A novel retinoblastoma therapy from genomic and epigenetic analyses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

Jinghui Zhang, Claudia A. Benavente, Justina McEvoy, Jacqueline Flores-Otero, Li Ding, Xiang Chen, Anatoly Ulyanov, Gang Wu, Matthew Wilson, Jianmin Wang, Rachel Brennan, Michael Rusch, Amity L. Manning, Jing Ma, John Easton, Sheila Shurtleff, Charles Mullighan, Stanley Pounds, Suraj Mukatira, Pankaj Gupta, Geoff Neale, David Zhao, Charles Lu, Robert S. Fulton, Lucinda L. Fulton, Xin Hong, David J. Dooling, Kerri Ochoa, Clayton Naeve, Nicholas J. Dyson, Elaine R. Mardis, Armita Bahrami, David Ellison, Richard K. Wilson, James R. Downing, Michael A. Dyer

ABSTRACT

Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known. Here we show that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated. To identify the mutations that cooperate with RB1 loss, we performed whole-genome sequencing of retinoblastomas. The overall mutational rate was very low; RB1 was the only known cancer gene mutated. We then evaluated the role of RB1 in genome stability and considered non-genetic mechanisms of cancer pathway deregulation. For example, the proto-oncogene SYK is upregulated in retinoblastoma and is required for tumour cell survival. Targeting SYK with a small-molecule inhibitor induced retinoblastoma tumour cell death in vitro and in vivo. Thus, retinoblastomas may develop quickly as a result of the epigenetic deregulation of key cancer pathways as a direct or indirect result of RB1 loss. More... »

PAGES

329

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature10733

DOI

http://dx.doi.org/10.1038/nature10733

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006780793

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22237022


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aneuploidy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Death", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomal Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Retinoblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Targeted Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinoblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinoblastoma Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Syk Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jinghui", 
        "id": "sg:person.011367065707.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011367065707.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Developmental Neurobiology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benavente", 
        "givenName": "Claudia A.", 
        "id": "sg:person.01071322677.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071322677.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Developmental Neurobiology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McEvoy", 
        "givenName": "Justina", 
        "id": "sg:person.0665717454.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665717454.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Developmental Neurobiology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Flores-Otero", 
        "givenName": "Jacqueline", 
        "id": "sg:person.01205551277.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205551277.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ding", 
        "givenName": "Li", 
        "id": "sg:person.01253664477.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253664477.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Xiang", 
        "id": "sg:person.015526027337.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015526027337.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ulyanov", 
        "givenName": "Anatoly", 
        "id": "sg:person.01214042627.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214042627.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Gang", 
        "id": "sg:person.01025334467.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025334467.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA", 
            "Department of Surgery, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Matthew", 
        "id": "sg:person.012757303467.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012757303467.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Hartwell Center for Biotechnology & Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Jianmin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Developmental Neurobiology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brennan", 
        "givenName": "Rachel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rusch", 
        "givenName": "Michael", 
        "id": "sg:person.01027354037.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027354037.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manning", 
        "givenName": "Amity L.", 
        "id": "sg:person.01046257270.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046257270.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Jing", 
        "id": "sg:person.01031501027.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031501027.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Computational Biology and Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Easton", 
        "givenName": "John", 
        "id": "sg:person.0721607077.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721607077.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shurtleff", 
        "givenName": "Sheila", 
        "id": "sg:person.01217544003.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217544003.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mullighan", 
        "givenName": "Charles", 
        "id": "sg:person.0671073025.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671073025.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Biostatistics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pounds", 
        "givenName": "Stanley", 
        "id": "sg:person.013021764377.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013021764377.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Hartwell Center for Biotechnology & Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukatira", 
        "givenName": "Suraj", 
        "id": "sg:person.01026315253.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026315253.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Hartwell Center for Biotechnology & Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gupta", 
        "givenName": "Pankaj", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Hartwell Center for Biotechnology & Bioinformatics, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neale", 
        "givenName": "Geoff", 
        "id": "sg:person.011676646405.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011676646405.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Information Sciences, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "David", 
        "id": "sg:person.01035342127.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035342127.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Charles", 
        "id": "sg:person.01101330337.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101330337.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fulton", 
        "givenName": "Robert S.", 
        "id": "sg:person.0647562645.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647562645.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fulton", 
        "givenName": "Lucinda L.", 
        "id": "sg:person.010365471537.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010365471537.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Xin", 
        "id": "sg:person.01263672137.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263672137.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dooling", 
        "givenName": "David J.", 
        "id": "sg:person.01332005337.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332005337.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ochoa", 
        "givenName": "Kerri", 
        "id": "sg:person.0606401237.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606401237.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Information Sciences, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naeve", 
        "givenName": "Clayton", 
        "id": "sg:person.01331736326.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331736326.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dyson", 
        "givenName": "Nicholas J.", 
        "id": "sg:person.010622267457.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010622267457.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA", 
            "Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mardis", 
        "givenName": "Elaine R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bahrami", 
