The clonal and mutational evolution spectrum of primary triple-negative breast cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06

AUTHORS

Sohrab P. Shah, Andrew Roth, Rodrigo Goya, Arusha Oloumi, Gavin Ha, Yongjun Zhao, Gulisa Turashvili, Jiarui Ding, Kane Tse, Gholamreza Haffari, Ali Bashashati, Leah M. Prentice, Jaswinder Khattra, Angela Burleigh, Damian Yap, Virginie Bernard, Andrew McPherson, Karey Shumansky, Anamaria Crisan, Ryan Giuliany, Alireza Heravi-Moussavi, Jamie Rosner, Daniel Lai, Inanc Birol, Richard Varhol, Angela Tam, Noreen Dhalla, Thomas Zeng, Kevin Ma, Simon K. Chan, Malachi Griffith, Annie Moradian, S.-W. Grace Cheng, Gregg B. Morin, Peter Watson, Karen Gelmon, Stephen Chia, Suet-Feung Chin, Christina Curtis, Oscar M. Rueda, Paul D. Pharoah, Sambasivarao Damaraju, John Mackey, Kelly Hoon, Timothy Harkins, Vasisht Tadigotla, Mahvash Sigaroudinia, Philippe Gascard, Thea Tlsty, Joseph F. Costello, Irmtraud M. Meyer, Connie J. Eaves, Wyeth W. Wasserman, Steven Jones, David Huntsman, Martin Hirst, Carlos Caldas, Marco A. Marra, Samuel Aparicio

ABSTRACT

Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breast cancers. Here we show in 104 TNBC cases that at the time of diagnosis these cancers exhibit a wide and continuous spectrum of genomic evolution, with some having only a handful of coding somatic aberrations in a few pathways, whereas others contain hundreds of coding somatic mutations. High-throughput RNA sequencing (RNA-seq) revealed that only approximately 36% of mutations are expressed. Using deep re-sequencing measurements of allelic abundance for 2,414 somatic mutations, we determine for the first time-to our knowledge-in an epithelial tumour subtype, the relative abundance of clonal frequencies among cases representative of the population. We show that TNBCs vary widely in their clonal frequencies at the time of diagnosis, with the basal subtype of TNBC showing more variation than non-basal TNBC. Although p53 (also known as TP53), PIK3CA and PTEN somatic mutations seem to be clonally dominant compared to other genes, in some tumours their clonal frequencies are incompatible with founder status. Mutations in cytoskeletal, cell shape and motility proteins occurred at lower clonal frequencies, suggesting that they occurred later during tumour progression. Taken together, our results show that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes. More... »

