Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Alexej Abyzov, Jessica Mariani, Dean Palejev, Ying Zhang, Michael Seamus Haney, Livia Tomasini, Anthony F. Ferrandino, Lior A. Rosenberg Belmaker, Anna Szekely, Michael Wilson, Arif Kocabas, Nathaniel E. Calixto, Elena L. Grigorenko, Anita Huttner, Katarzyna Chawarska, Sherman Weissman, Alexander Eckehart Urban, Mark Gerstein, Flora M. Vaccarino

ABSTRACT

Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variation. To explore this issue, here we perform a whole-genome and transcriptome analysis of 20 human iPSC lines derived from the primary skin fibroblasts of seven individuals using next-generation sequencing. We find that, on average, an iPSC line manifests two copy number variants (CNVs) not apparent in the fibroblasts from which the iPSC was derived. Using PCR and digital droplet PCR, we show that at least 50% of those CNVs are present as low-frequency somatic genomic variants in parental fibroblasts (that is, the fibroblasts from which each corresponding human iPSC line is derived), and are manifested in iPSC lines owing to their clonal origin. Hence, reprogramming does not necessarily lead to de novo CNVs in iPSCs, because most of the line-manifested CNVs reflect somatic mosaicism in the human skin. Moreover, our findings demonstrate that clonal expansion, and iPSC lines in particular, can be used as a discovery tool to reliably detect low-frequency CNVs in the tissue of origin. Overall, we estimate that approximately 30% of the fibroblast cells have somatic CNVs in their genomes, suggesting widespread somatic mosaicism in the human body. Our study paves the way to understanding the fundamental question of the extent to which cells of the human body normally acquire structural alterations in their DNA post-zygotically. More... »

