Structure and function of the initially transcribing RNA polymerase II–TFIIB complex View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-11-14

AUTHORS

Sarah Sainsbury, Jürgen Niesser, Patrick Cramer

ABSTRACT

Crystal structures of the Pol II–TFIIB complex in free form and bound by the DNA template and a short RNA product are reported; the latter complex represents an initially transcribing complex, a critical transient state in the pathway from transcription initiation to elongation.

PAGES

437-440

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature11715

DOI

http://dx.doi.org/10.1038/nature11715

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011975079

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23151482


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biocatalysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Subunits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Polymerase II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structure-Activity Relationship", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Templates, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor TFIIB", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Initiation, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Feodor-Lynen-Str. 25, 81377 Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Feodor-Lynen-Str. 25, 81377 Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sainsbury", 
        "givenName": "Sarah", 
        "id": "sg:person.01211613126.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211613126.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Feodor-Lynen-Str. 25, 81377 Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Feodor-Lynen-Str. 25, 81377 Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niesser", 
        "givenName": "J\u00fcrgen", 
        "id": "sg:person.01305734037.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305734037.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Feodor-Lynen-Str. 25, 81377 Munich, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Feodor-Lynen-Str. 25, 81377 Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cramer", 
        "givenName": "Patrick", 
        "id": "sg:person.01045113153.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045113153.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053504154", 
          "https://doi.org/10.1038/nature752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009664227", 
          "https://doi.org/10.1038/nature08548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003871257", 
          "https://doi.org/10.1038/nsmb.2334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048079849", 
          "https://doi.org/10.1038/nature05931"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-11-14", 
    "datePublishedReg": "2012-11-14", 
    "description": "Crystal structures of the Pol II\u2013TFIIB complex in free form and bound by the DNA template and a short RNA product are reported; the latter complex represents an initially transcribing complex, a critical transient state in the pathway from transcription initiation to elongation.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nature11715", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7432", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "493"
      }
    ], 
    "keywords": [
      "transcription initiation", 
      "RNA polymerase", 
      "RNA products", 
      "DNA template", 
      "short RNA products", 
      "complexes", 
      "free form", 
      "polymerase", 
      "crystal structure", 
      "pathway", 
      "Pol", 
      "latter complex", 
      "elongation", 
      "initiation", 
      "structure", 
      "function", 
      "template", 
      "form", 
      "products", 
      "transient state", 
      "state"
    ], 
    "name": "Structure and function of the initially transcribing RNA polymerase II\u2013TFIIB complex", 
    "pagination": "437-440", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011975079"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature11715"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23151482"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature11715", 
      "https://app.dimensions.ai/details/publication/pub.1011975079"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_567.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nature11715"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature11715'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature11715'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature11715'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature11715'


 

This table displays all metadata directly associated to this object as RDF triples.

