", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "499"
          }
        ], 
        "name": "Mutational heterogeneity in cancer and the search for new cancer-associated genes", 
        "pagination": "214", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "67ae7edd99d76cf1a353ea03c5365dc23f53a988df8ca2f307568945265ff516"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23770567"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature12213"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1021761707"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature12213", 
          "https://app.dimensions.ai/details/publication/pub.1021761707"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature12213"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature12213'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature12213'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature12213'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature12213'


     

    This table displays all metadata directly associated to this object as RDF triples.

    748 TRIPLES      21 PREDICATES      75 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature12213 schema:about N063338915b36408d9d8a95fbad538bec
    2 N0fb26ba9248f49d3a105feee2d00de37
    3 N3ad79fc12bb3477fa9fb8a425c7904c6
    4 N421c8c5a75c446ab9a8518ca6525b9b4
    5 N526b50d189fd4474b9b4fff3ac52be2c
    6 N637783fe0cce47a083dbc39ebef7e382
    7 N8f0f2a1423974620a2f36ec00ef3c603
    8 N964ab530c91c4c37af6c5b85e32fde72
    9 N967c67793dc746acba321ac1ac4e3855
    10 N988f9f50b860429f99a7cb2728b75d17
    11 Nb74b7ad1888f4623b60384476728dea9
    12 Nc100404d403e4c20beba3cdb05944dfd
    13 Nda330b490d2b4fad854a38b564fb2015
    14 Ne129f7df47e742b9a8c8069008316c5c
    15 Nebc3137420264cb7b4f49131f4634c6a
    16 Nfe2cf12a89c046c7b222d29d4ff715c3
    17 anzsrc-for:06
    18 anzsrc-for:0604
    19 schema:author N7163888cedd94ed2b8320c0380bb93a2
    20 schema:citation sg:pub.10.1038/cr.2008.6
    21 sg:pub.10.1038/nature05610
    22 sg:pub.10.1038/nature07385
    23 sg:pub.10.1038/nature07423
    24 sg:pub.10.1038/nature08629
    25 sg:pub.10.1038/nature08658
    26 sg:pub.10.1038/nature09208
    27 sg:pub.10.1038/nature09837
    28 sg:pub.10.1038/nature10166
    29 sg:pub.10.1038/nature10351
    30 sg:pub.10.1038/nature11017
    31 sg:pub.10.1038/nature11071
    32 sg:pub.10.1038/nature11252
    33 sg:pub.10.1038/nature11404
    34 sg:pub.10.1038/nbt.2514
    35 sg:pub.10.1038/ng.363
    36 sg:pub.10.1038/nrg3098
    37 https://doi.org/10.1002/(sici)1096-9896(199909)189:1<12::aid-path431>3.0.co;2-f
    38 https://doi.org/10.1016/j.ajhg.2012.10.018
    39 https://doi.org/10.1016/j.cell.2012.04.024
    40 https://doi.org/10.1016/j.cell.2013.01.019
    41 https://doi.org/10.1016/j.molcel.2012.03.030
    42 https://doi.org/10.1056/nejmoa1109016
    43 https://doi.org/10.1073/pnas.0806268105
    44 https://doi.org/10.1073/pnas.1121343109
    45 https://doi.org/10.1101/gr.098947.109
    46 https://doi.org/10.1126/science.1153201
    47 https://doi.org/10.1126/science.1164382
    48 https://doi.org/10.1126/science.1208130
    49 https://doi.org/10.4111/kju.2012.53.4.240
    50 schema:datePublished 2013-07
    51 schema:datePublishedReg 2013-07-01
    52 schema:description Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched tumour-normal samples followed by mathematical analysis to identify those genes in which mutations occur more frequently than expected by random chance. Here we describe a fundamental problem with cancer genome studies: as the sample size increases, the list of putatively significant genes produced by current analytical methods burgeons into the hundreds. The list includes many implausible genes (such as those encoding olfactory receptors and the muscle protein titin), suggesting extensive false-positive findings that overshadow true driver events. We show that this problem stems largely from mutational heterogeneity and provide a novel analytical methodology, MutSigCV, for resolving the problem. We apply MutSigCV to exome sequences from 3,083 tumour-normal pairs and discover extraordinary variation in mutation frequency and spectrum within cancer types, which sheds light on mutational processes and disease aetiology, and in mutation frequency across the genome, which is strongly correlated with DNA replication timing and also with transcriptional activity. By incorporating mutational heterogeneity into the analyses, MutSigCV is able to eliminate most of the apparent artefactual findings and enable the identification of genes truly associated with cancer.
