Replication stress links structural and numerical cancer chromosomal instability View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02

AUTHORS

Rebecca A. Burrell, Sarah E. McClelland, David Endesfelder, Petra Groth, Marie-Christine Weller, Nadeem Shaikh, Enric Domingo, Nnennaya Kanu, Sally M. Dewhurst, Eva Gronroos, Su Kit Chew, Andrew J. Rowan, Arne Schenk, Michal Sheffer, Michael Howell, Maik Kschischo, Axel Behrens, Thomas Helleday, Jiri Bartek, Ian P. Tomlinson, Charles Swanton

ABSTRACT

Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome number and structure and generates intratumour heterogeneity. CIN is observed in most solid tumours and is associated with both poor prognosis and drug resistance. Understanding a mechanistic basis for CIN is therefore paramount. Here we find evidence for impaired replication fork progression and increased DNA replication stress in CIN(+) colorectal cancer (CRC) cells relative to CIN(-) CRC cells, with structural chromosome abnormalities precipitating chromosome missegregation in mitosis. We identify three new CIN-suppressor genes (PIGN (also known as MCD4), MEX3C (RKHD2) and ZNF516 (KIAA0222)) encoded on chromosome 18q that are subject to frequent copy number loss in CIN(+) CRC. Chromosome 18q loss was temporally associated with aneuploidy onset at the adenoma-carcinoma transition. CIN-suppressor gene silencing leads to DNA replication stress, structural chromosome abnormalities and chromosome missegregation. Supplementing cells with nucleosides, to alleviate replication-associated damage, reduces the frequency of chromosome segregation errors after CIN-suppressor gene silencing, and attenuates segregation errors and DNA damage in CIN(+) cells. These data implicate a central role for replication stress in the generation of structural and numerical CIN, which may inform new therapeutic approaches to limit intratumour heterogeneity. More... »

PAGES

492

References to SciGraph publications

  • 2012-04. A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens in NATURE METHODS
  • 2009-01. DNA copy number alterations correlate with survival of esophageal adenocarcinoma patients in MODERN PATHOLOGY
  • 2011-04. Chromosomes and cancer cells in CHROMOSOME RESEARCH
  • 2012-01-11. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing in NATURE
  • 1998-12. Genetic instabilities in human cancers in NATURE
  • 2005-04. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis in NATURE
  • 2007-10. High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer in GENOME BIOLOGY
  • 2009-06. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis in NATURE CELL BIOLOGY
  • 2012-07. Comprehensive molecular characterization of human colon and rectal cancer in NATURE
  • 2009-11. Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays in GENOME BIOLOGY
  • 2008-12. Classification of chromosome segregation errors in cancer in CHROMOSOMA
  • 2009-12. Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-01-18. DNA breaks and chromosome pulverization from errors in mitosis in NATURE
  • 2000-08. Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2011-03. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress in NATURE CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature11935

