Crystal structure of a bacterial homologue of glucose transporters GLUT1–4 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-10

AUTHORS

Linfeng Sun, Xin Zeng, Chuangye Yan, Xiuyun Sun, Xinqi Gong, Yu Rao, Nieng Yan

ABSTRACT

Glucose transporters are essential for metabolism of glucose in cells of diverse organisms from microbes to humans, exemplified by the disease-related human proteins GLUT1, 2, 3 and 4. Despite rigorous efforts, the structural information for GLUT1-4 or their homologues remains largely unknown. Here we report three related crystal structures of XylE, an Escherichia coli homologue of GLUT1-4, in complex with d-xylose, d-glucose and 6-bromo-6-deoxy-D-glucose, at resolutions of 2.8, 2.9 and 2.6 Å, respectively. The structure consists of a typical major facilitator superfamily fold of 12 transmembrane segments and a unique intracellular four-helix domain. XylE was captured in an outward-facing, partly occluded conformation. Most of the important amino acids responsible for recognition of D-xylose or d-glucose are invariant in GLUT1-4, suggesting functional and mechanistic conservations. Structure-based modelling of GLUT1-4 allows mapping and interpretation of disease-related mutations. The structural and biochemical information reported here constitutes an important framework for mechanistic understanding of glucose transporters and sugar porters in general. More... »

PAGES

361

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature11524

DOI

http://dx.doi.org/10.1038/nature11524

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035673999

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23075985


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxyglucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Escherichia coli", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Escherichia coli Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose Transport Proteins, Facilitative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose Transporter Type 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen Bonding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structural Homology, Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structure-Activity Relationship", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substrate Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Symporters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xylose", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, Tsinghua University, Beijing 100084, China", 
            "School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China", 
            "Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Linfeng", 
        "id": "sg:person.0753533603.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753533603.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, Tsinghua University, Beijing 100084, China", 
            "School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China", 
            "Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeng", 
        "givenName": "Xin", 
        "id": "sg:person.0734714670.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734714670.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, Tsinghua University, Beijing 100084, China", 
            "School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China", 
            "Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yan", 
        "givenName": "Chuangye", 
        "id": "sg:person.01274436253.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274436253.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Xiuyun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, Tsinghua University, Beijing 100084, China", 
            "School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China", 
            "Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gong", 
        "givenName": "Xinqi", 
        "id": "sg:person.01342551453.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342551453.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rao", 
        "givenName": "Yu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, Tsinghua University, Beijing 100084, China", 
            "School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China", 
            "Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yan", 
        "givenName": "Nieng", 
        "id": "sg:person.0675167270.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675167270.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.braindev.2009.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000213881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2007.03.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001737936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-200108000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002323101", 
          "https://doi.org/10.1203/00006450-200108000-00015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.01970-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003906114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.47.33244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004745860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/325641a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004764127", 
          "https://doi.org/10.1038/325641a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)76066-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004907170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1500627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005714537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1500627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005714537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje.0.1500627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005714537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00004.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006476675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006570730", 
          "https://doi.org/10.1038/nature08741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006570730", 
          "https://doi.org/10.1038/nature08741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2229-11-168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007719315", 
          "https://doi.org/10.1186/1471-2229-11-168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1173654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007843251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1173654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007843251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14728220903307509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010410173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.1990.0020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012352788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012412735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889807021206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012753217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.1222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012774261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.20331", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015078031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2010.309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015715487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016664325", 
          "https://doi.org/10.1038/nature09406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016664325", 
          "https://doi.org/10.1038/nature09406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904019158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020495727", 
          "https://doi.org/10.1038/nature08201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020495727", 
          "https://doi.org/10.1038/nature08201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444902011678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021532775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe-09-0037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022365366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1994.tb18550.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023670544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/prot.21099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025034562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444994003112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00762961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031018088", 
          "https://doi.org/10.1007/bf00762961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0148607104028005364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031432879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1197-324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031901217", 
          "https://doi.org/10.1038/ng1197-324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.90388.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034455146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biophys.35.040405.102005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036989658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038074732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.22.4673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042438223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1528-1167.2008.01833.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043446106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044030985", 
          "https://doi.org/10.1038/nature09885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00712.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045477249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m509422200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048489555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2007.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048628045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkj001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048681044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1088196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048930272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050775411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444902016657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051282549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051414479", 
          "https://doi.org/10.1038/nature07819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1056-8727(93)90038-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052620916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi900521n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055209756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi900521n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055209756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1087619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062448393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1125629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062453617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1160406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062458423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3839598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062621983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318248a245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318248a245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e318248a245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064356766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074517305", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079410352", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081702019", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082089423", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082560155", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083238181", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-10", 
    "datePublishedReg": "2012-10-01", 
    "description": "Glucose transporters are essential for metabolism of glucose in cells of diverse organisms from microbes to humans, exemplified by the disease-related human proteins GLUT1, 2, 3 and 4. Despite rigorous efforts, the structural information for GLUT1-4 or their homologues remains largely unknown. Here we report three related crystal structures of XylE, an Escherichia coli homologue of GLUT1-4, in complex with d-xylose, d-glucose and 6-bromo-6-deoxy-D-glucose, at resolutions of 2.8, 2.9 and 2.6\u2009\u00c5, respectively. The structure consists of a typical major facilitator superfamily fold of 12 transmembrane segments and a unique intracellular four-helix domain. XylE was captured in an outward-facing, partly occluded conformation. Most of the important amino acids responsible for recognition of D-xylose or d-glucose are invariant in GLUT1-4, suggesting functional and mechanistic conservations. Structure-based modelling of GLUT1-4 allows mapping and interpretation of disease-related mutations. The structural and biochemical information reported here constitutes an important framework for mechanistic understanding of glucose transporters and sugar porters in general.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature11524", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6977096", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6978784", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7420", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "490"
      }
    ], 
    "name": "Crystal structure of a bacterial homologue of glucose transporters GLUT1\u20134", 
    "pagination": "361", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a9f0455730f49dbfb1b6aa1b74c51a5f211f6f08be23b76822f51bd4885716c4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23075985"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature11524"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035673999"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature11524", 
      "https://app.dimensions.ai/details/publication/pub.1035673999"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature11524"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature11524'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature11524'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature11524'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature11524'


