BATF–JUN is critical for IRF4-mediated transcription in T cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-09-19

AUTHORS

Peng Li, Rosanne Spolski, Wei Liao, Lu Wang, Theresa L. Murphy, Kenneth M. Murphy, Warren J. Leonard

ABSTRACT

Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in lymphoid development and in regulating the immune response. IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cells increases binding affinity, allowing IRF4 to regulate genes containing ETS-IRF composite elements (EICEs; 5'-GGAAnnGAAA-3'). Here we show that in mouse CD4(+) T cells, where PU.1/SPIB expression is low, and in B cells, where PU.1 is well expressed, IRF4 unexpectedly can cooperate with activator protein-1 (AP1) complexes to bind to AP1-IRF4 composite (5'-TGAnTCA/GAAA-3') motifs that we denote as AP1-IRF composite elements (AICEs). Moreover, BATF-JUN family protein complexes cooperate with IRF4 in binding to AICEs in pre-activated CD4(+) T cells stimulated with IL-21 and in T(H)17 differentiated cells. Importantly, BATF binding was diminished in Irf4(-/-) T cells and IRF4 binding was diminished in Batf(-/-) T cells, consistent with functional cooperation between these factors. Moreover, we show that AP1 and IRF complexes cooperatively promote transcription of the Il10 gene, which is expressed in T(H)17 cells and potently regulated by IL-21. These findings reveal that IRF4 can signal via complexes containing ETS or AP1 motifs depending on the cellular context, thus indicating new approaches for modulating IRF4-dependent transcription. More... »