    53 schema:genre research_article
    54 schema:inLanguage en
    55 schema:isAccessibleForFree true
    56 schema:isPartOf N0f831e1f61ee46bb93d1ef159cbbe3ef
    57 N89abd5b676f14688b48a2762b28d5f8f
    58 sg:journal.1018957
    59 schema:name Mutational heterogeneity in cancer and the search for new cancer-associated genes
    60 schema:pagination 214
    61 schema:productId N0db15d9bdf424eb6abfc701b3b775b0b
    62 N36fa6d697b1a4cf083429246abbdc950
    63 N5273a35044d24989a1c21dbf41ac4622
    64 Ncf7c37b2132e403abdd51b20a27a4825
    65 Ndf501a04d40a4dde858b071778c6b529
    66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021761707
    67 https://doi.org/10.1038/nature12213
    68 schema:sdDatePublished 2019-04-11T00:03
    69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    70 schema:sdPublisher N21b249a2fdb74e5ba91c180d5d8da8ab
    71 schema:url https://www.nature.com/articles/nature12213
    72 sgo:license sg:explorer/license/
    73 sgo:sdDataset articles
    74 rdf:type schema:ScholarlyArticle
    75 N019575807e6145e58e44919209cb032c rdf:first sg:person.01240025770.54
    76 rdf:rest N3c6a39b9c9374b0fb70406edbc74d645
    77 N026b58a5c1a5463bb1661dbd8548d721 rdf:first sg:person.01066471003.08
    78 rdf:rest N6a6c41c075074302b4ec1a3f0437a659
    79 N0343f491799f414e8767f4a9f607a5c3 rdf:first N207171f6932c495f96dfdab7f3bab667
    80 rdf:rest N25bdf4bf451e408a93db9c8a8c746feb
    81 N063338915b36408d9d8a95fbad538bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    82 schema:name DNA Replication Timing
    83 rdf:type schema:DefinedTerm
    84 N0a0319d59b95431cbb689f0fe422f566 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    85 schema:familyName Hernandez
    86 schema:givenName Bryan
    87 rdf:type schema:Person
    88 N0db15d9bdf424eb6abfc701b3b775b0b schema:name nlm_unique_id
    89 schema:value 0410462
    90 rdf:type schema:PropertyValue
    91 N0f831e1f61ee46bb93d1ef159cbbe3ef schema:volumeNumber 499
    92 rdf:type schema:PublicationVolume
    93 N0fb26ba9248f49d3a105feee2d00de37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Artifacts
    95 rdf:type schema:DefinedTerm
    96 N11f04f7d578c4c2c904661ed6ce0606d rdf:first sg:person.01265531737.50
    97 rdf:rest N82f8e7f66b8f4222a727caa34ee5e342
    98 N120b5b8933ea4049aa6132a76f8d051e schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    99 schema:familyName Voet
    100 schema:givenName Douglas
    101 rdf:type schema:Person
    102 N19b11ac814524433939e87bf10406f5b rdf:first Naa8a00b5a53b4568afb2c857db1b268c
    103 rdf:rest N44e41dc53d824fe686e73b0a59684820
    104 N1df4864cd6aa4c218aa89d53ac749678 rdf:first sg:person.01364476163.20
    105 rdf:rest N59776ff463e94578b187047d9621ba7d
    106 N1f85327551a64802b7db623dcd45317f rdf:first sg:person.01311401332.13
    107 rdf:rest N1fa2a9580a0943008397dab856206004
    108 N1fa2a9580a0943008397dab856206004 rdf:first sg:person.01175212076.22
    109 rdf:rest N7427189f6ca441da915340a480262945
    110 N207171f6932c495f96dfdab7f3bab667 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    111 schema:familyName Zou
    112 schema:givenName Lihua
    113 rdf:type schema:Person
    114 N21b249a2fdb74e5ba91c180d5d8da8ab schema:name Springer Nature - SN SciGraph project
    115 rdf:type schema:Organization
    116 N24aacc8523484ec0a2d218aba82cebf7 rdf:first N0a0319d59b95431cbb689f0fe422f566
    117 rdf:rest N37a5c1deb92a46cbae06abad83238440
    118 N25bdf4bf451e408a93db9c8a8c746feb rdf:first sg:person.01260766452.93
    119 rdf:rest N6a4734d9cd1046c9a125ac78bc093383
    120 N2c95aa728dcf45f6b4ad61b9dc205f10 rdf:first sg:person.01113243415.98
    121 rdf:rest N0343f491799f414e8767f4a9f607a5c3
    122 N2fc9cb74d4864d5a8a65a857772826cf rdf:first sg:person.01260666165.62
    123 rdf:rest Nac906d4767454e32b0c862163799bdc3
    124 N3600a0309265402da425da3e4e42243e rdf:first N4e2f828f381e41b1ba2e221962b145f2
    125 rdf:rest N98e261fa3c8e44db8ab0e5ab1bdd3b2e
    126 N36fa6d697b1a4cf083429246abbdc950 schema:name dimensions_id
    127 schema:value pub.1021761707
    128 rdf:type schema:PropertyValue
    129 N374e59a2c64a43e48d479463b3e1ea9e rdf:first sg:person.01001427435.01
    130 rdf:rest Nf1a82565a54441c58db7325ac9f2d9cd
    131 N37a5c1deb92a46cbae06abad83238440 rdf:first sg:person.0767312615.75
    132 rdf:rest N59ea2ce51a474c5b938e111613e58638