 

This table displays all metadata directly associated to this object as RDF triples.

358 TRIPLES      21 PREDICATES      103 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature11524 schema:about N09da830f9949422ba85ed0598d97739d
2 N242afeeb078143b3a9ed798f2b17046d
3 N533ddbb0622344d99ff7d645974b4504
4 N617cfeec1aaf47baa7273b4ea243bfb4
5 N6526d6e1fd66425ea18f1b72136afaca
6 N7218a4894f9548939b659b6c11ca2464
7 N77affad67f26460996ef616b29c1d705
8 N7b65992cd5d84a8c9e1f4572bbec3bdd
9 N952d7f97855a45efa23b32f650bd8385
10 Nab814ed3a138415389c05f227ca81fe0
11 Naff09ae16e284e6f85a970bdcffc88c0
12 Nba47a24f3eb74cdcaaee9e516a3cd864
13 Ncb78bf507fdb409683a9cc658efba699
14 Nd28e698200d6479892bee5618bcc6940
15 Ned4ebb375a684535b50adb9bcce36bb1
16 Nee475e26e56c47978790318dc935ebe4
17 Nf485b63bd24d48acac75b65bc1a78b09
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N67113a4aac5743b2a2614121390d0c77
21 schema:citation sg:pub.10.1007/bf00762961
22 sg:pub.10.1038/325641a0
23 sg:pub.10.1038/nature07819
24 sg:pub.10.1038/nature08201
25 sg:pub.10.1038/nature08741
26 sg:pub.10.1038/nature09406
27 sg:pub.10.1038/nature09885
28 sg:pub.10.1038/ng1197-324
29 sg:pub.10.1186/1471-2229-11-168
30 sg:pub.10.1203/00006450-200108000-00015
31 https://app.dimensions.ai/details/publication/pub.1074517305
32 https://app.dimensions.ai/details/publication/pub.1079410352
33 https://app.dimensions.ai/details/publication/pub.1081702019
34 https://app.dimensions.ai/details/publication/pub.1082089423
35 https://app.dimensions.ai/details/publication/pub.1082560155
36 https://app.dimensions.ai/details/publication/pub.1083238181
37 https://doi.org/10.1002/ana.1222
38 https://doi.org/10.1002/ana.20331
39 https://doi.org/10.1002/jcp.20166
40 https://doi.org/10.1002/prot.21099
41 https://doi.org/10.1016/1056-8727(93)90038-z
42 https://doi.org/10.1016/j.braindev.2009.02.008
43 https://doi.org/10.1016/j.febslet.2007.03.016
44 https://doi.org/10.1016/j.jsb.2007.01.011
45 https://doi.org/10.1016/s0076-6879(97)76066-x
46 https://doi.org/10.1021/bi900521n
47 https://doi.org/10.1038/emboj.2010.309
48 https://doi.org/10.1074/jbc.274.47.33244
49 https://doi.org/10.1074/jbc.m509422200
50 https://doi.org/10.1093/nar/22.22.4673
51 https://doi.org/10.1093/nar/gkj001
52 https://doi.org/10.1093/nar/gkm067
53 https://doi.org/10.1093/nar/gkn862
54 https://doi.org/10.1098/rstb.1990.0020
55 https://doi.org/10.1107/s0021889807021206
56 https://doi.org/10.1107/s0907444902011678
57 https://doi.org/10.1107/s0907444902016657
58 https://doi.org/10.1107/s0907444904019158
59 https://doi.org/10.1107/s0907444994003112
60 https://doi.org/10.1111/j.1432-1033.1994.tb18550.x
61 https://doi.org/10.1111/j.1528-1167.2008.01833.x
62 https://doi.org/10.1126/science.1087619
63 https://doi.org/10.1126/science.1088196
64 https://doi.org/10.1126/science.1125629
65 https://doi.org/10.1126/science.1160406
66 https://doi.org/10.1126/science.1173654
67 https://doi.org/10.1126/science.3839598
68 https://doi.org/10.1128/aem.01970-09
69 https://doi.org/10.1146/annurev.biophys.35.040405.102005
70 https://doi.org/10.1152/ajpendo.00004.2009
71 https://doi.org/10.1152/ajpendo.00712.2009
72 https://doi.org/10.1152/ajpendo.90388.2008
73 https://doi.org/10.1177/0148607104028005364
74 https://doi.org/10.1212/wnl.0b013e318248a245
75 https://doi.org/10.1517/14728220903307509
76 https://doi.org/10.1530/eje.0.1500627
77 https://doi.org/10.1677/joe-09-0037
78 schema:datePublished 2012-10
79 schema:datePublishedReg 2012-10-01
80 schema:description Glucose transporters are essential for metabolism of glucose in cells of diverse organisms from microbes to humans, exemplified by the disease-related human proteins GLUT1, 2, 3 and 4. Despite rigorous efforts, the structural information for GLUT1-4 or their homologues remains largely unknown. Here we report three related crystal structures of XylE, an Escherichia coli homologue of GLUT1-4, in complex with d-xylose, d-glucose and 6-bromo-6-deoxy-D-glucose, at resolutions of 2.8, 2.9 and 2.6 Å, respectively. The structure consists of a typical major facilitator superfamily fold of 12 transmembrane segments and a unique intracellular four-helix domain. XylE was captured in an outward-facing, partly occluded conformation. Most of the important amino acids responsible for recognition of D-xylose or d-glucose are invariant in GLUT1-4, suggesting functional and mechanistic conservations. Structure-based modelling of GLUT1-4 allows mapping and interpretation of disease-related mutations. The structural and biochemical information reported here constitutes an important framework for mechanistic understanding of glucose transporters and sugar porters in general.
81 schema:genre research_article
82 schema:inLanguage en
83 schema:isAccessibleForFree false
84 schema:isPartOf N20e28d87a11b4b9aa640fb140b62d43c
85 N680097e408bc4f17815a308385e6cc4a
86 sg:journal.1018957
87 schema:name Crystal structure of a bacterial homologue of glucose transporters GLUT1–4