    DOI

    http://dx.doi.org/10.1038/nature11935

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009189689

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23446422


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aneuploidy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomal Instability", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosome Segregation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human, Pair 18", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Copy Number Variations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Damage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Replication", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Deletion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Silencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Tumor Suppressor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nucleosides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphotransferases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA-Binding Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Burrell", 
            "givenName": "Rebecca A.", 
            "id": "sg:person.01072376652.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072376652.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McClelland", 
            "givenName": "Sarah E.", 
            "id": "sg:person.01140512052.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140512052.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK", 
                "University of Applied Sciences Koblenz, RheinAhrCampus, Department of Mathematics and Technology, Joseph-Rovan-Allee 2, 53424 Remagen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Endesfelder", 
            "givenName": "David", 
            "id": "sg:person.01200512626.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200512626.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Karolinska Institute", 
              "id": "https://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Box 1031, Stockholm S-171 21, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Groth", 
            "givenName": "Petra", 
            "id": "sg:person.01005211431.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005211431.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Karolinska Institute", 
              "id": "https://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Box 1031, Stockholm S-171 21, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weller", 
            "givenName": "Marie-Christine", 
            "id": "sg:person.01323053652.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323053652.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shaikh", 
            "givenName": "Nadeem", 
            "id": "sg:person.01371167052.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371167052.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Centre for Human Genetics", 
              "id": "https://www.grid.ac/institutes/grid.270683.8", 
              "name": [
                "Molecular and Population Genetics and NIHR Biomedical Research Centre, The Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Domingo", 
            "givenName": "Enric", 
            "id": "sg:person.0753633043.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753633043.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanu", 
            "givenName": "Nnennaya", 
            "id": "sg:person.0755513155.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755513155.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dewhurst", 
            "givenName": "Sally M.", 
            "id": "sg:person.0714201412.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714201412.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gronroos", 
            "givenName": "Eva", 
            "id": "sg:person.0664034155.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664034155.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College London", 
              "id": "https://www.grid.ac/institutes/grid.83440.3b", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK", 
                "UCL Cancer Institute, Paul O\u2019Gorman Building, Huntley Street, London WC1E 6BT, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chew", 
            "givenName": "Su Kit", 
            "id": "sg:person.01337153725.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337153725.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rowan", 
            "givenName": "Andrew J.", 
            "id": "sg:person.0700015771.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700015771.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "University of Applied Sciences Koblenz, RheinAhrCampus, Department of Mathematics and Technology, Joseph-Rovan-Allee 2, 53424 Remagen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schenk", 
            "givenName": "Arne", 
            "id": "sg:person.01144656412.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144656412.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Weizmann Institute of Science", 
              "id": "https://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sheffer", 
            "givenName": "Michal", 
            "id": "sg:person.0610204552.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610204552.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Howell", 
            "givenName": "Michael", 
            "id": "sg:person.01261105012.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261105012.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "University of Applied Sciences Koblenz, RheinAhrCampus, Department of Mathematics and Technology, Joseph-Rovan-Allee 2, 53424 Remagen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kschischo", 
            "givenName": "Maik", 
            "id": "sg:person.01145623447.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145623447.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Behrens", 
            "givenName": "Axel", 
            "id": "sg:person.01243644755.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243644755.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Karolinska Institute", 
              "id": "https://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Box 1031, Stockholm S-171 21, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Helleday", 
            "givenName": "Thomas", 
            "id": "sg:person.01040307025.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040307025.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Palack\u00fd University, Olomouc", 
              "id": "https://www.grid.ac/institutes/grid.10979.36", 
              "name": [
                "Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark", 
                "Institute of Molecular and Translational Medicine, Palacky University Olomouc, CZ-775 15, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bartek", 
            "givenName": "Jiri", 
            "id": "sg:person.01167156053.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167156053.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome Centre for Human Genetics", 
              "id": "https://www.grid.ac/institutes/grid.270683.8", 
              "name": [
                "Molecular and Population Genetics and NIHR Biomedical Research Centre, The Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tomlinson", 
            "givenName": "Ian P.", 
            "id": "sg:person.01177572330.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177572330.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College London", 
              "id": "https://www.grid.ac/institutes/grid.83440.3b", 
              "name": [
                "Cancer Research UK London Research Institute, 44 Lincoln\u2019s Inn Fields, London WC2A 3LY, UK", 
                "UCL Cancer Institute, Paul O\u2019Gorman Building, Huntley Street, London WC1E 6BT, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Swanton", 
            "givenName": "Charles", 
            "id": "sg:person.0610422247.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610422247.65"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1053/j.gastro.2008.10.086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000121753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003206661", 
