Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-07-04

AUTHORS

Ravid Straussman, Teppei Morikawa, Kevin Shee, Michal Barzily-Rokni, Zhi Rong Qian, Jinyan Du, Ashli Davis, Margaret M. Mongare, Joshua Gould, Dennie T. Frederick, Zachary A. Cooper, Paul B. Chapman, David B. Solit, Antoni Ribas, Roger S. Lo, Keith T. Flaherty, Shuji Ogino, Jennifer A. Wargo, Todd R. Golub

ABSTRACT

The secretion of hepatocyte growth factor by stromal cells in the tumour micro-environment can make melanoma resistant to RAF inhibitors, through the activation of the MET signalling pathway, but a combination of RAF and MET inhibitors can overcome this resistance.

PAGES

500-504

Journal

TITLE

Nature

ISSUE

7408

VOLUME

487

Related Patents

  • Pyrido[2,3-B]Pyrazin-8-Substituted Compounds And Their Use
  • Macrocycle Kinase Inhibitors
  • Pharmaceutical Compositions And Methods For Treating Cancer And Biomarkers For Drug Screening
  • Pharmaceutical Compositions And Methods For Treating Cancer And Biomarkers For Drug Screening
  • 1-(5-Tert-Butyl-2-Phenyl-2h-Pyrazol-3-Yl)-3-[2-Fluoro-4-(1-Methyl-2-Oxo-2,3-Dihydro-1h-Imidazo[4,5-B]Pyridin-7-Yloxy)-Phenyl]-Urea And Related Compounds And Their Use In Therapy
  • Macrocyclic Compounds And Uses Thereof
  • Therapeutic Targeting Of Myeloproliferative Neoplasms By Dusp1 Inhibition
  • 1-(5-Tert-Butyl-2-Aryl-Pyrazol-3-Yl)-3-[2-Fluoro-4-[(3-Oxo-4h-Pyrido[2,3-B]Pyrazin-8-Yl)Oxy]Phenyl]Urea Derivatives As Raf Inhibitors For The Treatment Of Cancer
  • Pyrido[2,3-B]Pyrazin-8-Substituted Compounds And Their Use
  • Chiral Diaryl Macrocycles As Modulators Of Protein Kinases
  • Methods And Compositions For Treating Melanoma
  • 1-(5-Tert-Butyl-2-Aryl-Pyrazol-3-Yl)-3-[2-Fluoro-4-[(3-Oxo-4h-Pyrido [2, 3-B]Pyrazin- 8-Yl)Oxy]Phenyl]Urea Derivatives As Raf Inhibitors For The Treatment Of Cancer
  • Methods Of Identifying Responses To Map Kinase Inhibition Therapy
  • Process For The Preparation Of 8-(4-Aminophenoxy)-4h-Pyrido[2,3-B]Pyrazin-3-One Derivatives
  • Therapy For Kinase-Dependent Malignancies
  • Antibody-Drug Conjugates And Immunotoxins
  • Combination Treatments With Sonic Hedgehog Inhibitors
  • Vitamin D Receptor Agonists To Treat Diseases Involving Cxcl12 Activity
  • Diaryl Macrocycles As Modulators Of Protein Kinases
  • Macrocyclic Compounds And Uses Thereof
