Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01-04

AUTHORS

Dan H. Barouch, Jinyan Liu, Hualin Li, Lori F. Maxfield, Peter Abbink, Diana M. Lynch, M. Justin Iampietro, Adam SanMiguel, Michael S. Seaman, Guido Ferrari, Donald N. Forthal, Ilnour Ourmanov, Vanessa M. Hirsch, Angela Carville, Keith G. Mansfield, Donald Stablein, Maria G. Pau, Hanneke Schuitemaker, Jerald C. Sadoff, Erik A. Billings, Mangala Rao, Merlin L. Robb, Jerome H. Kim, Mary A. Marovich, Jaap Goudsmit, Nelson L. Michael

ABSTRACT

Preclinical studies of human immunodeficiency virus type 1 (HIV-1) vaccine candidates have typically shown post-infection virological control, but protection against acquisition of infection has previously only been reported against neutralization-sensitive virus challenges. Here we demonstrate vaccine protection against acquisition of fully heterologous, neutralization-resistant simian immunodeficiency virus (SIV) challenges in rhesus monkeys. Adenovirus/poxvirus and adenovirus/adenovirus-vector-based vaccines expressing SIV(SME543) Gag, Pol and Env antigens resulted in an 80% or greater reduction in the per-exposure probability of infection against repetitive, intrarectal SIV(MAC251) challenges in rhesus monkeys. Protection against acquisition of infection showed distinct immunological correlates compared with post-infection virological control and required the inclusion of Env in the vaccine regimen. These data demonstrate the proof-of-concept that optimized HIV-1 vaccine candidates can block acquisition of stringent, heterologous, neutralization-resistant virus challenges in rhesus monkeys. More... »