88 schema:pagination 361
89 schema:productId N30efcf4178ce4d83b6f9ec5c8f4d6c39
90 N4cc047c2f0ff4527a611586be71c71e6
91 N5b499dae43bd4efe850cd38dc07976f5
92 N6b64a1905c0b40d19d0abcb572566e51
93 N91f8f5ff965a47d1b015873dab8eb7b2
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035673999
95 https://doi.org/10.1038/nature11524
96 schema:sdDatePublished 2019-04-10T16:30
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N8f92d8259ec84eb7a418840b684dd5e1
99 schema:url https://www.nature.com/articles/nature11524
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N09da830f9949422ba85ed0598d97739d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Structure-Activity Relationship
105 rdf:type schema:DefinedTerm
106 N199c57528e494c4ab93a61b1ba36c7dc rdf:first N1f938090b61547389b977d761f3f754a
107 rdf:rest N313861b5470843ab8ceffcc4100fa88e
108 N1f938090b61547389b977d761f3f754a schema:affiliation https://www.grid.ac/institutes/grid.12527.33
109 schema:familyName Rao
110 schema:givenName Yu
111 rdf:type schema:Person
112 N20e28d87a11b4b9aa640fb140b62d43c schema:issueNumber 7420
113 rdf:type schema:PublicationIssue
114 N242afeeb078143b3a9ed798f2b17046d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Protein Conformation
116 rdf:type schema:DefinedTerm
117 N30efcf4178ce4d83b6f9ec5c8f4d6c39 schema:name nlm_unique_id
118 schema:value 0410462
119 rdf:type schema:PropertyValue
120 N313861b5470843ab8ceffcc4100fa88e rdf:first sg:person.0675167270.86
121 rdf:rest rdf:nil
122 N47ed739b03bb49f49511bd87a461ca58 rdf:first N6a9af44df3374a0cb3e17d1626dd602e
123 rdf:rest N7a82977847d14661bf3d688f44c8ce39
124 N4cc047c2f0ff4527a611586be71c71e6 schema:name doi
125 schema:value 10.1038/nature11524
126 rdf:type schema:PropertyValue
127 N533ddbb0622344d99ff7d645974b4504 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Symporters
129 rdf:type schema:DefinedTerm
130 N5b499dae43bd4efe850cd38dc07976f5 schema:name pubmed_id
131 schema:value 23075985
132 rdf:type schema:PropertyValue
133 N617cfeec1aaf47baa7273b4ea243bfb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Substrate Specificity
135 rdf:type schema:DefinedTerm
136 N6526d6e1fd66425ea18f1b72136afaca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Biological Transport
138 rdf:type schema:DefinedTerm
139 N67113a4aac5743b2a2614121390d0c77 rdf:first sg:person.0753533603.01
140 rdf:rest Nf93e1d2aedc94b3da56c20afef77b7ca
141 N680097e408bc4f17815a308385e6cc4a schema:volumeNumber 490
142 rdf:type schema:PublicationVolume
143 N6a9af44df3374a0cb3e17d1626dd602e schema:affiliation https://www.grid.ac/institutes/grid.12527.33
144 schema:familyName Sun
145 schema:givenName Xiuyun
146 rdf:type schema:Person
147 N6b64a1905c0b40d19d0abcb572566e51 schema:name readcube_id
148 schema:value a9f0455730f49dbfb1b6aa1b74c51a5f211f6f08be23b76822f51bd4885716c4
149 rdf:type schema:PropertyValue
150 N7218a4894f9548939b659b6c11ca2464 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Models, Molecular
152 rdf:type schema:DefinedTerm
153 N77affad67f26460996ef616b29c1d705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Escherichia coli
155 rdf:type schema:DefinedTerm
156 N7a82977847d14661bf3d688f44c8ce39 rdf:first sg:person.01342551453.39
157 rdf:rest N199c57528e494c4ab93a61b1ba36c7dc
158 N7b65992cd5d84a8c9e1f4572bbec3bdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Glucose Transport Proteins, Facilitative
160 rdf:type schema:DefinedTerm
161 N8f92d8259ec84eb7a418840b684dd5e1 schema:name Springer Nature - SN SciGraph project
162 rdf:type schema:Organization
163 N91f8f5ff965a47d1b015873dab8eb7b2 schema:name dimensions_id
164 schema:value pub.1035673999
165 rdf:type schema:PropertyValue
166 N952d7f97855a45efa23b32f650bd8385 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Crystallography, X-Ray
168 rdf:type schema:DefinedTerm
169 Nab814ed3a138415389c05f227ca81fe0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Xylose
171 rdf:type schema:DefinedTerm
172 Naff09ae16e284e6f85a970bdcffc88c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Hydrogen Bonding
174 rdf:type schema:DefinedTerm
175 Nba47a24f3eb74cdcaaee9e516a3cd864 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Escherichia coli Proteins
177 rdf:type schema:DefinedTerm
178 Ncb78bf507fdb409683a9cc658efba699 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Glucose
180 rdf:type schema:DefinedTerm
181 Nd28e698200d6479892bee5618bcc6940 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Glucose Transporter Type 1
183 rdf:type schema:DefinedTerm
184 Ned4ebb375a684535b50adb9bcce36bb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Humans
186 rdf:type schema:DefinedTerm
187 Nee475e26e56c47978790318dc935ebe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Deoxyglucose
189 rdf:type schema:DefinedTerm
190 Nf2ff435deb594c0091a65e2153176a98 rdf:first sg:person.01274436253.23
191 rdf:rest N47ed739b03bb49f49511bd87a461ca58