PAGES

543

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature11530

DOI

http://dx.doi.org/10.1038/nature11530

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016712454

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22992523


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Basic-Leucine Zipper Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon Regulatory Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-10", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleotide Motifs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-jun", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th17 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor AP-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Peng", 
        "id": "sg:person.01074554463.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074554463.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spolski", 
        "givenName": "Rosanne", 
        "id": "sg:person.01017373767.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017373767.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liao", 
        "givenName": "Wei", 
        "id": "sg:person.01042610734.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042610734.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Lu", 
        "id": "sg:person.01134036261.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134036261.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murphy", 
        "givenName": "Theresa L.", 
        "id": "sg:person.01277127034.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277127034.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA", 
            "Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murphy", 
        "givenName": "Kenneth M.", 
        "id": "sg:person.014746743102.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014746743102.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Heart Lung and Blood Institute", 
          "id": "https://www.grid.ac/institutes/grid.279885.9", 
          "name": [
            "Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leonard", 
        "givenName": "Warren J.", 
        "id": "sg:person.01052534741.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052534741.63"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ni1488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002269423", 
          "https://doi.org/10.1038/ni1488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1996.0547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002557771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.182425099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002900668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003715761", 
          "https://doi.org/10.1038/sj.onc.1203491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003715761", 
          "https://doi.org/10.1038/sj.onc.1203491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m205895200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004510020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004683401", 
          "https://doi.org/10.1038/ni1500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/dxg001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013503229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.191.8.1281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014693693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molimm.2008.07.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017954717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019949298", 
          "https://doi.org/10.1038/nri1552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019949298", 
          "https://doi.org/10.1038/nri1552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021301372", 
          "https://doi.org/10.1038/ni.1867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021301372", 
          "https://doi.org/10.1038/ni.1867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00703-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021842078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2008-9-9-r137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027608848", 
          "https://doi.org/10.1186/gb-2008-9-9-r137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2010.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031862964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.19.1.623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032206790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035445598", 
          "https://doi.org/10.1038/nature05970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.10.7138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036831319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037682433", 
          "https://doi.org/10.1038/nature05969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038119253", 
          "https://doi.org/10.1038/nature08114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038119253", 
          "https://doi.org/10.1038/nature08114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20011128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038256322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040215931", 
          "https://doi.org/10.1038/nature11531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2009.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041173117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2005.03.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041814043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2005.03.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041814043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2012.02.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043727761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0802978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044828684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0901233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047471901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.2030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049283010", 
          "https://doi.org/10.1038/ni.2030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1102994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049422979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2009-10-3-r25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049583368", 
          "https://doi.org/10.1186/gb-2009-10-3-r25"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.18.2335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051633910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/107999002753452728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059207046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082424111", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082863215", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-09-19", 