PAGES

395

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature10933

DOI

http://dx.doi.org/10.1038/nature10933

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027457561

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22495314


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clone Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Copy Number Variations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "High-Throughput Nucleotide Sequencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "INDEL Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Point Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precision Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, RNA", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shah", 
        "givenName": "Sohrab P.", 
        "id": "sg:person.01201274527.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201274527.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roth", 
        "givenName": "Andrew", 
        "id": "sg:person.01130720202.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130720202.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goya", 
        "givenName": "Rodrigo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oloumi", 
        "givenName": "Arusha", 
        "id": "sg:person.0630530027.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630530027.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ha", 
        "givenName": "Gavin", 
        "id": "sg:person.01011335463.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011335463.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Yongjun", 
        "id": "sg:person.013415760017.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013415760017.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turashvili", 
        "givenName": "Gulisa", 
        "id": "sg:person.013356375234.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013356375234.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ding", 
        "givenName": "Jiarui", 
        "id": "sg:person.01370541761.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370541761.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tse", 
        "givenName": "Kane", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haffari", 
        "givenName": "Gholamreza", 
        "id": "sg:person.01240607363.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240607363.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bashashati", 
        "givenName": "Ali", 
        "id": "sg:person.01056245563.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056245563.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prentice", 
        "givenName": "Leah M.", 
        "id": "sg:person.0714313413.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714313413.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khattra", 
        "givenName": "Jaswinder", 
        "id": "sg:person.01062254540.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062254540.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burleigh", 
        "givenName": "Angela", 
        "id": "sg:person.01321747137.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321747137.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yap", 
        "givenName": "Damian", 
        "id": "sg:person.01165547170.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165547170.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Centre for Molecular Medicine and Therapeutics, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bernard", 
        "givenName": "Virginie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McPherson", 
        "givenName": "Andrew", 
        "id": "sg:person.0703707310.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703707310.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shumansky", 
        "givenName": "Karey", 
        "id": "sg:person.0713074677.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713074677.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crisan", 
        "givenName": "Anamaria", 
        "id": "sg:person.0773331013.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773331013.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giuliany", 
        "givenName": "Ryan", 
        "id": "sg:person.01066355745.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066355745.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heravi-Moussavi", 
        "givenName": "Alireza", 
        "id": "sg:person.01137412457.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137412457.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosner", 
        "givenName": "Jamie", 
        "id": "sg:person.01143551677.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143551677.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lai", 
        "givenName": "Daniel", 
        "id": "sg:person.0730334601.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730334601.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Birol", 
        "givenName": "Inanc", 
        "id": "sg:person.01120102220.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120102220.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Varhol", 
        "givenName": "Richard", 
        "id": "sg:person.01001443427.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001443427.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tam", 
        "givenName": "Angela", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dhalla", 
        "givenName": "Noreen", 
        "id": "sg:person.01015542103.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015542103.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeng", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Kevin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chan", 
        "givenName": "Simon K.", 
        "id": "sg:person.0725127421.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725127421.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Griffith", 
        "givenName": "Malachi", 
        "id": "sg:person.0670670604.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670670604.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moradian", 
        "givenName": "Annie", 
        "id": "sg:person.01177106743.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177106743.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canada's Michael Smith Genome Sciences Centre", 
          "id": "https://www.grid.ac/institutes/grid.434706.2", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "S.-W. Grace", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada", 
            "Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morin", 
        "givenName": "Gregg B.", 
        "id": "sg:person.01133556662.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133556662.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watson", 
        "givenName": "Peter", 
        "id": "sg:person.0630140513.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630140513.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gelmon", 
        "givenName": "Karen", 
        "id": "sg:person.01173252503.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173252503.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chia", 
        "givenName": "Stephen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK", 
            "Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chin", 
        "givenName": "Suet-Feung", 
        "id": "sg:person.01256717077.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256717077.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Southern California", 
          "id": "https://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK", 
            "Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK", 
            "Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Curtis", 
        "givenName": "Christina", 
        "id": "sg:person.0674303034.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674303034.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK", 
            "Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rueda", 
        "givenName": "Oscar M.", 
        "id": "sg:person.01362465631.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362465631.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK Cambridge Institute", 
          "id": "https://www.grid.ac/institutes/grid.470869.4", 
          "name": [
            "Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pharoah", 
        "givenName": "Paul D.", 
        "id": "sg:person.01034602463.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034602463.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alberta", 
          "id": "https://www.grid.ac/institutes/grid.17089.37", 
          "name": [
            "Departments of Oncology and Laboratory Medicine and Pathology, University of Alberta, 11560 University Avenue, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Damaraju", 
        "givenName": "Sambasivarao", 
        "id": "sg:person.01233057504.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233057504.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alberta", 
          "id": "https://www.grid.ac/institutes/grid.17089.37", 
          "name": [
            "Departments of Oncology and Laboratory Medicine and Pathology, University of Alberta, 11560 University Avenue, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mackey", 
        "givenName": "John", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thermo Fisher Scientific (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418190.5", 
          "name": [
            "Life Technologies, 101 Lincoln Centre Dr., Foster City, California 94404, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoon", 
        "givenName": "Kelly", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thermo Fisher Scientific (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418190.5", 
          "name": [
            "Life Technologies, 101 Lincoln Centre Dr., Foster City, California 94404, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harkins", 
        "givenName": "Timothy", 
        "id": "sg:person.011003353627.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011003353627.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Thermo Fisher Scientific (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418190.5", 
          "name": [
            "Life Technologies, 101 Lincoln Centre Dr., Foster City, California 94404, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tadigotla", 
        "givenName": "Vasisht", 
        "id": "sg:person.01312751201.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312751201.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sigaroudinia", 
        "givenName": "Mahvash", 
        "id": "sg:person.0660324777.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660324777.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gascard", 
        "givenName": "Philippe", 
        "id": "sg:person.0735014054.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735014054.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tlsty", 
        "givenName": "Thea", 
        "id": "sg:person.0662010442.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662010442.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Costello", 
        "givenName": "Joseph F.", 
        "id": "sg:person.013474410037.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013474410037.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada", 
            "Department of Computer Science, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada", 
            "Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meyer", 
        "givenName": "Irmtraud M.", 
        "id": "sg:person.01035275715.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035275715.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Terry Fox Laboratory, BC Cancer Agency, 675 W 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eaves", 
        "givenName": "Connie J.", 
        "id": "sg:person.01034353664.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034353664.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Centre for Molecular Medicine and Therapeutics, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, Canada", 
            "Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wasserman", 
        "givenName": "Wyeth W.", 
        "id": "sg:person.01164162122.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164162122.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada", 
            "Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada", 
            "Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A1S6, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Steven", 
        "id": "sg:person.011076371162.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada", 
            "Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Ave, Vancouver, British Columbia V5Z 4E6, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huntsman", 
        "givenName": "David", 
        "id": "sg:person.015140454124.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015140454124.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada", 
            "Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada", 
            "Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirst", 
        "givenName": "Martin", 
        "id": "sg:person.0601713543.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601713543.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Addenbrooke's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK", 
            "Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK", 
            "Cambridge Breast Unit, Addenbrookes Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK", 
            "Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caldas", 
        "givenName": "Carlos", 
        "id": "sg:person.01072152660.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072152660.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada", 
            "Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marra", 
        "givenName": "Marco A.", 
        "id": "sg:person.01150455763.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada", 
            "Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aparicio", 
        "givenName": "Samuel", 
        "id": "sg:person.0720022504.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720022504.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature10166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000736346", 
          "https://doi.org/10.1038/nature10166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002735811", 
          "https://doi.org/10.1038/nature08768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002735811", 
          "https://doi.org/10.1038/nature08768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr2142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005607697", 
          "https://doi.org/10.1186/bcr2142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006711248", 
          "https://doi.org/10.1038/nature08489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006711248", 
          "https://doi.org/10.1038/nature08489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btr629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011156122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2010-11-5-r53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012013843", 
          "https://doi.org/10.1186/gb-2010-11-5-r53"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014607335", 
          "https://doi.org/10.1038/nature10983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1000279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015285825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019649945", 
          "https://doi.org/10.1038/nature10351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1009941107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025477249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.10174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028777391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35021093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033846543", 
          "https://doi.org/10.1038/35021093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.191367098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034333528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1208130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038068253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1208130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038068253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042545988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044282578", 
          "https://doi.org/10.1038/nature07423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.1370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045851448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr1675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046353392", 
          "https://doi.org/10.1186/bcr1675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050729897", 
          "https://doi.org/10.1038/nature08645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050729897", 
          "https://doi.org/10.1038/nature08645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2010.01.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051517999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051657357", 
          "https://doi.org/10.1038/nature08989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051657357", 
          "https://doi.org/10.1038/nature08989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052710367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1206923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062464764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1206923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062464764"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-06", 
    "datePublishedReg": "2012-06-01", 
    "description": "Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breast cancers. Here we show in 104 TNBC cases that at the time of diagnosis these cancers exhibit a wide and continuous spectrum of genomic evolution, with some having only a handful of coding somatic aberrations in a few pathways, whereas others contain hundreds of coding somatic mutations. High-throughput RNA sequencing (RNA-seq) revealed that only approximately 36% of mutations are expressed. Using deep re-sequencing measurements of allelic abundance for 2,414 somatic mutations, we determine for the first time-to our knowledge-in an epithelial tumour subtype, the relative abundance of clonal frequencies among cases representative of the population. We show that TNBCs vary widely in their clonal frequencies at the time of diagnosis, with the basal subtype of TNBC showing more variation than non-basal TNBC. Although p53 (also known as TP53), PIK3CA and PTEN somatic mutations seem to be clonally dominant compared to other genes, in some tumours their clonal frequencies are incompatible with founder status. Mutations in cytoskeletal, cell shape and motility proteins occurred at lower clonal frequencies, suggesting that they occurred later during tumour progression. Taken together, our results show that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature10933", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2690499", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2520061", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7403", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "486"
      }
    ], 
    "name": "The clonal and mutational evolution spectrum of primary triple-negative breast cancers", 
    "pagination": "395", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "82cc68c9383a6db9049a5ec2f984227dbed73205fba38662fdc5b3dc063de96c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22495314"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature10933"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027457561"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature10933", 
      "https://app.dimensions.ai/details/publication/pub.1027457561"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature10933"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature10933'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature10933'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature10933'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature10933'