    133 N37bbb64d2dbf484b88001e74d9ebc53f schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    134 schema:familyName Cibulskis
    135 schema:givenName Kristian
    136 rdf:type schema:Person
    137 N38e86a87c3f34890b78c393d5b65c8b5 rdf:first sg:person.01244337231.29
    138 rdf:rest N5c4a2c4c86b14e7e8fbfdba4c7330f7d
    139 N3ad79fc12bb3477fa9fb8a425c7904c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name False Positive Reactions
    141 rdf:type schema:DefinedTerm
    142 N3bd8442e1207402fa55acc4c209cef2f rdf:first sg:person.012151177437.05
    143 rdf:rest N617f7ae888f34d418737f64ccf9b9f6a
    144 N3c6a39b9c9374b0fb70406edbc74d645 rdf:first sg:person.016012720777.47
    145 rdf:rest Nd38728b373664f3f95f273c8dddfa8df
    146 N3da898e2dca149688a936754a47ef21d rdf:first sg:person.01316543563.28
    147 rdf:rest N8a36651b2d9c4e4a87ad5dde3420099a
    148 N41113c4f4adf49289c2f6e7e2f0208ec rdf:first sg:person.01331401712.29
    149 rdf:rest N2c95aa728dcf45f6b4ad61b9dc205f10
    150 N421c8c5a75c446ab9a8518ca6525b9b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Mutation Rate
    152 rdf:type schema:DefinedTerm
    153 N44e41dc53d824fe686e73b0a59684820 rdf:first sg:person.0727475244.45
    154 rdf:rest N74798a9a61674c73aa6a28bf891c40a1
    155 N47664fbacb5446cf9ec9fb7b20e7c686 rdf:first N84a7051e6df64849bfe1f5d2bededb3e
    156 rdf:rest Na0e535513d3844429752e912871d4951
    157 N4e2f828f381e41b1ba2e221962b145f2 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    158 schema:familyName Wu
    159 schema:givenName Catherine J.
    160 rdf:type schema:Person
    161 N526b50d189fd4474b9b4fff3ac52be2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Lung Neoplasms
    163 rdf:type schema:DefinedTerm
    164 N5273a35044d24989a1c21dbf41ac4622 schema:name pubmed_id
    165 schema:value 23770567
    166 rdf:type schema:PropertyValue
    167 N558df3c88ece4eabba08237f9cafc747 rdf:first sg:person.01132741370.54
    168 rdf:rest Nd34c19b55d704501a6dd4f4a37ed43e1
    169 N575680f997374d4abe403be307594104 rdf:first sg:person.01131126727.99
    170 rdf:rest N3bd8442e1207402fa55acc4c209cef2f
    171 N59776ff463e94578b187047d9621ba7d rdf:first N37bbb64d2dbf484b88001e74d9ebc53f
    172 rdf:rest Nabc7d8ea993646c0840e6d596895cfe0
    173 N59ea2ce51a474c5b938e111613e58638 rdf:first sg:person.01222257656.28
    174 rdf:rest N1f85327551a64802b7db623dcd45317f
    175 N5c4a2c4c86b14e7e8fbfdba4c7330f7d rdf:first sg:person.01144144366.08
    176 rdf:rest Nbeb2d4c76d7642bfac542f3c57d214fd
    177 N617f7ae888f34d418737f64ccf9b9f6a rdf:first sg:person.012404741132.65
    178 rdf:rest N374e59a2c64a43e48d479463b3e1ea9e
    179 N637783fe0cce47a083dbc39ebef7e382 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Genetic Heterogeneity
    181 rdf:type schema:DefinedTerm
    182 N653d3f24b2804247a7237611d8f51415 rdf:first sg:person.0672531221.74
    183 rdf:rest N38e86a87c3f34890b78c393d5b65c8b5
    184 N6857583ce5ed4f48b4e6ef353cc738b3 rdf:first sg:person.0736420010.83
    185 rdf:rest N653d3f24b2804247a7237611d8f51415
    186 N6a4734d9cd1046c9a125ac78bc093383 rdf:first sg:person.011314310445.23
    187 rdf:rest Ne5753c197bcd4142a882a6807af77b1c
    188 N6a6c41c075074302b4ec1a3f0437a659 rdf:first sg:person.01204572121.64
    189 rdf:rest Nab576d3dc2964f4ca5530dd2b09162e0
    190 N6a9f96ccbf4d431ea08a31755e70f733 rdf:first sg:person.01354065210.34
    191 rdf:rest Nbee82c49314d423289887d80f852b1bc
    192 N6cedfa366ea644da9d5ab40b871f7246 rdf:first Na11ae4984500478d9551dc6f0db25698
    193 rdf:rest N9e67d62f79e54b78a7814a1824a33ae5
    194 N7163888cedd94ed2b8320c0380bb93a2 rdf:first Nbd0058fbf6074677a5de4ff43509934b
    195 rdf:rest Nfed7a1a2d2e44d0b8cc8f7825a3f3ef5
    196 N7427189f6ca441da915340a480262945 rdf:first sg:person.0770137570.47
    197 rdf:rest N3600a0309265402da425da3e4e42243e
    198 N74379321da644982afb1e8243339e77d rdf:first sg:person.01154617550.29
    199 rdf:rest N41113c4f4adf49289c2f6e7e2f0208ec
    200 N74798a9a61674c73aa6a28bf891c40a1 rdf:first sg:person.01011536500.23
    201 rdf:rest N558df3c88ece4eabba08237f9cafc747
    202 N82f8e7f66b8f4222a727caa34ee5e342 rdf:first sg:person.01310516710.30
    203 rdf:rest N2fc9cb74d4864d5a8a65a857772826cf
    204 N84a7051e6df64849bfe1f5d2bededb3e schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    205 schema:familyName Cortés
    206 schema:givenName Maria L.