              "https://doi.org/10.1038/nature10738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1140735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004337817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006057690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.20749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006057690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2011.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006070582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008061452", 
              "https://doi.org/10.1038/nature10802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-2178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009837046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010619765", 
              "https://doi.org/10.1038/nature11252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1542-3565(05)00618-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011092690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1542-3565(05)00618-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011092690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2009-10-11-r128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014476773", 
              "https://doi.org/10.1186/gb-2009-10-11-r128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015009843", 
              "https://doi.org/10.1038/nmeth.1898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-008-0169-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015226870", 
              "https://doi.org/10.1007/s00412-008-0169-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-008-0169-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015226870", 
              "https://doi.org/10.1007/s00412-008-0169-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201011083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015517042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2010.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020271641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022562579", 
              "https://doi.org/10.1038/nsmb.1725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molonc.2011.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023940657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2010.01.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026724662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0008821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028523614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1113205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031166230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1210214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031573445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.03.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031796760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/25292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033871070", 
              "https://doi.org/10.1038/25292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/25292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033871070", 
              "https://doi.org/10.1038/25292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0710052104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034562854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-3604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034584563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037091000", 
              "https://doi.org/10.1038/nature03482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037091000", 
              "https://doi.org/10.1038/nature03482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037394989", 
              "https://doi.org/10.1038/ncb1882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10577-010-9179-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038110804", 
              "https://doi.org/10.1007/s10577-010-9179-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2008.150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038936419", 
              "https://doi.org/10.1038/modpathol.2008.150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2000.02171.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039155839", 
              "https://doi.org/10.1111/j.1572-0241.2000.02171.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2007-8-10-r215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040885527", 
              "https://doi.org/10.1186/gb-2007-8-10-r215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041212899", 
              "https://doi.org/10.1038/ncb2201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bti525", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045066552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/biostatistics/kxp045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046814516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200712029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048708351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2012.61", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052716727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/106652701753216530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059204907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.19.9513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075003252", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-02", 
        "datePublishedReg": "2013-02-01", 
        "description": "Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome number and structure and generates intratumour heterogeneity. CIN is observed in most solid tumours and is associated with both poor prognosis and drug resistance. Understanding a mechanistic basis for CIN is therefore paramount. Here we find evidence for impaired replication fork progression and increased DNA replication stress in CIN(+) colorectal cancer (CRC) cells relative to CIN(-) CRC cells, with structural chromosome abnormalities precipitating chromosome missegregation in mitosis. We identify three new CIN-suppressor genes (PIGN (also known as MCD4), MEX3C (RKHD2) and ZNF516 (KIAA0222)) encoded on chromosome 18q that are subject to frequent copy number loss in CIN(+) CRC. Chromosome 18q loss was temporally associated with aneuploidy onset at the adenoma-carcinoma transition. CIN-suppressor gene silencing leads to DNA replication stress, structural chromosome abnormalities and chromosome missegregation. Supplementing cells with nucleosides, to alleviate replication-associated damage, reduces the frequency of chromosome segregation errors after CIN-suppressor gene silencing, and attenuates segregation errors and DNA damage in CIN(+) cells. These data implicate a central role for replication stress in the generation of structural and numerical CIN, which may inform new therapeutic approaches to limit intratumour heterogeneity.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature11935", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5147094", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3636942", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5136937", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5147389", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5135654", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7438", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "494"
          }
        ], 
        "name": "Replication stress links structural and numerical cancer chromosomal instability", 
        "pagination": "492", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2bc73ae01ec7f9ce2784305fabec2e9d1d017c3a309c42510be2a907de59c89b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23446422"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature11935"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1009189689"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature11935", 
          "https://app.dimensions.ai/details/publication/pub.1009189689"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T20:34", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000422.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature11935"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature11935'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature11935'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature11935'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature11935'