PAGES

89

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature10766

DOI

http://dx.doi.org/10.1038/nature10766

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051805279

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22217938


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AIDS Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Neutralizing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca mulatta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutralization Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SAIDS Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Simian Immunodeficiency Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Vaccines", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ragon Institute of MGH, MIT and Harvard", 
          "id": "https://www.grid.ac/institutes/grid.461656.6", 
          "name": [
            "Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA", 
            "Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts 02114, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barouch", 
        "givenName": "Dan H.", 
        "id": "sg:person.0644324362.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644324362.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Jinyan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Hualin", 
        "id": "sg:person.010525220067.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010525220067.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maxfield", 
        "givenName": "Lori F.", 
        "id": "sg:person.0576443457.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576443457.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abbink", 
        "givenName": "Peter", 
        "id": "sg:person.0620102025.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620102025.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lynch", 
        "givenName": "Diana M.", 
        "id": "sg:person.0703763241.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703763241.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iampietro", 
        "givenName": "M. Justin", 
        "id": "sg:person.0737721057.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737721057.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "SanMiguel", 
        "givenName": "Adam", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seaman", 
        "givenName": "Michael S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Duke University Medical Center, Durham, North Carolina 27710, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrari", 
        "givenName": "Guido", 
        "id": "sg:person.01102304345.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102304345.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Irvine", 
          "id": "https://www.grid.ac/institutes/grid.266093.8", 
          "name": [
            "University of California Irvine School of Medicine, Irvine, Californian 92697, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forthal", 
        "givenName": "Donald N.", 
        "id": "sg:person.012552664107.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012552664107.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "National Institute of Allergy and Infectious Diseases, Bethesda, Massachusetts 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ourmanov", 
        "givenName": "Ilnour", 
        "id": "sg:person.01253131267.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253131267.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "National Institute of Allergy and Infectious Diseases, Bethesda, Massachusetts 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirsch", 
        "givenName": "Vanessa M.", 
        "id": "sg:person.0662760246.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662760246.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "New England Primate Research Center, Southborough, Massachusetts 01772, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carville", 
        "givenName": "Angela", 
        "id": "sg:person.011724101747.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011724101747.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "New England Primate Research Center, Southborough, Massachusetts 01772, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mansfield", 
        "givenName": "Keith G.", 
        "id": "sg:person.012773173677.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012773173677.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emmes Corporation", 
          "id": "https://www.grid.ac/institutes/grid.280434.9", 
          "name": [
            "EMMES Corporation, Rockville, Maryland 20850, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stablein", 
        "givenName": "Donald", 
        "id": "sg:person.015705106257.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015705106257.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Netherlands)", 
          "id": "https://www.grid.ac/institutes/grid.497529.4", 
          "name": [
            "Crucell Holland BV, 2301 CA, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pau", 
        "givenName": "Maria G.", 
        "id": "sg:person.01205063422.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205063422.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Netherlands)", 
          "id": "https://www.grid.ac/institutes/grid.497529.4", 
          "name": [
            "Crucell Holland BV, 2301 CA, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schuitemaker", 
        "givenName": "Hanneke", 
        "id": "sg:person.0622150141.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622150141.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Netherlands)", 
          "id": "https://www.grid.ac/institutes/grid.497529.4", 
          "name": [
            "Crucell Holland BV, 2301 CA, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sadoff", 
        "givenName": "Jerald C.", 
        "id": "sg:person.0626540123.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626540123.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United States Army Medical Research and Materiel Command", 
          "id": "https://www.grid.ac/institutes/grid.420210.5", 
          "name": [
            "US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Billings", 
        "givenName": "Erik A.", 
        "id": "sg:person.016033455477.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016033455477.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United States Army Medical Research and Materiel Command", 
          "id": "https://www.grid.ac/institutes/grid.420210.5", 
          "name": [
            "US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rao", 
        "givenName": "Mangala", 
        "id": "sg:person.01302574024.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302574024.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United States Army Medical Research and Materiel Command", 
          "id": "https://www.grid.ac/institutes/grid.420210.5", 
          "name": [
            "US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robb", 
        "givenName": "Merlin L.", 
        "id": "sg:person.014275302657.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014275302657.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United States Army Medical Research and Materiel Command", 
          "id": "https://www.grid.ac/institutes/grid.420210.5", 
          "name": [
            "US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jerome H.", 
        "id": "sg:person.01021250610.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021250610.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United States Army Medical Research and Materiel Command", 
          "id": "https://www.grid.ac/institutes/grid.420210.5", 