    207 rdf:type schema:Person
    208 N88cb3d7c3eca4b34b2e8c9359ccf2b2e rdf:first sg:person.01346637410.20
    209 rdf:rest N575680f997374d4abe403be307594104
    210 N89abd5b676f14688b48a2762b28d5f8f schema:issueNumber 7457
    211 rdf:type schema:PublicationIssue
    212 N8a36651b2d9c4e4a87ad5dde3420099a rdf:first sg:person.01347663634.53
    213 rdf:rest N6857583ce5ed4f48b4e6ef353cc738b3
    214 N8f0f2a1423974620a2f36ec00ef3c603 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Oncogenes
    216 rdf:type schema:DefinedTerm
    217 N921ad52584fd4d74a48b0ff9787aecfd rdf:first N120b5b8933ea4049aa6132a76f8d051e
    218 rdf:rest N6cedfa366ea644da9d5ab40b871f7246
    219 N92b8cd3e013f4299a5a388a996461e63 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    220 schema:familyName Parkin
    221 schema:givenName Melissa
    222 rdf:type schema:Person
    223 N95bcff6a739e4da1ad2730c8dfc38697 rdf:first Nb2aa8697a8334fe29abc2778af686b63
    224 rdf:rest N026b58a5c1a5463bb1661dbd8548d721
    225 N964ab530c91c4c37af6c5b85e32fde72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Gene Expression
    227 rdf:type schema:DefinedTerm
    228 N967c67793dc746acba321ac1ac4e3855 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Neoplasms
    230 rdf:type schema:DefinedTerm
    231 N988f9f50b860429f99a7cb2728b75d17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Genome, Human
    233 rdf:type schema:DefinedTerm
    234 N9897f1ea7c7e4907aea4f986aaa5995d rdf:first Nc330e6abbdd54fb38626512825820a45
    235 rdf:rest N95bcff6a739e4da1ad2730c8dfc38697
    236 N98e261fa3c8e44db8ab0e5ab1bdd3b2e rdf:first sg:person.0617251630.69
    237 rdf:rest N3da898e2dca149688a936754a47ef21d
    238 N9e67d62f79e54b78a7814a1824a33ae5 rdf:first sg:person.01321575735.59
    239 rdf:rest Nd0b89f627d494d4ebb9c213cfe11420d
    240 Na0e535513d3844429752e912871d4951 rdf:first sg:person.01237362200.80
    241 rdf:rest Nc1adc10d12fb40c09809dcd8d870f7e4
    242 Na11ae4984500478d9551dc6f0db25698 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    243 schema:familyName Noble
    244 schema:givenName Michael
    245 rdf:type schema:Person
    246 Na17eb5bd763444bba18a1985a8705f27 rdf:first sg:person.01111016005.45
    247 rdf:rest N6a9f96ccbf4d431ea08a31755e70f733
    248 Naa8a00b5a53b4568afb2c857db1b268c schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    249 schema:familyName Kim
    250 schema:givenName Jaegil
    251 rdf:type schema:Person
    252 Naaf8ad5f535f4c6cbba123129ed2f911 rdf:first sg:person.0737423437.40
    253 rdf:rest N19b11ac814524433939e87bf10406f5b
    254 Nab576d3dc2964f4ca5530dd2b09162e0 rdf:first sg:person.01274672135.88
    255 rdf:rest N74379321da644982afb1e8243339e77d
    256 Nabc7d8ea993646c0840e6d596895cfe0 rdf:first sg:person.0715340031.86
    257 rdf:rest N9897f1ea7c7e4907aea4f986aaa5995d
    258 Nac048c6164244d62ad84f22452905c43 rdf:first Ndea88c8457f846fb82a36544ca587e5f
    259 rdf:rest N019575807e6145e58e44919209cb032c
    260 Nac906d4767454e32b0c862163799bdc3 rdf:first sg:person.01316313531.32
    261 rdf:rest rdf:nil
    262 Nb2aa8697a8334fe29abc2778af686b63 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    263 schema:familyName Stewart
    264 schema:givenName Chip
    265 rdf:type schema:Person
    266 Nb58ad939dbb34505b4f101796aacbb5f rdf:first N92b8cd3e013f4299a5a388a996461e63
    267 rdf:rest N88cb3d7c3eca4b34b2e8c9359ccf2b2e
    268 Nb74b7ad1888f4623b60384476728dea9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    269 schema:name Humans
    270 rdf:type schema:DefinedTerm
    271 Nb876954bca334463906d4dfaec03e233 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    272 schema:familyName Lin
    273 schema:givenName Pei
    274 rdf:type schema:Person
    275 Nbd0058fbf6074677a5de4ff43509934b schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    276 schema:familyName Lawrence
    277 schema:givenName Michael S.