    "datePublishedReg": "2012-09-19", 
    "description": "Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in lymphoid development and in regulating the immune response. IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cells increases binding affinity, allowing IRF4 to regulate genes containing ETS-IRF composite elements (EICEs; 5'-GGAAnnGAAA-3'). Here we show that in mouse CD4(+) T cells, where PU.1/SPIB expression is low, and in B cells, where PU.1 is well expressed, IRF4 unexpectedly can cooperate with activator protein-1 (AP1) complexes to bind to AP1-IRF4 composite (5'-TGAnTCA/GAAA-3') motifs that we denote as AP1-IRF composite elements (AICEs). Moreover, BATF-JUN family protein complexes cooperate with IRF4 in binding to AICEs in pre-activated CD4(+) T cells stimulated with IL-21 and in T(H)17 differentiated cells. Importantly, BATF binding was diminished in Irf4(-/-) T cells and IRF4 binding was diminished in Batf(-/-) T cells, consistent with functional cooperation between these factors. Moreover, we show that AP1 and IRF complexes cooperatively promote transcription of the Il10 gene, which is expressed in T(H)17 cells and potently regulated by IL-21. These findings reveal that IRF4 can signal via complexes containing ETS or AP1 motifs depending on the cellular context, thus indicating new approaches for modulating IRF4-dependent transcription.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature11530", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2725863", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438969", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2725864", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2726631", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2726786", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7421", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "490"
      }
    ], 
    "name": "BATF\u2013JUN is critical for IRF4-mediated transcription in T cells", 
    "pagination": "543", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4fa0c1fd49202a1049d9c2eb9428863d264139f52f3768701622361ae3b099b1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22992523"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature11530"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016712454"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature11530", 
      "https://app.dimensions.ai/details/publication/pub.1016712454"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000549.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature11530"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature11530'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature11530'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature11530'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature11530'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      87 URIs      46 LITERALS      35 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature11530 schema:about N00ec297ed8ed400aa95b26015dcfff21
2 N0cdf631c7d8644378b0fa3c116592ed5
3 N181ba6f0bb344d03844e4b6b497ccaff
4 N2147f6bbcea3413a8c320a89a4ead26c
5 N35b1633ea300475180185b974c00ef87
6 N3b014b09d1074d88927aa449d03fa862
7 N403f4d3ff2374e9aaac431623c54534e
8 N4651b18bd0f74dc784006760cdc1dea8
9 N5d714f59f2bc4c4a91214e517971830f
10 N5d942e7a20c6479aa290a3e38a8eb5a9
11 N61fdd9c0f4974b77a6f8ac0f1e04c655
12 N6403df000d7245bc8dc51b690f25dd57
13 N6de100044519470cb75f146830b3eaa9
14 N70996639042d455f88a3f563bb7241bd
15 N73fc07b1cb4f454583e7420ce33f1bf6
16 N7cda3a99f2cc4fe9badb0fb806ac7398
17 N8e0541f1ff5441d8a979d0b8d90b7cca
18 Na31b5752d4a04dd0a80e1527fa11566b
19 Nac75f23a8758476785dc920a505b0f02
20 Nb49a39c4dc074294b5e75490496affa3
21 Nbe149e11f06143c7bfde45df1a796576
22 Ncc472397b83d4281b201b7b699860311
23 Nccc02fd1aedf4cbfa7bc622474b7f26c
24 Ne28f7ede69e64d92b7bd0366948b9e09
25 Neeb7b698ff754d39afb1bc49e0fd2f64
26 Nf83916fb523e4436b7782ca699771260
27 anzsrc-for:11
28 anzsrc-for:1107
29 schema:author Ne9a6199a37134072b58bf952df1fb84a
30 schema:citation sg:pub.10.1038/nature05969
31 sg:pub.10.1038/nature05970
32 sg:pub.10.1038/nature08114
33 sg:pub.10.1038/nature11531
34 sg:pub.10.1038/ni.1867
35 sg:pub.10.1038/ni.2030
36 sg:pub.10.1038/ni1488
37 sg:pub.10.1038/ni1500
38 sg:pub.10.1038/nri1552
39 sg:pub.10.1038/sj.onc.1203491
40 sg:pub.10.1186/gb-2008-9-9-r137
41 sg:pub.10.1186/gb-2009-10-3-r25
42 https://app.dimensions.ai/details/publication/pub.1082424111
43 https://app.dimensions.ai/details/publication/pub.1082863215
44 https://doi.org/10.1006/geno.1996.0547
45 https://doi.org/10.1016/j.immuni.2005.03.016
46 https://doi.org/10.1016/j.immuni.2009.10.008
47 https://doi.org/10.1016/j.immuni.2010.07.014
48 https://doi.org/10.1016/j.immuni.2012.02.017
49 https://doi.org/10.1016/j.molimm.2008.07.037
50 https://doi.org/10.1016/s1097-2765(02)00703-7
51 https://doi.org/10.1073/pnas.182425099
52 https://doi.org/10.1074/jbc.m205895200
53 https://doi.org/10.1084/jem.191.8.1281
54 https://doi.org/10.1084/jem.20011128
55 https://doi.org/10.1089/107999002753452728
56 https://doi.org/10.1093/intimm/dxg001
57 https://doi.org/10.1101/gad.10.18.2335
58 https://doi.org/10.1128/mcb.19.10.7138
59 https://doi.org/10.1146/annurev.immunol.19.1.623
60 https://doi.org/10.4049/jimmunol.0802978
61 https://doi.org/10.4049/jimmunol.0901233
62 https://doi.org/10.4049/jimmunol.1102994
63 schema:datePublished 2012-09-19
64 schema:datePublishedReg 2012-09-19
65 schema:description Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in lymphoid development and in regulating the immune response. IRF4 binds DNA weakly owing to a carboxy-terminal auto-inhibitory domain, but cooperative binding with factors such as PU.1 or SPIB in B cells increases binding affinity, allowing IRF4 to regulate genes containing ETS-IRF composite elements (EICEs; 5'-GGAAnnGAAA-3'). Here we show that in mouse CD4(+) T cells, where PU.1/SPIB expression is low, and in B cells, where PU.1 is well expressed, IRF4 unexpectedly can cooperate with activator protein-1 (AP1) complexes to bind to AP1-IRF4 composite (5'-TGAnTCA/GAAA-3') motifs that we denote as AP1-IRF composite elements (AICEs). Moreover, BATF-JUN family protein complexes cooperate with IRF4 in binding to AICEs in pre-activated CD4(+) T cells stimulated with IL-21 and in T(H)17 differentiated cells. Importantly, BATF binding was diminished in Irf4(-/-) T cells and IRF4 binding was diminished in Batf(-/-) T cells, consistent with functional cooperation between these factors. Moreover, we show that AP1 and IRF complexes cooperatively promote transcription of the Il10 gene, which is expressed in T(H)17 cells and potently regulated by IL-21. These findings reveal that IRF4 can signal via complexes containing ETS or AP1 motifs depending on the cellular context, thus indicating new approaches for modulating IRF4-dependent transcription.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf N4318646cb270415385def8cb5f3d2d18