          "name": [
            "US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marovich", 
        "givenName": "Mary A.", 
        "id": "sg:person.0611234430.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611234430.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Netherlands)", 
          "id": "https://www.grid.ac/institutes/grid.497529.4", 
          "name": [
            "Crucell Holland BV, 2301 CA, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goudsmit", 
        "givenName": "Jaap", 
        "id": "sg:person.01213452424.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213452424.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "United States Army Medical Research and Materiel Command", 
          "id": "https://www.grid.ac/institutes/grid.420210.5", 
          "name": [
            "US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michael", 
        "givenName": "Nelson L.", 
        "id": "sg:person.01250357245.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250357245.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1086/600891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000694015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471142735.im1211s64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000844152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jir199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000975071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20070567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001272473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02252-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003938261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1187659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008550585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00171-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012988087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20070567082907c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013659228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.80.10.5074-5077.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014804885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1178746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015274711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1178746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015274711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00171-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016582165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02616-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017395887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02696-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017566347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02533-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020278248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20082831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022734421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01155-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025616553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1541-0420.2009.01189.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029328655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033531216", 
          "https://doi.org/10.1038/nm.2089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034281259", 
          "https://doi.org/10.1038/nature07469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037326848", 
          "https://doi.org/10.1038/nature10003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00895-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042147239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.15.6953-6961.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046005657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.74.6.2740-2751.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046552615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3002351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048534642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.77.15.8263-8271.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048816043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050080479", 
          "https://doi.org/10.1038/nature08757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050080479", 
          "https://doi.org/10.1038/nature08757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.77.4.2736-2740.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050169865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050972669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0908492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052060526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.1.29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074964084"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-01-04", 
    "datePublishedReg": "2012-01-04", 
    "description": "Preclinical studies of human immunodeficiency virus type 1 (HIV-1) vaccine candidates have typically shown post-infection virological control, but protection against acquisition of infection has previously only been reported against neutralization-sensitive virus challenges. Here we demonstrate vaccine protection against acquisition of fully heterologous, neutralization-resistant simian immunodeficiency virus (SIV) challenges in rhesus monkeys. Adenovirus/poxvirus and adenovirus/adenovirus-vector-based vaccines expressing SIV(SME543) Gag, Pol and Env antigens resulted in an 80% or greater reduction in the per-exposure probability of infection against repetitive, intrarectal SIV(MAC251) challenges in rhesus monkeys. Protection against acquisition of infection showed distinct immunological correlates compared with post-infection virological control and required the inclusion of Env in the vaccine regimen. These data demonstrate the proof-of-concept that optimized HIV-1 vaccine candidates can block acquisition of stringent, heterologous, neutralization-resistant virus challenges in rhesus monkeys.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature10766", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2441136", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2695891", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438712", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2458792", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2457315", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2695783", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2421695", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2723074", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2695832", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2424342", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7383", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "482"
      }
    ], 
    "name": "Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys", 
    "pagination": "89", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f6c5a1cedc20ffda716a03a585929e350dc039eff88ed12399ec50704c885c3e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22217938"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature10766"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051805279"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature10766", 
      "https://app.dimensions.ai/details/publication/pub.1051805279"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature10766"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature10766'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature10766'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature10766'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature10766'


