Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01-22

AUTHORS

Lynn M. Boyden, Murim Choi, Keith A. Choate, Carol J. Nelson-Williams, Anita Farhi, Hakan R. Toka, Irina R. Tikhonova, Robert Bjornson, Shrikant M. Mane, Giacomo Colussi, Marcel Lebel, Richard D. Gordon, Ben A. Semmekrot, Alain Poujol, Matti J. Välimäki, Maria E. De Ferrari, Sami A. Sanjad, Michael Gutkin, Fiona E. Karet, Joseph R. Tucci, Jim R. Stockigt, Kim M. Keppler-Noreuil, Craig C. Porter, Sudhir K. Anand, Margo L. Whiteford, Ira D. Davis, Stephanie B. Dewar, Alberto Bettinelli, Jeffrey J. Fadrowski, Craig W. Belsha, Tracy E. Hunley, Raoul D. Nelson, Howard Trachtman, Trevor R. P. Cole, Maury Pinsk, Detlef Bockenhauer, Mohan Shenoy, Priya Vaidyanathan, John W. Foreman, Majid Rasoulpour, Farook Thameem, Hania Z. Al-Shahrouri, Jai Radhakrishnan, Ali G. Gharavi, Beatrice Goilav, Richard P. Lifton

ABSTRACT

Hypertension affects one billion people and is a principal reversible risk factor for cardiovascular disease. Pseudohypoaldosteronism type II (PHAII), a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis, has revealed previously unrecognized physiology orchestrating the balance between renal salt reabsorption and K(+) and H(+) excretion. Here we used exome sequencing to identify mutations in kelch-like 3 (KLHL3) or cullin 3 (CUL3) in PHAII patients from 41 unrelated families. KLHL3 mutations are either recessive or dominant, whereas CUL3 mutations are dominant and predominantly de novo. CUL3 and BTB-domain-containing kelch proteins such as KLHL3 are components of cullin-RING E3 ligase complexes that ubiquitinate substrates bound to kelch propeller domains. Dominant KLHL3 mutations are clustered in short segments within the kelch propeller and BTB domains implicated in substrate and cullin binding, respectively. Diverse CUL3 mutations all result in skipping of exon 9, producing an in-frame deletion. Because dominant KLHL3 and CUL3 mutations both phenocopy recessive loss-of-function KLHL3 mutations, they may abrogate ubiquitination of KLHL3 substrates. Disease features are reversed by thiazide diuretics, which inhibit the Na-Cl cotransporter in the distal nephron of the kidney; KLHL3 and CUL3 are expressed in this location, suggesting a mechanistic link between KLHL3 and CUL3 mutations, increased Na-Cl reabsorption, and disease pathogenesis. These findings demonstrate the utility of exome sequencing in disease gene identification despite the combined complexities of locus heterogeneity, mixed models of transmission and frequent de novo mutation, and establish a fundamental role for KLHL3 and CUL3 in blood pressure, K(+) and pH homeostasis. More... »

PAGES

98

References to SciGraph publications

  • 2003-11. Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases in NATURE CELL BIOLOGY
  • 1999-08-26. Primer3 on the WWW for General Users and for Biologist Programmers in BIOINFORMATICS METHODS AND PROTOCOLS
  • 2002-04. Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex in NATURE
  • 2003-12. Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals in BMC BIOINFORMATICS
  • 2008. Phylogenetic, Structural and Functional Relationships between WD- and Kelch-Repeat Proteins in THE CORONIN FAMILY OF PROTEINS
  • 2002-01. Merlin—rapid analysis of dense genetic maps using sparse gene flow trees in NATURE GENETICS
  • 2005-10. Sequence and structural analysis of BTB domain proteins in GENOME BIOLOGY
  • 2011-04. The cullin protein family in GENOME BIOLOGY
  • 1996-10. Genetic heterogeneity of Barter's syndrome revealed by mutations in the K+ channel, ROMK in NATURE GENETICS
  • 1993-02. Cloning and expression of apical membrane water channel of rat kidney collecting tubule in NATURE
  • 1999-09. Sodium transport-related proteins in the mammalian distal nephron – distribution, ontogeny and functional aspects in BRAIN STRUCTURE AND FUNCTION
  • 2003-12. WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion in NATURE GENETICS
  • 1999-01. Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness in NATURE GENETICS
  • 2011-01. Integrative genomics viewer in NATURE BIOTECHNOLOGY
  • 2006-10. Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule in NATURE GENETICS
  • Journal

    TITLE

    Nature

    ISSUE

    7383

    VOLUME

    482

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature10814

    DOI

    http://dx.doi.org/10.1038/nature10814

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039812741

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22266938


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