Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-11-11

AUTHORS

Cedric R. Clapier, Bradley R. Cairns

ABSTRACT

Two separate regulatory regions on the Drosophila chromatin remodeller ISWI are defined, AutoN and NegC, which negatively regulate ATP hydrolysis and the coupling of ATP hydrolysis to productive DNA translocation, respectively; epitopes on nucleosomes activate ISWI by inhibiting these negative regulatory domains, ensuring that remodelling occurs only in the appropriate chromatin context. More... »

PAGES

280-284

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature11625

DOI

http://dx.doi.org/10.1038/nature11625

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033618941

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23143334


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