  • Antibody-Drug Conjugates And Immunotoxins
  • Compositions And Methods For Combination Therapy With Dengue Virus And Dendritic Cells
  • Macrocyclic Compounds For Treating Disease
  • Diaryl Macrocycle Polymorph
  • Macrocyclic Compounds For Treating Disease
  • Combination Therapy For The Treatment Of Cancer Using An Anti-C-Met Antibody
  • Methods Of Reducing Kinase Inhibitor Resistance
  • Ex-Vivo Culture System And Methods Of Using Same
  • Compositions And Methods For Combination Therapy With Dengue Virus And Dendritic Cells
  • Macrocyclic Compounds And Uses Thereof
  • Method Of Treating Cancer Using Anti-C-Met Antibody And Fgfr Inhibitor Combination Therapy
  • Chiral Diaryl Macrocycles As Modulators Of Protein Kinases
  • Compositions And Methods For Combination Therapy With Dengue Virus And Dendritic Cells
  • Formulations Of A Compound Modulating Kinases
  • Plx-8394 Or Plx-7904 For Use In The Treatment Of Braf-V600-Related Diseases
  • Diagnostic And Treatment Methods In Patients Having Or At Risk Of Developing Resistance To Cancer Therapy
  • Antibody-Drug Conjugates And Immunotoxins
  • Process For The Preparation Of 8-(4-Aminophenoxy)-4h-Pyrido[2,3-B]Pyrazin-3-One Derivatives
  • 1-(5-Tert-Butyl-2-Phenyl-2h-Pyrazol-3-Yl)-3-[2-Fluoro-4-(1-Methyl-2-Oxo-2,3-Dihydro-1h-Imidazo[4,5-B]Pyridin-7-Yloxy)-Phenyl]-Urea And Related Compounds And Their Use In Therapy
  • Combination Therapy Involving Diaryl Macrocyclic Compounds
  • 1-(5-Tert-Butyl-2-Phenyl-2h-Pyrazol-3-Yl)-3-[2-Fluoro-4-(1-Methyl-2-Oxo-2,3-Dihydro-1h-Imidazo[4,5-B]Pyridin-7-Yloxy)-Phenyl]-Urea And Related Compounds And Their Use In Therapy
  • Compositions And Methods For Combination Therapy With Dengue Virus And Dendritic Cells
  • Glucocorticoid Inhibitors For Treatment Of Prostate Cancer
  • Combination Immunotherapies For Treatment Of Cancer
  • Combination Immunotherapies For Treatment Of Cancer
  • Compositions And Methods For Producing Dendritic Cells
  • Chiral Diaryl Macrocycles And Uses Thereof
  • Diaryl Macrocycles As Modulators Of Protein Kinases
  • Compositions And Methods For Combination Therapy With Dengue Virus And Dendritic Cells
  • Improved Methods For The Selection Of Patients For Pd-1 Or B7-H4 Targeted Therapies, And Combination Therapies Thereof
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature11183