 

This table displays all metadata directly associated to this object as RDF triples.

674 TRIPLES      21 PREDICATES      71 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature10933 schema:about N04c2a6957a6144528ffc09b31e501c6c
2 N0f627ca5fed444dca3fdf6d8cd5885f5
3 N10e1e10fc7bd467799193ed4de43f989
4 N2504e222688a487fa5e8002d9a90f0f2
5 N28464506b86b4aa198a67c37a162270d
6 N2db0bf221f0d48809b0f869d3b5b468b
7 N4ec1b1e2b78341098290bd509a119a92
8 N68c2457d95754f859f854e9f01a38770
9 N73911a6b14b6440a805c288975d12221
10 N763a1b0950404265a1ab1658f25b02e4
11 N798e1eb8cfec4d9a864c718939ef59d8
12 N8113e4e444c84bf29bf575521c4e053a
13 N9c8ebd04657a415f883fdcd7512b5e7f
14 Nb3f598fe600749b89bcd7fd85110f1ed
15 Nc3d8a75c83fc467b9420a9ffd75c7038
16 Nd62fb3d0a9af4d7190b8d2fa16a720bd
17 Nef2d975af5064788a6883c92aa1a7eb0
18 Nf066867e42244a1ab440b114bc1586e9
19 Nf6a8f59ff80a40b4822c8ed57ac60960
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N7497dfa676b744f39a8070f20828da28
23 schema:citation sg:pub.10.1038/35021093
24 sg:pub.10.1038/nature07423
25 sg:pub.10.1038/nature08489
26 sg:pub.10.1038/nature08645
27 sg:pub.10.1038/nature08768
28 sg:pub.10.1038/nature08989
29 sg:pub.10.1038/nature10166
30 sg:pub.10.1038/nature10351
31 sg:pub.10.1038/nature10983
32 sg:pub.10.1186/bcr1675
33 sg:pub.10.1186/bcr2142
34 sg:pub.10.1186/gb-2010-11-5-r53
35 https://doi.org/10.1002/humu.10174
36 https://doi.org/10.1016/j.ccr.2010.01.023
37 https://doi.org/10.1073/pnas.1009941107
38 https://doi.org/10.1073/pnas.191367098
39 https://doi.org/10.1093/bioinformatics/btq630
40 https://doi.org/10.1093/bioinformatics/btr629
41 https://doi.org/10.1093/bioinformatics/bts053
42 https://doi.org/10.1126/science.1206923
43 https://doi.org/10.1126/science.1208130
44 https://doi.org/10.1200/jco.2008.18.1370
45 https://doi.org/10.1371/journal.pmed.1000279
46 schema:datePublished 2012-06
47 schema:datePublishedReg 2012-06-01
48 schema:description Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breast cancers. Here we show in 104 TNBC cases that at the time of diagnosis these cancers exhibit a wide and continuous spectrum of genomic evolution, with some having only a handful of coding somatic aberrations in a few pathways, whereas others contain hundreds of coding somatic mutations. High-throughput RNA sequencing (RNA-seq) revealed that only approximately 36% of mutations are expressed. Using deep re-sequencing measurements of allelic abundance for 2,414 somatic mutations, we determine for the first time-to our knowledge-in an epithelial tumour subtype, the relative abundance of clonal frequencies among cases representative of the population. We show that TNBCs vary widely in their clonal frequencies at the time of diagnosis, with the basal subtype of TNBC showing more variation than non-basal TNBC. Although p53 (also known as TP53), PIK3CA and PTEN somatic mutations seem to be clonally dominant compared to other genes, in some tumours their clonal frequencies are incompatible with founder status. Mutations in cytoskeletal, cell shape and motility proteins occurred at lower clonal frequencies, suggesting that they occurred later during tumour progression. Taken together, our results show that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf N1893ce36febc4a98bade1d72ae53e6ba
53 N2dc3edf2274c4bb0b926fae6142dc8f5
54 sg:journal.1018957
55 schema:name The clonal and mutational evolution spectrum of primary triple-negative breast cancers
56 schema:pagination 395
57 schema:productId N00d6dd223f7342cd85cacf60ebb95272
58 N39716ac603d14776aad2fb633f62f7a9
59 N6eb57c33311a445689abe4c24d69a70f
60 N748c7a7acd20467e99a8c777fd39db37
61 N7ed192d08e874e69a35c9301fad9bb23
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027457561
63 https://doi.org/10.1038/nature10933
64 schema:sdDatePublished 2019-04-11T01:48
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N540f2368757543fdb90d2ef8c0785e4f
67 schema:url https://www.nature.com/articles/nature10933
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N00d6dd223f7342cd85cacf60ebb95272 schema:name dimensions_id
72 schema:value pub.1027457561
73 rdf:type schema:PropertyValue
74 N04c2a6957a6144528ffc09b31e501c6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name High-Throughput Nucleotide Sequencing
76 rdf:type schema:DefinedTerm
77 N0cd2913726c349bfb49be81c257b39c7 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
78 schema:familyName Zeng
79 schema:givenName Thomas
80 rdf:type schema:Person
81 N0f627ca5fed444dca3fdf6d8cd5885f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name INDEL Mutation
83 rdf:type schema:DefinedTerm
84 N10e1e10fc7bd467799193ed4de43f989 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Genotype
86 rdf:type schema:DefinedTerm
87 N12587913ea014e66906556e7610cd396 rdf:first sg:person.01240607363.20
88 rdf:rest N53d68daa5fc844d996d5e720365abd49
89 N1287343e82b6406aa1fd6d27aefcf697 rdf:first sg:person.0714313413.19
90 rdf:rest N180d70c4f985424f8e5690717ee93212
91 N180d70c4f985424f8e5690717ee93212 rdf:first sg:person.01062254540.86
92 rdf:rest N9fe56f5f606043f6bf2cba83fc200ede
93 N1893ce36febc4a98bade1d72ae53e6ba schema:volumeNumber 486
94 rdf:type schema:PublicationVolume
95 N1c74ffd07af4427cb9946c69bba74753 rdf:first sg:person.01256717077.95
96 rdf:rest Nfd85d6e75b934d2181693cb085cec495
97 N2504e222688a487fa5e8002d9a90f0f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Sequence Analysis, RNA
99 rdf:type schema:DefinedTerm
100 N28464506b86b4aa198a67c37a162270d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Female
102 rdf:type schema:DefinedTerm
103 N29ffd9ab214a4288a579e85a8e3e42d4 rdf:first N5285e6fd7aed479dbf147af7527dd66f
104 rdf:rest Nda9cd87e87ad4337a75d9ec190afe1d7
105 N2ad99e3253874b7d800faba2c838c398 schema:affiliation https://www.grid.ac/institutes/grid.418190.5
106 schema:familyName Hoon
107 schema:givenName Kelly
108 rdf:type schema:Person
109 N2b69993dd369472cbdef8da03a04cacd rdf:first sg:person.01165547170.62
110 rdf:rest N756af84b04b04dd9b0c28df39117eb2d