70 N970984e3b73041f9b98a0c93d71b1bf5
71 sg:journal.1018957
72 schema:name BATF–JUN is critical for IRF4-mediated transcription in T cells
73 schema:pagination 543
74 schema:productId N6bd64480186d4d7aa2238a5368a258c4
75 Na955135341e140e0b7c88e38c769b28c
76 Nbfb2e830166344c080641e1cbe965238
77 Nf46a19f6b88f490fa8779b19bafebea6
78 Nfe244551d34f49e7b05938cbb823d688
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016712454
80 https://doi.org/10.1038/nature11530
81 schema:sdDatePublished 2019-04-10T22:39
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N2c8aa71d89c940a080e690c0ebf760cb
84 schema:url https://www.nature.com/articles/nature11530
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N00ec297ed8ed400aa95b26015dcfff21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Molecular Sequence Data
90 rdf:type schema:DefinedTerm
91 N0cdf631c7d8644378b0fa3c116592ed5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name CD4-Positive T-Lymphocytes
93 rdf:type schema:DefinedTerm
94 N181ba6f0bb344d03844e4b6b497ccaff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Transcription Factor AP-1
96 rdf:type schema:DefinedTerm
97 N1b89f17bb84d476eb5b9d32509ecc517 rdf:first sg:person.01277127034.31
98 rdf:rest Nd0303fa1c92b436eaa0c1da451766444
99 N2147f6bbcea3413a8c320a89a4ead26c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Mice
101 rdf:type schema:DefinedTerm
102 N2c8aa71d89c940a080e690c0ebf760cb schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N35b1633ea300475180185b974c00ef87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Nucleotide Motifs
106 rdf:type schema:DefinedTerm
107 N3b014b09d1074d88927aa449d03fa862 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Th17 Cells
109 rdf:type schema:DefinedTerm
110 N403f4d3ff2374e9aaac431623c54534e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Interferon Regulatory Factors
112 rdf:type schema:DefinedTerm
113 N4318646cb270415385def8cb5f3d2d18 schema:volumeNumber 490
114 rdf:type schema:PublicationVolume
115 N4651b18bd0f74dc784006760cdc1dea8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cell Differentiation
117 rdf:type schema:DefinedTerm
118 N5d714f59f2bc4c4a91214e517971830f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Lymphocyte Activation
120 rdf:type schema:DefinedTerm
121 N5d942e7a20c6479aa290a3e38a8eb5a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Interleukins
123 rdf:type schema:DefinedTerm
124 N61fdd9c0f4974b77a6f8ac0f1e04c655 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Basic-Leucine Zipper Transcription Factors
126 rdf:type schema:DefinedTerm
127 N6403df000d7245bc8dc51b690f25dd57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Animals
129 rdf:type schema:DefinedTerm
130 N6bd64480186d4d7aa2238a5368a258c4 schema:name doi
131 schema:value 10.1038/nature11530
132 rdf:type schema:PropertyValue
133 N6de100044519470cb75f146830b3eaa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name B-Lymphocytes
135 rdf:type schema:DefinedTerm
136 N70996639042d455f88a3f563bb7241bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Mice, Inbred C57BL
138 rdf:type schema:DefinedTerm
139 N73fc07b1cb4f454583e7420ce33f1bf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Female
141 rdf:type schema:DefinedTerm
142 N7cda3a99f2cc4fe9badb0fb806ac7398 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Proto-Oncogene Proteins
144 rdf:type schema:DefinedTerm
145 N80070efe849745b0813d649e11c61e80 rdf:first sg:person.01042610734.97
146 rdf:rest Nb173b30b220743d29f481247c514ca86
147 N8ca35f2639e94a839a4e02ab72df8500 rdf:first sg:person.01052534741.63
148 rdf:rest rdf:nil
149 N8e0541f1ff5441d8a979d0b8d90b7cca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Base Sequence
151 rdf:type schema:DefinedTerm
152 N970984e3b73041f9b98a0c93d71b1bf5 schema:issueNumber 7421
153 rdf:type schema:PublicationIssue
154 N97ffa59dc1c84bb6a033a71e1022a735 rdf:first sg:person.01017373767.21
155 rdf:rest N80070efe849745b0813d649e11c61e80
156 Na31b5752d4a04dd0a80e1527fa11566b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Binding Sites
158 rdf:type schema:DefinedTerm
159 Na955135341e140e0b7c88e38c769b28c schema:name nlm_unique_id
160 schema:value 0410462
161 rdf:type schema:PropertyValue
162 Nac75f23a8758476785dc920a505b0f02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Proto-Oncogene Proteins c-jun
164 rdf:type schema:DefinedTerm
165 Nb173b30b220743d29f481247c514ca86 rdf:first sg:person.01134036261.26
166 rdf:rest N1b89f17bb84d476eb5b9d32509ecc517
167 Nb49a39c4dc074294b5e75490496affa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Trans-Activators
169 rdf:type schema:DefinedTerm
170 Nbe149e11f06143c7bfde45df1a796576 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Interleukin-10
172 rdf:type schema:DefinedTerm
173 Nbfb2e830166344c080641e1cbe965238 schema:name pubmed_id
174 schema:value 22992523
175 rdf:type schema:PropertyValue
176 Ncc472397b83d4281b201b7b699860311 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Signal Transduction
178 rdf:type schema:DefinedTerm
179 Nccc02fd1aedf4cbfa7bc622474b7f26c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Transcription, Genetic
181 rdf:type schema:DefinedTerm
182 Nd0303fa1c92b436eaa0c1da451766444 rdf:first sg:person.014746743102.46
183 rdf:rest N8ca35f2639e94a839a4e02ab72df8500
184 Ne28f7ede69e64d92b7bd0366948b9e09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Amino Acid Motifs
186 rdf:type schema:DefinedTerm
187 Ne9a6199a37134072b58bf952df1fb84a rdf:first sg:person.01074554463.41
188 rdf:rest N97ffa59dc1c84bb6a033a71e1022a735
189 Neeb7b698ff754d39afb1bc49e0fd2f64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Male
191 rdf:type schema:DefinedTerm
192 Nf46a19f6b88f490fa8779b19bafebea6 schema:name dimensions_id
193 schema:value pub.1016712454
194 rdf:type schema:PropertyValue
195 Nf83916fb523e4436b7782ca699771260 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Up-Regulation
197 rdf:type schema:DefinedTerm
198 Nfe244551d34f49e7b05938cbb823d688 schema:name readcube_id
199 schema:value 4fa0c1fd49202a1049d9c2eb9428863d264139f52f3768701622361ae3b099b1
200 rdf:type schema:PropertyValue
201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
202 schema:name Medical and Health Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
205 schema:name Immunology
206 rdf:type schema:DefinedTerm
207 sg:grant.2438969 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11530
208 rdf:type schema:MonetaryGrant
209 sg:grant.2725863 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11530
210 rdf:type schema:MonetaryGrant
211 sg:grant.2725864 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11530
212 rdf:type schema:MonetaryGrant
213 sg:grant.2726631 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11530
214 rdf:type schema:MonetaryGrant