        "givenName": "Armita", 
        "id": "sg:person.0621024167.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621024167.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellison", 
        "givenName": "David", 
        "id": "sg:person.0711352500.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711352500.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA", 
            "Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA", 
            "Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilson", 
        "givenName": "Richard K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "St. Jude Children's Research Hospital", 
          "id": "https://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Department of Pathology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Downing", 
        "givenName": "James R.", 
        "id": "sg:person.0776022700.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776022700.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute", 
          "id": "https://www.grid.ac/institutes/grid.413575.1", 
          "name": [
            "Department of Developmental Neurobiology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee 38105, USA", 
            "Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA", 
            "Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dyer", 
        "givenName": "Michael A.", 
        "id": "sg:person.0723007550.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723007550.69"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1000500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000710446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-05-158618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002228366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116910", 
          "https://doi.org/10.1038/nrc1279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009116910", 
          "https://doi.org/10.1038/nrc1279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010008721", 
          "https://doi.org/10.1038/nature02820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010008721", 
          "https://doi.org/10.1038/nature02820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011040031", 
          "https://doi.org/10.1038/onc.2009.179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011040031", 
          "https://doi.org/10.1038/onc.2009.179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-0058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011054559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013013054", 
          "https://doi.org/10.1038/nrc2876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(99)00277-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013830529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-07-233692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014660259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014745794", 
          "https://doi.org/10.1038/nature08136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014745794", 
          "https://doi.org/10.1038/nature08136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015786715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2010-03-275180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016446577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-07-100115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021248381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1626308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021728790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023540354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb0908-998b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023653221", 
          "https://doi.org/10.1038/nsmb0908-998b"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e08-12-1224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023768792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024822529", 
          "https://doi.org/10.1038/ng.865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0610279104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029669389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2008.346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030591731", 
          "https://doi.org/10.1038/leu.2008.346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/leu.2008.77", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030817785", 
          "https://doi.org/10.1038/leu.2008.77"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032090698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddi113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032163609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00295364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032218263", 
          "https://doi.org/10.1007/bf00295364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/5947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033054502", 
          "https://doi.org/10.1038/5947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/5947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033054502", 
          "https://doi.org/10.1038/5947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/323643a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033717519", 
          "https://doi.org/10.1038/323643a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034796960", 
          "https://doi.org/10.1038/nature07485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1917310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039001842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.20457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039294726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.20457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039294726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.68.4.820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043776590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-5-38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045801155", 
          "https://doi.org/10.1186/1476-4598-5-38"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2121-10-79", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048818606", 
          "https://doi.org/10.1186/1471-2121-10-79"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-01", 
    "datePublishedReg": "2012-01-01", 
    "description": "Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known. Here we show that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated. To identify the mutations that cooperate with RB1 loss, we performed whole-genome sequencing of retinoblastomas. The overall mutational rate was very low; RB1 was the only known cancer gene mutated. We then evaluated the role of RB1 in genome stability and considered non-genetic mechanisms of cancer pathway deregulation. For example, the proto-oncogene SYK is upregulated in retinoblastoma and is required for tumour cell survival. Targeting SYK with a small-molecule inhibitor induced retinoblastoma tumour cell death in vitro and in vivo. Thus, retinoblastomas may develop quickly as a result of the epigenetic deregulation of key cancer pathways as a direct or indirect result of RB1 loss.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature10733", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438833", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2507148", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2481206", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2519675", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2507638", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2472060", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7381", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "481"
      }
    ], 
    "name": "A novel retinoblastoma therapy from genomic and epigenetic analyses", 
    "pagination": "329", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "204c89aca91e05d616fc5802b050b2651c86d10a72c671108bed6c64e6e3e585"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22237022"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature10733"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006780793"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature10733", 
      "https://app.dimensions.ai/details/publication/pub.1006780793"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000549.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature10733"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature10733'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature10733'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature10733'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature10733'


 

This table displays all metadata directly associated to this object as RDF triples.