192 Nf485b63bd24d48acac75b65bc1a78b09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Structural Homology, Protein
194 rdf:type schema:DefinedTerm
195 Nf93e1d2aedc94b3da56c20afef77b7ca rdf:first sg:person.0734714670.52
196 rdf:rest Nf2ff435deb594c0091a65e2153176a98
197 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
198 schema:name Biological Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
201 schema:name Biochemistry and Cell Biology
202 rdf:type schema:DefinedTerm
203 sg:grant.6977096 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11524
204 rdf:type schema:MonetaryGrant
205 sg:grant.6978784 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11524
206 rdf:type schema:MonetaryGrant
207 sg:journal.1018957 schema:issn 0090-0028
208 1476-4687
209 schema:name Nature
210 rdf:type schema:Periodical
211 sg:person.01274436253.23 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
212 schema:familyName Yan
213 schema:givenName Chuangye
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274436253.23
215 rdf:type schema:Person
216 sg:person.01342551453.39 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
217 schema:familyName Gong
218 schema:givenName Xinqi
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342551453.39
220 rdf:type schema:Person
221 sg:person.0675167270.86 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
222 schema:familyName Yan
223 schema:givenName Nieng
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675167270.86
225 rdf:type schema:Person
226 sg:person.0734714670.52 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
227 schema:familyName Zeng
228 schema:givenName Xin
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734714670.52
230 rdf:type schema:Person
231 sg:person.0753533603.01 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
232 schema:familyName Sun
233 schema:givenName Linfeng
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753533603.01
235 rdf:type schema:Person
236 sg:pub.10.1007/bf00762961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031018088
237 https://doi.org/10.1007/bf00762961
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/325641a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004764127
240 https://doi.org/10.1038/325641a0
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/nature07819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051414479
243 https://doi.org/10.1038/nature07819
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/nature08201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020495727
246 https://doi.org/10.1038/nature08201
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nature08741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006570730
249 https://doi.org/10.1038/nature08741
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nature09406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016664325
252 https://doi.org/10.1038/nature09406
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nature09885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044030985
255 https://doi.org/10.1038/nature09885
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/ng1197-324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031901217
258 https://doi.org/10.1038/ng1197-324
259 rdf:type schema:CreativeWork
260 sg:pub.10.1186/1471-2229-11-168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007719315
261 https://doi.org/10.1186/1471-2229-11-168
262 rdf:type schema:CreativeWork
263 sg:pub.10.1203/00006450-200108000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002323101
264 https://doi.org/10.1203/00006450-200108000-00015
265 rdf:type schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1074517305 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1079410352 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1081702019 schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1082089423 schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1082560155 schema:CreativeWork
271 https://app.dimensions.ai/details/publication/pub.1083238181 schema:CreativeWork
272 https://doi.org/10.1002/ana.1222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012774261
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/ana.20331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015078031
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1002/jcp.20166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050775411
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1002/prot.21099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025034562
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/1056-8727(93)90038-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1052620916
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.braindev.2009.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000213881
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.febslet.2007.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001737936