PAGES

438

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature11629

DOI

http://dx.doi.org/10.1038/nature11629

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002086310

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23160490


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cellular Reprogramming", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clone Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Copy Number Variations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Induced Pluripotent Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mosaicism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Program in Computation Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abyzov", 
        "givenName": "Alexej", 
        "id": "sg:person.0602715071.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602715071.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mariani", 
        "givenName": "Jessica", 
        "id": "sg:person.01034763651.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034763651.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palejev", 
        "givenName": "Dean", 
        "id": "sg:person.0754731357.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754731357.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Genetics, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Ying", 
        "id": "sg:person.0636200564.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636200564.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA", 
            "Department of Genetics, School of Medicine, Stanford University, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haney", 
        "givenName": "Michael Seamus", 
        "id": "sg:person.0704313764.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704313764.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomasini", 
        "givenName": "Livia", 
        "id": "sg:person.0700652263.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700652263.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrandino", 
        "givenName": "Anthony F.", 
        "id": "sg:person.01220257047.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220257047.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belmaker", 
        "givenName": "Lior A. Rosenberg", 
        "id": "sg:person.012326633611.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012326633611.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Genetics, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Neurology, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szekely", 
        "givenName": "Anna", 
        "id": "sg:person.01134770764.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134770764.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Program in Computation Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Michael", 
        "id": "sg:person.01203104164.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203104164.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kocabas", 
        "givenName": "Arif", 
        "id": "sg:person.01251217364.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251217364.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calixto", 
        "givenName": "Nathaniel E.", 
        "id": "sg:person.01322706015.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322706015.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Psychology, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grigorenko", 
        "givenName": "Elena L.", 
        "id": "sg:person.01207514351.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207514351.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Pathology, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huttner", 
        "givenName": "Anita", 
        "id": "sg:person.01224732544.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224732544.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chawarska", 
        "givenName": "Katarzyna", 
        "id": "sg:person.011562641567.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011562641567.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Genetics, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weissman", 
        "givenName": "Sherman", 
        "id": "sg:person.01274452741.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274452741.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA", 
            "Department of Genetics, School of Medicine, Stanford University, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Urban", 
        "givenName": "Alexander Eckehart", 
        "id": "sg:person.01032007115.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032007115.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Program in Computation Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Computer Science, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gerstein", 
        "givenName": "Mark", 
        "id": "sg:person.011677655217.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011677655217.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA", 
            "Child Study Center, Yale University, New Haven, Connecticut 06520, USA", 
            "Department of Neurobiology, Yale University, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaccarino", 
        "givenName": "Flora M.", 
        "id": "sg:person.01307641521.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307641521.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.1007753108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002889199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12033-010-9294-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003236372", 
          "https://doi.org/10.1007/s12033-010-9294-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12033-010-9294-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003236372", 
          "https://doi.org/10.1007/s12033-010-9294-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006292268", 
          "https://doi.org/10.1038/nrg906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006292268", 
          "https://doi.org/10.1038/nrg906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006292268", 
          "https://doi.org/10.1038/nrg906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2010.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006346979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0805638105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006999883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac202028g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007559257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac202028g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007559257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c400479200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007614091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008876090", 
          "https://doi.org/10.1038/nrg2809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008876090", 
          "https://doi.org/10.1038/nrg2809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1109272108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010001830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010904856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012031985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012425816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2012.03538.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013000575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.114876.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015143403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000095916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016648693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2012.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017044076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e07-01-0029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018776426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019109862", 
          "https://doi.org/10.1038/nature05944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2011.07.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019172057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019569385", 
          "https://doi.org/10.1038/nature08248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019569385", 
          "https://doi.org/10.1038/nature08248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1103388108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020122535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2007-0993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022216096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022999884", 
          "https://doi.org/10.1038/nature10531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023014918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0711983105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024490582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029065430", 
          "https://doi.org/10.1038/nature11247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030607442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030748565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.080069.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031677055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031957365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2012.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032020998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034732435", 
          "https://doi.org/10.1038/nature09708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-7610.2010.02348.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034914893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037241836", 
          "https://doi.org/10.1038/nbt.1600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037241836", 
          "https://doi.org/10.1038/nbt.1600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.20815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038849539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0009591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039849010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042468824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044017606", 
          "https://doi.org/10.1038/nature08320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044017606", 
          "https://doi.org/10.1038/nature08320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2010.07.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044463353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4560-04.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045679749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046010238", 
          "https://doi.org/10.1038/nature09871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2011.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046470596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.07.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047970638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2009-10-2-r23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048248560", 
          "https://doi.org/10.1186/gb-2009-10-2-r23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2011.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048415610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1151526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048905674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0027859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052224359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052579867", 
          "https://doi.org/10.1038/nbt.1580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052579867", 
          "https://doi.org/10.1038/nbt.1580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1010209107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053190529"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variation. To explore this issue, here we perform a whole-genome and transcriptome analysis of 20 human iPSC lines derived from the primary skin fibroblasts of seven individuals using next-generation sequencing. We find that, on average, an iPSC line manifests two copy number variants (CNVs) not apparent in the fibroblasts from which the iPSC was derived. Using PCR and digital droplet PCR, we show that at least 50% of those CNVs are present as low-frequency somatic genomic variants in parental fibroblasts (that is, the fibroblasts from which each corresponding human iPSC line is derived), and are manifested in iPSC lines owing to their clonal origin. Hence, reprogramming does not necessarily lead to de novo CNVs in iPSCs, because most of the line-manifested CNVs reflect somatic mosaicism in the human skin. Moreover, our findings demonstrate that clonal expansion, and iPSC lines in particular, can be used as a discovery tool to reliably detect low-frequency CNVs in the tissue of origin. Overall, we estimate that approximately 30% of the fibroblast cells have somatic CNVs in their genomes, suggesting widespread somatic mosaicism in the human body. Our study paves the way to understanding the fundamental question of the extent to which cells of the human body normally acquire structural alterations in their DNA post-zygotically.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature11629", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2632095", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2615775", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440972", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2674130", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2552155", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7429", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "492"
      }
    ], 
    "name": "Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells", 
    "pagination": "438", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "09ef7bb5cb663f0eecb81d7c64119c0db5d8ed1de2597dd74d057820c8ea7e40"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23160490"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature11629"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002086310"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature11629", 
      "https://app.dimensions.ai/details/publication/pub.1002086310"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature11629"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature11629'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature11629'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature11629'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature11629'


 

This table displays all metadata directly associated to this object as RDF triples.