111 N2c8ed4c47fc040b087d126b812646451 rdf:first sg:person.01233057504.97
112 rdf:rest N29ffd9ab214a4288a579e85a8e3e42d4
113 N2db0bf221f0d48809b0f869d3b5b468b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name DNA Mutational Analysis
115 rdf:type schema:DefinedTerm
116 N2dc3edf2274c4bb0b926fae6142dc8f5 schema:issueNumber 7403
117 rdf:type schema:PublicationIssue
118 N2e79cb9aa2204327b262bba4d286e1b4 rdf:first sg:person.0713074677.52
119 rdf:rest Na1506c940a144feb85a9fd614abf358a
120 N32e649baf36146feb104b39c6f766ae5 rdf:first sg:person.0662010442.25
121 rdf:rest N9d551b1c45d24369865aeaeedd98ba11
122 N33ba9ab12de74f558f02f067a2bad336 rdf:first sg:person.0601713543.66
123 rdf:rest N59738d2fd67f414e8e83dd977cd23424
124 N39716ac603d14776aad2fb633f62f7a9 schema:name readcube_id
125 schema:value 82cc68c9383a6db9049a5ec2f984227dbed73205fba38662fdc5b3dc063de96c
126 rdf:type schema:PropertyValue
127 N3a350ee4f373416a84ea46c3174dc5f3 rdf:first sg:person.01066355745.31
128 rdf:rest N676eb1aafa8f44008da4c049f18846bb
129 N43bfaea65bd745ea8266349dd01c5d21 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
130 schema:familyName Bernard
131 schema:givenName Virginie
132 rdf:type schema:Person
133 N49ea067d3127487f8ece810ebc639869 rdf:first sg:person.01035275715.08
134 rdf:rest Nffe6c985fc034a3894b1440b7fb07bad
135 N4b146044fb6148c4899b43943ce60021 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
136 schema:familyName Ma
137 schema:givenName Kevin
138 rdf:type schema:Person
139 N4b7c302d49834b1d8cb43075d5c8860e rdf:first Na48a54fc693142aeb17c90fae09c164f
140 rdf:rest Nf82dbacc7f3345b4a2f029bdf4d7452f
141 N4e17a58d44ae43f2b2297ba08de6c28e rdf:first sg:person.01312751201.22
142 rdf:rest N592601a9f0214f58966a854c386eb30a
143 N4ec1b1e2b78341098290bd509a119a92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Breast Neoplasms
145 rdf:type schema:DefinedTerm
146 N5285e6fd7aed479dbf147af7527dd66f schema:affiliation https://www.grid.ac/institutes/grid.17089.37
147 schema:familyName Mackey
148 schema:givenName John
149 rdf:type schema:Person
150 N53d68daa5fc844d996d5e720365abd49 rdf:first sg:person.01056245563.36
151 rdf:rest N1287343e82b6406aa1fd6d27aefcf697
152 N540f2368757543fdb90d2ef8c0785e4f schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 N551e1f2b6bb946199e8147b3e2aefe36 rdf:first Nd188797d3a614c8d86a9e3473091fa7f
155 rdf:rest N599061475b7c447bad4cb6c0e98e441d
156 N592601a9f0214f58966a854c386eb30a rdf:first sg:person.0660324777.47
157 rdf:rest Nf764f1cc096b4dc294d1e1335e1215a3
158 N59738d2fd67f414e8e83dd977cd23424 rdf:first sg:person.01072152660.47
159 rdf:rest Ndca14ef68df246fba18e02a3ac7aaf95
160 N599061475b7c447bad4cb6c0e98e441d rdf:first sg:person.01133556662.16
161 rdf:rest N88922f66388e4959bfd6ce109e0106bb
162 N60870655659747a98f79e1dbbb60bf95 rdf:first sg:person.01130720202.21
163 rdf:rest N4b7c302d49834b1d8cb43075d5c8860e
164 N61e2e9bfb616492cbb314824a7dafa7d rdf:first N4b146044fb6148c4899b43943ce60021
165 rdf:rest Nc7a826432d1e4497b5ccb6aeb62e75e1
166 N64c054faf23241c6bf767ca84fc8413b rdf:first sg:person.0720022504.02
167 rdf:rest rdf:nil
168 N676eb1aafa8f44008da4c049f18846bb rdf:first sg:person.01137412457.66
169 rdf:rest Ncb3b6280a37d443095c5007c0f137539
170 N68c2457d95754f859f854e9f01a38770 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Clone Cells
172 rdf:type schema:DefinedTerm
173 N6b86a4d7110f43088f24a50d8d0316ba schema:affiliation https://www.grid.ac/institutes/grid.434706.2
174 schema:familyName Tam
175 schema:givenName Angela
176 rdf:type schema:Person
177 N6eb57c33311a445689abe4c24d69a70f schema:name doi
178 schema:value 10.1038/nature10933
179 rdf:type schema:PropertyValue
180 N723cfa0dce6e45aeaf9fa9e10e6b8cb2 rdf:first sg:person.015140454124.62
181 rdf:rest N33ba9ab12de74f558f02f067a2bad336
182 N725ec36e2d334a0089dae883955ab02d rdf:first sg:person.01370541761.21
183 rdf:rest N93a64db4459a44d38480e5062f6bc12c
184 N73911a6b14b6440a805c288975d12221 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name DNA Copy Number Variations
186 rdf:type schema:DefinedTerm
187 N748c7a7acd20467e99a8c777fd39db37 schema:name pubmed_id
188 schema:value 22495314
189 rdf:type schema:PropertyValue
190 N7497dfa676b744f39a8070f20828da28 rdf:first sg:person.01201274527.46
191 rdf:rest N60870655659747a98f79e1dbbb60bf95
192 N756af84b04b04dd9b0c28df39117eb2d rdf:first N43bfaea65bd745ea8266349dd01c5d21
193 rdf:rest Nabf3f45b5bfd4aac9748bb063a23b29b
194 N763a1b0950404265a1ab1658f25b02e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Mutation
196 rdf:type schema:DefinedTerm
197 N798e1eb8cfec4d9a864c718939ef59d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Gene Expression Profiling
199 rdf:type schema:DefinedTerm
200 N7ed192d08e874e69a35c9301fad9bb23 schema:name nlm_unique_id
201 schema:value 0410462
202 rdf:type schema:PropertyValue
203 N8113e4e444c84bf29bf575521c4e053a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Disease Progression
205 rdf:type schema:DefinedTerm
206 N875269be99144e34864d550d3f25a5a6 rdf:first sg:person.0730334601.77
207 rdf:rest Nd18160d24ab04a9b869bae3527190416
208 N87f8723d077648c686b06955ad7d2b4b rdf:first sg:person.01011335463.10
209 rdf:rest N8fe80a126b74418db34c48f44b36f782
210 N88922f66388e4959bfd6ce109e0106bb rdf:first sg:person.0630140513.21
211 rdf:rest Ne8622c1119f843318de8ce83282f2a32
212 N8b10196eb36a46e5b2a502685f2e726b rdf:first sg:person.011076371162.80
213 rdf:rest N723cfa0dce6e45aeaf9fa9e10e6b8cb2
214 N8fe80a126b74418db34c48f44b36f782 rdf:first sg:person.013415760017.30
215 rdf:rest Nf93fc9076e1f4340b94ce0ff5578fc89
216 N92e90918217343a4b821aee6df000e42 rdf:first sg:person.0670670604.42
217 rdf:rest Ne3060dc6b392479ba43736a15862d8c2
218 N93a64db4459a44d38480e5062f6bc12c rdf:first Nce25c766d1c74b109b3b257d00aacf36
219 rdf:rest N12587913ea014e66906556e7610cd396
220 N956c71f5930f456dbfac848ca5343b77 rdf:first sg:person.01362465631.14
221 rdf:rest Ne76fcd23d0864d929518b5622e98d4d5
222 N9c8ebd04657a415f883fdcd7512b5e7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Reproducibility of Results