     

    This table displays all metadata directly associated to this object as RDF triples.

    437 TRIPLES      21 PREDICATES      84 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature11935 schema:about N084a25b8b2b942b4b0fa5e600ea37d95
    2 N08caa35907bf41ef96756629049a40a9
    3 N09e74f7d0d584a97bf1b88fdf656688c
    4 N0c086a2c05ac466b843cb8349fcc6597
    5 N286b57bdcc284c08860a8347d76c1a19
    6 N2df35de5f9424d3781c81efbfa3bb910
    7 N3feabc0e1aa54e54a6bb9a4a6096e132
    8 N564ffca0dd0b4d0bb2cc4d4bd76307be
    9 N7dd79f91769f4776ae13b0780c65f0f7
    10 N8afec04bac6e4b4fad941e29128895ff
    11 N95ea8e026f664284aab8b9bb9ced3660
    12 N996e3d68d68042a2abd0efaeb4c0cbca
    13 Na86793a3da464ab99e3d9f9f07c8f49c
    14 Nba0862f947944587bb4297824f1771e7
    15 Nbec53bb2fab148c6a1cc7dcd7b1d97ef
    16 Ndadbdfeadb5b4f5cbdddb2ab683d64ff
    17 Ne8aaa517ba3646a797d0b887983f574d
    18 anzsrc-for:06
    19 anzsrc-for:0604
    20 schema:author N57ee632c15e448eaaef0a1df9ba776cf
    21 schema:citation sg:pub.10.1007/s00412-008-0169-1
    22 sg:pub.10.1007/s10577-010-9179-y
    23 sg:pub.10.1038/25292
    24 sg:pub.10.1038/modpathol.2008.150
    25 sg:pub.10.1038/nature03482
    26 sg:pub.10.1038/nature10738
    27 sg:pub.10.1038/nature10802
    28 sg:pub.10.1038/nature11252
    29 sg:pub.10.1038/ncb1882
    30 sg:pub.10.1038/ncb2201
    31 sg:pub.10.1038/nmeth.1898
    32 sg:pub.10.1038/nsmb.1725
    33 sg:pub.10.1111/j.1572-0241.2000.02171.x
    34 sg:pub.10.1186/gb-2007-8-10-r215
    35 sg:pub.10.1186/gb-2009-10-11-r128
    36 https://app.dimensions.ai/details/publication/pub.1075003252
    37 https://doi.org/10.1002/gcc.20749
    38 https://doi.org/10.1016/j.cell.2011.03.044
    39 https://doi.org/10.1016/j.jmb.2010.07.010
    40 https://doi.org/10.1016/j.molcel.2011.02.006
    41 https://doi.org/10.1016/j.molonc.2011.05.002
    42 https://doi.org/10.1016/s1542-3565(05)00618-x
    43 https://doi.org/10.1038/embor.2012.61
    44 https://doi.org/10.1053/j.gastro.2008.10.086
    45 https://doi.org/10.1053/j.gastro.2010.01.033
    46 https://doi.org/10.1056/nejmoa1113205
    47 https://doi.org/10.1073/pnas.0710052104
    48 https://doi.org/10.1083/jcb.200712029
    49 https://doi.org/10.1083/jcb.201011083
    50 https://doi.org/10.1089/106652701753216530
    51 https://doi.org/10.1093/bioinformatics/bti525
    52 https://doi.org/10.1093/biostatistics/kxp045
    53 https://doi.org/10.1126/science.1140735
    54 https://doi.org/10.1126/science.1210214
    55 https://doi.org/10.1158/0008-5472.can-06-2178
    56 https://doi.org/10.1158/0008-5472.can-10-3604
    57 https://doi.org/10.1371/journal.pone.0008821
    58 https://doi.org/10.4161/cc.8.19.9513
    59 schema:datePublished 2013-02
    60 schema:datePublishedReg 2013-02-01
    61 schema:description Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome number and structure and generates intratumour heterogeneity. CIN is observed in most solid tumours and is associated with both poor prognosis and drug resistance. Understanding a mechanistic basis for CIN is therefore paramount. Here we find evidence for impaired replication fork progression and increased DNA replication stress in CIN(+) colorectal cancer (CRC) cells relative to CIN(-) CRC cells, with structural chromosome abnormalities precipitating chromosome missegregation in mitosis. We identify three new CIN-suppressor genes (PIGN (also known as MCD4), MEX3C (RKHD2) and ZNF516 (KIAA0222)) encoded on chromosome 18q that are subject to frequent copy number loss in CIN(+) CRC. Chromosome 18q loss was temporally associated with aneuploidy onset at the adenoma-carcinoma transition. CIN-suppressor gene silencing leads to DNA replication stress, structural chromosome abnormalities and chromosome missegregation. Supplementing cells with nucleosides, to alleviate replication-associated damage, reduces the frequency of chromosome segregation errors after CIN-suppressor gene silencing, and attenuates segregation errors and DNA damage in CIN(+) cells. These data implicate a central role for replication stress in the generation of structural and numerical CIN, which may inform new therapeutic approaches to limit intratumour heterogeneity.
    62 schema:genre research_article
    63 schema:inLanguage en
    64 schema:isAccessibleForFree true
    65 schema:isPartOf N379302d78d974b0588f0b0628dfe0b9e
    66 Neadbf2a5b7ab4313af33dc1535faad22
    67 sg:journal.1018957
    68 schema:name Replication stress links structural and numerical cancer chromosomal instability
    69 schema:pagination 492
    70 schema:productId N71500207875443c2b8c2e36e8058f561
    71 Na96e7ff718ea45b98fce66768a7102dc
    72 Nc332b4dfa7b949818a59832b0325f4d4
    73 Nd37a70c47a2349459a0bb28a5c429bbd
    74 Ne89ddb5484734b559dd00c38a7a20aec
    75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009189689
    76 https://doi.org/10.1038/nature11935
    77 schema:sdDatePublished 2019-04-10T20:34
    78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    79 schema:sdPublisher Nffcfe0099a0b49b086b544642700d9b5
    80 schema:url https://www.nature.com/articles/nature11935