444 TRIPLES      21 PREDICATES      94 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature11629 schema:about N0d922e1345fa41e5b8cbe5758d5807de
2 N352a915867a1477cb493c1d8a092d7e6
3 N54c8bc2cb43945538e03009dff025bcd
4 N5a20b85c84ae42299b27849ebf9fd976
5 N5b04219c34ef44fcb8c43f9410edad20
6 N63d1e23488c64048985696659b8fbeef
7 N6f62be391ad6494f8824d40cd9fcc7ae
8 Nb22ac5186c2d48fd97cb22ab84b1265d
9 Ncf88924127484186b9e07cacaf830ce2
10 Ne716bd400f3f4f32b98ed1b276f40abb
11 Nefa4068702b74be486ce111d7ac73de5
12 Nf3779713acb04954b8b618c1bc125ada
13 Nf8dd0378b6974f83a0eeaf089c928543
14 Nf9b18324936545d28f28fc4834775633
15 Nfb4a2d0067e3448c914d5366120b5b8d
16 Nfbf08f8dab2348d997e479b3e0f9f82a
17 anzsrc-for:06
18 anzsrc-for:0604
19 schema:author N826c3543bda5463c9b5db49164a023cc
20 schema:citation sg:pub.10.1007/s12033-010-9294-1
21 sg:pub.10.1038/nature05944
22 sg:pub.10.1038/nature08248
23 sg:pub.10.1038/nature08320
24 sg:pub.10.1038/nature09708
25 sg:pub.10.1038/nature09871
26 sg:pub.10.1038/nature10531
27 sg:pub.10.1038/nature11247
28 sg:pub.10.1038/nbt.1580
29 sg:pub.10.1038/nbt.1600
30 sg:pub.10.1038/nrg2809
31 sg:pub.10.1038/nrg906
32 sg:pub.10.1186/gb-2009-10-2-r23
33 https://doi.org/10.1002/humu.20815
34 https://doi.org/10.1002/stem.762
35 https://doi.org/10.1016/j.cell.2007.11.019
36 https://doi.org/10.1016/j.cell.2008.07.041
37 https://doi.org/10.1016/j.neuron.2011.05.002
38 https://doi.org/10.1016/j.neuron.2012.03.010
39 https://doi.org/10.1016/j.stem.2010.07.017
40 https://doi.org/10.1016/j.stem.2010.12.003
41 https://doi.org/10.1016/j.stem.2011.07.018
42 https://doi.org/10.1016/j.stem.2012.01.005
43 https://doi.org/10.1016/j.tig.2011.03.002
44 https://doi.org/10.1021/ac202028g
45 https://doi.org/10.1073/pnas.0711983105
46 https://doi.org/10.1073/pnas.0805638105
47 https://doi.org/10.1073/pnas.1007753108
48 https://doi.org/10.1073/pnas.1010209107
49 https://doi.org/10.1073/pnas.1103388108
50 https://doi.org/10.1073/pnas.1109272108
51 https://doi.org/10.1074/jbc.c400479200
52 https://doi.org/10.1091/mbc.e07-01-0029
53 https://doi.org/10.1093/bioinformatics/btp120
54 https://doi.org/10.1093/bioinformatics/btp352
55 https://doi.org/10.1093/bioinformatics/btp698
56 https://doi.org/10.1093/bioinformatics/btq643
57 https://doi.org/10.1093/bioinformatics/btq713
58 https://doi.org/10.1093/nar/gkn518
59 https://doi.org/10.1101/gr.080069.108
60 https://doi.org/10.1101/gr.114876.110
61 https://doi.org/10.1111/j.1469-7610.2010.02348.x
62 https://doi.org/10.1111/j.1528-1167.2012.03538.x
63 https://doi.org/10.1126/science.1151526
64 https://doi.org/10.1159/000095916
65 https://doi.org/10.1371/journal.pone.0009591
66 https://doi.org/10.1371/journal.pone.0027859
67 https://doi.org/10.1523/jneurosci.4560-04.2005
68 https://doi.org/10.1634/stemcells.2007-0993
69 schema:datePublished 2012-12
70 schema:datePublishedReg 2012-12-01
71 schema:description Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variation. To explore this issue, here we perform a whole-genome and transcriptome analysis of 20 human iPSC lines derived from the primary skin fibroblasts of seven individuals using next-generation sequencing. We find that, on average, an iPSC line manifests two copy number variants (CNVs) not apparent in the fibroblasts from which the iPSC was derived. Using PCR and digital droplet PCR, we show that at least 50% of those CNVs are present as low-frequency somatic genomic variants in parental fibroblasts (that is, the fibroblasts from which each corresponding human iPSC line is derived), and are manifested in iPSC lines owing to their clonal origin. Hence, reprogramming does not necessarily lead to de novo CNVs in iPSCs, because most of the line-manifested CNVs reflect somatic mosaicism in the human skin. Moreover, our findings demonstrate that clonal expansion, and iPSC lines in particular, can be used as a discovery tool to reliably detect low-frequency CNVs in the tissue of origin. Overall, we estimate that approximately 30% of the fibroblast cells have somatic CNVs in their genomes, suggesting widespread somatic mosaicism in the human body. Our study paves the way to understanding the fundamental question of the extent to which cells of the human body normally acquire structural alterations in their DNA post-zygotically.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree true
75 schema:isPartOf N95e6f1629e2146d99ec993078fa44b34
76 Ne3fde5e8091b451f96343e53a523a04d
77 sg:journal.1018957
78 schema:name Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells
79 schema:pagination 438
80 schema:productId N58d81b27ddb8434481ae47ee0267679d
81 N9bf43d60297146da89aea3714235152c
82 Nb47b049265e84a488d8bcc3e689d5f44
83 Nbc21a24f5b1c403abb90acd0dce24b46
84 Ne692cca507534dbfac7e4da062c8940d
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002086310
86 https://doi.org/10.1038/nature11629