    278 rdf:type schema:Person
    279 Nbeb2d4c76d7642bfac542f3c57d214fd rdf:first sg:person.01234470615.07
    280 rdf:rest Nb58ad939dbb34505b4f101796aacbb5f
    281 Nbee82c49314d423289887d80f852b1bc rdf:first sg:person.0707456775.47
    282 rdf:rest Nd2e50eab3d9e4a438c9142d623787006
    283 Nc100404d403e4c20beba3cdb05944dfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    284 schema:name Reproducibility of Results
    285 rdf:type schema:DefinedTerm
    286 Nc1adc10d12fb40c09809dcd8d870f7e4 rdf:first sg:person.01027152075.90
    287 rdf:rest N921ad52584fd4d74a48b0ff9787aecfd
    288 Nc330e6abbdd54fb38626512825820a45 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    289 schema:familyName Carter
    290 schema:givenName Scott L.
    291 rdf:type schema:Person
    292 Ncf7c37b2132e403abdd51b20a27a4825 schema:name doi
    293 schema:value 10.1038/nature12213
    294 rdf:type schema:PropertyValue
    295 Nd0b89f627d494d4ebb9c213cfe11420d rdf:first Nb876954bca334463906d4dfaec03e233
    296 rdf:rest Nac048c6164244d62ad84f22452905c43
    297 Nd2e50eab3d9e4a438c9142d623787006 rdf:first Nda77ba71e7d742e384b62c52d195400f
    298 rdf:rest N11f04f7d578c4c2c904661ed6ce0606d
    299 Nd34c19b55d704501a6dd4f4a37ed43e1 rdf:first sg:person.01075022055.19
    300 rdf:rest N47664fbacb5446cf9ec9fb7b20e7c686
    301 Nd38728b373664f3f95f273c8dddfa8df rdf:first sg:person.01107557716.26
    302 rdf:rest N24aacc8523484ec0a2d218aba82cebf7
    303 Nda330b490d2b4fad854a38b564fb2015 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    304 schema:name Mutation
    305 rdf:type schema:DefinedTerm
    306 Nda77ba71e7d742e384b62c52d195400f schema:affiliation https://www.grid.ac/institutes/grid.413575.1
    307 schema:familyName Golub
    308 schema:givenName Todd R.
    309 rdf:type schema:Person
    310 Ndea88c8457f846fb82a36544ca587e5f schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    311 schema:familyName Lichtenstein
    312 schema:givenName Lee
    313 rdf:type schema:Person
    314 Ndf501a04d40a4dde858b071778c6b529 schema:name readcube_id
    315 schema:value 67ae7edd99d76cf1a353ea03c5365dc23f53a988df8ca2f307568945265ff516
    316 rdf:type schema:PropertyValue
    317 Ne129f7df47e742b9a8c8069008316c5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    318 schema:name Exome
    319 rdf:type schema:DefinedTerm
    320 Ne5753c197bcd4142a882a6807af77b1c rdf:first sg:person.01007052650.66
    321 rdf:rest Naaf8ad5f535f4c6cbba123129ed2f911
    322 Nebc3137420264cb7b4f49131f4634c6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    323 schema:name Neoplasms, Squamous Cell
    324 rdf:type schema:DefinedTerm
    325 Nee0cabe607a147bebf527ef0e240176b rdf:first sg:person.0624257534.57
    326 rdf:rest N1df4864cd6aa4c218aa89d53ac749678
    327 Nf1a82565a54441c58db7325ac9f2d9cd rdf:first sg:person.01323203047.64
    328 rdf:rest Na17eb5bd763444bba18a1985a8705f27
    329 Nfe2cf12a89c046c7b222d29d4ff715c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    330 schema:name Sample Size
    331 rdf:type schema:DefinedTerm
    332 Nfed7a1a2d2e44d0b8cc8f7825a3f3ef5 rdf:first sg:person.01307024142.40
    333 rdf:rest Nee0cabe607a147bebf527ef0e240176b
    334 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    335 schema:name Biological Sciences
    336 rdf:type schema:DefinedTerm
    337 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    338 schema:name Genetics
    339 rdf:type schema:DefinedTerm
    340 sg:grant.2682491 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12213
    341 rdf:type schema:MonetaryGrant
    342 sg:grant.2682506 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12213
    343 rdf:type schema:MonetaryGrant
    344 sg:grant.2683815 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12213
    345 rdf:type schema:MonetaryGrant
    346 sg:grant.2696334 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12213
    347 rdf:type schema:MonetaryGrant
    348 sg:grant.2699326 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12213
    349 rdf:type schema:MonetaryGrant
    350 sg:grant.2717523 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12213
    351 rdf:type schema:MonetaryGrant
    352 sg:grant.2725232 http://pending.schema.org/fundedItem sg:pub.10.1038/nature12213
    353 rdf:type schema:MonetaryGrant
    354 sg:journal.1018957 schema:issn 0090-0028
    355 1476-4687
    356 schema:name Nature
    357 rdf:type schema:Periodical
    358 sg:person.01001427435.01 schema:affiliation https://www.grid.ac/institutes/grid.239552.a
    359 schema:familyName Biegel
    360 schema:givenName Jaclyn A.