    81 sgo:license sg:explorer/license/
    82 sgo:sdDataset articles
    83 rdf:type schema:ScholarlyArticle
    84 N084a25b8b2b942b4b0fa5e600ea37d95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Chromosomal Instability
    86 rdf:type schema:DefinedTerm
    87 N08caa35907bf41ef96756629049a40a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    88 schema:name DNA Damage
    89 rdf:type schema:DefinedTerm
    90 N09e74f7d0d584a97bf1b88fdf656688c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Gene Deletion
    92 rdf:type schema:DefinedTerm
    93 N0c086a2c05ac466b843cb8349fcc6597 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Phosphotransferases
    95 rdf:type schema:DefinedTerm
    96 N16827afeb7eb43abb50fa4e8513c0f01 schema:name University of Applied Sciences Koblenz, RheinAhrCampus, Department of Mathematics and Technology, Joseph-Rovan-Allee 2, 53424 Remagen, Germany
    97 rdf:type schema:Organization
    98 N286b57bdcc284c08860a8347d76c1a19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Nucleosides
    100 rdf:type schema:DefinedTerm
    101 N2df35de5f9424d3781c81efbfa3bb910 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Chromosomes, Human, Pair 18
    103 rdf:type schema:DefinedTerm
    104 N379302d78d974b0588f0b0628dfe0b9e schema:volumeNumber 494
    105 rdf:type schema:PublicationVolume
    106 N3feabc0e1aa54e54a6bb9a4a6096e132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Gene Silencing
    108 rdf:type schema:DefinedTerm
    109 N526560f52d644e88aecec946ff8947ee rdf:first sg:person.01145623447.52
    110 rdf:rest N69776cdc71514257bd78c9a4c39e877a
    111 N564ffca0dd0b4d0bb2cc4d4bd76307be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Aneuploidy
    113 rdf:type schema:DefinedTerm
    114 N57ee632c15e448eaaef0a1df9ba776cf rdf:first sg:person.01072376652.61
    115 rdf:rest N76dedffa4dd94b90b173778f6f108a07
    116 N5fb81fd5cc024c91b5e536df30393569 rdf:first sg:person.01337153725.28
    117 rdf:rest N620690390fb44f76b347d3ce17c97bec
    118 N620690390fb44f76b347d3ce17c97bec rdf:first sg:person.0700015771.26
    119 rdf:rest Nc2c3884dc2ee46fdbbd0ed2bb455dbb4
    120 N6693b3117c7e4a98b62d0a86bc60a3d9 rdf:first sg:person.0755513155.13
    121 rdf:rest N9db1f9c7dc834de48c31fa4d92fe25d5
    122 N687b60ef6ff9445792d38a12023d1b3d rdf:first sg:person.01005211431.00
    123 rdf:rest Nd58ac8bf2c6c48ecaccf6b6c3db344c3
    124 N69776cdc71514257bd78c9a4c39e877a rdf:first sg:person.01243644755.05
    125 rdf:rest Na2cb1c4292a6480f81544caad7b5c087
    126 N6abd299bb1be4a3291b595b38441b986 rdf:first sg:person.01261105012.50
    127 rdf:rest N526560f52d644e88aecec946ff8947ee
    128 N71500207875443c2b8c2e36e8058f561 schema:name dimensions_id
    129 schema:value pub.1009189689
    130 rdf:type schema:PropertyValue
    131 N76dedffa4dd94b90b173778f6f108a07 rdf:first sg:person.01140512052.57
    132 rdf:rest Nb17c7eda3308436caaa1193a0a2dcc69
    133 N7dd79f91769f4776ae13b0780c65f0f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Chromosome Segregation
    135 rdf:type schema:DefinedTerm
    136 N8afec04bac6e4b4fad941e29128895ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Cell Line, Tumor
    138 rdf:type schema:DefinedTerm
    139 N95ea8e026f664284aab8b9bb9ced3660 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name RNA-Binding Proteins
    141 rdf:type schema:DefinedTerm
    142 N996e3d68d68042a2abd0efaeb4c0cbca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name DNA Copy Number Variations
    144 rdf:type schema:DefinedTerm
    145 N9db1f9c7dc834de48c31fa4d92fe25d5 rdf:first sg:person.0714201412.62
    146 rdf:rest Nee2fcb5a7b324217ac951f2f8ebb6999
    147 Na2cb1c4292a6480f81544caad7b5c087 rdf:first sg:person.01040307025.97
    148 rdf:rest Nade7b70282fb412587d89f657fef3ea8
    149 Na86793a3da464ab99e3d9f9f07c8f49c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Genes, Tumor Suppressor
    151 rdf:type schema:DefinedTerm
    152 Na92bee57889d4f03982197aa530a4fb6 rdf:first sg:person.0753633043.29
    153 rdf:rest N6693b3117c7e4a98b62d0a86bc60a3d9
    154 Na96e7ff718ea45b98fce66768a7102dc schema:name nlm_unique_id
    155 schema:value 0410462
    156 rdf:type schema:PropertyValue
    157 Nade7b70282fb412587d89f657fef3ea8 rdf:first sg:person.01167156053.40
    158 rdf:rest Naff9abbbaec34644b43418759f305a08
    159 Naff9abbbaec34644b43418759f305a08 rdf:first sg:person.01177572330.00
    160 rdf:rest Nd92453e8a8fd44eb82db8a6b07907ad5
    161 Nb17c7eda3308436caaa1193a0a2dcc69 rdf:first sg:person.01200512626.38
    162 rdf:rest N687b60ef6ff9445792d38a12023d1b3d
    163 Nba0862f947944587bb4297824f1771e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Mitosis
    165 rdf:type schema:DefinedTerm
    166 Nbec53bb2fab148c6a1cc7dcd7b1d97ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Colorectal Neoplasms
    168 rdf:type schema:DefinedTerm
    169 Nc2c3884dc2ee46fdbbd0ed2bb455dbb4 rdf:first sg:person.01144656412.67
    170 rdf:rest Ne8e409593e4e40a7a5a66979cee9b10d
    171 Nc332b4dfa7b949818a59832b0325f4d4 schema:name readcube_id
    172 schema:value 2bc73ae01ec7f9ce2784305fabec2e9d1d017c3a309c42510be2a907de59c89b