    DOI

    http://dx.doi.org/10.1038/nature11183

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053677952

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22763439


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coculture Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepatocyte Growth Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Indoles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Melanoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Targeted Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphatidylinositol 3-Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Kinase Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins B-raf", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-met", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stromal Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sulfonamides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Microenvironment", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vemurafenib", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Straussman", 
            "givenName": "Ravid", 
            "id": "sg:person.01261573344.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261573344.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morikawa", 
            "givenName": "Teppei", 
            "id": "sg:person.01164446451.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164446451.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shee", 
            "givenName": "Kevin", 
            "id": "sg:person.0641770754.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641770754.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barzily-Rokni", 
            "givenName": "Michal", 
            "id": "sg:person.0743427111.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743427111.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qian", 
            "givenName": "Zhi Rong", 
            "id": "sg:person.01074021634.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074021634.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Du", 
            "givenName": "Jinyan", 
            "id": "sg:person.0637564336.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637564336.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davis", 
            "givenName": "Ashli", 
            "id": "sg:person.01125770711.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125770711.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mongare", 
            "givenName": "Margaret M.", 
            "id": "sg:person.01174104111.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174104111.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gould", 
            "givenName": "Joshua", 
            "id": "sg:person.01242217311.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242217311.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Surgical Oncology, Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Division of Surgical Oncology, Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Frederick", 
            "givenName": "Dennie T.", 
            "id": "sg:person.01310332511.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310332511.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Surgical Oncology, Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Division of Surgical Oncology, Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cooper", 
            "givenName": "Zachary A.", 
            "id": "sg:person.01354045521.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354045521.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, Memorial Sloan-Kettering Cancer Center, 10065, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Medicine, Memorial Sloan-Kettering Cancer Center, 10065, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chapman", 
            "givenName": "Paul B.", 
            "id": "sg:person.01155324177.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155324177.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, 10065, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Medicine, Memorial Sloan-Kettering Cancer Center, 10065, New York, New York, USA", 
                "Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, 10065, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Solit", 
            "givenName": "David B.", 
            "id": "sg:person.0656335277.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656335277.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular and Medical Pharmacology, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Division of Hematology and Oncology, Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA", 
                "Department of Molecular and Medical Pharmacology, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ribas", 
            "givenName": "Antoni", 
            "id": "sg:person.0627244670.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627244670.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Dermatology, Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Molecular and Medical Pharmacology, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA", 
                "Division of Dermatology, Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lo", 
            "givenName": "Roger S.", 
            "id": "sg:person.0701722423.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701722423.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Surgical Oncology, Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Division of Surgical Oncology, Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Flaherty", 
            "givenName": "Keith T.", 
            "id": "sg:person.01365026210.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365026210.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School, 02115, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA", 
                "Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School, 02115, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogino", 
            "givenName": "Shuji", 
            "id": "sg:person.01006336021.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006336021.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Surgical Oncology, Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA", 
              "id": "http://www.grid.ac/institutes/grid.32224.35", 
              "name": [
                "Division of Surgical Oncology, Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wargo", 
            "givenName": "Jennifer A.", 
            "id": "sg:person.0637157757.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637157757.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, 20815, Chevy Chase, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.413575.1", 
              "name": [
                "The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
                "Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA", 
                "Harvard Medical School, 02115, Boston, Massachusetts, USA", 
                "Howard Hughes Medical Institute, 20815, Chevy Chase, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Golub", 
            "givenName": "Todd R.", 
            "id": "sg:person.01152644406.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152644406.14"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrc2618", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049326401", 
              "https://doi.org/10.1038/nrc2618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09626", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035733152", 
              "https://doi.org/10.1038/nature09626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041808919", 
              "https://doi.org/10.1038/nbt.1513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006053948", 
              "https://doi.org/10.1038/nature11249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005907434", 
              "https://doi.org/10.1038/nature09627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028779172", 
              "https://doi.org/10.1038/nrd1609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028208693", 
              "https://doi.org/10.1038/nature10662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038374700", 
              "https://doi.org/10.1038/nature10868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032620847", 
              "https://doi.org/10.1038/nature09454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018293106", 
              "https://doi.org/10.1038/nm.2112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036672274", 
              "https://doi.org/10.1038/nrc1877"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-07-04", 
        "datePublishedReg": "2012-07-04", 
        "description": "The secretion of hepatocyte growth factor by stromal cells in the tumour micro-environment can make melanoma resistant to RAF inhibitors, through the activation of the MET signalling pathway, but a combination of RAF and MET inhibitors can overcome this resistance.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nature11183", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3493693", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2481873", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2699023", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440177", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7408", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "487"
          }
        ], 
        "keywords": [
          "RAF inhibitors", 
          "hepatocyte growth factor", 
          "combination of RAF", 
          "MET inhibitors", 
          "HGF secretion", 
          "stromal cells", 
          "growth factor", 
          "secretion", 
          "inhibitors", 
          "tumors", 
          "melanoma", 
          "MetS", 
          "elicits", 
          "activation", 
          "cells", 
          "resistance", 
          "pathway", 
          "Raf", 
          "factors", 
          "combination"
        ], 
        "name": "Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion", 
        "pagination": "500-504", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1053677952"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature11183"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22763439"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature11183", 
          "https://app.dimensions.ai/details/publication/pub.1053677952"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T20:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_578.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nature11183"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature11183'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature11183'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature11183'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature11183'


     

    This table displays all metadata directly associated to this object as RDF triples.