87 schema:sdDatePublished 2019-04-10T22:20
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher Nd48aaf6b725d463885fb932641dbad08
90 schema:url https://www.nature.com/articles/nature11629
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N090ce3a4fca84720be2e10af0f131ec2 rdf:first sg:person.0754731357.90
95 rdf:rest N379e33b587214efb8144c408f90ddd70
96 N0d922e1345fa41e5b8cbe5758d5807de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Cell Differentiation
98 rdf:type schema:DefinedTerm
99 N14a9091365de4e17a1051ef831e08f1d rdf:first sg:person.01224732544.32
100 rdf:rest N8f5fc41a71774a41bccd86cacdcdeb4e
101 N1c9b705eb6ea472fbdb15925296b7ee8 rdf:first sg:person.01034763651.81
102 rdf:rest N090ce3a4fca84720be2e10af0f131ec2
103 N2cdda83cefb7429ab0372ad1307fc0ef rdf:first sg:person.011677655217.83
104 rdf:rest Na634f803f50f41038cd4d9be019b71cc
105 N2de6097ffdb14cf0b1fc0ccdf6015502 rdf:first sg:person.0700652263.19
106 rdf:rest Nff13e008ce924e6b95cc4b921db41b1d
107 N352a915867a1477cb493c1d8a092d7e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Male
109 rdf:type schema:DefinedTerm
110 N379e33b587214efb8144c408f90ddd70 rdf:first sg:person.0636200564.18
111 rdf:rest Nb0144625225740308bc0ce03ca068754
112 N38b6bef5d3b64ea5862415643642b5c0 rdf:first sg:person.01134770764.21
113 rdf:rest N5ad14658f7104aa19d800d4881f70b3c
114 N4078505b19814dc3a31a418b650a6452 rdf:first sg:person.01251217364.40
115 rdf:rest N80ba7209dfb04327a87ccc874c4173cd
116 N54c8bc2cb43945538e03009dff025bcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Humans
118 rdf:type schema:DefinedTerm
119 N58d81b27ddb8434481ae47ee0267679d schema:name nlm_unique_id
120 schema:value 0410462
121 rdf:type schema:PropertyValue
122 N5a20b85c84ae42299b27849ebf9fd976 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Cells, Cultured
124 rdf:type schema:DefinedTerm
125 N5ad14658f7104aa19d800d4881f70b3c rdf:first sg:person.01203104164.47
126 rdf:rest N4078505b19814dc3a31a418b650a6452
127 N5b04219c34ef44fcb8c43f9410edad20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Cellular Reprogramming
129 rdf:type schema:DefinedTerm
130 N63d1e23488c64048985696659b8fbeef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Fibroblasts
132 rdf:type schema:DefinedTerm
133 N6f62be391ad6494f8824d40cd9fcc7ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name DNA Copy Number Variations
135 rdf:type schema:DefinedTerm
136 N7c9aabe26cb7410b9a428ac608146a74 rdf:first sg:person.012326633611.29
137 rdf:rest N38b6bef5d3b64ea5862415643642b5c0
138 N80ba7209dfb04327a87ccc874c4173cd rdf:first sg:person.01322706015.06
139 rdf:rest Neaa5ec909927443da719e8dd0ac0374a
140 N826c3543bda5463c9b5db49164a023cc rdf:first sg:person.0602715071.65
141 rdf:rest N1c9b705eb6ea472fbdb15925296b7ee8
142 N8f5fc41a71774a41bccd86cacdcdeb4e rdf:first sg:person.011562641567.48
143 rdf:rest N9750510968f34d899a9ba1d7195c3d8d
144 N95e6f1629e2146d99ec993078fa44b34 schema:volumeNumber 492
145 rdf:type schema:PublicationVolume
146 N9750510968f34d899a9ba1d7195c3d8d rdf:first sg:person.01274452741.92
147 rdf:rest Ndda4af2e4ca44ebca975a2b60c7a3978
148 N9bf43d60297146da89aea3714235152c schema:name dimensions_id
149 schema:value pub.1002086310
150 rdf:type schema:PropertyValue
151 Na634f803f50f41038cd4d9be019b71cc rdf:first sg:person.01307641521.47
152 rdf:rest rdf:nil
153 Nb0144625225740308bc0ce03ca068754 rdf:first sg:person.0704313764.74
154 rdf:rest N2de6097ffdb14cf0b1fc0ccdf6015502
155 Nb22ac5186c2d48fd97cb22ab84b1265d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Neurons
157 rdf:type schema:DefinedTerm
158 Nb47b049265e84a488d8bcc3e689d5f44 schema:name pubmed_id
159 schema:value 23160490
160 rdf:type schema:PropertyValue
161 Nbc21a24f5b1c403abb90acd0dce24b46 schema:name readcube_id
162 schema:value 09ef7bb5cb663f0eecb81d7c64119c0db5d8ed1de2597dd74d057820c8ea7e40
163 rdf:type schema:PropertyValue
164 Ncf88924127484186b9e07cacaf830ce2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Induced Pluripotent Stem Cells
166 rdf:type schema:DefinedTerm
167 Nd48aaf6b725d463885fb932641dbad08 schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 Ndda4af2e4ca44ebca975a2b60c7a3978 rdf:first sg:person.01032007115.29
170 rdf:rest N2cdda83cefb7429ab0372ad1307fc0ef
171 Ne3fde5e8091b451f96343e53a523a04d schema:issueNumber 7429
172 rdf:type schema:PublicationIssue
173 Ne692cca507534dbfac7e4da062c8940d schema:name doi
174 schema:value 10.1038/nature11629
175 rdf:type schema:PropertyValue
176 Ne716bd400f3f4f32b98ed1b276f40abb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Skin
178 rdf:type schema:DefinedTerm
179 Neaa5ec909927443da719e8dd0ac0374a rdf:first sg:person.01207514351.67
180 rdf:rest N14a9091365de4e17a1051ef831e08f1d
181 Nefa4068702b74be486ce111d7ac73de5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Mosaicism
183 rdf:type schema:DefinedTerm