 

This table displays all metadata directly associated to this object as RDF triples.

445 TRIPLES      21 PREDICATES      71 URIs      33 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature10766 schema:about N0754251af2904c8ba30f7baa18b9fe57
2 N3644b7e545f34339b463f255f18f3b45
3 N4d6940c72432490b844cdf5d20e4bc34
4 N5507627e61424f06b1d7f458537ba3e4
5 N5602e7f860f5463693ff1b474f493b1d
6 N7ae16579682d495095e2acb05615d2f6
7 N87bc67f5dd464af5a0946b3f85835678
8 N8b5554db0005420296fde3142f69fa4f
9 N9e8265c708e7463abc3e479e0708cce6
10 Na63fb9c4aa6f456cbee1dffc453bdb00
11 Nc9246c55f1ac4577b99526561924f262
12 Nf3ba2c97799f48949bd384549e07b336
13 Nf9477b15c0914ab98d2572144dc6fe37
14 anzsrc-for:11
15 anzsrc-for:1108
16 schema:author N7abb2cee39164bb5a4fcef7cd7fece78
17 schema:citation sg:pub.10.1038/nature07469
18 sg:pub.10.1038/nature08757
19 sg:pub.10.1038/nature10003
20 sg:pub.10.1038/nm.2089
21 https://doi.org/10.1002/0471142735.im1211s64
22 https://doi.org/10.1056/nejmoa0908492
23 https://doi.org/10.1084/jem.20070567
24 https://doi.org/10.1084/jem.20070567082907c
25 https://doi.org/10.1084/jem.20082831
26 https://doi.org/10.1086/600891
27 https://doi.org/10.1093/infdis/jir199
28 https://doi.org/10.1111/j.1541-0420.2009.01189.x
29 https://doi.org/10.1126/science.1178746
30 https://doi.org/10.1126/science.1187659
31 https://doi.org/10.1126/scitranslmed.3002351
32 https://doi.org/10.1128/jvi.00171-06
33 https://doi.org/10.1128/jvi.00171-11
34 https://doi.org/10.1128/jvi.00895-07
35 https://doi.org/10.1128/jvi.01155-10
36 https://doi.org/10.1128/jvi.02252-09
37 https://doi.org/10.1128/jvi.02533-09
38 https://doi.org/10.1128/jvi.02616-07
39 https://doi.org/10.1128/jvi.02696-06
40 https://doi.org/10.1128/jvi.74.6.2740-2751.2000
41 https://doi.org/10.1128/jvi.75.15.6953-6961.2001
42 https://doi.org/10.1128/jvi.77.15.8263-8271.2003
43 https://doi.org/10.1128/jvi.77.4.2736-2740.2003
44 https://doi.org/10.1128/jvi.80.10.5074-5077.2006
45 https://doi.org/10.1371/journal.ppat.1000738
46 https://doi.org/10.4049/jimmunol.168.1.29
47 schema:datePublished 2012-01-04
48 schema:datePublishedReg 2012-01-04
49 schema:description Preclinical studies of human immunodeficiency virus type 1 (HIV-1) vaccine candidates have typically shown post-infection virological control, but protection against acquisition of infection has previously only been reported against neutralization-sensitive virus challenges. Here we demonstrate vaccine protection against acquisition of fully heterologous, neutralization-resistant simian immunodeficiency virus (SIV) challenges in rhesus monkeys. Adenovirus/poxvirus and adenovirus/adenovirus-vector-based vaccines expressing SIV(SME543) Gag, Pol and Env antigens resulted in an 80% or greater reduction in the per-exposure probability of infection against repetitive, intrarectal SIV(MAC251) challenges in rhesus monkeys. Protection against acquisition of infection showed distinct immunological correlates compared with post-infection virological control and required the inclusion of Env in the vaccine regimen. These data demonstrate the proof-of-concept that optimized HIV-1 vaccine candidates can block acquisition of stringent, heterologous, neutralization-resistant virus challenges in rhesus monkeys.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf N22256d13102244c6af514589902e52ed
54 N6fe6704574024428ba91596339b235a0
55 sg:journal.1018957
56 schema:name Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys
57 schema:pagination 89
58 schema:productId N06c89ed21da347d4b2fab14e0a99ed76
59 N227db4cb8cb1401e94c6248f5e048e82
60 N228ae5c2bfde4ec09e366b610cc7b306
61 N86f4d90cf7274f769f61f7c1c0f62002
62 Nc4b5833a368249068fb9600b40cc96a9
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051805279
64 https://doi.org/10.1038/nature10766
65 schema:sdDatePublished 2019-04-10T13:01
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N8d2e59c2795c45b99883455171df559f
68 schema:url https://www.nature.com/articles/nature10766
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N06c89ed21da347d4b2fab14e0a99ed76 schema:name doi
73 schema:value 10.1038/nature10766
74 rdf:type schema:PropertyValue
75 N0754251af2904c8ba30f7baa18b9fe57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Male
77 rdf:type schema:DefinedTerm
78 N0bf9276fea26402dbc226e11b3b71347 rdf:first sg:person.0626540123.73
79 rdf:rest Nfadbafa58a47443891037af0f31a3057
80 N0d8adae9b75f46b9940ff6642a36575b schema:affiliation N338be9ccbae84fb6b9ae2417b17fd852
81 schema:familyName Liu
82 schema:givenName Jinyan
83 rdf:type schema:Person
84 N0f7ac103c21049a6b33b0ec703213387 rdf:first sg:person.0611234430.42
85 rdf:rest Nc05950dcf328483da26c28afe508f014
86 N11307c2298c94dcdb7e771f091e96f4d rdf:first sg:person.011724101747.84
87 rdf:rest N9647f1e021ba4011ab4a6461e4473ccc
88 N11e50a7ef60547d09c506c72f8f8928f rdf:first sg:person.01021250610.88
89 rdf:rest N0f7ac103c21049a6b33b0ec703213387