    374 TRIPLES      21 PREDICATES      78 URIs      59 LITERALS      29 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature11183 schema:about N048cec2a36334cab9e2523478bc35389
    2 N15b9f40cf567418ea5e4649465a8e0fa
    3 N1a680baeb4854793bc88a2d46673f103
    4 N1c04968ce31543a8a148eec7241e6c0d
    5 N1d3687bc1c9f4b71bd5ce975a05e6542
    6 N2fbde2e98c3e4729b109ec7706b664cf
    7 N3a2457aaf3b647968311d4c6b2386ef7
    8 N41179f57b72f46b59de43bdfabdab125
    9 N5232f35603504d37a79f8f14dc8f255c
    10 N5268f8dc9db242daa608e26deddb8ace
    11 N71c6c8e9739447ff8e7f521060a3cf9e
    12 N746789a0aab74d6fac6d747bc7cb2edb
    13 N883ff3d4052144c7b3c7ab171ae17550
    14 Na1393e814d4e416fa7b1ad455077ed25
    15 Na17e57ff139a4ac6a28597ccabc3dedb
    16 Na2495a584a814240b650c28f1e48abb9
    17 Nacaa97a0727f498ba84405f5c667c633
    18 Nbb79bbd8146e4487bfa2ebd6ba96f032
    19 Nca3ffbcb8a2c4021985108af28185e91
    20 Ndb3c103eb66b4ef59ce70a4a4d8316df
    21 Ne4ab421540014191ac271e96bad56f1a
    22 Nf7c258aa079c460fa2ec03a8f5652a89
    23 anzsrc-for:11
    24 anzsrc-for:1112
    25 schema:author N16712a1b65f6424f8bb3a57adadf84be
    26 schema:citation sg:pub.10.1038/nature09454
    27 sg:pub.10.1038/nature09626
    28 sg:pub.10.1038/nature09627
    29 sg:pub.10.1038/nature10662
    30 sg:pub.10.1038/nature10868
    31 sg:pub.10.1038/nature11249
    32 sg:pub.10.1038/nbt.1513
    33 sg:pub.10.1038/nm.2112
    34 sg:pub.10.1038/nrc1877
    35 sg:pub.10.1038/nrc2618
    36 sg:pub.10.1038/nrd1609
    37 schema:datePublished 2012-07-04
    38 schema:datePublishedReg 2012-07-04
    39 schema:description The secretion of hepatocyte growth factor by stromal cells in the tumour micro-environment can make melanoma resistant to RAF inhibitors, through the activation of the MET signalling pathway, but a combination of RAF and MET inhibitors can overcome this resistance.
    40 schema:genre article
    41 schema:isAccessibleForFree true
    42 schema:isPartOf N1a024f9fd4494a4f9f6a43b3f0c0efe9
    43 N9f475c6ee66240e5a8af578bae04a449
    44 sg:journal.1018957
    45 schema:keywords HGF secretion
    46 MET inhibitors
    47 MetS
    48 RAF inhibitors
    49 Raf
    50 activation
    51 cells
    52 combination
    53 combination of RAF
    54 elicits
    55 factors
    56 growth factor
    57 hepatocyte growth factor
    58 inhibitors
    59 melanoma
    60 pathway
    61 resistance
    62 secretion
    63 stromal cells
    64 tumors
    65 schema:name Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
    66 schema:pagination 500-504
    67 schema:productId N0703057225d84f3bb7edeeefa9ca6120
    68 Nb08174b072504bdd94333157ee0624c7
    69 Ne9a861133be54c9fa5c381a47876263b
    70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053677952
    71 https://doi.org/10.1038/nature11183
    72 schema:sdDatePublished 2022-11-24T20:57
    73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    74 schema:sdPublisher Nf9a05de92eb44923ba75543982c7f9b5
    75 schema:url https://doi.org/10.1038/nature11183
    76 sgo:license sg:explorer/license/
    77 sgo:sdDataset articles
    78 rdf:type schema:ScholarlyArticle
    79 N01f314320f3949e2b9a83688d3f50d00 rdf:first sg:person.01074021634.28
    80 rdf:rest Na3b44ed66d674e9daf568f639f9f4763
    81 N048cec2a36334cab9e2523478bc35389 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    82 schema:name Indoles
    83 rdf:type schema:DefinedTerm
    84 N0567bc0427704c0290b8c62cffe38490 rdf:first sg:person.0743427111.22
    85 rdf:rest N01f314320f3949e2b9a83688d3f50d00
    86 N0703057225d84f3bb7edeeefa9ca6120 schema:name dimensions_id
    87 schema:value pub.1053677952
    88 rdf:type schema:PropertyValue
    89 N106513ac50864d578f6d0405ebdab161 rdf:first sg:person.01125770711.72
    90 rdf:rest N9ce8754f358c4b3b9b3793bdae493fcd
    91 N15b9f40cf567418ea5e4649465a8e0fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Vemurafenib
    93 rdf:type schema:DefinedTerm