541 TRIPLES      21 PREDICATES      83 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature10733 schema:about N009a334a751a494ab0827400834913d3
2 N0eb6ae40d4074e12b3aca6fc4298cc31
3 N18d25b070b5b48e7b1834b1d99e781ba
4 N2a3d87efbc0c41abb1939c234ee4d0aa
5 N2c87fd797f2d493aaf674126ad567f44
6 N3ce5b50541c546afbada0c8a201ba2b3
7 N456bb4ef71c24969a53ad43004424fcb
8 N601e68d0f1794d75b8b4cf5739d90019
9 N766d9f97410b4e28978f013e7c9e41de
10 N80fd83c5f9bd4c609f17d2ea508488e9
11 N8b7adc7be0944e2a926a05a222a48902
12 N8ffbb746a7ed4643b56c398e68e760d3
13 N98f4840fa4f74f8f9ab58b4d177124bb
14 Na056413c50b34571b6021eaa16667a54
15 Nadc023b9fc3444ffaa64500bc4d28520
16 Nd2c7876b81ce457a82937b3e45943533
17 Nd7ba8e14db6f4f8f93758803fc8a724f
18 Nddae66ef80d74655b46f5798212dc0b7
19 Ndfea2898dde54784a6c9ea1510581cb7
20 Ne31bffb0afa14888b5c259286547c78f
21 Ne8b0e5c5a50f40abbfbe7bc4236f037f
22 Nf25b866fa9ad457a87f7d1c05834c196
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author N47d98ba0b56c4ea287f6133fa0ed8474
26 schema:citation sg:pub.10.1007/bf00295364
27 sg:pub.10.1038/323643a0
28 sg:pub.10.1038/5947
29 sg:pub.10.1038/leu.2008.346
30 sg:pub.10.1038/leu.2008.77
31 sg:pub.10.1038/nature02820
32 sg:pub.10.1038/nature07485
33 sg:pub.10.1038/nature08136
34 sg:pub.10.1038/ng.865
35 sg:pub.10.1038/nrc1279
36 sg:pub.10.1038/nrc2876
37 sg:pub.10.1038/nsmb0908-998b
38 sg:pub.10.1038/onc.2009.179
39 sg:pub.10.1186/1471-2121-10-79
40 sg:pub.10.1186/1476-4598-5-38
41 https://doi.org/10.1002/gcc.20457
42 https://doi.org/10.1016/j.ccr.2009.08.018
43 https://doi.org/10.1016/j.ccr.2011.07.005
44 https://doi.org/10.1016/j.cell.2011.02.013
45 https://doi.org/10.1016/s0959-8049(99)00277-4
46 https://doi.org/10.1056/nejmoa1000500
47 https://doi.org/10.1073/pnas.0610279104
48 https://doi.org/10.1073/pnas.68.4.820
49 https://doi.org/10.1091/mbc.e08-12-1224
50 https://doi.org/10.1093/hmg/ddi113
51 https://doi.org/10.1101/gad.1626308
52 https://doi.org/10.1101/gad.1917310
53 https://doi.org/10.1158/0008-5472.can-11-0058
54 https://doi.org/10.1182/blood-2007-07-100115
55 https://doi.org/10.1182/blood-2008-05-158618
56 https://doi.org/10.1182/blood-2009-07-233692
57 https://doi.org/10.1182/blood-2010-03-275180
58 schema:datePublished 2012-01
59 schema:datePublishedReg 2012-01-01
60 schema:description Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known. Here we show that the retinoblastoma genome is stable, but that multiple cancer pathways can be epigenetically deregulated. To identify the mutations that cooperate with RB1 loss, we performed whole-genome sequencing of retinoblastomas. The overall mutational rate was very low; RB1 was the only known cancer gene mutated. We then evaluated the role of RB1 in genome stability and considered non-genetic mechanisms of cancer pathway deregulation. For example, the proto-oncogene SYK is upregulated in retinoblastoma and is required for tumour cell survival. Targeting SYK with a small-molecule inhibitor induced retinoblastoma tumour cell death in vitro and in vivo. Thus, retinoblastomas may develop quickly as a result of the epigenetic deregulation of key cancer pathways as a direct or indirect result of RB1 loss.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N92471a2dbe804a4da9e60b638b46d8ee
65 Nbda5cf3d88294248915b0360091bdac1
66 sg:journal.1018957
67 schema:name A novel retinoblastoma therapy from genomic and epigenetic analyses
68 schema:pagination 329
69 schema:productId N8476bddf87e246cb8908ba1492c4972c
70 Nae85a68f4c9b476e86552fec7b51be6a
71 Nc92b2f091cdc46adaf0a9f33537b8cc9
72 Ncf78b301f7d24d3dbc54c267de537a3d
73 Nf3e5fff69151447eadbf3eaf91f913d0
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006780793
75 https://doi.org/10.1038/nature10733
76 schema:sdDatePublished 2019-04-10T20:03
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N37bbed10a28a4d83a5aafe4eb70b7c09
79 schema:url https://www.nature.com/articles/nature10733