    361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001427435.01
    362 rdf:type schema:Person
    363 sg:person.01007052650.66 schema:affiliation https://www.grid.ac/institutes/grid.497611.c
    364 schema:familyName Stransky
    365 schema:givenName Nicolas
    366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007052650.66
    367 rdf:type schema:Person
    368 sg:person.01011536500.23 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    369 schema:familyName Ambrogio
    370 schema:givenName Lauren
    371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011536500.23
    372 rdf:type schema:Person
    373 sg:person.01027152075.90 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    374 schema:familyName Saksena
    375 schema:givenName Gordon
    376 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027152075.90
    377 rdf:type schema:Person
    378 sg:person.01066471003.08 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
    379 schema:familyName Mermel
    380 schema:givenName Craig H.
    381 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066471003.08
    382 rdf:type schema:Person
    383 sg:person.01075022055.19 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    384 schema:familyName Shefler
    385 schema:givenName Erica
    386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075022055.19
    387 rdf:type schema:Person
    388 sg:person.01107557716.26 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
    389 schema:familyName Imielinski
    390 schema:givenName Marcin
    391 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107557716.26
    392 rdf:type schema:Person
    393 sg:person.01111016005.45 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    394 schema:familyName Bass
    395 schema:givenName Adam J.
    396 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111016005.45
    397 rdf:type schema:Person
    398 sg:person.01113243415.98 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
    399 schema:familyName Drier
    400 schema:givenName Yotam
    401 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113243415.98
    402 rdf:type schema:Person
    403 sg:person.01131126727.99 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    404 schema:familyName Ardlie
    405 schema:givenName Kristin
    406 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131126727.99
    407 rdf:type schema:Person
    408 sg:person.011314310445.23 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    409 schema:familyName Pugh
    410 schema:givenName Trevor J.
    411 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011314310445.23
    412 rdf:type schema:Person
    413 sg:person.01132741370.54 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    414 schema:familyName Nickerson
    415 schema:givenName Elizabeth
    416 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132741370.54
    417 rdf:type schema:Person
    418 sg:person.01144144366.08 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
    419 schema:familyName Crompton
    420 schema:givenName Brian
    421 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144144366.08
    422 rdf:type schema:Person
    423 sg:person.01154617550.29 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    424 schema:familyName Hammerman
    425 schema:givenName Peter S.
    426 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154617550.29
    427 rdf:type schema:Person
    428 sg:person.01175212076.22 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    429 schema:familyName Lohr
    430 schema:givenName Jens
    431 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175212076.22
    432 rdf:type schema:Person
    433 sg:person.01204572121.64 schema:affiliation https://www.grid.ac/institutes/grid.280664.e
    434 schema:familyName Roberts
    435 schema:givenName Steven A.
    436 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204572121.64
    437 rdf:type schema:Person
    438 sg:person.012151177437.05 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    439 schema:familyName Gabriel
    440 schema:givenName Stacey B.
    441 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012151177437.05
    442 rdf:type schema:Person
    443 sg:person.01222257656.28 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    444 schema:familyName Baca
    445 schema:givenName Sylvan
    446 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222257656.28
    447 rdf:type schema:Person
    448 sg:person.01234470615.07 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    449 schema:familyName Onofrio
    450 schema:givenName Robert
    451 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234470615.07
    452 rdf:type schema:Person
    453 sg:person.01237362200.80 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    454 schema:familyName Auclair
    455 schema:givenName Daniel
    456 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237362200.80
    457 rdf:type schema:Person
    458 sg:person.01240025770.54 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    459 schema:familyName Heiman
    460 schema:givenName David I.
    461 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240025770.54
    462 rdf:type schema:Person
    463 sg:person.012404741132.65 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
    464 schema:familyName Roberts
    465 schema:givenName Charles W. M.
    466 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012404741132.65
    467 rdf:type schema:Person
    468 sg:person.01244337231.29 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
    469 schema:familyName Lee
    470 schema:givenName Ryan S.
    471 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244337231.29
    472 rdf:type schema:Person
    473 sg:person.01260666165.62 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    474 schema:familyName Lander
    475 schema:givenName Eric S.
    476 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260666165.62
    477 rdf:type schema:Person
    478 sg:person.01260766452.93 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    479 schema:familyName Ramos
    480 schema:givenName Alex H.
    481 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260766452.93
    482 rdf:type schema:Person
    483 sg:person.01265531737.50 schema:affiliation https://www.grid.ac/institutes/grid.280664.e
    484 schema:familyName Gordenin
    485 schema:givenName Dmitry A.
    486 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265531737.50
    487 rdf:type schema:Person
    488 sg:person.01274672135.88 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    489 schema:familyName Kiezun
    490 schema:givenName Adam
    491 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274672135.88
    492 rdf:type schema:Person
    493 sg:person.01307024142.40 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    494 schema:familyName Stojanov
    495 schema:givenName Petar
    496 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307024142.40
    497 rdf:type schema:Person
    498 sg:person.01310516710.30 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
    499 schema:familyName Sunyaev
    500 schema:givenName Shamil
    501 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310516710.30
    502 rdf:type schema:Person
    503 sg:person.01311401332.13 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    504 schema:familyName Dulak
    505 schema:givenName Austin M.
