Ontology type: schema:ScholarlyArticle
2013-03
AUTHORSThomas B. Hansen, Trine I. Jensen, Bettina H. Clausen, Jesper B. Bramsen, Bente Finsen, Christian K. Damgaard, Jørgen Kjems
ABSTRACTMicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that act by direct base pairing to target sites within untranslated regions of messenger RNAs. Recently, miRNA activity has been shown to be affected by the presence of miRNA sponge transcripts, the so-called competing endogenous RNA in humans and target mimicry in plants. We previously identified a highly expressed circular RNA (circRNA) in human and mouse brain. Here we show that this circRNA acts as a miR-7 sponge; we term this circular transcript ciRS-7 (circular RNA sponge for miR-7). ciRS-7 contains more than 70 selectively conserved miRNA target sites, and it is highly and widely associated with Argonaute (AGO) proteins in a miR-7-dependent manner. Although the circRNA is completely resistant to miRNA-mediated target destabilization, it strongly suppresses miR-7 activity, resulting in increased levels of miR-7 targets. In the mouse brain, we observe overlapping co-expression of ciRS-7 and miR-7, particularly in neocortical and hippocampal neurons, suggesting a high degree of endogenous interaction. We further show that the testis-specific circRNA, sex-determining region Y (Sry), serves as a miR-138 sponge, suggesting that miRNA sponge effects achieved by circRNA formation are a general phenomenon. This study serves as the first, to our knowledge, functional analysis of a naturally expressed circRNA. More... »
PAGES384
http://scigraph.springernature.com/pub.10.1038/nature11993
DOIhttp://dx.doi.org/10.1038/nature11993
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1050833467
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23446346
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Argonaute Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HEK293 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HeLa Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred C57BL",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "MicroRNAs",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sex-Determining Region Y Protein",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Aarhus University",
"id": "https://www.grid.ac/institutes/grid.7048.b",
"name": [
"Department of Molecular Biology and Genetics, Aarhus University, C.F. M\u00f8llers Alle 3, 8000C, Aarhus, Denmark"
],
"type": "Organization"
},
"familyName": "Hansen",
"givenName": "Thomas B.",
"id": "sg:person.0720515064.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720515064.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aarhus University",
"id": "https://www.grid.ac/institutes/grid.7048.b",
"name": [
"Department of Molecular Biology and Genetics, Aarhus University, C.F. M\u00f8llers Alle 3, 8000C, Aarhus, Denmark"
],
"type": "Organization"
},
"familyName": "Jensen",
"givenName": "Trine I.",
"id": "sg:person.0606314447.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606314447.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Southern Denmark",
"id": "https://www.grid.ac/institutes/grid.10825.3e",
"name": [
"Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsl\u00f8wsvej 25, 5000C, Odense, Denmark"
],
"type": "Organization"
},
"familyName": "Clausen",
"givenName": "Bettina H.",
"id": "sg:person.01105541111.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105541111.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aarhus University",
"id": "https://www.grid.ac/institutes/grid.7048.b",
"name": [
"Department of Molecular Biology and Genetics, Aarhus University, C.F. M\u00f8llers Alle 3, 8000C, Aarhus, Denmark",
"Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav\u2009Wiedsvej 14, 8000C, Aarhus, Denmark"
],
"type": "Organization"
},
"familyName": "Bramsen",
"givenName": "Jesper B.",
"id": "sg:person.01122005666.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122005666.89"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Southern Denmark",
"id": "https://www.grid.ac/institutes/grid.10825.3e",
"name": [
"Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsl\u00f8wsvej 25, 5000C, Odense, Denmark"
],
"type": "Organization"
},
"familyName": "Finsen",
"givenName": "Bente",
"id": "sg:person.01021713024.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021713024.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aarhus University",
"id": "https://www.grid.ac/institutes/grid.7048.b",
"name": [
"Department of Molecular Biology and Genetics, Aarhus University, C.F. M\u00f8llers Alle 3, 8000C, Aarhus, Denmark"
],
"type": "Organization"
},
"familyName": "Damgaard",
"givenName": "Christian K.",
"id": "sg:person.01153372710.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153372710.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aarhus University",
"id": "https://www.grid.ac/institutes/grid.7048.b",
"name": [
"Department of Molecular Biology and Genetics, Aarhus University, C.F. M\u00f8llers Alle 3, 8000C, Aarhus, Denmark",
"Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav\u2009Wiedsvej 14, 8000C, Aarhus, Denmark"
],
"type": "Organization"
},
"familyName": "Kjems",
"givenName": "J\u00f8rgen",
"id": "sg:person.01100525057.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100525057.10"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/ng2079",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000182181",
"https://doi.org/10.1038/ng2079"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/emboj/20.23.6877",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004775429"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0378-1119(95)00639-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005590983"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20100859",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008685778"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20100859",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008685778"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20100859",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008685778"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(93)90279-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008757749"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0030733",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008798616"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0030733",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008798616"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1274",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014076938",