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N00644f829f554f2396b68a59f317d241 rdf:first sg:person.01025334467.64
84 rdf:rest N7583d09e6fec4d6cab7203741b7a2f32
85 N009a334a751a494ab0827400834913d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Molecular Targeted Therapy
87 rdf:type schema:DefinedTerm
88 N07b304e180d346959a63b3098c68bede rdf:first sg:person.01332005337.50
89 rdf:rest Ndbe65a5491e84f73a518a85819af2bf7
90 N0bc9767c0d7e491b8782696701959a41 rdf:first N2a57fa701f6045dfba5c9b2a7fdd1978
91 rdf:rest N61ca00e54e6f4270a2581b1bde147d15
92 N0eb6ae40d4074e12b3aca6fc4298cc31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Protein Kinase Inhibitors
94 rdf:type schema:DefinedTerm
95 N12aa0f069a5d4eb29e5892b42e1159f9 rdf:first sg:person.0723007550.69
96 rdf:rest rdf:nil
97 N13d118193ff64300b966fdf779a51a4c rdf:first sg:person.01263672137.22
98 rdf:rest N07b304e180d346959a63b3098c68bede
99 N1627952a7fc7404eb58c0e660a21d275 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
100 schema:familyName Gupta
101 schema:givenName Pankaj
102 rdf:type schema:Person
103 N18d25b070b5b48e7b1834b1d99e781ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Intracellular Signaling Peptides and Proteins
105 rdf:type schema:DefinedTerm
106 N1fc104df97054c70bd3c233630a8f99b rdf:first sg:person.013021764377.67
107 rdf:rest N456e218966494f87a0278e633e417035
108 N254769dc548241168d29794d97d575cf rdf:first sg:person.0711352500.88
109 rdf:rest N0bc9767c0d7e491b8782696701959a41
110 N2a3d87efbc0c41abb1939c234ee4d0aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Sequence Analysis, DNA
112 rdf:type schema:DefinedTerm
113 N2a57fa701f6045dfba5c9b2a7fdd1978 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
114 schema:familyName Wilson
115 schema:givenName Richard K.
116 rdf:type schema:Person
117 N2b98b983a8c9441f93fbf4d46887b4d3 rdf:first sg:person.01027354037.45
118 rdf:rest N5a6e7c583cd5472098e295ac43a9e943
119 N2c87fd797f2d493aaf674126ad567f44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Epigenesis, Genetic
121 rdf:type schema:DefinedTerm
122 N2e09646be6aa4603b7d041fd89b19e70 rdf:first sg:person.01035342127.27
123 rdf:rest N66f12bf4b1b343ba8fc59314f0e38123
124 N32393c3b7457402984d6078224fd3d28 rdf:first sg:person.01331736326.18
125 rdf:rest N390f33e20b68469cb601f1935030a8f5
126 N357bd946f36249f6b269dfe90f26db77 rdf:first Nf4d94cb73ac24243a01133ad96c3905a
127 rdf:rest N40faf7788f82493398d7d778e43ee34f
128 N37bbed10a28a4d83a5aafe4eb70b7c09 schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N390f33e20b68469cb601f1935030a8f5 rdf:first sg:person.010622267457.44
131 rdf:rest N357bd946f36249f6b269dfe90f26db77
132 N3b7017b2be024cc49976fc9fe84ac04c rdf:first Na7ea1690f5c94c9bb6a6bc77da7f88db
133 rdf:rest N5e9ad374c3aa4793a5935805dd4d4d24
134 N3ce5b50541c546afbada0c8a201ba2b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Chromosomal Instability
136 rdf:type schema:DefinedTerm
137 N40faf7788f82493398d7d778e43ee34f rdf:first sg:person.0621024167.17
138 rdf:rest N254769dc548241168d29794d97d575cf
139 N456bb4ef71c24969a53ad43004424fcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Retinoblastoma Protein
141 rdf:type schema:DefinedTerm
142 N456e218966494f87a0278e633e417035 rdf:first sg:person.01026315253.37
143 rdf:rest Nff2aaccb13994a8b93eb6c464c22c30c
144 N47d98ba0b56c4ea287f6133fa0ed8474 rdf:first sg:person.011367065707.90
145 rdf:rest Na768f43e421244c9bcb9dcf2427cb758
146 N4c9684c2cafa41b381707b7939fb3dda rdf:first sg:person.010365471537.46
147 rdf:rest N13d118193ff64300b966fdf779a51a4c
148 N536957603cac432f9f01a451312266cd rdf:first sg:person.0665717454.53
149 rdf:rest Ne9783e63125b48b5bee0f1002b156209
150 N5a6e7c583cd5472098e295ac43a9e943 rdf:first sg:person.01046257270.67
151 rdf:rest Nb4692c9d8f4a4ca5b7c120c5ce6553d0
152 N5e9ad374c3aa4793a5935805dd4d4d24 rdf:first Nb7e9cc9371e147309301bc2c83d8b308
153 rdf:rest N2b98b983a8c9441f93fbf4d46887b4d3
