APOBEC3B is an enzymatic source of mutation in breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02-06

AUTHORS

Michael B. Burns, Lela Lackey, Michael A. Carpenter, Anurag Rathore, Allison M. Land, Brandon Leonard, Eric W. Refsland, Delshanee Kotandeniya, Natalia Tretyakova, Jason B. Nikas, Douglas Yee, Nuri A. Temiz, Duncan E. Donohue, Rebecca M. McDougle, William L. Brown, Emily K. Law, Reuben S. Harris

ABSTRACT

The DNA cytosine deaminase APOBEC3B is shown to be overexpressed and highly active in most breast cancers; deamination by APOBEC3B could serve as an endogenous, continual source of DNA damage leading to mutations, including C-to-T transitions and other aberrations seen in many breast tumours.

PAGES

366-370

Journal

TITLE

Nature

ISSUE

7437

VOLUME

494

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature11881

DOI

http://dx.doi.org/10.1038/nature11881

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032796931

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23389445


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348 schema:name In Silico Research Centers of Excellence, Advanced Biomedical Computing Center, Information Systems Program, SAIC-Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA
349 rdf:type schema:Organization
 




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