90 N1ee075ef204a4bbb8ad97da922861ec9 rdf:first sg:person.0703763241.80
91 rdf:rest N9e3ce7f4d97d4089be50ed54c5f7706f
92 N208ca42f163344dc80255df033389450 schema:name Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
93 rdf:type schema:Organization
94 N22256d13102244c6af514589902e52ed schema:issueNumber 7383
95 rdf:type schema:PublicationIssue
96 N227db4cb8cb1401e94c6248f5e048e82 schema:name dimensions_id
97 schema:value pub.1051805279
98 rdf:type schema:PropertyValue
99 N228ae5c2bfde4ec09e366b610cc7b306 schema:name pubmed_id
100 schema:value 22217938
101 rdf:type schema:PropertyValue
102 N2ab23dc03c36457ba6c175165936794f rdf:first sg:person.01102304345.32
103 rdf:rest Nd88c7ddd756347fbbdca800797affb8f
104 N3276a7750d3140768e37f6dccb914f57 rdf:first sg:person.01253131267.86
105 rdf:rest N7d419082347c4af4a2dfaa49b11b8f78
106 N338be9ccbae84fb6b9ae2417b17fd852 schema:name Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
107 rdf:type schema:Organization
108 N35cf9a1f189f49889d55affbc5843936 rdf:first Nda16af1b4036418782d57caba8e8a52a
109 rdf:rest N79bc67d31ad546e5b5d7542bd1a22b9b
110 N3644b7e545f34339b463f255f18f3b45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name HIV-1
112 rdf:type schema:DefinedTerm
113 N488c3e06ba2b4c789d96baa4ade2fd3d rdf:first sg:person.0576443457.97
114 rdf:rest N9e65b9e44d6d4a1ba3bd5ff7e0d7630b
115 N4d6940c72432490b844cdf5d20e4bc34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Neutralization Tests
117 rdf:type schema:DefinedTerm
118 N5507627e61424f06b1d7f458537ba3e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Animals
120 rdf:type schema:DefinedTerm
121 N5528b765f77045a4a8b6c9c065a96769 schema:affiliation Nf9070ffa618d4af5b837f5b914cc78a7
122 schema:familyName Seaman
123 schema:givenName Michael S.
124 rdf:type schema:Person
125 N5602e7f860f5463693ff1b474f493b1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Adenoviridae
127 rdf:type schema:DefinedTerm
128 N5aac67fd874f4e6da5ef3eab7660c8a3 rdf:first sg:person.01250357245.06
129 rdf:rest rdf:nil
130 N624e71cb3e62413e8ec51e98b50e0e05 schema:name Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
131 rdf:type schema:Organization
132 N6bcdd541dc344834a4582bf133954d4a rdf:first sg:person.0622150141.11
133 rdf:rest N0bf9276fea26402dbc226e11b3b71347
134 N6c641737f21145fc9263650a7f16b38c rdf:first sg:person.01302574024.29
135 rdf:rest Nb9e773f20fe847be8534465b227705b8
136 N6fe6704574024428ba91596339b235a0 schema:volumeNumber 482
137 rdf:type schema:PublicationVolume
138 N79bc67d31ad546e5b5d7542bd1a22b9b rdf:first N5528b765f77045a4a8b6c9c065a96769
139 rdf:rest N2ab23dc03c36457ba6c175165936794f
140 N7abb2cee39164bb5a4fcef7cd7fece78 rdf:first sg:person.0644324362.10
141 rdf:rest Nb68766a96216402ca598a98962cc24b1
142 N7ae16579682d495095e2acb05615d2f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Macaca mulatta
144 rdf:type schema:DefinedTerm
145 N7d419082347c4af4a2dfaa49b11b8f78 rdf:first sg:person.0662760246.68
146 rdf:rest N11307c2298c94dcdb7e771f091e96f4d
147 N85570429baba4ae8979f9bacadebe78f rdf:first sg:person.010525220067.63
148 rdf:rest N488c3e06ba2b4c789d96baa4ade2fd3d
149 N86f4d90cf7274f769f61f7c1c0f62002 schema:name readcube_id
150 schema:value f6c5a1cedc20ffda716a03a585929e350dc039eff88ed12399ec50704c885c3e
151 rdf:type schema:PropertyValue
152 N87bc67f5dd464af5a0946b3f85835678 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Female
154 rdf:type schema:DefinedTerm
155 N89ce6a52fb9e4c118c714bca443d7fb6 rdf:first sg:person.015705106257.23
156 rdf:rest Ndd456a45bfa04886b03d4e8ead65b895
157 N8b5554db0005420296fde3142f69fa4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Viral Vaccines
159 rdf:type schema:DefinedTerm
160 N8d2e59c2795c45b99883455171df559f schema:name Springer Nature - SN SciGraph project
161 rdf:type schema:Organization
162 N9647f1e021ba4011ab4a6461e4473ccc rdf:first sg:person.012773173677.14
163 rdf:rest N89ce6a52fb9e4c118c714bca443d7fb6
164 N9e3ce7f4d97d4089be50ed54c5f7706f rdf:first sg:person.0737721057.80
165 rdf:rest N35cf9a1f189f49889d55affbc5843936
166 N9e65b9e44d6d4a1ba3bd5ff7e0d7630b rdf:first sg:person.0620102025.63
167 rdf:rest N1ee075ef204a4bbb8ad97da922861ec9
168 N9e8265c708e7463abc3e479e0708cce6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name SAIDS Vaccines
170 rdf:type schema:DefinedTerm
171 Na63fb9c4aa6f456cbee1dffc453bdb00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name AIDS Vaccines
173 rdf:type schema:DefinedTerm
174 Nadc6f6f983614a7f9fd57d101feedf2f schema:name Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
175 rdf:type schema:Organization
176 Nb68766a96216402ca598a98962cc24b1 rdf:first N0d8adae9b75f46b9940ff6642a36575b
177 rdf:rest N85570429baba4ae8979f9bacadebe78f
178 Nb8a8aa8bf9f74f21a8950bedc53bc733 schema:name Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
179 rdf:type schema:Organization
180 Nb9e773f20fe847be8534465b227705b8 rdf:first sg:person.014275302657.99