154 N601e68d0f1794d75b8b4cf5739d90019 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mice
156 rdf:type schema:DefinedTerm
157 N61ca00e54e6f4270a2581b1bde147d15 rdf:first sg:person.0776022700.87
158 rdf:rest N12aa0f069a5d4eb29e5892b42e1159f9
159 N66f12bf4b1b343ba8fc59314f0e38123 rdf:first sg:person.01101330337.31
160 rdf:rest N67f2e249869c4de1a7176e48ce14f3c7
161 N67f2e249869c4de1a7176e48ce14f3c7 rdf:first sg:person.0647562645.17
162 rdf:rest N4c9684c2cafa41b381707b7939fb3dda
163 N74e9748d74164fbb8834bb6cb66f4e70 rdf:first sg:person.015526027337.83
164 rdf:rest Nac154d5a664041aeae1e7ade18a7ef59
165 N7583d09e6fec4d6cab7203741b7a2f32 rdf:first sg:person.012757303467.59
166 rdf:rest N3b7017b2be024cc49976fc9fe84ac04c
167 N766d9f97410b4e28978f013e7c9e41de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Cell Death
169 rdf:type schema:DefinedTerm
170 N786609c8d00b44d99aa4323befcc0231 rdf:first sg:person.011676646405.25
171 rdf:rest N2e09646be6aa4603b7d041fd89b19e70
172 N7a0afbea4a7e457a848571d1f2784144 rdf:first sg:person.01217544003.46
173 rdf:rest N9894f42e05bd4ccbbff451b0ce56d78a
174 N7fdff67c0a4847769afe166bf00921b8 rdf:first sg:person.01253664477.70
175 rdf:rest N74e9748d74164fbb8834bb6cb66f4e70
176 N80fd83c5f9bd4c609f17d2ea508488e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Protein-Tyrosine Kinases
178 rdf:type schema:DefinedTerm
179 N8476bddf87e246cb8908ba1492c4972c schema:name pubmed_id
180 schema:value 22237022
181 rdf:type schema:PropertyValue
182 N8b7adc7be0944e2a926a05a222a48902 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Humans
184 rdf:type schema:DefinedTerm
185 N8ffbb746a7ed4643b56c398e68e760d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Aneuploidy
187 rdf:type schema:DefinedTerm
188 N92471a2dbe804a4da9e60b638b46d8ee schema:issueNumber 7381
189 rdf:type schema:PublicationIssue
190 N9894f42e05bd4ccbbff451b0ce56d78a rdf:first sg:person.0671073025.86
191 rdf:rest N1fc104df97054c70bd3c233630a8f99b
192 N98f4840fa4f74f8f9ab58b4d177124bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Retinoblastoma
194 rdf:type schema:DefinedTerm
195 Na056413c50b34571b6021eaa16667a54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Mutation
197 rdf:type schema:DefinedTerm
198 Na768f43e421244c9bcb9dcf2427cb758 rdf:first sg:person.01071322677.55
199 rdf:rest N536957603cac432f9f01a451312266cd
200 Na7ea1690f5c94c9bb6a6bc77da7f88db schema:affiliation https://www.grid.ac/institutes/grid.240871.8
201 schema:familyName Wang
202 schema:givenName Jianmin
203 rdf:type schema:Person
204 Nac154d5a664041aeae1e7ade18a7ef59 rdf:first sg:person.01214042627.80
205 rdf:rest N00644f829f554f2396b68a59f317d241
206 Nadc023b9fc3444ffaa64500bc4d28520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Syk Kinase
208 rdf:type schema:DefinedTerm
209 Nae85a68f4c9b476e86552fec7b51be6a schema:name nlm_unique_id
210 schema:value 0410462
211 rdf:type schema:PropertyValue
212 Nb4692c9d8f4a4ca5b7c120c5ce6553d0 rdf:first sg:person.01031501027.30
213 rdf:rest Ncaa4050138474e858e461fd5767924c2
214 Nb7e9cc9371e147309301bc2c83d8b308 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
215 schema:familyName Brennan
216 schema:givenName Rachel
217 rdf:type schema:Person
218 Nbda5cf3d88294248915b0360091bdac1 schema:volumeNumber 481
219 rdf:type schema:PublicationVolume
220 Nc92b2f091cdc46adaf0a9f33537b8cc9 schema:name dimensions_id
221 schema:value pub.1006780793
222 rdf:type schema:PropertyValue
223 Ncaa4050138474e858e461fd5767924c2 rdf:first sg:person.0721607077.65
224 rdf:rest N7a0afbea4a7e457a848571d1f2784144
225 Ncf78b301f7d24d3dbc54c267de537a3d schema:name readcube_id
226 schema:value 204c89aca91e05d616fc5802b050b2651c86d10a72c671108bed6c64e6e3e585
227 rdf:type schema:PropertyValue
228 Nd2c7876b81ce457a82937b3e45943533 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Cell Line
230 rdf:type schema:DefinedTerm