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.jsb.2007.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048628045
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s0076-6879(97)76066-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004907170
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1021/bi900521n schema:sameAs https://app.dimensions.ai/details/publication/pub.1055209756
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1038/emboj.2010.309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015715487
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1074/jbc.274.47.33244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004745860
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1074/jbc.m509422200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048489555
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/nar/22.22.4673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042438223
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/nar/gkj001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048681044
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1093/nar/gkm067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012412735
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1093/nar/gkn862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038074732
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1098/rstb.1990.0020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012352788
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1107/s0021889807021206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012753217
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1107/s0907444902011678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021532775
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1107/s0907444902016657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051282549
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1107/s0907444994003112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573949
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1111/j.1432-1033.1994.tb18550.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023670544
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1111/j.1528-1167.2008.01833.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043446106
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1126/science.1087619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448393
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1126/science.1088196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048930272
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1126/science.1125629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453617
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1126/science.1160406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062458423
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1126/science.1173654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007843251
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1126/science.3839598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621983
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1128/aem.01970-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003906114
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1146/annurev.biophys.35.040405.102005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036989658
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1152/ajpendo.00004.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006476675
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1152/ajpendo.00712.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045477249
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1152/ajpendo.90388.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034455146
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1177/0148607104028005364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031432879
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1212/wnl.0b013e318248a245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064356766
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1517/14728220903307509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010410173
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1530/eje.0.1500627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005714537
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1677/joe-09-0037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022365366
353 rdf:type schema:CreativeWork
354 https://www.grid.ac/institutes/grid.12527.33 schema:alternateName Tsinghua University
355 schema:name School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
356 State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, Tsinghua University, Beijing 100084, China
357 Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China
358 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...