172 TRIPLES      21 PREDICATES      65 URIs      53 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature11715 schema:about N05b78ad0f0f34a35be417d0a950933c0
2 N07eaeed154fc4fdd8c34ccfd6a51d310
3 N107475629d1c4c948210e1245969cc85
4 N253dcf6c22804357bb03dd7f0b001b89
5 N30f7b0733d9e4acc9e63cfc94241d57e
6 N3dd25f52b19f4e54867d87a5f77ffb8f
7 N41dbbd1f5ac84202ab228b44f14ed9fb
8 N483229b370dd4a618ed994863ee67039
9 N5875a07560a64af6940c792d1f029721
10 N75b51c2ca3c247f186f07aedbc4349b7
11 N8427e136f9164816b8c6d06331322726
12 N8e4b4bb4820340658e15cb5d75f1fff5
13 Naacb99a189a34540b3874ef29f55cc5e
14 Nd3ec16fa3b75483895b23e84c57acb08
15 Ndb437ca111c748d9b57b17edf5c3150e
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author N8392ce63609446ee8b70fd2847c51338
19 schema:citation sg:pub.10.1038/nature05931
20 sg:pub.10.1038/nature08548
21 sg:pub.10.1038/nature752
22 sg:pub.10.1038/nsmb.2334
23 schema:datePublished 2012-11-14
24 schema:datePublishedReg 2012-11-14
25 schema:description Crystal structures of the Pol II–TFIIB complex in free form and bound by the DNA template and a short RNA product are reported; the latter complex represents an initially transcribing complex, a critical transient state in the pathway from transcription initiation to elongation.
26 schema:genre article
27 schema:isAccessibleForFree true
28 schema:isPartOf N5807d41050ed469c8505f90a4a9a8b9e
29 Nfb7a517568dc4366b8d68039790f4bb8
30 sg:journal.1018957
31 schema:keywords DNA template
32 Pol
33 RNA polymerase
34 RNA products
35 complexes
36 crystal structure
37 elongation
38 form
39 free form
40 function
41 initiation
42 latter complex
43 pathway
44 polymerase
45 products
46 short RNA products
47 state
48 structure
49 template
50 transcription initiation
51 transient state
52 schema:name Structure and function of the initially transcribing RNA polymerase II–TFIIB complex
53 schema:pagination 437-440
54 schema:productId N3a3a82c06e4f4a60ab0e7208f75a49f3
55 N8932039c14ad4ace81c86ad57180d6cd
56 Nf0103454de584112a29e2cdb2a3d6207
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011975079
58 https://doi.org/10.1038/nature11715
59 schema:sdDatePublished 2022-09-02T15:56
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N9e198c5bde0340d5adad459c05e68ee2
62 schema:url https://doi.org/10.1038/nature11715
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N05b78ad0f0f34a35be417d0a950933c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Transcription Initiation, Genetic
68 rdf:type schema:DefinedTerm
69 N07eaeed154fc4fdd8c34ccfd6a51d310 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Protein Subunits
71 rdf:type schema:DefinedTerm
72 N107475629d1c4c948210e1245969cc85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Saccharomyces cerevisiae
74 rdf:type schema:DefinedTerm
75 N253dcf6c22804357bb03dd7f0b001b89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name DNA
77 rdf:type schema:DefinedTerm
78 N30f7b0733d9e4acc9e63cfc94241d57e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Models, Molecular
80 rdf:type schema:DefinedTerm
81 N3a3a82c06e4f4a60ab0e7208f75a49f3 schema:name pubmed_id
82 schema:value 23151482
83 rdf:type schema:PropertyValue
84 N3dd25f52b19f4e54867d87a5f77ffb8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name RNA, Messenger
86 rdf:type schema:DefinedTerm
87 N41dbbd1f5ac84202ab228b44f14ed9fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Templates, Genetic
89 rdf:type schema:DefinedTerm
90 N483229b370dd4a618ed994863ee67039 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Molecular Sequence Data
92 rdf:type schema:DefinedTerm
93 N5807d41050ed469c8505f90a4a9a8b9e schema:issueNumber 7432
94 rdf:type schema:PublicationIssue
95 N5875a07560a64af6940c792d1f029721 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Protein Structure, Tertiary
97 rdf:type schema:DefinedTerm
98 N75b51c2ca3c247f186f07aedbc4349b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Crystallography, X-Ray
100 rdf:type schema:DefinedTerm
101 N818e5ebd092f43d9aa3f3aecdc6a3769 rdf:first sg:person.01045113153.17
102 rdf:rest rdf:nil
103 N8392ce63609446ee8b70fd2847c51338 rdf:first sg:person.01211613126.65
104 rdf:rest Nb916a8550133436ab3f2a7fbbe0888d5
105 N8427e136f9164816b8c6d06331322726 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Amino Acid Sequence
107 rdf:type schema:DefinedTerm
108 N8932039c14ad4ace81c86ad57180d6cd schema:name doi
109 schema:value 10.1038/nature11715
110 rdf:type schema:PropertyValue
111 N8e4b4bb4820340658e15cb5d75f1fff5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Biocatalysis
113 rdf:type schema:DefinedTerm
114 N9e198c5bde0340d5adad459c05e68ee2 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 Naacb99a189a34540b3874ef29f55cc5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Structure-Activity Relationship
118 rdf:type schema:DefinedTerm
119 Nb916a8550133436ab3f2a7fbbe0888d5 rdf:first sg:person.01305734037.03
120 rdf:rest N818e5ebd092f43d9aa3f3aecdc6a3769
121 Nd3ec16fa3b75483895b23e84c57acb08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Transcription Factor TFIIB
123 rdf:type schema:DefinedTerm
124 Ndb437ca111c748d9b57b17edf5c3150e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name RNA Polymerase II
126 rdf:type schema:DefinedTerm
127 Nf0103454de584112a29e2cdb2a3d6207 schema:name dimensions_id
128 schema:value pub.1011975079
129 rdf:type schema:PropertyValue
130 Nfb7a517568dc4366b8d68039790f4bb8 schema:volumeNumber 493
131 rdf:type schema:PublicationVolume
132 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
133 schema:name Biological Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
136 schema:name Biochemistry and Cell Biology
137 rdf:type schema:DefinedTerm
138 sg:journal.1018957 schema:issn 0028-0836
139 1476-4687
140 schema:name Nature
141 schema:publisher Springer Nature
142 rdf:type schema:Periodical
143 sg:person.01045113153.17 schema:affiliation grid-institutes:grid.5252.0
144 schema:familyName Cramer
145 schema:givenName Patrick
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045113153.17
147 rdf:type schema:Person
148 sg:person.01211613126.65 schema:affiliation grid-institutes:grid.5252.0
149 schema:familyName Sainsbury
150 schema:givenName Sarah
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211613126.65
152 rdf:type schema:Person
153 sg:person.01305734037.03 schema:affiliation grid-institutes:grid.5252.0
154 schema:familyName Niesser
155 schema:givenName Jürgen
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305734037.03
157 rdf:type schema:Person
158 sg:pub.10.1038/nature05931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048079849
159 https://doi.org/10.1038/nature05931
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/nature08548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009664227
162 https://doi.org/10.1038/nature08548
163 rdf:type schema:CreativeWork
164 sg:pub.10.1038/nature752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053504154
165 https://doi.org/10.1038/nature752
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/nsmb.2334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003871257
168 https://doi.org/10.1038/nsmb.2334
169 rdf:type schema:CreativeWork
170 grid-institutes:grid.5252.0 schema:alternateName Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany
171 schema:name Gene Center and Department of Biochemistry, Center for Integrated Protein Science CIPSM, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany
172 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...