224 rdf:type schema:DefinedTerm
225 N9d551b1c45d24369865aeaeedd98ba11 rdf:first sg:person.013474410037.15
226 rdf:rest N49ea067d3127487f8ece810ebc639869
227 N9fe56f5f606043f6bf2cba83fc200ede rdf:first sg:person.01321747137.85
228 rdf:rest N2b69993dd369472cbdef8da03a04cacd
229 Na1506c940a144feb85a9fd614abf358a rdf:first sg:person.0773331013.87
230 rdf:rest N3a350ee4f373416a84ea46c3174dc5f3
231 Na48a54fc693142aeb17c90fae09c164f schema:affiliation https://www.grid.ac/institutes/grid.434706.2
232 schema:familyName Goya
233 schema:givenName Rodrigo
234 rdf:type schema:Person
235 Na92b2b56c0f94a11b228d30ea297baa2 rdf:first sg:person.01001443427.34
236 rdf:rest Nb6bcb15931494564ba5f5076dfd81282
237 Nabf3f45b5bfd4aac9748bb063a23b29b rdf:first sg:person.0703707310.56
238 rdf:rest N2e79cb9aa2204327b262bba4d286e1b4
239 Nb3f598fe600749b89bcd7fd85110f1ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Humans
241 rdf:type schema:DefinedTerm
242 Nb6bcb15931494564ba5f5076dfd81282 rdf:first N6b86a4d7110f43088f24a50d8d0316ba
243 rdf:rest Nc283a37025594c6189d3372be492fc16
244 Nb8ca2213724141bc92175a4957ceb122 rdf:first sg:person.01164162122.26
245 rdf:rest N8b10196eb36a46e5b2a502685f2e726b
246 Nc283a37025594c6189d3372be492fc16 rdf:first sg:person.01015542103.81
247 rdf:rest Nf9a873c5c63645b2b92f9000ba9ade00
248 Nc3d8a75c83fc467b9420a9ffd75c7038 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
249 schema:name Gene Expression Regulation, Neoplastic
250 rdf:type schema:DefinedTerm
251 Nc7a826432d1e4497b5ccb6aeb62e75e1 rdf:first sg:person.0725127421.25
252 rdf:rest N92e90918217343a4b821aee6df000e42
253 Ncb3b6280a37d443095c5007c0f137539 rdf:first sg:person.01143551677.71
254 rdf:rest N875269be99144e34864d550d3f25a5a6
255 Nce25c766d1c74b109b3b257d00aacf36 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
256 schema:familyName Tse
257 schema:givenName Kane
258 rdf:type schema:Person
259 Nd18160d24ab04a9b869bae3527190416 rdf:first sg:person.01120102220.26
260 rdf:rest Na92b2b56c0f94a11b228d30ea297baa2
261 Nd188797d3a614c8d86a9e3473091fa7f schema:affiliation https://www.grid.ac/institutes/grid.434706.2
262 schema:familyName Cheng
263 schema:givenName S.-W. Grace
264 rdf:type schema:Person
265 Nd19b00baba804e069160a69c568bfd23 rdf:first Nf9b7181ac17d4fff97150de40411267f
266 rdf:rest N1c74ffd07af4427cb9946c69bba74753
267 Nd62fb3d0a9af4d7190b8d2fa16a720bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
268 schema:name Alleles
269 rdf:type schema:DefinedTerm
270 Nda9cd87e87ad4337a75d9ec190afe1d7 rdf:first N2ad99e3253874b7d800faba2c838c398
271 rdf:rest Nde482da002c84261a696eb1d8954ff04
272 Ndca14ef68df246fba18e02a3ac7aaf95 rdf:first sg:person.01150455763.02
273 rdf:rest N64c054faf23241c6bf767ca84fc8413b
274 Nde482da002c84261a696eb1d8954ff04 rdf:first sg:person.011003353627.22
275 rdf:rest N4e17a58d44ae43f2b2297ba08de6c28e
276 Ne3060dc6b392479ba43736a15862d8c2 rdf:first sg:person.01177106743.92
277 rdf:rest N551e1f2b6bb946199e8147b3e2aefe36
278 Ne76fcd23d0864d929518b5622e98d4d5 rdf:first sg:person.01034602463.88
279 rdf:rest N2c8ed4c47fc040b087d126b812646451
280 Ne8622c1119f843318de8ce83282f2a32 rdf:first sg:person.01173252503.80
281 rdf:rest Nd19b00baba804e069160a69c568bfd23
282 Nef2d975af5064788a6883c92aa1a7eb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
283 schema:name Point Mutation
284 rdf:type schema:DefinedTerm
285 Nf066867e42244a1ab440b114bc1586e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
286 schema:name Precision Medicine
287 rdf:type schema:DefinedTerm
288 Nf6a8f59ff80a40b4822c8ed57ac60960 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
289 schema:name Evolution, Molecular
290 rdf:type schema:DefinedTerm
291 Nf764f1cc096b4dc294d1e1335e1215a3 rdf:first sg:person.0735014054.21
292 rdf:rest N32e649baf36146feb104b39c6f766ae5
293 Nf82dbacc7f3345b4a2f029bdf4d7452f rdf:first sg:person.0630530027.74
294 rdf:rest N87f8723d077648c686b06955ad7d2b4b
295 Nf93fc9076e1f4340b94ce0ff5578fc89 rdf:first sg:person.013356375234.86
296 rdf:rest N725ec36e2d334a0089dae883955ab02d
297 Nf9a873c5c63645b2b92f9000ba9ade00 rdf:first N0cd2913726c349bfb49be81c257b39c7
298 rdf:rest N61e2e9bfb616492cbb314824a7dafa7d
299 Nf9b7181ac17d4fff97150de40411267f schema:affiliation https://www.grid.ac/institutes/grid.248762.d
300 schema:familyName Chia
301 schema:givenName Stephen
302 rdf:type schema:Person
303 Nfd85d6e75b934d2181693cb085cec495 rdf:first sg:person.0674303034.04
304 rdf:rest N956c71f5930f456dbfac848ca5343b77
305 Nffe6c985fc034a3894b1440b7fb07bad rdf:first sg:person.01034353664.50
306 rdf:rest Nb8ca2213724141bc92175a4957ceb122
307 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
308 schema:name Medical and Health Sciences
309 rdf:type schema:DefinedTerm
310 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
311 schema:name Oncology and Carcinogenesis
312 rdf:type schema:DefinedTerm
313 sg:grant.2520061 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10933
314 rdf:type schema:MonetaryGrant
315 sg:grant.2690499 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10933
316 rdf:type schema:MonetaryGrant
317 sg:journal.1018957 schema:issn 0090-0028
318 1476-4687
319 schema:name Nature
320 rdf:type schema:Periodical
321 sg:person.01001443427.34 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
322 schema:familyName Varhol
323 schema:givenName Richard
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001443427.34
325 rdf:type schema:Person
326 sg:person.01011335463.10 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
327 schema:familyName Ha
328 schema:givenName Gavin
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011335463.10
330 rdf:type schema:Person
331 sg:person.01015542103.81 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
332 schema:familyName Dhalla
333 schema:givenName Noreen
334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015542103.81
335 rdf:type schema:Person
336 sg:person.01034353664.50 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