181 rdf:rest N11e50a7ef60547d09c506c72f8f8928f
182 Nc05950dcf328483da26c28afe508f014 rdf:first sg:person.01213452424.71
183 rdf:rest N5aac67fd874f4e6da5ef3eab7660c8a3
184 Nc4b5833a368249068fb9600b40cc96a9 schema:name nlm_unique_id
185 schema:value 0410462
186 rdf:type schema:PropertyValue
187 Nc9246c55f1ac4577b99526561924f262 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Enzyme-Linked Immunosorbent Assay
189 rdf:type schema:DefinedTerm
190 Nd1e164ab194540ea9cd6a623b1f73f6e schema:name Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
191 rdf:type schema:Organization
192 Nd88c7ddd756347fbbdca800797affb8f rdf:first sg:person.012552664107.04
193 rdf:rest N3276a7750d3140768e37f6dccb914f57
194 Nda16af1b4036418782d57caba8e8a52a schema:affiliation Nf81251576fc14efd8d56b07f862e59fe
195 schema:familyName SanMiguel
196 schema:givenName Adam
197 rdf:type schema:Person
198 Ndd456a45bfa04886b03d4e8ead65b895 rdf:first sg:person.01205063422.66
199 rdf:rest N6bcdd541dc344834a4582bf133954d4a
200 Nf3ba2c97799f48949bd384549e07b336 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Simian Immunodeficiency Virus
202 rdf:type schema:DefinedTerm
203 Nf81251576fc14efd8d56b07f862e59fe schema:name Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
204 rdf:type schema:Organization
205 Nf9070ffa618d4af5b837f5b914cc78a7 schema:name Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
206 rdf:type schema:Organization
207 Nf9477b15c0914ab98d2572144dc6fe37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Antibodies, Neutralizing
209 rdf:type schema:DefinedTerm
210 Nfadbafa58a47443891037af0f31a3057 rdf:first sg:person.016033455477.80
211 rdf:rest N6c641737f21145fc9263650a7f16b38c
212 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
213 schema:name Medical and Health Sciences
214 rdf:type schema:DefinedTerm
215 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
216 schema:name Medical Microbiology
217 rdf:type schema:DefinedTerm
218 sg:grant.2421695 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10766
219 rdf:type schema:MonetaryGrant
220 sg:grant.2424342 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10766
221 rdf:type schema:MonetaryGrant
222 sg:grant.2438712 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10766
223 rdf:type schema:MonetaryGrant
224 sg:grant.2441136 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10766
225 rdf:type schema:MonetaryGrant
226 sg:grant.2457315 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10766
227 rdf:type schema:MonetaryGrant
228 sg:grant.2458792 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10766
229 rdf:type schema:MonetaryGrant
230 sg:grant.2695783 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10766
231 rdf:type schema:MonetaryGrant
232 sg:grant.2695832 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10766
233 rdf:type schema:MonetaryGrant
234 sg:grant.2695891 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10766
235 rdf:type schema:MonetaryGrant
236 sg:grant.2723074 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10766
237 rdf:type schema:MonetaryGrant
238 sg:journal.1018957 schema:issn 0090-0028
239 1476-4687
240 schema:name Nature
241 rdf:type schema:Periodical
242 sg:person.01021250610.88 schema:affiliation https://www.grid.ac/institutes/grid.420210.5
243 schema:familyName Kim
244 schema:givenName Jerome H.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021250610.88
246 rdf:type schema:Person
247 sg:person.010525220067.63 schema:affiliation N208ca42f163344dc80255df033389450
248 schema:familyName Li
249 schema:givenName Hualin
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010525220067.63
251 rdf:type schema:Person
252 sg:person.01102304345.32 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
253 schema:familyName Ferrari
254 schema:givenName Guido
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102304345.32
256 rdf:type schema:Person
257 sg:person.011724101747.84 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
258 schema:familyName Carville
259 schema:givenName Angela
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011724101747.84
261 rdf:type schema:Person
262 sg:person.01205063422.66 schema:affiliation https://www.grid.ac/institutes/grid.497529.4
263 schema:familyName Pau
264 schema:givenName Maria G.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205063422.66
266 rdf:type schema:Person
267 sg:person.01213452424.71 schema:affiliation https://www.grid.ac/institutes/grid.497529.4
268 schema:familyName Goudsmit
269 schema:givenName Jaap
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213452424.71
271 rdf:type schema:Person
272 sg:person.01250357245.06 schema:affiliation https://www.grid.ac/institutes/grid.420210.5
273 schema:familyName Michael
274 schema:givenName Nelson L.
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250357245.06
276 rdf:type schema:Person