231 Nd7ba8e14db6f4f8f93758803fc8a724f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Gene Expression Regulation, Neoplastic
233 rdf:type schema:DefinedTerm
234 Ndbe65a5491e84f73a518a85819af2bf7 rdf:first sg:person.0606401237.66
235 rdf:rest N32393c3b7457402984d6078224fd3d28
236 Nddae66ef80d74655b46f5798212dc0b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Xenograft Model Antitumor Assays
238 rdf:type schema:DefinedTerm
239 Ndfea2898dde54784a6c9ea1510581cb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
240 schema:name Genomics
241 rdf:type schema:DefinedTerm
242 Ne31bffb0afa14888b5c259286547c78f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
243 schema:name Animals
244 rdf:type schema:DefinedTerm
245 Ne8b0e5c5a50f40abbfbe7bc4236f037f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
246 schema:name Cell Survival
247 rdf:type schema:DefinedTerm
248 Ne9783e63125b48b5bee0f1002b156209 rdf:first sg:person.01205551277.47
249 rdf:rest N7fdff67c0a4847769afe166bf00921b8
250 Nf25b866fa9ad457a87f7d1c05834c196 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
251 schema:name Genes, Retinoblastoma
252 rdf:type schema:DefinedTerm
253 Nf3e5fff69151447eadbf3eaf91f913d0 schema:name doi
254 schema:value 10.1038/nature10733
255 rdf:type schema:PropertyValue
256 Nf4d94cb73ac24243a01133ad96c3905a schema:affiliation https://www.grid.ac/institutes/grid.4367.6
257 schema:familyName Mardis
258 schema:givenName Elaine R.
259 rdf:type schema:Person
260 Nff2aaccb13994a8b93eb6c464c22c30c rdf:first N1627952a7fc7404eb58c0e660a21d275
261 rdf:rest N786609c8d00b44d99aa4323befcc0231
262 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
263 schema:name Medical and Health Sciences
264 rdf:type schema:DefinedTerm
265 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
266 schema:name Oncology and Carcinogenesis
267 rdf:type schema:DefinedTerm
268 sg:grant.2438833 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10733
269 rdf:type schema:MonetaryGrant
270 sg:grant.2472060 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10733
271 rdf:type schema:MonetaryGrant
272 sg:grant.2481206 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10733
273 rdf:type schema:MonetaryGrant
274 sg:grant.2507148 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10733
275 rdf:type schema:MonetaryGrant
276 sg:grant.2507638 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10733
277 rdf:type schema:MonetaryGrant
278 sg:grant.2519675 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10733
279 rdf:type schema:MonetaryGrant
280 sg:journal.1018957 schema:issn 0090-0028
281 1476-4687
282 schema:name Nature
283 rdf:type schema:Periodical
284 sg:person.01025334467.64 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
285 schema:familyName Wu
286 schema:givenName Gang
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025334467.64
288 rdf:type schema:Person
289 sg:person.01026315253.37 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
290 schema:familyName Mukatira
291 schema:givenName Suraj
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026315253.37
293 rdf:type schema:Person
294 sg:person.01027354037.45 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
295 schema:familyName Rusch
296 schema:givenName Michael
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027354037.45
298 rdf:type schema:Person
299 sg:person.01031501027.30 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
300 schema:familyName Ma
301 schema:givenName Jing
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031501027.30
303 rdf:type schema:Person
304 sg:person.01035342127.27 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
305 schema:familyName Zhao
306 schema:givenName David
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035342127.27
308 rdf:type schema:Person
309 sg:person.010365471537.46 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
310 schema:familyName Fulton
311 schema:givenName Lucinda L.