    506 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311401332.13
    507 rdf:type schema:Person
    508 sg:person.01316313531.32 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
    509 schema:familyName Getz
    510 schema:givenName Gad
    511 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316313531.32
    512 rdf:type schema:Person
    513 sg:person.01316543563.28 schema:affiliation https://www.grid.ac/institutes/grid.452651.1
    514 schema:familyName Hidalgo-Miranda
    515 schema:givenName Alfredo
    516 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316543563.28
    517 rdf:type schema:Person
    518 sg:person.01321575735.59 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    519 schema:familyName DiCara
    520 schema:givenName Daniel
    521 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321575735.59
    522 rdf:type schema:Person
    523 sg:person.01323203047.64 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
    524 schema:familyName Stegmaier
    525 schema:givenName Kimberly
    526 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323203047.64
    527 rdf:type schema:Person
    528 sg:person.01331401712.29 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    529 schema:familyName McKenna
    530 schema:givenName Aaron
    531 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331401712.29
    532 rdf:type schema:Person
    533 sg:person.01346637410.20 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    534 schema:familyName Winckler
    535 schema:givenName Wendy
    536 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346637410.20
    537 rdf:type schema:Person
    538 sg:person.01347663634.53 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    539 schema:familyName Koren
    540 schema:givenName Amnon
    541 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347663634.53
    542 rdf:type schema:Person
    543 sg:person.01354065210.34 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    544 schema:familyName Garraway
    545 schema:givenName Levi A.
    546 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354065210.34
    547 rdf:type schema:Person
    548 sg:person.01364476163.20 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
    549 schema:familyName Kryukov
    550 schema:givenName Gregory V.
    551 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364476163.20
    552 rdf:type schema:Person
    553 sg:person.016012720777.47 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    554 schema:familyName Fennell
    555 schema:givenName Timothy
    556 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016012720777.47
    557 rdf:type schema:Person
    558 sg:person.0617251630.69 schema:affiliation https://www.grid.ac/institutes/grid.452651.1
    559 schema:familyName Melendez-Zajgla
    560 schema:givenName Jorge
    561 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617251630.69
    562 rdf:type schema:Person
    563 sg:person.0624257534.57 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
    564 schema:familyName Polak
    565 schema:givenName Paz
    566 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624257534.57
    567 rdf:type schema:Person
    568 sg:person.0672531221.74 schema:affiliation https://www.grid.ac/institutes/grid.411160.3
    569 schema:familyName Mora
    570 schema:givenName Jaume
    571 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672531221.74
    572 rdf:type schema:Person
    573 sg:person.0707456775.47 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    574 schema:familyName Meyerson
    575 schema:givenName Matthew
    576 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707456775.47
    577 rdf:type schema:Person
    578 sg:person.0715340031.86 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    579 schema:familyName Sivachenko
    580 schema:givenName Andrey
    581 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715340031.86
    582 rdf:type schema:Person
    583 sg:person.0727475244.45 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    584 schema:familyName Sougnez
    585 schema:givenName Carrie
    586 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727475244.45
    587 rdf:type schema:Person
    588 sg:person.0736420010.83 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    589 schema:familyName McCarroll
    590 schema:givenName Steven A.
    591 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736420010.83
    592 rdf:type schema:Person
    593 sg:person.0737423437.40 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    594 schema:familyName Helman
    595 schema:givenName Elena
    596 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737423437.40
    597 rdf:type schema:Person
    598 sg:person.0767312615.75 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
    599 schema:familyName Hodis
    600 schema:givenName Eran
    601 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767312615.75
    602 rdf:type schema:Person
    603 sg:person.0770137570.47 schema:affiliation https://www.grid.ac/institutes/grid.433818.5
    604 schema:familyName Landau
    605 schema:givenName Dan-Avi
    606 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770137570.47
    607 rdf:type schema:Person
    608 sg:pub.10.1038/cr.2008.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023098761
    609 https://doi.org/10.1038/cr.2008.6
    610 rdf:type schema:CreativeWork
    611 sg:pub.10.1038/nature05610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033482125
    612 https://doi.org/10.1038/nature05610
    613 rdf:type schema:CreativeWork
    614 sg:pub.10.1038/nature07385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039570773
    615 https://doi.org/10.1038/nature07385
    616 rdf:type schema:CreativeWork
    617 sg:pub.10.1038/nature07423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044282578
    618 https://doi.org/10.1038/nature07423
    619 rdf:type schema:CreativeWork
    620 sg:pub.10.1038/nature08629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041012667
    621 https://doi.org/10.1038/nature08629
    622 rdf:type schema:CreativeWork
    623 sg:pub.10.1038/nature08658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014288207
    624 https://doi.org/10.1038/nature08658
    625 rdf:type schema:CreativeWork
    626 sg:pub.10.1038/nature09208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048324405
    627 https://doi.org/10.1038/nature09208
    628 rdf:type schema:CreativeWork
    629 sg:pub.10.1038/nature09837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007161398
    630 https://doi.org/10.1038/nature09837
    631 rdf:type schema:CreativeWork
    632 sg:pub.10.1038/nature10166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736346
    633 https://doi.org/10.1038/nature10166
    634 rdf:type schema:CreativeWork
    635 sg:pub.10.1038/nature10351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019649945
    636 https://doi.org/10.1038/nature10351
    637 rdf:type schema:CreativeWork
    638 sg:pub.10.1038/nature11017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034041413
    639 https://doi.org/10.1038/nature11017
