RNA-guided genetic silencing systems in bacteria and archaea View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-02

AUTHORS

Blake Wiedenheft, Samuel H. Sternberg, Jennifer A. Doudna

ABSTRACT

Clustered regularly interspaced short palindromic repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are widespread in bacteria and archaea. Similar to RNA interference (RNAi) pathways in eukaryotes, CRISPR-mediated immune systems rely on small RNAs for sequence-specific detection and silencing of foreign nucleic acids, including viruses and plasmids. However, the mechanism of RNA-based bacterial immunity is distinct from RNAi. Understanding how small RNAs are used to find and destroy foreign nucleic acids will provide new insights into the diverse mechanisms of RNA-controlled genetic silencing systems. More... »

PAGES

331

References to SciGraph publications

  • 2010-05. Bacteriophage resistance mechanisms in NATURE REVIEWS MICROBIOLOGY
  • 2007-12. CRISPR Recognition Tool (CRT): a tool for automatic detection of clustered regularly interspaced palindromic repeats in BMC BIOINFORMATICS
  • 2009-11. Explaining microbial population genomics through phage predation in NATURE REVIEWS MICROBIOLOGY
  • 2010-03. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea in NATURE REVIEWS GENETICS
  • 2011-06. Evolution and classification of the CRISPR–Cas systems in NATURE REVIEWS MICROBIOLOGY
  • 2008-01. A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli in NATURE METHODS
  • 2011-06. An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-06. Recognition and maturation of effector RNAs in a CRISPR interference pathway in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2007-12. PILER-CR: Fast and accurate identification of CRISPR repeats in BMC BIOINFORMATICS
  • 2005-02. Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements in JOURNAL OF MOLECULAR EVOLUTION
  • 2006-12. A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action in BIOLOGY DIRECT
  • 2010-01. Self versus non-self discrimination during CRISPR RNA-directed immunity in NATURE
  • 2008-03. CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea in NATURE REVIEWS MICROBIOLOGY
  • 2011-03. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III in NATURE
  • 2011-05. Structural basis for CRISPR RNA-guided DNA recognition by Cascade in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-08. Mammalian microRNAs predominantly act to decrease target mRNA levels in NATURE
  • 2007-06. Evolutionary conservation of sequence and secondary structures in CRISPR repeats in GENOME BIOLOGY
  • 2011-09. Structures of the RNA-guided surveillance complex from a bacterial immune system in NATURE
  • 2010-11. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    7385

    VOLUME

    482

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature10886

    DOI

    http://dx.doi.org/10.1038/nature10886

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053669571

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22337052


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