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010365471537.46
313 rdf:type schema:Person
314 sg:person.01046257270.67 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
315 schema:familyName Manning
316 schema:givenName Amity L.
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046257270.67
318 rdf:type schema:Person
319 sg:person.010622267457.44 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
320 schema:familyName Dyson
321 schema:givenName Nicholas J.
322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010622267457.44
323 rdf:type schema:Person
324 sg:person.01071322677.55 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
325 schema:familyName Benavente
326 schema:givenName Claudia A.
327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071322677.55
328 rdf:type schema:Person
329 sg:person.01101330337.31 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
330 schema:familyName Lu
331 schema:givenName Charles
332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101330337.31
333 rdf:type schema:Person
334 sg:person.011367065707.90 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
335 schema:familyName Zhang
336 schema:givenName Jinghui
337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011367065707.90
338 rdf:type schema:Person
339 sg:person.011676646405.25 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
340 schema:familyName Neale
341 schema:givenName Geoff
342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011676646405.25
343 rdf:type schema:Person
344 sg:person.01205551277.47 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
345 schema:familyName Flores-Otero
346 schema:givenName Jacqueline
347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205551277.47
348 rdf:type schema:Person
349 sg:person.01214042627.80 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
350 schema:familyName Ulyanov
351 schema:givenName Anatoly
352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214042627.80
353 rdf:type schema:Person
354 sg:person.01217544003.46 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
355 schema:familyName Shurtleff
356 schema:givenName Sheila
357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217544003.46
358 rdf:type schema:Person
359 sg:person.01253664477.70 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
360 schema:familyName Ding
361 schema:givenName Li
362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253664477.70
363 rdf:type schema:Person
364 sg:person.01263672137.22 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
365 schema:familyName Hong
366 schema:givenName Xin
367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263672137.22
368 rdf:type schema:Person
369 sg:person.012757303467.59 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
370 schema:familyName Wilson
371 schema:givenName Matthew
372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012757303467.59
373 rdf:type schema:Person
374 sg:person.013021764377.67 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
375 schema:familyName Pounds
376 schema:givenName Stanley
377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013021764377.67
378 rdf:type schema:Person
379 sg:person.01331736326.18 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
380 schema:familyName Naeve
381 schema:givenName Clayton
382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331736326.18
383 rdf:type schema:Person
384 sg:person.01332005337.50 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
385 schema:familyName Dooling
386 schema:givenName David J.
387 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332005337.50
388 rdf:type schema:Person
389 sg:person.015526027337.83 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
390 schema:familyName Chen
391 schema:givenName Xiang
392 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015526027337.83
393 rdf:type schema:Person
394 sg:person.0606401237.66 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
395 schema:familyName Ochoa
396 schema:givenName Kerri
397 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606401237.66
398 rdf:type schema:Person
399 sg:person.0621024167.17 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
400 schema:familyName Bahrami
401 schema:givenName Armita
402 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621024167.17
403 rdf:type schema:Person
404 sg:person.0647562645.17 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
405 schema:familyName Fulton
406 schema:givenName Robert S.
407 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647562645.17
408 rdf:type schema:Person
409 sg:person.0665717454.53 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
410 schema:familyName McEvoy
411 schema:givenName Justina
412 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665717454.53
413 rdf:type schema:Person
414 sg:person.0671073025.86 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
415 schema:familyName Mullighan
416 schema:givenName Charles
417 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671073025.86
418 rdf:type schema:Person
419 sg:person.0711352500.88 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
420 schema:familyName Ellison
421 schema:givenName David
422 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711352500.88
423 rdf:type schema:Person
424 sg:person.0721607077.65 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
425 schema:familyName Easton
426 schema:givenName John
427 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721607077.65
428 rdf:type schema:Person
429 sg:person.0723007550.69 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
430 schema:familyName Dyer
431 schema:givenName Michael A.
432 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723007550.69
433 rdf:type schema:Person
434 sg:person.0776022700.87 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
435 schema:familyName Downing
436 schema:givenName James R.