337 schema:familyName Eaves
338 schema:givenName Connie J.
339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034353664.50
340 rdf:type schema:Person
341 sg:person.01034602463.88 schema:affiliation https://www.grid.ac/institutes/grid.470869.4
342 schema:familyName Pharoah
343 schema:givenName Paul D.
344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034602463.88
345 rdf:type schema:Person
346 sg:person.01035275715.08 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
347 schema:familyName Meyer
348 schema:givenName Irmtraud M.
349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035275715.08
350 rdf:type schema:Person
351 sg:person.01056245563.36 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
352 schema:familyName Bashashati
353 schema:givenName Ali
354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056245563.36
355 rdf:type schema:Person
356 sg:person.01062254540.86 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
357 schema:familyName Khattra
358 schema:givenName Jaswinder
359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062254540.86
360 rdf:type schema:Person
361 sg:person.01066355745.31 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
362 schema:familyName Giuliany
363 schema:givenName Ryan
364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066355745.31
365 rdf:type schema:Person
366 sg:person.01072152660.47 schema:affiliation https://www.grid.ac/institutes/grid.120073.7
367 schema:familyName Caldas
368 schema:givenName Carlos
369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072152660.47
370 rdf:type schema:Person
371 sg:person.011003353627.22 schema:affiliation https://www.grid.ac/institutes/grid.418190.5
372 schema:familyName Harkins
373 schema:givenName Timothy
374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011003353627.22
375 rdf:type schema:Person
376 sg:person.011076371162.80 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
377 schema:familyName Jones
378 schema:givenName Steven
379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80
380 rdf:type schema:Person
381 sg:person.01120102220.26 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
382 schema:familyName Birol
383 schema:givenName Inanc
384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120102220.26
385 rdf:type schema:Person
386 sg:person.01130720202.21 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
387 schema:familyName Roth
388 schema:givenName Andrew
389 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130720202.21
390 rdf:type schema:Person
391 sg:person.01133556662.16 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
392 schema:familyName Morin
393 schema:givenName Gregg B.
394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133556662.16
395 rdf:type schema:Person
396 sg:person.01137412457.66 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
397 schema:familyName Heravi-Moussavi
398 schema:givenName Alireza
399 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137412457.66
400 rdf:type schema:Person
401 sg:person.01143551677.71 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
402 schema:familyName Rosner
403 schema:givenName Jamie
404 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143551677.71
405 rdf:type schema:Person
406 sg:person.01150455763.02 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
407 schema:familyName Marra
408 schema:givenName Marco A.
409 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150455763.02
410 rdf:type schema:Person
411 sg:person.01164162122.26 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
412 schema:familyName Wasserman
413 schema:givenName Wyeth W.
414 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164162122.26
415 rdf:type schema:Person
416 sg:person.01165547170.62 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
417 schema:familyName Yap
418 schema:givenName Damian
419 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165547170.62
420 rdf:type schema:Person
421 sg:person.01173252503.80 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
422 schema:familyName Gelmon
423 schema:givenName Karen
424 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173252503.80
425 rdf:type schema:Person
426 sg:person.01177106743.92 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
427 schema:familyName Moradian
428 schema:givenName Annie
429 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177106743.92
430 rdf:type schema:Person
431 sg:person.01201274527.46 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
432 schema:familyName Shah
433 schema:givenName Sohrab P.
434 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201274527.46
435 rdf:type schema:Person
436 sg:person.01233057504.97 schema:affiliation https://www.grid.ac/institutes/grid.17089.37
437 schema:familyName Damaraju
438 schema:givenName Sambasivarao
439 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233057504.97
440 rdf:type schema:Person
441 sg:person.01240607363.20 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
442 schema:familyName Haffari
443 schema:givenName Gholamreza
444 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240607363.20
445 rdf:type schema:Person
446 sg:person.01256717077.95 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
447 schema:familyName Chin
448 schema:givenName Suet-Feung
449 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256717077.95
450 rdf:type schema:Person
451 sg:person.01312751201.22 schema:affiliation https://www.grid.ac/institutes/grid.418190.5
452 schema:familyName Tadigotla
453 schema:givenName Vasisht
454 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312751201.22
455 rdf:type schema:Person
456 sg:person.01321747137.85 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
457 schema:familyName Burleigh
458 schema:givenName Angela
459 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321747137.85
460 rdf:type schema:Person
461 sg:person.013356375234.86 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