277 sg:person.01253131267.86 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
278 schema:familyName Ourmanov
279 schema:givenName Ilnour
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253131267.86
281 rdf:type schema:Person
282 sg:person.012552664107.04 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
283 schema:familyName Forthal
284 schema:givenName Donald N.
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012552664107.04
286 rdf:type schema:Person
287 sg:person.012773173677.14 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
288 schema:familyName Mansfield
289 schema:givenName Keith G.
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012773173677.14
291 rdf:type schema:Person
292 sg:person.01302574024.29 schema:affiliation https://www.grid.ac/institutes/grid.420210.5
293 schema:familyName Rao
294 schema:givenName Mangala
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302574024.29
296 rdf:type schema:Person
297 sg:person.014275302657.99 schema:affiliation https://www.grid.ac/institutes/grid.420210.5
298 schema:familyName Robb
299 schema:givenName Merlin L.
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014275302657.99
301 rdf:type schema:Person
302 sg:person.015705106257.23 schema:affiliation https://www.grid.ac/institutes/grid.280434.9
303 schema:familyName Stablein
304 schema:givenName Donald
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015705106257.23
306 rdf:type schema:Person
307 sg:person.016033455477.80 schema:affiliation https://www.grid.ac/institutes/grid.420210.5
308 schema:familyName Billings
309 schema:givenName Erik A.
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016033455477.80
311 rdf:type schema:Person
312 sg:person.0576443457.97 schema:affiliation N624e71cb3e62413e8ec51e98b50e0e05
313 schema:familyName Maxfield
314 schema:givenName Lori F.
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576443457.97
316 rdf:type schema:Person
317 sg:person.0611234430.42 schema:affiliation https://www.grid.ac/institutes/grid.420210.5
318 schema:familyName Marovich
319 schema:givenName Mary A.
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611234430.42
321 rdf:type schema:Person
322 sg:person.0620102025.63 schema:affiliation Nd1e164ab194540ea9cd6a623b1f73f6e
323 schema:familyName Abbink
324 schema:givenName Peter
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620102025.63
326 rdf:type schema:Person
327 sg:person.0622150141.11 schema:affiliation https://www.grid.ac/institutes/grid.497529.4
328 schema:familyName Schuitemaker
329 schema:givenName Hanneke
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622150141.11
331 rdf:type schema:Person
332 sg:person.0626540123.73 schema:affiliation https://www.grid.ac/institutes/grid.497529.4
333 schema:familyName Sadoff
334 schema:givenName Jerald C.
335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626540123.73
336 rdf:type schema:Person
337 sg:person.0644324362.10 schema:affiliation https://www.grid.ac/institutes/grid.461656.6
338 schema:familyName Barouch
339 schema:givenName Dan H.
340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644324362.10
341 rdf:type schema:Person
342 sg:person.0662760246.68 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
343 schema:familyName Hirsch
344 schema:givenName Vanessa M.
345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662760246.68
346 rdf:type schema:Person
347 sg:person.0703763241.80 schema:affiliation Nb8a8aa8bf9f74f21a8950bedc53bc733
348 schema:familyName Lynch
349 schema:givenName Diana M.
350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703763241.80
351 rdf:type schema:Person
352 sg:person.0737721057.80 schema:affiliation Nadc6f6f983614a7f9fd57d101feedf2f
353 schema:familyName Iampietro
354 schema:givenName M. Justin
355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737721057.80
356 rdf:type schema:Person
357 sg:pub.10.1038/nature07469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034281259
358 https://doi.org/10.1038/nature07469
359 rdf:type schema:CreativeWork
360 sg:pub.10.1038/nature08757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050080479
361 https://doi.org/10.1038/nature08757
362 rdf:type schema:CreativeWork
363 sg:pub.10.1038/nature10003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037326848
364 https://doi.org/10.1038/nature10003
365 rdf:type schema:CreativeWork
366 sg:pub.10.1038/nm.2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033531216
367 https://doi.org/10.1038/nm.2089
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1002/0471142735.im1211s64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000844152
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1056/nejmoa0908492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052060526
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1084/jem.20070567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001272473