    94 N16712a1b65f6424f8bb3a57adadf84be rdf:first sg:person.01261573344.96
    95 rdf:rest Ned26c4a1d4534f8dad64036145af7475
    96 N1a024f9fd4494a4f9f6a43b3f0c0efe9 schema:issueNumber 7408
    97 rdf:type schema:PublicationIssue
    98 N1a680baeb4854793bc88a2d46673f103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Signal Transduction
    100 rdf:type schema:DefinedTerm
    101 N1c04968ce31543a8a148eec7241e6c0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Proto-Oncogene Proteins B-raf
    103 rdf:type schema:DefinedTerm
    104 N1d3687bc1c9f4b71bd5ce975a05e6542 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Antineoplastic Combined Chemotherapy Protocols
    106 rdf:type schema:DefinedTerm
    107 N2fbde2e98c3e4729b109ec7706b664cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Prognosis
    109 rdf:type schema:DefinedTerm
    110 N3a2457aaf3b647968311d4c6b2386ef7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Proto-Oncogene Proteins c-met
    112 rdf:type schema:DefinedTerm
    113 N41179f57b72f46b59de43bdfabdab125 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Coculture Techniques
    115 rdf:type schema:DefinedTerm
    116 N5232f35603504d37a79f8f14dc8f255c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Hepatocyte Growth Factor
    118 rdf:type schema:DefinedTerm
    119 N5268f8dc9db242daa608e26deddb8ace schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Protein Kinase Inhibitors
    121 rdf:type schema:DefinedTerm
    122 N53f9b1f6404b442c81ef06b00f124bc6 rdf:first sg:person.0637157757.45
    123 rdf:rest N6788431a9a304ed89cf76d343cc0a0b1
    124 N6788431a9a304ed89cf76d343cc0a0b1 rdf:first sg:person.01152644406.14
    125 rdf:rest rdf:nil
    126 N6958325a3f084957b8e0073eb2511557 rdf:first sg:person.01365026210.96
    127 rdf:rest Ne0d7e818b5c74df8ba707650ae4ec797
    128 N718e29f108b64f188c1e5dadab65fef3 rdf:first sg:person.01354045521.83
    129 rdf:rest Ne7b570b4f53349b783961dd2bdb6508d
    130 N71c6c8e9739447ff8e7f521060a3cf9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Antineoplastic Agents
    132 rdf:type schema:DefinedTerm
    133 N746789a0aab74d6fac6d747bc7cb2edb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Cell Line, Tumor
    135 rdf:type schema:DefinedTerm
    136 N8583a188a342467c95919c6f46d0ffba rdf:first sg:person.0656335277.50
    137 rdf:rest N8697c993e41642ecab8fca96d2b56ec5
    138 N8697c993e41642ecab8fca96d2b56ec5 rdf:first sg:person.0627244670.28
    139 rdf:rest Ncfd9eaafc57d49fda077e2d22102423e
    140 N883ff3d4052144c7b3c7ab171ae17550 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Proteomics
    142 rdf:type schema:DefinedTerm
    143 N9ce8754f358c4b3b9b3793bdae493fcd rdf:first sg:person.01174104111.93
    144 rdf:rest Nb13a685320794f8da164fd51c72dcf0c
    145 N9f475c6ee66240e5a8af578bae04a449 schema:volumeNumber 487
    146 rdf:type schema:PublicationVolume
    147 Na1393e814d4e416fa7b1ad455077ed25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Tumor Microenvironment
    149 rdf:type schema:DefinedTerm
    150 Na17e57ff139a4ac6a28597ccabc3dedb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Sulfonamides
    152 rdf:type schema:DefinedTerm
    153 Na2495a584a814240b650c28f1e48abb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Phosphatidylinositol 3-Kinases
    155 rdf:type schema:DefinedTerm
    156 Na3b44ed66d674e9daf568f639f9f4763 rdf:first sg:person.0637564336.69
    157 rdf:rest N106513ac50864d578f6d0405ebdab161
    158 Na61108b86942475aadd1ee444cf79742 rdf:first sg:person.01310332511.21
    159 rdf:rest N718e29f108b64f188c1e5dadab65fef3
    160 Nacaa97a0727f498ba84405f5c667c633 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Mutation
    162 rdf:type schema:DefinedTerm
    163 Nb08174b072504bdd94333157ee0624c7 schema:name pubmed_id
    164 schema:value 22763439
    165 rdf:type schema:PropertyValue
    166 Nb13a685320794f8da164fd51c72dcf0c rdf:first sg:person.01242217311.44