462 schema:familyName Turashvili
463 schema:givenName Gulisa
464 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013356375234.86
465 rdf:type schema:Person
466 sg:person.013415760017.30 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
467 schema:familyName Zhao
468 schema:givenName Yongjun
469 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013415760017.30
470 rdf:type schema:Person
471 sg:person.013474410037.15 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
472 schema:familyName Costello
473 schema:givenName Joseph F.
474 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013474410037.15
475 rdf:type schema:Person
476 sg:person.01362465631.14 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
477 schema:familyName Rueda
478 schema:givenName Oscar M.
479 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362465631.14
480 rdf:type schema:Person
481 sg:person.01370541761.21 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
482 schema:familyName Ding
483 schema:givenName Jiarui
484 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370541761.21
485 rdf:type schema:Person
486 sg:person.015140454124.62 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
487 schema:familyName Huntsman
488 schema:givenName David
489 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015140454124.62
490 rdf:type schema:Person
491 sg:person.0601713543.66 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
492 schema:familyName Hirst
493 schema:givenName Martin
494 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601713543.66
495 rdf:type schema:Person
496 sg:person.0630140513.21 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
497 schema:familyName Watson
498 schema:givenName Peter
499 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630140513.21
500 rdf:type schema:Person
501 sg:person.0630530027.74 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
502 schema:familyName Oloumi
503 schema:givenName Arusha
504 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630530027.74
505 rdf:type schema:Person
506 sg:person.0660324777.47 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
507 schema:familyName Sigaroudinia
508 schema:givenName Mahvash
509 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660324777.47
510 rdf:type schema:Person
511 sg:person.0662010442.25 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
512 schema:familyName Tlsty
513 schema:givenName Thea
514 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662010442.25
515 rdf:type schema:Person
516 sg:person.0670670604.42 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
517 schema:familyName Griffith
518 schema:givenName Malachi
519 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670670604.42
520 rdf:type schema:Person
521 sg:person.0674303034.04 schema:affiliation https://www.grid.ac/institutes/grid.42505.36
522 schema:familyName Curtis
523 schema:givenName Christina
524 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674303034.04
525 rdf:type schema:Person
526 sg:person.0703707310.56 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
527 schema:familyName McPherson
528 schema:givenName Andrew
529 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703707310.56
530 rdf:type schema:Person
531 sg:person.0713074677.52 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
532 schema:familyName Shumansky
533 schema:givenName Karey
534 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713074677.52
535 rdf:type schema:Person
536 sg:person.0714313413.19 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
537 schema:familyName Prentice
538 schema:givenName Leah M.
539 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714313413.19
540 rdf:type schema:Person
541 sg:person.0720022504.02 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
542 schema:familyName Aparicio
543 schema:givenName Samuel
544 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720022504.02
545 rdf:type schema:Person
546 sg:person.0725127421.25 schema:affiliation https://www.grid.ac/institutes/grid.434706.2
547 schema:familyName Chan
548 schema:givenName Simon K.
549 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725127421.25
550 rdf:type schema:Person
551 sg:person.0730334601.77 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
552 schema:familyName Lai
553 schema:givenName Daniel
554 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730334601.77
555 rdf:type schema:Person
556 sg:person.0735014054.21 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
557 schema:familyName Gascard
558 schema:givenName Philippe
559 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735014054.21
560 rdf:type schema:Person
561 sg:person.0773331013.87 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
562 schema:familyName Crisan
563 schema:givenName Anamaria
564 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773331013.87
565 rdf:type schema:Person
566 sg:pub.10.1038/35021093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033846543
567 https://doi.org/10.1038/35021093
568 rdf:type schema:CreativeWork
569 sg:pub.10.1038/nature07423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044282578
570 https://doi.org/10.1038/nature07423
571 rdf:type schema:CreativeWork
572 sg:pub.10.1038/nature08489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006711248
573 https://doi.org/10.1038/nature08489
574 rdf:type schema:CreativeWork
575 sg:pub.10.1038/nature08645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050729897
576 https://doi.org/10.1038/nature08645
577 rdf:type schema:CreativeWork
578 sg:pub.10.1038/nature08768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002735811
579 https://doi.org/10.1038/nature08768
580 rdf:type schema:CreativeWork
581 sg:pub.10.1038/nature08989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051657357
582 https://doi.org/10.1038/nature08989
583 rdf:type schema:CreativeWork
584 sg:pub.10.1038/nature10166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736346