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1084/jem.20070567082907c schema:sameAs https://app.dimensions.ai/details/publication/pub.1013659228
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1084/jem.20082831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022734421
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1086/600891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000694015
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1093/infdis/jir199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000975071
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1111/j.1541-0420.2009.01189.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029328655
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1126/science.1178746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015274711
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1126/science.1187659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008550585
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1126/scitranslmed.3002351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048534642
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1128/jvi.00171-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016582165
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1128/jvi.00171-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012988087
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1128/jvi.00895-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042147239
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1128/jvi.01155-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025616553
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1128/jvi.02252-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003938261
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1128/jvi.02533-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020278248
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1128/jvi.02616-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017395887
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1128/jvi.02696-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017566347
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1128/jvi.74.6.2740-2751.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046552615
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1128/jvi.75.15.6953-6961.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046005657
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1128/jvi.77.15.8263-8271.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048816043
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1128/jvi.77.4.2736-2740.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050169865
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1128/jvi.80.10.5074-5077.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014804885
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1371/journal.ppat.1000738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050972669
418 rdf:type schema:CreativeWork
419 https://doi.org/10.4049/jimmunol.168.1.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074964084
420 rdf:type schema:CreativeWork
421 https://www.grid.ac/institutes/grid.189509.c schema:alternateName Duke University Hospital
422 schema:name Duke University Medical Center, Durham, North Carolina 27710, USA
423 rdf:type schema:Organization
424 https://www.grid.ac/institutes/grid.266093.8 schema:alternateName University of California, Irvine
425 schema:name University of California Irvine School of Medicine, Irvine, Californian 92697, USA
426 rdf:type schema:Organization
427 https://www.grid.ac/institutes/grid.280434.9 schema:alternateName Emmes Corporation
428 schema:name EMMES Corporation, Rockville, Maryland 20850, USA
429 rdf:type schema:Organization
430 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
431 schema:name New England Primate Research Center, Southborough, Massachusetts 01772, USA
432 rdf:type schema:Organization
433 https://www.grid.ac/institutes/grid.419681.3 schema:alternateName National Institute of Allergy and Infectious Diseases
434 schema:name National Institute of Allergy and Infectious Diseases, Bethesda, Massachusetts 20892, USA
435 rdf:type schema:Organization
436 https://www.grid.ac/institutes/grid.420210.5 schema:alternateName United States Army Medical Research and Materiel Command
437 schema:name US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
438 rdf:type schema:Organization
439 https://www.grid.ac/institutes/grid.461656.6 schema:alternateName Ragon Institute of MGH, MIT and Harvard
440 schema:name Division of Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
441 Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts 02114, USA
442 rdf:type schema:Organization
443 https://www.grid.ac/institutes/grid.497529.4 schema:alternateName Janssen (Netherlands)
444 schema:name Crucell Holland BV, 2301 CA, Leiden, The Netherlands
445 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...