184 Nf3779713acb04954b8b618c1bc125ada schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Gene Expression Profiling
186 rdf:type schema:DefinedTerm
187 Nf8dd0378b6974f83a0eeaf089c928543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Genome, Human
189 rdf:type schema:DefinedTerm
190 Nf9b18324936545d28f28fc4834775633 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Polymerase Chain Reaction
192 rdf:type schema:DefinedTerm
193 Nfb4a2d0067e3448c914d5366120b5b8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Clone Cells
195 rdf:type schema:DefinedTerm
196 Nfbf08f8dab2348d997e479b3e0f9f82a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Reproducibility of Results
198 rdf:type schema:DefinedTerm
199 Nff13e008ce924e6b95cc4b921db41b1d rdf:first sg:person.01220257047.65
200 rdf:rest N7c9aabe26cb7410b9a428ac608146a74
201 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
202 schema:name Biological Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
205 schema:name Genetics
206 rdf:type schema:DefinedTerm
207 sg:grant.2440972 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11629
208 rdf:type schema:MonetaryGrant
209 sg:grant.2552155 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11629
210 rdf:type schema:MonetaryGrant
211 sg:grant.2615775 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11629
212 rdf:type schema:MonetaryGrant
213 sg:grant.2632095 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11629
214 rdf:type schema:MonetaryGrant
215 sg:grant.2674130 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11629
216 rdf:type schema:MonetaryGrant
217 sg:journal.1018957 schema:issn 0090-0028
218 1476-4687
219 schema:name Nature
220 rdf:type schema:Periodical
221 sg:person.01032007115.29 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
222 schema:familyName Urban
223 schema:givenName Alexander Eckehart
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032007115.29
225 rdf:type schema:Person
226 sg:person.01034763651.81 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
227 schema:familyName Mariani
228 schema:givenName Jessica
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034763651.81
230 rdf:type schema:Person
231 sg:person.01134770764.21 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
232 schema:familyName Szekely
233 schema:givenName Anna
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134770764.21
235 rdf:type schema:Person
236 sg:person.011562641567.48 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
237 schema:familyName Chawarska
238 schema:givenName Katarzyna
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011562641567.48
240 rdf:type schema:Person
241 sg:person.011677655217.83 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
242 schema:familyName Gerstein
243 schema:givenName Mark
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011677655217.83
245 rdf:type schema:Person
246 sg:person.01203104164.47 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
247 schema:familyName Wilson
248 schema:givenName Michael
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203104164.47
250 rdf:type schema:Person
251 sg:person.01207514351.67 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
252 schema:familyName Grigorenko
253 schema:givenName Elena L.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207514351.67
255 rdf:type schema:Person
256 sg:person.01220257047.65 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
257 schema:familyName Ferrandino
258 schema:givenName Anthony F.
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220257047.65
260 rdf:type schema:Person
261 sg:person.01224732544.32 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
262 schema:familyName Huttner
263 schema:givenName Anita
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224732544.32
265 rdf:type schema:Person
266 sg:person.012326633611.29 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
267 schema:familyName Belmaker
268 schema:givenName Lior A. Rosenberg
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012326633611.29
270 rdf:type schema:Person
271 sg:person.01251217364.40 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
272 schema:familyName Kocabas
273 schema:givenName Arif
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251217364.40
275 rdf:type schema:Person
276 sg:person.01274452741.92 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
277 schema:familyName Weissman
278 schema:givenName Sherman
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274452741.92
280 rdf:type schema:Person
281 sg:person.01307641521.47 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
282 schema:familyName Vaccarino
283 schema:givenName Flora M.
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307641521.47
285 rdf:type schema:Person
