Structure of a presenilin family intramembrane aspartate protease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-12-19

AUTHORS

Xiaochun Li, Shangyu Dang, Chuangye Yan, Xinqi Gong, Jiawei Wang, Yigong Shi

ABSTRACT

Presenilin and signal peptide peptidase (SPP) are intramembrane aspartyl proteases that regulate important biological functions in eukaryotes. Mechanistic understanding of presenilin and SPP has been hampered by lack of relevant structural information. Here we report the crystal structure of a presenilin/SPP homologue (PSH) from the archaeon Methanoculleus marisnigri JR1. The protease, comprising nine transmembrane segments (TMs), adopts a previously unreported protein fold. The amino-terminal domain, consisting of TM1-6, forms a horseshoe-shaped structure, surrounding TM7-9 of the carboxy-terminal domain. The two catalytic aspartate residues are located on the cytoplasmic side of TM6 and TM7, spatially close to each other and approximately 8 Å into the lipid membrane surface. Water molecules gain constant access to the catalytic aspartates through a large cavity between the amino- and carboxy-terminal domains. Structural analysis reveals insights into the presenilin/SPP family of intramembrane proteases. More... »

PAGES

56

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature11801

DOI

http://dx.doi.org/10.1038/nature11801

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003146650

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23254940


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