    167 rdf:rest Na61108b86942475aadd1ee444cf79742
    168 Nbb79bbd8146e4487bfa2ebd6ba96f032 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Humans
    170 rdf:type schema:DefinedTerm
    171 Nca3ffbcb8a2c4021985108af28185e91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Molecular Targeted Therapy
    173 rdf:type schema:DefinedTerm
    174 Ncfd9eaafc57d49fda077e2d22102423e rdf:first sg:person.0701722423.70
    175 rdf:rest N6958325a3f084957b8e0073eb2511557
    176 Ndb3c103eb66b4ef59ce70a4a4d8316df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Stromal Cells
    178 rdf:type schema:DefinedTerm
    179 Ne0d7e818b5c74df8ba707650ae4ec797 rdf:first sg:person.01006336021.57
    180 rdf:rest N53f9b1f6404b442c81ef06b00f124bc6
    181 Ne4ab421540014191ac271e96bad56f1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Melanoma
    183 rdf:type schema:DefinedTerm
    184 Ne7b570b4f53349b783961dd2bdb6508d rdf:first sg:person.01155324177.77
    185 rdf:rest N8583a188a342467c95919c6f46d0ffba
    186 Ne9a861133be54c9fa5c381a47876263b schema:name doi
    187 schema:value 10.1038/nature11183
    188 rdf:type schema:PropertyValue
    189 Neb7b4328b7474dba8033cc7222cf4633 rdf:first sg:person.0641770754.41
    190 rdf:rest N0567bc0427704c0290b8c62cffe38490
    191 Ned26c4a1d4534f8dad64036145af7475 rdf:first sg:person.01164446451.02
    192 rdf:rest Neb7b4328b7474dba8033cc7222cf4633
    193 Nf7c258aa079c460fa2ec03a8f5652a89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Drug Resistance, Neoplasm
    195 rdf:type schema:DefinedTerm
    196 Nf9a05de92eb44923ba75543982c7f9b5 schema:name Springer Nature - SN SciGraph project
    197 rdf:type schema:Organization
    198 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    199 schema:name Medical and Health Sciences
    200 rdf:type schema:DefinedTerm
    201 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    202 schema:name Oncology and Carcinogenesis
    203 rdf:type schema:DefinedTerm
    204 sg:grant.2440177 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11183
    205 rdf:type schema:MonetaryGrant
    206 sg:grant.2481873 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11183
    207 rdf:type schema:MonetaryGrant
    208 sg:grant.2699023 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11183
    209 rdf:type schema:MonetaryGrant
    210 sg:grant.3493693 http://pending.schema.org/fundedItem sg:pub.10.1038/nature11183
    211 rdf:type schema:MonetaryGrant
    212 sg:journal.1018957 schema:issn 0028-0836
    213 1476-4687
    214 schema:name Nature
    215 schema:publisher Springer Nature
    216 rdf:type schema:Periodical
    217 sg:person.01006336021.57 schema:affiliation grid-institutes:grid.38142.3c
    218 schema:familyName Ogino
    219 schema:givenName Shuji
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006336021.57
    221 rdf:type schema:Person
    222 sg:person.01074021634.28 schema:affiliation grid-institutes:grid.65499.37
    223 schema:familyName Qian
    224 schema:givenName Zhi Rong
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074021634.28
    226 rdf:type schema:Person
    227 sg:person.01125770711.72 schema:affiliation grid-institutes:grid.66859.34
    228 schema:familyName Davis
    229 schema:givenName Ashli
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125770711.72
    231 rdf:type schema:Person
    232 sg:person.01152644406.14 schema:affiliation grid-institutes:grid.413575.1
    233 schema:familyName Golub
    234 schema:givenName Todd R.
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152644406.14
    236 rdf:type schema:Person
    237 sg:person.01155324177.77 schema:affiliation grid-institutes:grid.51462.34
    238 schema:familyName Chapman
    239 schema:givenName Paul B.
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155324177.77
    241 rdf:type schema:Person
    242 sg:person.01164446451.02 schema:affiliation grid-institutes:grid.65499.37
    243 schema:familyName Morikawa
