Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-07-04

AUTHORS

Ravid Straussman, Teppei Morikawa, Kevin Shee, Michal Barzily-Rokni, Zhi Rong Qian, Jinyan Du, Ashli Davis, Margaret M. Mongare, Joshua Gould, Dennie T. Frederick, Zachary A. Cooper, Paul B. Chapman, David B. Solit, Antoni Ribas, Roger S. Lo, Keith T. Flaherty, Shuji Ogino, Jennifer A. Wargo, Todd R. Golub

ABSTRACT

The secretion of hepatocyte growth factor by stromal cells in the tumour micro-environment can make melanoma resistant to RAF inhibitors, through the activation of the MET signalling pathway, but a combination of RAF and MET inhibitors can overcome this resistance.

PAGES

500-504

Journal

TITLE

Nature

ISSUE

7408

VOLUME

487

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature11183

    DOI

    http://dx.doi.org/10.1038/nature11183

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053677952

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22763439


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