    640 rdf:type schema:CreativeWork
    641 sg:pub.10.1038/nature11071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015512980
    642 https://doi.org/10.1038/nature11071
    643 rdf:type schema:CreativeWork
    644 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
    645 https://doi.org/10.1038/nature11252
    646 rdf:type schema:CreativeWork
    647 sg:pub.10.1038/nature11404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006014163
    648 https://doi.org/10.1038/nature11404
    649 rdf:type schema:CreativeWork
    650 sg:pub.10.1038/nbt.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000477771
    651 https://doi.org/10.1038/nbt.2514
    652 rdf:type schema:CreativeWork
    653 sg:pub.10.1038/ng.363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011180194
    654 https://doi.org/10.1038/ng.363
    655 rdf:type schema:CreativeWork
    656 sg:pub.10.1038/nrg3098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023931311
    657 https://doi.org/10.1038/nrg3098
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.1002/(sici)1096-9896(199909)189:1<12::aid-path431>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1021762873
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.1016/j.ajhg.2012.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026704061
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.1016/j.cell.2012.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045709558
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.1016/j.cell.2013.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012051399
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.1016/j.molcel.2012.03.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051674590
    668 rdf:type schema:CreativeWork
    669 https://doi.org/10.1056/nejmoa1109016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012874418
    670 rdf:type schema:CreativeWork
    671 https://doi.org/10.1073/pnas.0806268105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005899106
    672 rdf:type schema:CreativeWork
    673 https://doi.org/10.1073/pnas.1121343109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014174095
    674 rdf:type schema:CreativeWork
    675 https://doi.org/10.1101/gr.098947.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037742049
    676 rdf:type schema:CreativeWork
    677 https://doi.org/10.1126/science.1153201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457319
    678 rdf:type schema:CreativeWork
    679 https://doi.org/10.1126/science.1164382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048029720
    680 rdf:type schema:CreativeWork
    681 https://doi.org/10.1126/science.1208130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038068253
    682 rdf:type schema:CreativeWork
    683 https://doi.org/10.4111/kju.2012.53.4.240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048649629
    684 rdf:type schema:CreativeWork
    685 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
    686 schema:name Harvard Medical School, Boston, Massachusetts 02115, USA
    687 Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    688 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    689 rdf:type schema:Organization
    690 https://www.grid.ac/institutes/grid.239552.a schema:alternateName Children's Hospital of Philadelphia
    691 schema:name Children’s Hospital, Philadelphia, Pennsylvania 19104, USA
    692 rdf:type schema:Organization
    693 https://www.grid.ac/institutes/grid.2515.3 schema:alternateName Boston Children's Hospital
    694 schema:name Boston Children’s Hospital, Boston, Massachusetts 02115, USA
    695 Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
    696 Harvard Medical School, Boston, Massachusetts 02115, USA
    697 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    698 rdf:type schema:Organization
    699 https://www.grid.ac/institutes/grid.280664.e schema:alternateName National Institute of Environmental Health Sciences
    700 schema:name Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Durham, North Carolina 27709, USA
    701 rdf:type schema:Organization
    702 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
    703 schema:name Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    704 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    705 rdf:type schema:Organization
    706 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
    707 schema:name Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    708 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    709 rdf:type schema:Organization
    710 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    711 schema:name Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
    712 Harvard Medical School, Boston, Massachusetts 02115, USA
    713 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    714 rdf:type schema:Organization
    715 https://www.grid.ac/institutes/grid.411160.3 schema:alternateName Hospital Sant Joan de Déu Barcelona
    716 schema:name Department of Pediatric Oncology, Hospital Sant Joan de Déu, Barcelona 08950, Spain
    717 rdf:type schema:Organization
    718 https://www.grid.ac/institutes/grid.413575.1 schema:alternateName Howard Hughes Medical Institute
    719 schema:name Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
    720 Harvard Medical School, Boston, Massachusetts 02115, USA
    721 Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
    722 Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    723 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    724 rdf:type schema:Organization
    725 https://www.grid.ac/institutes/grid.433818.5 schema:alternateName Yale Cancer Center
    726 schema:name Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
    727 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    728 Yale Cancer Center, Department of Hematology, New Haven, Connecticut 06510, USA
    729 rdf:type schema:Organization
    730 https://www.grid.ac/institutes/grid.452651.1 schema:alternateName National Institute of Genomic Medicine
    731 schema:name Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico
    732 rdf:type schema:Organization
    733 https://www.grid.ac/institutes/grid.497611.c schema:alternateName Blueprint Medicines (United States)
    734 schema:name Blueprint Medicines, Cambridge, Massachusetts 02142, USA
    735 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    736 rdf:type schema:Organization
    737 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
    738 schema:name Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    739 Harvard Medical School, Boston, Massachusetts 02115, USA
    740 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    741 rdf:type schema:Organization
    742 https://www.grid.ac/institutes/grid.65499.37 schema:alternateName Dana–Farber Cancer Institute
    743 schema:name Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA
    744 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    745 rdf:type schema:Organization
    746 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
    747 schema:name The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    748 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...