    173 rdf:type schema:PropertyValue
    174 Nd37a70c47a2349459a0bb28a5c429bbd schema:name doi
    175 schema:value 10.1038/nature11935
    176 rdf:type schema:PropertyValue
    177 Nd58ac8bf2c6c48ecaccf6b6c3db344c3 rdf:first sg:person.01323053652.55
    178 rdf:rest Nd893f2e2c61245a48b3b21148f78c763
    179 Nd893f2e2c61245a48b3b21148f78c763 rdf:first sg:person.01371167052.32
    180 rdf:rest Na92bee57889d4f03982197aa530a4fb6
    181 Nd92453e8a8fd44eb82db8a6b07907ad5 rdf:first sg:person.0610422247.65
    182 rdf:rest rdf:nil
    183 Ndadbdfeadb5b4f5cbdddb2ab683d64ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name DNA Replication
    185 rdf:type schema:DefinedTerm
    186 Ne89ddb5484734b559dd00c38a7a20aec schema:name pubmed_id
    187 schema:value 23446422
    188 rdf:type schema:PropertyValue
    189 Ne8aaa517ba3646a797d0b887983f574d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Humans
    191 rdf:type schema:DefinedTerm
    192 Ne8e409593e4e40a7a5a66979cee9b10d rdf:first sg:person.0610204552.65
    193 rdf:rest N6abd299bb1be4a3291b595b38441b986
    194 Neadbf2a5b7ab4313af33dc1535faad22 schema:issueNumber 7438
    195 rdf:type schema:PublicationIssue
    196 Nee2fcb5a7b324217ac951f2f8ebb6999 rdf:first sg:person.0664034155.27
    197 rdf:rest N5fb81fd5cc024c91b5e536df30393569
    198 Nee3b9f4649314aa3813ac0ab8961ad78 schema:name University of Applied Sciences Koblenz, RheinAhrCampus, Department of Mathematics and Technology, Joseph-Rovan-Allee 2, 53424 Remagen, Germany
    199 rdf:type schema:Organization
    200 Nffcfe0099a0b49b086b544642700d9b5 schema:name Springer Nature - SN SciGraph project
    201 rdf:type schema:Organization
    202 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Biological Sciences
    204 rdf:type schema:DefinedTerm
    205 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    206 schema:name Genetics
    207 rdf:type schema:DefinedTerm
    208 sg:grant.3636942 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11935
    209 rdf:type schema:MonetaryGrant
    210 sg:grant.5135654 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11935
    211 rdf:type schema:MonetaryGrant
    212 sg:grant.5136937 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11935
    213 rdf:type schema:MonetaryGrant
    214 sg:grant.5147094 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11935
    215 rdf:type schema:MonetaryGrant
    216 sg:grant.5147389 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11935
    217 rdf:type schema:MonetaryGrant
    218 sg:journal.1018957 schema:issn 0090-0028
    219 1476-4687
    220 schema:name Nature
    221 rdf:type schema:Periodical
    222 sg:person.01005211431.00 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
    223 schema:familyName Groth
    224 schema:givenName Petra
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005211431.00
    226 rdf:type schema:Person
    227 sg:person.01040307025.97 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
    228 schema:familyName Helleday
    229 schema:givenName Thomas
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040307025.97
    231 rdf:type schema:Person
    232 sg:person.01072376652.61 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    233 schema:familyName Burrell
    234 schema:givenName Rebecca A.
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072376652.61
    236 rdf:type schema:Person
    237 sg:person.01140512052.57 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    238 schema:familyName McClelland
    239 schema:givenName Sarah E.
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140512052.57
    241 rdf:type schema:Person
    242 sg:person.01144656412.67 schema:affiliation N16827afeb7eb43abb50fa4e8513c0f01
    243 schema:familyName Schenk
    244 schema:givenName Arne
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144656412.67
    246 rdf:type schema:Person
    247 sg:person.01145623447.52 schema:affiliation Nee3b9f4649314aa3813ac0ab8961ad78
    248 schema:familyName Kschischo
    249 schema:givenName Maik
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145623447.52
    251 rdf:type schema:Person
    252 sg:person.01167156053.40 schema:affiliation https://www.grid.ac/institutes/grid.10979.36
    253 schema:familyName Bartek
    254 schema:givenName Jiri
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167156053.40
    256 rdf:type schema:Person
    257 sg:person.01177572330.00 schema:affiliation https://www.grid.ac/institutes/grid.270683.8
    258 schema:familyName Tomlinson
    259 schema:givenName Ian P.
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177572330.00
    261 rdf:type schema:Person
    262 sg:person.01200512626.38 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    263 schema:familyName Endesfelder
    264 schema:givenName David
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200512626.38
    266 rdf:type schema:Person
    267 sg:person.01243644755.05 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    268 schema:familyName Behrens
    269 schema:givenName Axel