    244 schema:givenName Teppei
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164446451.02
    246 rdf:type schema:Person
    247 sg:person.01174104111.93 schema:affiliation grid-institutes:grid.66859.34
    248 schema:familyName Mongare
    249 schema:givenName Margaret M.
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174104111.93
    251 rdf:type schema:Person
    252 sg:person.01242217311.44 schema:affiliation grid-institutes:grid.66859.34
    253 schema:familyName Gould
    254 schema:givenName Joshua
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242217311.44
    256 rdf:type schema:Person
    257 sg:person.01261573344.96 schema:affiliation grid-institutes:grid.66859.34
    258 schema:familyName Straussman
    259 schema:givenName Ravid
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261573344.96
    261 rdf:type schema:Person
    262 sg:person.01310332511.21 schema:affiliation grid-institutes:grid.32224.35
    263 schema:familyName Frederick
    264 schema:givenName Dennie T.
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310332511.21
    266 rdf:type schema:Person
    267 sg:person.01354045521.83 schema:affiliation grid-institutes:grid.32224.35
    268 schema:familyName Cooper
    269 schema:givenName Zachary A.
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354045521.83
    271 rdf:type schema:Person
    272 sg:person.01365026210.96 schema:affiliation grid-institutes:grid.32224.35
    273 schema:familyName Flaherty
    274 schema:givenName Keith T.
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365026210.96
    276 rdf:type schema:Person
    277 sg:person.0627244670.28 schema:affiliation grid-institutes:grid.19006.3e
    278 schema:familyName Ribas
    279 schema:givenName Antoni
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627244670.28
    281 rdf:type schema:Person
    282 sg:person.0637157757.45 schema:affiliation grid-institutes:grid.32224.35
    283 schema:familyName Wargo
    284 schema:givenName Jennifer A.
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637157757.45
    286 rdf:type schema:Person
    287 sg:person.0637564336.69 schema:affiliation grid-institutes:grid.66859.34
    288 schema:familyName Du
    289 schema:givenName Jinyan
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637564336.69
    291 rdf:type schema:Person
    292 sg:person.0641770754.41 schema:affiliation grid-institutes:grid.66859.34
    293 schema:familyName Shee
    294 schema:givenName Kevin
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641770754.41
    296 rdf:type schema:Person
    297 sg:person.0656335277.50 schema:affiliation grid-institutes:grid.51462.34
    298 schema:familyName Solit
    299 schema:givenName David B.
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656335277.50
    301 rdf:type schema:Person
    302 sg:person.0701722423.70 schema:affiliation grid-institutes:grid.19006.3e
    303 schema:familyName Lo
    304 schema:givenName Roger S.
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701722423.70
    306 rdf:type schema:Person
    307 sg:person.0743427111.22 schema:affiliation grid-institutes:grid.66859.34
    308 schema:familyName Barzily-Rokni
    309 schema:givenName Michal
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743427111.22
    311 rdf:type schema:Person
    312 sg:pub.10.1038/nature09454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032620847
    313 https://doi.org/10.1038/nature09454
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/nature09626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035733152
    316 https://doi.org/10.1038/nature09626
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/nature09627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005907434
    319 https://doi.org/10.1038/nature09627
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/nature10662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028208693
