Crystal structure of the channelrhodopsin light-gated cation channel View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02

AUTHORS

Hideaki E. Kato, Feng Zhang, Ofer Yizhar, Charu Ramakrishnan, Tomohiro Nishizawa, Kunio Hirata, Jumpei Ito, Yusuke Aita, Tomoya Tsukazaki, Shigehiko Hayashi, Peter Hegemann, Andrés D. Maturana, Ryuichiro Ishitani, Karl Deisseroth, Osamu Nureki

ABSTRACT

Channelrhodopsins (ChRs) are light-gated cation channels derived from algae that have shown experimental utility in optogenetics; for example, neurons expressing ChRs can be optically controlled with high temporal precision within systems as complex as freely moving mammals. Although ChRs have been broadly applied to neuroscience research, little is known about the molecular mechanisms by which these unusual and powerful proteins operate. Here we present the crystal structure of a ChR (a C1C2 chimaera between ChR1 and ChR2 from Chlamydomonas reinhardtii) at 2.3 Å resolution. The structure reveals the essential molecular architecture of ChRs, including the retinal-binding pocket and cation conduction pathway. This integration of structural and electrophysiological analyses provides insight into the molecular basis for the remarkable function of ChRs, and paves the way for the precise and principled design of ChR variants with novel properties. More... »

PAGES

369

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature10870

DOI

http://dx.doi.org/10.1038/nature10870

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025722569

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22266941


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