215 sg:grant.2726786 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11530
216 rdf:type schema:MonetaryGrant
217 sg:journal.1018957 schema:issn 0090-0028
218 1476-4687
219 schema:name Nature
220 rdf:type schema:Periodical
221 sg:person.01017373767.21 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
222 schema:familyName Spolski
223 schema:givenName Rosanne
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017373767.21
225 rdf:type schema:Person
226 sg:person.01042610734.97 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
227 schema:familyName Liao
228 schema:givenName Wei
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042610734.97
230 rdf:type schema:Person
231 sg:person.01052534741.63 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
232 schema:familyName Leonard
233 schema:givenName Warren J.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052534741.63
235 rdf:type schema:Person
236 sg:person.01074554463.41 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
237 schema:familyName Li
238 schema:givenName Peng
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074554463.41
240 rdf:type schema:Person
241 sg:person.01134036261.26 schema:affiliation https://www.grid.ac/institutes/grid.279885.9
242 schema:familyName Wang
243 schema:givenName Lu
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134036261.26
245 rdf:type schema:Person
246 sg:person.01277127034.31 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
247 schema:familyName Murphy
248 schema:givenName Theresa L.
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277127034.31
250 rdf:type schema:Person
251 sg:person.014746743102.46 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
252 schema:familyName Murphy
253 schema:givenName Kenneth M.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014746743102.46
255 rdf:type schema:Person
256 sg:pub.10.1038/nature05969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037682433
257 https://doi.org/10.1038/nature05969
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nature05970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035445598
260 https://doi.org/10.1038/nature05970
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nature08114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038119253
263 https://doi.org/10.1038/nature08114
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nature11531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040215931
266 https://doi.org/10.1038/nature11531
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/ni.1867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021301372
269 https://doi.org/10.1038/ni.1867
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/ni.2030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049283010
272 https://doi.org/10.1038/ni.2030
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/ni1488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002269423
275 https://doi.org/10.1038/ni1488
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/ni1500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004683401
278 https://doi.org/10.1038/ni1500
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nri1552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019949298
281 https://doi.org/10.1038/nri1552
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/sj.onc.1203491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003715761
284 https://doi.org/10.1038/sj.onc.1203491
285 rdf:type schema:CreativeWork
286 sg:pub.10.1186/gb-2008-9-9-r137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027608848
287 https://doi.org/10.1186/gb-2008-9-9-r137
288 rdf:type schema:CreativeWork
289 sg:pub.10.1186/gb-2009-10-3-r25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049583368
290 https://doi.org/10.1186/gb-2009-10-3-r25
291 rdf:type schema:CreativeWork
292 https://app.dimensions.ai/details/publication/pub.1082424111 schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1082863215 schema:CreativeWork
294 https://doi.org/10.1006/geno.1996.0547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002557771
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.immuni.2005.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041814043
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.immuni.2009.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041173117
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.immuni.2010.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031862964
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.immuni.2012.02.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043727761
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.molimm.2008.07.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017954717
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/s1097-2765(02)00703-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021842078
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1073/pnas.182425099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002900668
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1074/jbc.m205895200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004510020
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1084/jem.191.8.1281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014693693
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1084/jem.20011128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038256322
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1089/107999002753452728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059207046
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1093/intimm/dxg001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013503229
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1101/gad.10.18.2335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051633910
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1128/mcb.19.10.7138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036831319
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1146/annurev.immunol.19.1.623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032206790
325 rdf:type schema:CreativeWork
326 https://doi.org/10.4049/jimmunol.0802978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044828684
327 rdf:type schema:CreativeWork
328 https://doi.org/10.4049/jimmunol.0901233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047471901
329 rdf:type schema:CreativeWork
330 https://doi.org/10.4049/jimmunol.1102994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049422979
331 rdf:type schema:CreativeWork
332 https://www.grid.ac/institutes/grid.279885.9 schema:alternateName National Heart Lung and Blood Institute
333 schema:name Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1674, USA
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
336 schema:name Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
337 Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...