    322 https://doi.org/10.1038/nature10662
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/nature10868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038374700
    325 https://doi.org/10.1038/nature10868
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nature11249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006053948
    328 https://doi.org/10.1038/nature11249
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nbt.1513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041808919
    331 https://doi.org/10.1038/nbt.1513
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nm.2112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018293106
    334 https://doi.org/10.1038/nm.2112
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/nrc1877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036672274
    337 https://doi.org/10.1038/nrc1877
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/nrc2618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049326401
    340 https://doi.org/10.1038/nrc2618
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/nrd1609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028779172
    343 https://doi.org/10.1038/nrd1609
    344 rdf:type schema:CreativeWork
    345 grid-institutes:grid.19006.3e schema:alternateName Department of Molecular and Medical Pharmacology, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA
    346 Division of Dermatology, Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA
    347 schema:name Department of Molecular and Medical Pharmacology, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA
    348 Division of Dermatology, Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA
    349 Division of Hematology and Oncology, Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, 90095, Los Angeles, California, USA
    350 rdf:type schema:Organization
    351 grid-institutes:grid.32224.35 schema:alternateName Division of Surgical Oncology, Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    352 schema:name Division of Surgical Oncology, Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    353 rdf:type schema:Organization
    354 grid-institutes:grid.38142.3c schema:alternateName Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, 02115, Boston, Massachusetts, USA
    355 schema:name Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA
    356 Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, 02115, Boston, Massachusetts, USA
    357 rdf:type schema:Organization
    358 grid-institutes:grid.413575.1 schema:alternateName Howard Hughes Medical Institute, 20815, Chevy Chase, Maryland, USA
    359 schema:name Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    360 Harvard Medical School, 02115, Boston, Massachusetts, USA
    361 Howard Hughes Medical Institute, 20815, Chevy Chase, Maryland, USA
    362 The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA
    363 rdf:type schema:Organization
    364 grid-institutes:grid.51462.34 schema:alternateName Department of Medicine, Memorial Sloan-Kettering Cancer Center, 10065, New York, New York, USA
    365 Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, 10065, New York, New York, USA
    366 schema:name Department of Medicine, Memorial Sloan-Kettering Cancer Center, 10065, New York, New York, USA
    367 Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, 10065, New York, New York, USA
    368 rdf:type schema:Organization
    369 grid-institutes:grid.65499.37 schema:alternateName Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA
    370 schema:name Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA
    371 rdf:type schema:Organization
    372 grid-institutes:grid.66859.34 schema:alternateName The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA
    373 schema:name The Eli and Edythe L. Broad Institute, 7 Cambridge Center, 02142, Cambridge, Massachusetts, USA
    374 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...