"https://doi.org/10.1038/ncb1274"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb1274",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014076938",
"https://doi.org/10.1038/ncb1274"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1282305",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015909772"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00221-006-0526-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016720226",
"https://doi.org/10.1007/s00221-006-0526-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00221-006-0526-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016720226",
"https://doi.org/10.1007/s00221-006-0526-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-2103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016862117"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2011.09.041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019142569"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2009.01.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023682432"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth1079",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028333288",
"https://doi.org/10.1038/nmeth1079"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/gkq1316",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034030947"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1742-2094-5-46",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036279804",
"https://doi.org/10.1186/1742-2094-5-46"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1261/rna.783108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038932587"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0906277106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040496385"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2011.09.028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041816546"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2011.09.032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044541376"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045137706",
"https://doi.org/10.1038/nature08170"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045137706",
"https://doi.org/10.1038/nature08170"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/emboj.2011.359",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046169131"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-6639",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046600339"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0002126",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049237260"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09144",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050391113",
"https://doi.org/10.1038/nature09144"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09144",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050391113",
"https://doi.org/10.1038/nature09144"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2011.09.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053383331"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1073827",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062446723"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082424111",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082924860",
"type": "CreativeWork"
}
],
"datePublished": "2013-03",
"datePublishedReg": "2013-03-01",
"description": "MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that act by direct base pairing to target sites within untranslated regions of messenger RNAs. Recently, miRNA activity has been shown to be affected by the presence of miRNA sponge transcripts, the so-called competing endogenous RNA in humans and target mimicry in plants. We previously identified a highly expressed circular RNA (circRNA) in human and mouse brain. Here we show that this circRNA acts as a miR-7 sponge; we term this circular transcript ciRS-7 (circular RNA sponge for miR-7). ciRS-7 contains more than 70 selectively conserved miRNA target sites, and it is highly and widely associated with Argonaute (AGO) proteins in a miR-7-dependent manner. Although the circRNA is completely resistant to miRNA-mediated target destabilization, it strongly suppresses miR-7 activity, resulting in increased levels of miR-7 targets. In the mouse brain, we observe overlapping co-expression of ciRS-7 and miR-7, particularly in neocortical and hippocampal neurons, suggesting a high degree of endogenous interaction. We further show that the testis-specific circRNA, sex-determining region Y (Sry), serves as a miR-138 sponge, suggesting that miRNA sponge effects achieved by circRNA formation are a general phenomenon. This study serves as the first, to our knowledge, functional analysis of a naturally expressed circRNA.",
"genre": "research_article",
"id": "sg:pub.10.1038/nature11993",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0090-0028",
"1476-4687"
],
"name": "Nature",
"type": "Periodical"
},
{
"issueNumber": "7441",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "495"
}
],
"name": "Natural RNA circles function as efficient microRNA sponges",
"pagination": "384",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"f2268c5ee977457f536be55d03f7964f94f888bb3463c876a82ab8d77c80ce69"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"23446346"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0410462"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nature11993"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1050833467"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nature11993",
"https://app.dimensions.ai/details/publication/pub.1050833467"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T17:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000426.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/nature11993"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature11993'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature11993'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature11993'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature11993'
This table displays all metadata directly associated to this object as RDF triples.
256 TRIPLES
21 PREDICATES
70 URIs
34 LITERALS
22 BLANK NODES