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243644755.05
    271 rdf:type schema:Person
    272 sg:person.01261105012.50 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    273 schema:familyName Howell
    274 schema:givenName Michael
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261105012.50
    276 rdf:type schema:Person
    277 sg:person.01323053652.55 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
    278 schema:familyName Weller
    279 schema:givenName Marie-Christine
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323053652.55
    281 rdf:type schema:Person
    282 sg:person.01337153725.28 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
    283 schema:familyName Chew
    284 schema:givenName Su Kit
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337153725.28
    286 rdf:type schema:Person
    287 sg:person.01371167052.32 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    288 schema:familyName Shaikh
    289 schema:givenName Nadeem
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371167052.32
    291 rdf:type schema:Person
    292 sg:person.0610204552.65 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
    293 schema:familyName Sheffer
    294 schema:givenName Michal
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610204552.65
    296 rdf:type schema:Person
    297 sg:person.0610422247.65 schema:affiliation https://www.grid.ac/institutes/grid.83440.3b
    298 schema:familyName Swanton
    299 schema:givenName Charles
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610422247.65
    301 rdf:type schema:Person
    302 sg:person.0664034155.27 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    303 schema:familyName Gronroos
    304 schema:givenName Eva
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664034155.27
    306 rdf:type schema:Person
    307 sg:person.0700015771.26 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    308 schema:familyName Rowan
    309 schema:givenName Andrew J.
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700015771.26
    311 rdf:type schema:Person
    312 sg:person.0714201412.62 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    313 schema:familyName Dewhurst
    314 schema:givenName Sally M.
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714201412.62
    316 rdf:type schema:Person
    317 sg:person.0753633043.29 schema:affiliation https://www.grid.ac/institutes/grid.270683.8
    318 schema:familyName Domingo
    319 schema:givenName Enric
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753633043.29
    321 rdf:type schema:Person
    322 sg:person.0755513155.13 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    323 schema:familyName Kanu
    324 schema:givenName Nnennaya
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755513155.13
    326 rdf:type schema:Person
    327 sg:pub.10.1007/s00412-008-0169-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015226870
    328 https://doi.org/10.1007/s00412-008-0169-1
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1007/s10577-010-9179-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1038110804
    331 https://doi.org/10.1007/s10577-010-9179-y
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/25292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033871070
    334 https://doi.org/10.1038/25292
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/modpathol.2008.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038936419
    337 https://doi.org/10.1038/modpathol.2008.150
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/nature03482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037091000
    340 https://doi.org/10.1038/nature03482
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/nature10738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003206661
    343 https://doi.org/10.1038/nature10738
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nature10802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008061452
    346 https://doi.org/10.1038/nature10802
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
    349 https://doi.org/10.1038/nature11252
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/ncb1882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037394989
    352 https://doi.org/10.1038/ncb1882
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/ncb2201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041212899
    355 https://doi.org/10.1038/ncb2201
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nmeth.1898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015009843
    358 https://doi.org/10.1038/nmeth.1898
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/nsmb.1725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022562579
    361 https://doi.org/10.1038/nsmb.1725
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1111/j.1572-0241.2000.02171.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039155839
    364 https://doi.org/10.1111/j.1572-0241.2000.02171.x
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1186/gb-2007-8-10-r215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040885527