286 sg:person.01322706015.06 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
287 schema:familyName Calixto
288 schema:givenName Nathaniel E.
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322706015.06
290 rdf:type schema:Person
291 sg:person.0602715071.65 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
292 schema:familyName Abyzov
293 schema:givenName Alexej
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602715071.65
295 rdf:type schema:Person
296 sg:person.0636200564.18 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
297 schema:familyName Zhang
298 schema:givenName Ying
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636200564.18
300 rdf:type schema:Person
301 sg:person.0700652263.19 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
302 schema:familyName Tomasini
303 schema:givenName Livia
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700652263.19
305 rdf:type schema:Person
306 sg:person.0704313764.74 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
307 schema:familyName Haney
308 schema:givenName Michael Seamus
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704313764.74
310 rdf:type schema:Person
311 sg:person.0754731357.90 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
312 schema:familyName Palejev
313 schema:givenName Dean
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754731357.90
315 rdf:type schema:Person
316 sg:pub.10.1007/s12033-010-9294-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003236372
317 https://doi.org/10.1007/s12033-010-9294-1
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/nature05944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019109862
320 https://doi.org/10.1038/nature05944
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/nature08248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019569385
323 https://doi.org/10.1038/nature08248
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/nature08320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044017606
326 https://doi.org/10.1038/nature08320
327 rdf:type schema:CreativeWork
328 sg:pub.10.1038/nature09708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034732435
329 https://doi.org/10.1038/nature09708
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/nature09871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046010238
332 https://doi.org/10.1038/nature09871
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/nature10531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022999884
335 https://doi.org/10.1038/nature10531
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
338 https://doi.org/10.1038/nature11247
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/nbt.1580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052579867
341 https://doi.org/10.1038/nbt.1580
342 rdf:type schema:CreativeWork
343 sg:pub.10.1038/nbt.1600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037241836
344 https://doi.org/10.1038/nbt.1600
345 rdf:type schema:CreativeWork
346 sg:pub.10.1038/nrg2809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008876090
347 https://doi.org/10.1038/nrg2809
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/nrg906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006292268
350 https://doi.org/10.1038/nrg906
351 rdf:type schema:CreativeWork
352 sg:pub.10.1186/gb-2009-10-2-r23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048248560
353 https://doi.org/10.1186/gb-2009-10-2-r23
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1002/humu.20815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038849539
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1002/stem.762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030607442
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1016/j.cell.2007.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010904856
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1016/j.cell.2008.07.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047970638
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/j.neuron.2011.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048415610
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1016/j.neuron.2012.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032020998
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1016/j.stem.2010.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044463353
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1016/j.stem.2010.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006346979
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1016/j.stem.2011.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019172057
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1016/j.stem.2012.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017044076
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1016/j.tig.2011.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046470596