437 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776022700.87
438 rdf:type schema:Person
439 sg:pub.10.1007/bf00295364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032218263
440 https://doi.org/10.1007/bf00295364
441 rdf:type schema:CreativeWork
442 sg:pub.10.1038/323643a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033717519
443 https://doi.org/10.1038/323643a0
444 rdf:type schema:CreativeWork
445 sg:pub.10.1038/5947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033054502
446 https://doi.org/10.1038/5947
447 rdf:type schema:CreativeWork
448 sg:pub.10.1038/leu.2008.346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030591731
449 https://doi.org/10.1038/leu.2008.346
450 rdf:type schema:CreativeWork
451 sg:pub.10.1038/leu.2008.77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030817785
452 https://doi.org/10.1038/leu.2008.77
453 rdf:type schema:CreativeWork
454 sg:pub.10.1038/nature02820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010008721
455 https://doi.org/10.1038/nature02820
456 rdf:type schema:CreativeWork
457 sg:pub.10.1038/nature07485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034796960
458 https://doi.org/10.1038/nature07485
459 rdf:type schema:CreativeWork
460 sg:pub.10.1038/nature08136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014745794
461 https://doi.org/10.1038/nature08136
462 rdf:type schema:CreativeWork
463 sg:pub.10.1038/ng.865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024822529
464 https://doi.org/10.1038/ng.865
465 rdf:type schema:CreativeWork
466 sg:pub.10.1038/nrc1279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009116910
467 https://doi.org/10.1038/nrc1279
468 rdf:type schema:CreativeWork
469 sg:pub.10.1038/nrc2876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013013054
470 https://doi.org/10.1038/nrc2876
471 rdf:type schema:CreativeWork
472 sg:pub.10.1038/nsmb0908-998b schema:sameAs https://app.dimensions.ai/details/publication/pub.1023653221
473 https://doi.org/10.1038/nsmb0908-998b
474 rdf:type schema:CreativeWork
475 sg:pub.10.1038/onc.2009.179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011040031
476 https://doi.org/10.1038/onc.2009.179
477 rdf:type schema:CreativeWork
478 sg:pub.10.1186/1471-2121-10-79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048818606
479 https://doi.org/10.1186/1471-2121-10-79
480 rdf:type schema:CreativeWork
481 sg:pub.10.1186/1476-4598-5-38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045801155
482 https://doi.org/10.1186/1476-4598-5-38
483 rdf:type schema:CreativeWork
484 https://doi.org/10.1002/gcc.20457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039294726
485 rdf:type schema:CreativeWork
486 https://doi.org/10.1016/j.ccr.2009.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015786715
487 rdf:type schema:CreativeWork
488 https://doi.org/10.1016/j.ccr.2011.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032090698
489 rdf:type schema:CreativeWork
490 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
491 rdf:type schema:CreativeWork
492 https://doi.org/10.1016/s0959-8049(99)00277-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013830529
493 rdf:type schema:CreativeWork
494 https://doi.org/10.1056/nejmoa1000500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000710446
495 rdf:type schema:CreativeWork
496 https://doi.org/10.1073/pnas.0610279104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029669389
497 rdf:type schema:CreativeWork
498 https://doi.org/10.1073/pnas.68.4.820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043776590
499 rdf:type schema:CreativeWork
500 https://doi.org/10.1091/mbc.e08-12-1224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023768792
501 rdf:type schema:CreativeWork
502 https://doi.org/10.1093/hmg/ddi113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032163609
503 rdf:type schema:CreativeWork
504 https://doi.org/10.1101/gad.1626308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021728790
505 rdf:type schema:CreativeWork
506 https://doi.org/10.1101/gad.1917310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039001842
507 rdf:type schema:CreativeWork
508 https://doi.org/10.1158/0008-5472.can-11-0058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011054559
509 rdf:type schema:CreativeWork
510 https://doi.org/10.1182/blood-2007-07-100115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021248381
511 rdf:type schema:CreativeWork
512 https://doi.org/10.1182/blood-2008-05-158618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002228366
513 rdf:type schema:CreativeWork
514 https://doi.org/10.1182/blood-2009-07-233692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014660259
515 rdf:type schema:CreativeWork
516 https://doi.org/10.1182/blood-2010-03-275180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016446577
517 rdf:type schema:CreativeWork
518 https://www.grid.ac/institutes/grid.240871.8 schema:alternateName St. Jude Children's Research Hospital
519 schema:name Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
520 Department of Computational Biology and Bioinformatics, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
521 Department of Developmental Neurobiology, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
522 Department of Information Sciences, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
523 Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
524 Department of Pathology, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
525 Department of Surgery, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
526 Hartwell Center for Biotechnology & Bioinformatics, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
527 rdf:type schema:Organization
528 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
529 schema:name Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
530 rdf:type schema:Organization
531 https://www.grid.ac/institutes/grid.413575.1 schema:alternateName Howard Hughes Medical Institute
532 schema:name Department of Developmental Neurobiology, St Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA
533 Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
534 Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
535 rdf:type schema:Organization
536 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
537 schema:name Department of Genetics, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA
538 Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA
539 Siteman Cancer Center, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA
540 The Genome Institute, Washington University School of Medicine in St Louis, St Louis, Missouri 63108, USA
541 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...