585 https://doi.org/10.1038/nature10166
586 rdf:type schema:CreativeWork
587 sg:pub.10.1038/nature10351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019649945
588 https://doi.org/10.1038/nature10351
589 rdf:type schema:CreativeWork
590 sg:pub.10.1038/nature10983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014607335
591 https://doi.org/10.1038/nature10983
592 rdf:type schema:CreativeWork
593 sg:pub.10.1186/bcr1675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046353392
594 https://doi.org/10.1186/bcr1675
595 rdf:type schema:CreativeWork
596 sg:pub.10.1186/bcr2142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005607697
597 https://doi.org/10.1186/bcr2142
598 rdf:type schema:CreativeWork
599 sg:pub.10.1186/gb-2010-11-5-r53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012013843
600 https://doi.org/10.1186/gb-2010-11-5-r53
601 rdf:type schema:CreativeWork
602 https://doi.org/10.1002/humu.10174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028777391
603 rdf:type schema:CreativeWork
604 https://doi.org/10.1016/j.ccr.2010.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051517999
605 rdf:type schema:CreativeWork
606 https://doi.org/10.1073/pnas.1009941107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025477249
607 rdf:type schema:CreativeWork
608 https://doi.org/10.1073/pnas.191367098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034333528
609 rdf:type schema:CreativeWork
610 https://doi.org/10.1093/bioinformatics/btq630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052710367
611 rdf:type schema:CreativeWork
612 https://doi.org/10.1093/bioinformatics/btr629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011156122
613 rdf:type schema:CreativeWork
614 https://doi.org/10.1093/bioinformatics/bts053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042545988
615 rdf:type schema:CreativeWork
616 https://doi.org/10.1126/science.1206923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062464764
617 rdf:type schema:CreativeWork
618 https://doi.org/10.1126/science.1208130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038068253
619 rdf:type schema:CreativeWork
620 https://doi.org/10.1200/jco.2008.18.1370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045851448
621 rdf:type schema:CreativeWork
622 https://doi.org/10.1371/journal.pmed.1000279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015285825
623 rdf:type schema:CreativeWork
624 https://www.grid.ac/institutes/grid.120073.7 schema:alternateName Addenbrooke's Hospital
625 schema:name Cambridge Breast Unit, Addenbrookes Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
626 Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK
627 Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
628 Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
629 rdf:type schema:Organization
630 https://www.grid.ac/institutes/grid.17089.37 schema:alternateName University of Alberta
631 schema:name Departments of Oncology and Laboratory Medicine and Pathology, University of Alberta, 11560 University Avenue, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada
632 rdf:type schema:Organization
633 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
634 schema:name Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
635 Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
636 Centre for Molecular Medicine and Therapeutics, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, Canada
637 Department of Computer Science, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
638 Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
639 Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
640 rdf:type schema:Organization
641 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
642 schema:name British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
643 Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Ave, Vancouver, British Columbia V5Z 4E6, Canada
644 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
645 Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada
646 Terry Fox Laboratory, BC Cancer Agency, 675 W 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
647 rdf:type schema:Organization
648 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
649 schema:name Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA
650 Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
651 rdf:type schema:Organization
652 https://www.grid.ac/institutes/grid.418190.5 schema:alternateName Thermo Fisher Scientific (United States)
653 schema:name Life Technologies, 101 Lincoln Centre Dr., Foster City, California 94404, USA
654 rdf:type schema:Organization
655 https://www.grid.ac/institutes/grid.42505.36 schema:alternateName University of Southern California
656 schema:name Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
657 Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
658 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
659 rdf:type schema:Organization
660 https://www.grid.ac/institutes/grid.434706.2 schema:alternateName Canada's Michael Smith Genome Sciences Centre
661 schema:name Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
662 rdf:type schema:Organization
663 https://www.grid.ac/institutes/grid.470869.4 schema:alternateName Cancer Research UK Cambridge Institute
664 schema:name Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
665 rdf:type schema:Organization
666 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
667 schema:name Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
668 Department of Oncology, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
669 rdf:type schema:Organization
670 https://www.grid.ac/institutes/grid.61971.38 schema:alternateName Simon Fraser University
671 schema:name Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
672 Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
673 Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Dr., Burnaby, British Columbia V5A1S6, Canada
674 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...