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1021/ac202028g schema:sameAs https://app.dimensions.ai/details/publication/pub.1007559257
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1073/pnas.0711983105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024490582
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1073/pnas.0805638105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006999883
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1073/pnas.1007753108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002889199
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1073/pnas.1010209107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053190529
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1073/pnas.1103388108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020122535
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1073/pnas.1109272108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010001830
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1074/jbc.c400479200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007614091
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1091/mbc.e07-01-0029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018776426
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1093/bioinformatics/btp120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012425816
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1093/bioinformatics/btp352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023014918
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1093/bioinformatics/btp698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012031985
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1093/bioinformatics/btq643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030748565
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1093/bioinformatics/btq713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042468824
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1093/nar/gkn518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031957365
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1101/gr.080069.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031677055
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1101/gr.114876.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015143403
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1111/j.1469-7610.2010.02348.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034914893
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1111/j.1528-1167.2012.03538.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013000575
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1126/science.1151526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048905674
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1159/000095916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016648693
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1371/journal.pone.0009591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039849010
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1371/journal.pone.0027859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052224359
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1523/jneurosci.4560-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045679749
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1634/stemcells.2007-0993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022216096
426 rdf:type schema:CreativeWork
427 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
428 schema:name Department of Genetics, School of Medicine, Stanford University, Stanford, California 94305, USA
429 Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305, USA
430 Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA
431 rdf:type schema:Organization
432 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
433 schema:name Child Study Center, Yale University, New Haven, Connecticut 06520, USA
434 Department of Computer Science, Yale University, New Haven, Connecticut 06520, USA
435 Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06520, USA
436 Department of Genetics, Yale University, New Haven, Connecticut 06520, USA
437 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
438 Department of Neurobiology, Yale University, New Haven, Connecticut 06520, USA
439 Department of Neurology, Yale University, New Haven, Connecticut 06520, USA
440 Department of Pathology, Yale University, New Haven, Connecticut 06520, USA
441 Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
442 Program in Computation Biology and Bioinformatics, Yale University, New Haven, Connecticut 06520, USA
443 Program in Neurodevelopment and Regeneration, Yale University, New Haven, Connecticut 06520, USA
444 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...