    367 https://doi.org/10.1186/gb-2007-8-10-r215
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1186/gb-2009-10-11-r128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014476773
    370 https://doi.org/10.1186/gb-2009-10-11-r128
    371 rdf:type schema:CreativeWork
    372 https://app.dimensions.ai/details/publication/pub.1075003252 schema:CreativeWork
    373 https://doi.org/10.1002/gcc.20749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006057690
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/j.cell.2011.03.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031796760
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/j.jmb.2010.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020271641
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1016/j.molcel.2011.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006070582
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1016/j.molonc.2011.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023940657
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1016/s1542-3565(05)00618-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011092690
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1038/embor.2012.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052716727
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1053/j.gastro.2008.10.086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000121753
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1053/j.gastro.2010.01.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026724662
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1056/nejmoa1113205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031166230
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1073/pnas.0710052104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034562854
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1083/jcb.200712029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048708351
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1083/jcb.201011083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015517042
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1089/106652701753216530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059204907
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1093/bioinformatics/bti525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045066552
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1093/biostatistics/kxp045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046814516
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1126/science.1140735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004337817
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1126/science.1210214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031573445
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1158/0008-5472.can-06-2178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009837046
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1158/0008-5472.can-10-3604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034584563
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1371/journal.pone.0008821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028523614
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.4161/cc.8.19.9513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300293
    416 rdf:type schema:CreativeWork
    417 https://www.grid.ac/institutes/grid.10979.36 schema:alternateName Palacký University, Olomouc
    418 schema:name Danish Cancer Society Research Center, Strandboulevarden 49, DK-2100 Copenhagen, Denmark
    419 Institute of Molecular and Translational Medicine, Palacky University Olomouc, CZ-775 15, Czech Republic
    420 rdf:type schema:Organization
    421 https://www.grid.ac/institutes/grid.13992.30 schema:alternateName Weizmann Institute of Science
    422 schema:name Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel
    423 rdf:type schema:Organization
    424 https://www.grid.ac/institutes/grid.270683.8 schema:alternateName Wellcome Centre for Human Genetics
    425 schema:name Molecular and Population Genetics and NIHR Biomedical Research Centre, The Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, UK
    426 rdf:type schema:Organization
    427 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
    428 schema:name Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
    429 University of Applied Sciences Koblenz, RheinAhrCampus, Department of Mathematics and Technology, Joseph-Rovan-Allee 2, 53424 Remagen, Germany
    430 rdf:type schema:Organization
    431 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
    432 schema:name Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Box 1031, Stockholm S-171 21, Sweden
    433 rdf:type schema:Organization
    434 https://www.grid.ac/institutes/grid.83440.3b schema:alternateName University College London
    435 schema:name Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
    436 UCL Cancer Institute, Paul O’Gorman Building, Huntley Street, London WC1E 6BT, UK
    437 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...